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GET /v1/research/project/?format=api&offset=1860&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1880&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1840&ordering=-end_effective", "results": [ { "id": 2309, "title": { "de": "TRPA1 als Biomarker für Chemikalienunverträglichkeit", "en": "TRPA1 as biomarker of multiple chemical sensitivity" }, "short": "TRPA_BIOMARKER_CHEMIKALIEN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2010-09-22T18:13:45+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51529, "contact": 51529, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2309-51529-10" ] }, { "id": 2257, "title": { "de": "Einfluss unterschiedlicher Lichtspektren am Arbeitsplatz auf Physiologie und circadiane Rhythmik", "en": "Physiological and circadian effects of light in the work-place" }, "short": "Wirkung von Licht am Arbeitsplatz", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-08-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2010-07-29T12:08:13+02:00", "program": 79, "subprogram": "Interdisziplinäre Humanmedizin", "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 51671, "contact": 51671, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "13891", "ethics_committee": null, "edudract_number": null, "persons": [ "2257-51671-10" ] }, { "id": 2765, "title": { "de": "Nanopartikel-Chancen und Risiken einer neuen Dimension", "en": "Nanoparticles- chances and risks of a new dimension " }, "short": "NANOPARTICLES CHANCES AND RISKS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-08-01T02:00:00+02:00", "begin_effective": "2010-08-01T02:00:00+02:00", "end_planned": "2012-07-30T02:00:00+02:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2012-01-23T16:27:35+01:00", "program": 58, "subprogram": null, "organization": 17230, "category": 10, "type": 10, "partner_function": 2, "manager": 53900, "contact": 53900, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2765-53900-10" ] }, { "id": 1434, "title": { "de": "Analyse der Virulenzmechanismen von Campylobacter fetus", "en": "Comparative Analysis of Campylobacter fetus virulence mechanisms" }, "short": "VIRULENZ_CAMPYLOBACTER_FETUS", "url": null, "abstract": { "de": "Das Gram-negative Bakterium Campylobacter fetus ist ein veterinärmedizinisch bedeutendes Pathogen, welches vor allem in der Rinderzucht durch das Verursachen epidemischer Aborte und Unfruchtbarkeit beträchtliche wirtschaftliche Schäden verursacht. Weiters ist es ein humanmedizinisch signifikanter Sepsiserreger, welcher besonders immunsupprimierte Patienten gefährdet. Bisher ist über die Virulenzmechanismen dieses Erregers, seine Infektionsstrategien und seine Interaktion mit Wirtszellen wenig bekannt. C. fetus wird durch zwei Subspecies repräsentiert, C. fetus subsp. fetus und C. fetus subsp. venerealis, welche sich genetisch nur geringfügig unterscheiden, andererseits aber eine äußerst unterschiedliche Wirtsspezifität besitzen. Daher stellt C. fetus ein exzellentes Model zur Erforschung der molekularen Determinanten von Wirtsspezifität und der Interaktion des Bakteriums mit seinen Wirtszellen dar. In einem Genomvergleich identifizierten wir Subspecies-spezifische genetische Elemente die mit großer Wahrscheinlichkeit Virulenzfaktoren darstellen. Darunter einen Typ IV Transportsystem (type IV secretion system) welcher typischerweise von Bakterien zum Export von Virulenzfaktoren (z. B. Toxine) in die Wirtszelle verwendet wird. Weiters ein Enzym welches für die Lipopolysaccharidbiosynthese verantwortlich ist und damit direkt die Eigenschaften der bakteriellen Zellwand beeinflusst. Unser Forschungsvorhaben untersucht die Beteiligung Subspezies-spezifischer Gene zum Wirtstropismus und zur Pathogenität von C. fetus. Es ist notwendig eine genaue Kenntnis des natürlichen Bildes einer C. fetus Infektion zu bekommen. Zu diesem Zweck werden histopathologische Untersuchungen von infiziertem Gewebe aus der Veterinärmedizin durchgeführt. Weiters wird mittels hochauflösender mikroskopischer Verfahren (Elektronenmikroskopie, Konfokale Laser-Scanning Mikroskopie) die Bakterien-Wirtszellinteraktion visualisiert. Mit dieser Information werden Zellkultur-basierte in-vitro-Infektionsmodelle entwickelt um die Beteiligung der Virulenzgene an spezifischen Phasen des Infektionsgeschehens wie zelluläre Adhärenz, Wirtszellinvasion aber auch die Reaktion der infizierten Zelle (z. B. Chemokinsekretion) zu untersuchen. Dazu werden mittels von uns entwickelter Verfahren diese Virulenzgene genetisch inaktiviert und in den in-vitro-Infektionsmodellen getestet. Diese Studie wird detaillierte Einsichten in die Funktion der Virulenzgene und ihren Beitrag zum Wirtstropismus von C. fetus liefern und damit die molekulare Basis der C. fetus Pathogenität besser definieren.", "en": "The bacterial species Campylobacter fetus is a significant animal pathogen, causing epidemic abortion and infertility in cattle. It is also an important human pathogen causing septicaemia, putting predominantly immunocompromised people at risk. Very little is understood about C. fetus virulence mechanisms and the interaction with its hosts. C. fetus consists of two subspecies, C. fetus subsp. fetus und C. fetus subsp. venerealis, which are extraordinarily closely related on the genetic level but exhibit striking differences in tissue and host specificity. Comparative analysis of these subspecies thus provides an excellent model to understand the molecular nature of this pathogens host and tissue tropism and to elucidate the molecular interactions with its host cells. We have compared the genomes of the subspecies and identified genome segments unique to each with a putative role in pathogenicity. These include a type IV macromolecular transport system (T4SS) typically involved in secretion of bacterial virulence proteins to eukaryotic host cells, and an enzyme linking LPS biosynthesis and structure to environmental cues. This research aims to determine the contribution of specific genes to the host tropism and virulence of C. fetus subspecies. To do so we require much more detailed understanding of the natural appearance of the C. fetus infection process. We propose a thorough histopathological analysis of infected tissues derived from the veterinary field. Insights gained here will be enhanced by fine resolution of host-pathogen interactions on the cellular level. C.fetus susceptible in vitro models of cultured animal and human cells will be developed to assess the functional contribution of putative virulence genes to stages of the C. fetus infection process. Techniques developed in this project should differentiate involvement of the virulence genes in bacterial adherence, cellular entry, proinflammatory activation of host cells, chemokine secretion and cytotoxicity. The important applications of these models will be not only to compare the divergent virulence properties of the C. fetus subspecies but to evaluate phenotypic differences in host-pathogen interactions following mutagenesis of putative virulence genes. We have established a new series of genetics tools for this organism which enable us to perform mutational analyses readily. These studies will provide much clearer insights into the function of specific genes in determining host preference and the molecular basis of C. fetus pathogenicity." }, "begin_planned": "2008-01-01T01:00:00+01:00", "begin_effective": "2008-02-01T01:00:00+01:00", "end_planned": "2010-12-31T01:00:00+01:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2008-01-03T16:38:23+01:00", "program": 72, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 50496, "contact": 50496, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P20479", "ethics_committee": null, "edudract_number": null, "persons": [ "1434-50496-10" ] }, { "id": 4261, "title": { "de": "TRPC\u2029 modulation \u2029by \u2029PKG\u2029 and \u2029Muscular \u2029Dystrophy", "en": "TRPC\u2029 modulation \u2029by \u2029PKG\u2029 and \u2029Muscular \u2029Dystrophy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2016-02-01T10:37:22+01:00", "program": 101, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 58906, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4261-58906-10" ] }, { "id": 1908, "title": { "de": "GATiB II - Subprojekt 1", "en": "GATiB II - Subproject 1" }, "short": "GATiB II - Subprojekt 1", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-05-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2009-09-03T17:01:48+02:00", "program": 73, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1908-51663-10" ] }, { "id": 2534, "title": { "de": "Bipolar affektive Erkrankung und Schwangerschaft, Geburt und Postpartum", "en": "Bipolar affective disorder in pregnancy and postpartum period" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-09-30T02:00:00+02:00", "assignment": "2011-07-15T14:17:12+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 50654, "contact": 50654, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2534-50654-10" ] }, { "id": 3202, "title": { "de": "Validierung des p62 transgenen Mausmodells für die Etablierung eines neuen Modells für das humane Hepatozelluläre Karzinom", "en": "Validation of the p62 transgenic mouse model for the establishment of a new model for human hepatocellular carcinoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-09-24T02:00:00+02:00", "begin_effective": "2012-12-23T01:00:00+01:00", "end_planned": "2012-12-23T01:00:00+01:00", "end_effective": "2012-09-24T02:00:00+02:00", "assignment": "2013-03-04T13:22:45+01:00", "program": 103, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 201 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2619, "title": { "de": "Etablierung des sogenannten Sector Ploidy Profilings zur Erforschung der intra-tumoralen Heterogenität in Prostatakarzinomen", "en": "Establishment of Sector Ploidy Profiling to elucidate intratumoral heterogeneity" }, "short": "SPP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-11-01T01:00:00+01:00", "begin_effective": "2011-11-01T01:00:00+01:00", "end_planned": "2012-10-31T01:00:00+01:00", "end_effective": "2012-08-31T02:00:00+02:00", "assignment": "2011-10-20T15:02:04+02:00", "program": null, "subprogram": "Land Steiermark A3", "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 50899, "contact": 50899, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2619-50899-10" ] }, { "id": 2334, "title": { "de": "Das Polycystische Ovar Syndrom - ein \"Frauenproblem\" über Generationen", "en": "Das Polycystische Ovar Syndrom - ein \"Frauenproblem\" über Generationen" }, "short": "FEMbart", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-09-01T02:00:00+02:00", "end_planned": "2012-08-31T02:00:00+02:00", "end_effective": "2012-08-31T02:00:00+02:00", "assignment": "2010-11-09T10:11:51+01:00", "program": 96, "subprogram": "FTI Projekte", "organization": 14080, "category": 10, "type": 10, "partner_function": 3, "manager": 51809, "contact": 51809, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2334-85701-12", "2334-51809-10" ] }, { "id": 2554, "title": { "de": "Veränderungen der intrazellulären Kalzium-Speicher in Spinalganglienneuronen von Ratten ohne hyperalgetischem Verhaltensmuster nach Nervenläsion.", "en": "Intracellular calcium store alterations in dorsal root ganglion neurons from non-hyperalgesic rats after peripheral nerve injury." }, "short": "Calcium store alterations ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2011-08-01T02:00:00+02:00", "end_planned": "2011-08-31T02:00:00+02:00", "end_effective": "2012-07-31T02:00:00+02:00", "assignment": "2011-08-18T16:47:42+02:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 50869, "contact": 50869, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2554-50869-10", "2554-71082-12" ] }, { "id": 2008, "title": { "de": "Ganganalysen bei Kindern mit Morbus Perthes", "en": "Ganganalysen bei Kindern mit Morbus Perthes" }, "short": "Morbus Perthes", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-04-01T02:00:00+02:00", "begin_effective": "2009-04-01T02:00:00+02:00", "end_planned": "2009-08-31T02:00:00+02:00", "end_effective": "2012-07-31T02:00:00+02:00", "assignment": "2009-12-04T11:57:57+01:00", "program": null, "subprogram": "Land Steiermark Abteilung 3", "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 65038, "contact": 65038, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2008-65038-10" ] }, { "id": 3007, "title": { "de": "Dynamik von CaV1.2 Kalziumkanälen in neuronaler Modulation", "en": "Dynamik von CaV1.2 Kalziumkanälen in neuronaler Modulation" }, "short": "T443 ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-08-01T02:00:00+02:00", "begin_effective": "2009-08-01T02:00:00+02:00", "end_planned": "2012-07-31T02:00:00+02:00", "end_effective": "2012-07-31T02:00:00+02:00", "assignment": null, "program": 86, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "T443", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2028, "title": { "de": "Characterization of breast cancer stem cells and their responsiveness to osteoporose treatment", "en": "Characterization of breast cancer stem cells and their responsiveness to osteoporose treatment" }, "short": "BREAST CANCER STEM CELLS_OSTEO_TREAT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-02-01T01:00:00+01:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2012-01-31T01:00:00+01:00", "end_effective": "2012-07-31T02:00:00+02:00", "assignment": "2009-12-22T15:26:56+01:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51063, "contact": 51063, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2028-51063-10" ] }, { "id": 2789, "title": { "de": "Charakterisierung der pro-apoptotischen Wirkung des alpha1-adrenergen Antagonisten Prazosin auf humane Tumorzellen", "en": "Characterization of the pro-apoptotic action of the alpha1-adrenergic antagonist prazosin on malignant cells." }, "short": "Prazosin induzierte Apoptose", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-07-01T02:00:00+02:00", "end_planned": "2012-07-01T02:00:00+02:00", "end_effective": "2012-07-01T02:00:00+02:00", "assignment": "2012-02-15T09:37:16+01:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2099, "title": { "de": "Funktionelle MRT zur Charakterisierung der neuralen Korrelate des Multi-Tasking unter besonderer Berücksichtigung geschlechtsbezogener Unterschiede", "en": "A functional MRI study probing sex-related effects in multi tasking" }, "short": "Funktionelle MRT ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-02-01T01:00:00+01:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2011-01-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-02-09T14:28:20+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 59566, "contact": 59566, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2099-59566-10" ] }, { "id": 2039, "title": { "de": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes", "en": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes" }, "short": "WILMS TUMOR NEPHROGENESIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-02-01T01:00:00+01:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2012-01-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-01-18T10:41:24+01:00", "program": 79, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": 52569, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2039-52569-10" ] }, { "id": 2641, "title": { "de": "Einfluss von Empfänger- und Spender-Cytochrom P450 3A5 Genotypen auf die Pharmakokinetik von Tacrolimus bei PatientInnen nach Lebertransplantation", "en": "Einfluss von Empfänger- und Spender-Cytochrom P450 3A5 Genotypen auf die Pharmakokinetik von Tacrolimus bei PatientInnen nach Lebertransplantation" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-11-01T01:00:00+01:00", "end_planned": "2013-10-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-11-18T13:45:47+01:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 58323, "contact": 58323, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2641-58323-10" ] }, { "id": 2620, "title": { "de": "Etablierung des Mutationsspektrums in zirkulierenden Tumorzellen von Patienntinnen und Patienten mit Mamma- oder Prostatakarzinomen _ONCOTYROL", "en": "Establishment of the mutation spectrum in circulating tumor cells of patients with breast and prostate cancer" }, "short": "ONCOTYROL", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-09-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-28T13:07:04+02:00", "program": 94, "subprogram": "Das K1 Zentrum ONCOTYROL - Center for Personalized Cancer Medicine ist im Rahmen des vom BMWA und BMVIT initiierten Strukturprogramms COMET in Zusammenarbeit mit\r\n\r\n * Land Tirol\r\n * Land Steiermark (Abteilung 3, Abteilung 14 und Wirtschaftsressort)\r\n * Steirische Wirtschaftsförderung\r\n * den drei regionalen Universitäten und der Industrie geschaffen worden.", "organization": 14021, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 416, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2363, "title": { "de": "Detektion der BRAF V600E Mutation in Lentigo Maligna Melanoma", "en": "Detection of the BRAF V600E mutation in Lentigo Maligna Melanoma lesions" }, "short": "BRAF V600E", "url": null, "abstract": { "de": "Das maligne Melanom (MM) gilt als eine der aggressivsten Formen von Hautkrebs mit einer hohen\r\nSterblichkeitsrate und oftmals inadäquaten Therapiemöglichkeiten, insbesondere bei\r\nMetastasierung. Die Voraussetzungen für die Gabe neuer, vielversprechender Therapien sind die\r\npräzise Diagnose und das Wissen über den Mutationsstatus des Tumors.\r\nDie Diagnose der Lentigo maligna melanoma (LMM), einer Sonderform des MM, wird durch klinische\r\nund histopathologische Ähnlichkeiten mit pigmentierter aktinischer Keratose (in situ\r\nPlattenepithelkarzinom) und solarer Lentigo (einfacher Pigmentfleck oder Altersfleck) erschwert.\r\nÜber den genetischen Charakter von LMM (insbesondere hinsichtlich BRAF), aber auch solarer\r\nLentigo ist bisher nur wenig bekannt.\r\nDie BRAF V600E Mutation ist das am häufigsten detektierte onkologische Ereignis beim MM. In der\r\nvorliegenden Studie wird der Mutationsstatus von BRAF V600E in einem genau charakterisierten\r\nKollektiv aus FFPE LMM Gewebeproben analysiert. Dazu werden drei verschiedene, auf PCR\r\nbasierende, Methoden zur Mutationsanalyse optimiert und validiert. Die BRAF V600E\r\nMutationshäufigkeit wird in einem großem LMM Kollektiv bestimmt und ihre diagnostische und\r\nklinische Relevanz durch den Vergleich mit dem Mutationsstatus bei aktinischer Keratose und solarer\r\nLentigo evaluiert. Die Ergebnisse dieser Studie sollen zur Verbesserung der Diagnostik und\r\nDifferenzialdiagnostik und auch der Therapie des MM beitragen.", "en": "Malignant melanoma (MM) is considered the most aggressive form of skin cancers with a high\r\nmortality and often ineffective treatment, especially for metastasis. Prerequisites for the application\r\nof new and promising therapies are the precise diagnosis and the knowledge of the mutational status\r\nof the tumor.\r\nDiagnosis of Lentigo maligna melanoma (LMM), a special form of MM, is complicated since\r\npigmented actinic keratosis (in situ squamous cell carcinoma) and solar lentigo (senile freckle) can\r\nresemble LMM clinically and histopathologically. Only few data is available concerning the genetic\r\ncharacter of both LMM and solar lentigo (especially regarding BRAF).\r\nThe BRAF V600E mutation is the most frequent oncogenic event detected in MM. The study at hand\r\nwill analyze the BRAF V600E mutational status in a well characterized collective of FFPE LMM tissue\r\nsamples. For this purpose we will optimize and validate three different PCR based methods for\r\nmutational analysis. The incidence of the BRAF V600E mutation will be determined in a large LMM\r\ncollective and the diagnostic and clinical relevance of mutated BRAF will be evaluated by comparison\r\nwith that in pigmented actinic keratosis and solar lentigo. The results of this study should help to\r\nimprove the diagnostics means and contribute to advance therapy options of MM." }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-12-16T11:07:50+01:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": null, "manager": 50563, "contact": 50563, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2363-50229-12", "2363-50563-10", "2363-51066-12", "2363-51618-11" ] } ] }