Project List
List projects.
Fields
id (integer)
Primary key.
Expansions
To activate relation expansion add the desired fields as a comma separated
list to the expand query parameter like this:
?expand=<field>,<field>,<field>,...
The following relational fields can be expanded:
organizationcategorytypepartner_functionmanagercontactstatusgrantresearcheventstudylanguageprogramfunders
Filters
To filter for exact value matches:
?<fieldname>=<value>
Possible exact filters:
organizationcategorymanagercontactstatusgrantresearchstudylanguagefundersprogram
For advanced filtering use lookups:
?<fieldname>__<lookup>=<value>
All fields with advanced lookups can also be used for exact value matches as described above.
Possible advanced lookups:
begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=1840&ordering=-end_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1860&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1820&ordering=-end_effective", "results": [ { "id": 1720, "title": { "de": "GATIB II, Genome Austria Tissue Bank (GEN-AU III)", "en": "GATIB II, Genome Austria Tissue Bank (GEN-AU III)" }, "short": "GATIB II_GENAU_III_Trauner", "url": null, "abstract": { "de": "Biobanken für die biomedizinische Forschung sind Sammlungen von biologischem Material (Gewebe, Zellen, Blut, Körperflüssigkeiten, inklusive der daraus isolierten Biomoleküle) und den zugehörigen Daten über den Probendonor. Diese biologischen Materialien enthalten wertvolle Informationen über genetische und nicht-genetische Krankheitsursachen und über Faktoren, die den Krankheitsverlauf beeinflussen. Aufgrund dieser Relevanz sehen mehrere internationale Organisationen biologische Materialien als essentielle Rohmaterialien, um den Fortschritt in Biotechnologie und Gesundheitswesen voranzutreiben.\r\nGATiB basiert auf einem einzigartigen Pathologiearchiv an der Medizinischen Universität Graz und enthält über 3 Millionen Proben von 800.000 Patienten, die nahezu alle Krankheiten einer mitteleuropäischen Bevölkerung in der natürlichen Häufigkeit abbilden.\r\n\r\nGEN-AU I förderte die Umwandlung dieses Archivs in eine Biobank (GATiB)\r\nSchwerpunkt in GEN-AU II war die Erhöhung des wissenschaftlichen Wertes und des Nutzens der 3 Millionen archivierter Proben durch halbautomatische Annotation der Proben mit medizinischen Daten und Patienten-Überlebensdaten.\r\nIn GEN-AU III wird GATiB II den Schwerpunkt auf die prospektive Sammlung von Proben und Daten, sowie internationale Integration legen. Es ist eine Probensammlung geplant, deren Design spezifisch die Forschung an metabolischen Erkrankungen unterstützt - eine anerkannte Stärke der Forschung an der Medizinischen Universität und den anderen Grazer Universitäten. Dies erfordert die Entwicklung verbesserter Gefrierkonservierungs- und Gefrierlagermethoden für Gewebe um das Potenzial moderner metabolomischer Analysemethoden optimal ausnützen zu können.", "en": "Biobanken für die biomedizinische Forschung sind Sammlungen von biologischem Material (Gewebe, Zellen, Blut, Körperflüssigkeiten, inklusive der daraus isolierten Biomoleküle) und den zugehörigen Daten über den Probendonor. Diese biologischen Materialien enthalten wertvolle Informationen über genetische und nicht-genetische Krankheitsursachen und über Faktoren, die den Krankheitsverlauf beeinflussen. Aufgrund dieser Relevanz sehen mehrere internationale Organisationen biologische Materialien als essentielle Rohmaterialien, um den Fortschritt in Biotechnologie und Gesundheitswesen voranzutreiben.\r\nGATiB basiert auf einem einzigartigen Pathologiearchiv an der Medizinischen Universität Graz und enthält über 3 Millionen Proben von 800.000 Patienten, die nahezu alle Krankheiten einer mitteleuropäischen Bevölkerung in der natürlichen Häufigkeit abbilden.\r\n\r\nGEN-AU I förderte die Umwandlung dieses Archivs in eine Biobank (GATiB)\r\nSchwerpunkt in GEN-AU II war die Erhöhung des wissenschaftlichen Wertes und des Nutzens der 3 Millionen archivierter Proben durch halbautomatische Annotation der Proben mit medizinischen Daten und Patienten-Überlebensdaten.\r\nIn GEN-AU III wird GATiB II den Schwerpunkt auf die prospektive Sammlung von Proben und Daten, sowie internationale Integration legen. Es ist eine Probensammlung geplant, deren Design spezifisch die Forschung an metabolischen Erkrankungen unterstützt - eine anerkannte Stärke der Forschung an der Medizinischen Universität und den anderen Grazer Universitäten. Dies erfordert die Entwicklung verbesserter Gefrierkonservierungs- und Gefrierlagermethoden für Gewebe um das Potenzial moderner metabolomischer Analysemethoden optimal ausnützen zu können." }, "begin_planned": "2009-05-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2009-01-15T10:32:33+01:00", "program": 73, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2039, "title": { "de": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes", "en": "Wilms Tumor Development as a Mirror of Nephrogenesis - The Role of Imprinted Genes" }, "short": "WILMS TUMOR NEPHROGENESIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-02-01T01:00:00+01:00", "begin_effective": "2010-02-01T01:00:00+01:00", "end_planned": "2012-01-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2010-01-18T10:41:24+01:00", "program": 79, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 52569, "contact": 52569, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2039-52569-10" ] }, { "id": 2872, "title": { "de": "Chordom - Charakterisierung der MUG-Chor1 Zelllinie", "en": "Chordoma - Characterizing MUG-Chor1 cell line" }, "short": "Chordoma", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2012-05-24T12:00:53+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": 54171, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2872-54171-10" ] }, { "id": 2614, "title": { "de": "Mechanismen der Kalzium-getriggerten Arrhythmien", "en": "Mechanisms of Ca2+-triggered arrhythmias" }, "short": "Buchkapitel", "url": null, "abstract": { "de": null, "en": "Calcium (Ca2+) - the simplest and most versatile intracellular messenger - couples an action potential with the contraction in cardiac myocytes. Abnormal changes in intracellular Ca2+ homeostasis may cause contractile dysfunction, subcellular Ca2+ alternans and oscillations of the myocyte membrane potential, such as early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs), both of which may evoke a number of triggered arrhythmias that cause sudden cardiac death. EAD occurs during excessive action potential prolongation mainly due to the reactivation of L-type Ca2+ channels. DAD, on the other hand, typically results from the increased diastolic SR Ca2+ release, which is caused by either defective regulation of the sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR2), increased SR Ca2+ load or a combination of both. Sufficient cytosolic Ca2+ elevation propagates along myocytes as Ca2+ waves, which may activate an arrhythmogenic depolarizing current largely carried by inward Na+/Ca2+ exchanger. DADs need to reach threshold potential for voltage-gated Na+ channels to evoke premature beats (ectopic activity). Ca2+-dependent triggered arrhythmias occur both in acquired (e.g. heart failure, atrial fibrillation) and in congenital cardiac diseases (e.g. cathecholaminergic polymorphic ventricular tachycardia, CPVT). CPVT is an inherited arrhythmia syndrome associated with mutations in either RyR2 or calsequestrin, SR Ca2+-binding protein. Both mutations destabilize the RyR2 Ca2+ release complex implying increased diastolic SR Ca2+ leak through RyR2 in the presence of beta-adrenergic stimulation (e.g. physical exercise or emotional stress). Several mechanisms underlying the increased diastolic Ca2+ leak in heart failure and CPVT have been proposed, including excessive RyR2 phosphorylation, altered Ca2+ sensitivity of the RyR2 at luminal or cytosolic sites, weaker interdomain interaction and lower threshold for store-overload-induced Ca2+ release. A better understanding of the similarities and differences between the mechanisms underlying triggered arrhythmias in acquired and inherited cardiac diseases, holds the promise to develop new specific diagnostic and therapeutic approaches for effective treatment of defective ion handling in these lethal arrhythmias. \r\nThis chapter will review common mechanisms that cause the susceptibility to, and initiation of, Ca2+-dependent arrhythmias with a focus on increased SR Ca2+ release due to congenital or acquired RyR2 dysfunction and increased SR Ca2+ load. Finally, RyR2 stabilizers (e.g. JTV-519, flecainide, dantrolene) and RyR2 phosphorylation inhibitors (e.g. CaMKII inhibitors) as novel therapeutic targets will be discussed. \t\t\r\n" }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2011-10-15T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-14T16:07:01+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 60041, "contact": 60041, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2614-60041-10" ] }, { "id": 2985, "title": { "de": "Grazer Studie über die hormonellen Ursachen des arteriellen Bluthochdruckes (GECOH Studie)", "en": "Graz Endocrine Causes of Hypertension (GECOH) Study" }, "short": "GECOH Study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-03-01T01:00:00+01:00", "end_planned": "2012-06-01T02:00:00+02:00", "end_effective": "2012-06-01T02:00:00+02:00", "assignment": "2012-09-24T12:56:43+02:00", "program": null, "subprogram": "Land Steiermark: Förderung wissenschaftlicher (Forschungs)Projekte", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 53344, "contact": 53344, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2985-53344-10" ] }, { "id": 2104, "title": { "de": "Refining the basophil activation test (BAT) for the diagnosis of Hymenoptera venom allergy", "en": "Refining the basophil activation test (BAT) for the diagnosis of Hymenoptera venom allergy" }, "short": "BAT_09", "url": null, "abstract": { "de": "Weiterentwicklung des Basophilen-Aktivierungstests (BAT) für die Diagnostik der Insektengiftallergie\r\n\r\nZur Routinediagnostik einer Insektengiftallergie gehören Anamnese, Hauttests und die Bestimmung spezifischer IgE Antikörper im Serum. Leider führen diese Verfahren manchmal zu inkonkulsiven Ergebnissen. In den letzten Jahren hat sich der Basophilenaktivierungstest (BAT) als nützliche zusätzliche Methode bewährt. Ein Nachteil des BAT ist jedoch, dass durch den Grad der Zellaktivierung im Test sich kein Rückschluss auf den Schweregrad der allergischen Reaktion ziehen lässt. Ferner sind Daten verschiedener Labors kaum vergleichbar, da es kein standardisiertes Protokoll gibt. Um nun die Möglichkeiten der Allergiediagnostik zu optimieren und für den betroffen Patienten die bestmögliche Versorgung sicherzustellen ist es unerlässlich, auf diesem Gebiet nach weiteren neuen Ansatzpunkten zu suchen. Ziel des Projektes ist es daher einen auf der Expression verschiedener neuer Oberflächenmarker basierenden Basophilenaktivierungstest für die Diagnostik der Insektengiftallergie zu entwickeln.\r\n", "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-05-01T02:00:00+02:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2010-02-10T17:29:56+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 87717, "contact": 87717, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2104-87717-10" ] }, { "id": 2480, "title": { "de": "FET FlagShip: Information Technology Future of Medicine", "en": "FET FlagShip: Information Technology Future of Medicine" }, "short": "IT FoM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-05-01T02:00:00+02:00", "end_planned": "2012-06-01T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2011-05-19T10:22:48+02:00", "program": 24, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": " 285609", "ethics_committee": null, "edudract_number": null, "persons": [ "2480-51663-10" ] }, { "id": 2780, "title": { "de": "Gelotophobie - Die Angst vor dem Lachen anderer - Studie zur Erforschung der zu Grunde liegenden emotionalen Prozesse in spontaner Interaktion.", "en": "Gelotophobia - A biopsychological approach" }, "short": "Gelotophobie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-02-01T01:00:00+01:00", "begin_effective": "2012-02-01T01:00:00+01:00", "end_planned": "2012-04-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2012-02-06T18:26:26+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": 64295, "contact": 64295, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2780-64295-10" ] }, { "id": 1735, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 8: Lipid droplet-associated proteins regulating lipid storage and release in macrophages and foam cells" }, "short": "GOLD3_KRATKY", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-22T11:56:26+01:00", "program": 73, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1735-51904-10", "1735-58794-11" ] }, { "id": 1714, "title": { "de": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling", "en": "GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling" }, "short": "GOLD3_BIRNER_GRUENBERGER", "url": null, "abstract": { "de": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.", "en": "Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.\r\nThe general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.\r\nThe proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis." }, "begin_planned": "2008-12-01T01:00:00+01:00", "begin_effective": "2009-02-01T01:00:00+01:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-01-14T12:15:11+01:00", "program": 73, "subprogram": null, "organization": 28394, "category": 10, "type": 10, "partner_function": 2, "manager": 58794, "contact": 58794, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1714-58794-10" ] }, { "id": 1822, "title": { "de": "Mechanisms of restoration of ß-cell function in relation to adipoinsular and enteroinsular axes after gastric bypass surgery in severly obese patients with type 2 diabetes - double-centre, prospective, controlled, longitudinal open study - short: Restoration of ß-cell function after gastric bypass", "en": "Mechanisms of restoration of ß-cell function in relation to adipoinsular and enteroinsular axes after gastric bypass surgery in severly obese patients with type 2 diabetes - double-centre, prospective, controlled, longitudinal open study - short: Restoration of ß-cell function after gastric bypass" }, "short": "Restoration of ß-cell function", "url": null, "abstract": { "de": "The presented project aims to: \r\n1) compare changes in â-cell function following gastric bypass in patients with short- and long-term history of type 2 diabetes (T2DM), \r\n2) evaluate the â-cell insulin response to oral and intravenous glucose load early and late after gastric bypass surgery,\r\n3) relate the early and long-term changes in â-cell function after gastric bypass to changes in parameters of adipoinsular and enteroinsular axes in patients with and without T2DM and \r\n4) compare the changes of adipoinsular and enteroinsular axes after weight loss achieved after gastric bypass with BMI-matched controls without bariatric surgery.", "en": "The presented project aims to: \r\n1) compare changes in â-cell function following gastric bypass in patients with short- and long-term history of type 2 diabetes (T2DM), \r\n2) evaluate the â-cell insulin response to oral and intravenous glucose load early and late after gastric bypass surgery,\r\n3) relate the early and long-term changes in â-cell function after gastric bypass to changes in parameters of adipoinsular and enteroinsular axes in patients with and without T2DM and \r\n4) compare the changes of adipoinsular and enteroinsular axes after weight loss achieved after gastric bypass with BMI-matched controls without bariatric surgery." }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-07-01T02:00:00+02:00", "end_planned": "2011-06-30T02:00:00+02:00", "end_effective": "2012-04-30T02:00:00+02:00", "assignment": "2009-05-18T17:08:39+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1822-51831-10" ] }, { "id": 2198, "title": { "de": "Kommunikation als Screeninginstrument", "en": "Kommunikation als Screeninginstrument" }, "short": "KOMMUNIK_SCREENING", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-10-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-05-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T16:16:27+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 54332, "contact": 54332, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 70 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2198-54332-10" ] }, { "id": 981, "title": { "de": "SFB LIPOTOXICITY - Part 07: Myeloperoxidase-mediated lipotoxicity in the central nervous system", "en": "SFB LIPOTOXICITY" }, "short": "SFB LIPOTOXICITY", "url": null, "abstract": { "de": "Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten.", "en": "Das Ziel des SFB-LIPOTOX ist die Zusammenführung relevanter Forschungsgruppen um gemeinsam ein zentrales Thema zu bearbeiten, Lipotoxizität. Unter Lipotoxizität versteht man die fehlgesteuerte Aufnahme bzw. Produktion von Fettsäuren und Lipiden, die zur Bildung (lipo)toxischer Substanzen führen, die Dysfunktion von Zellen und Geweben bewirken und im Zelltod enden können. Wir wollen jene metabolischen Vorgänge und molekularen Mechanismen untersuchen, die durch lipotoxische Effektoren ausgelöst werden und die pathologische Basis prävalenter Erkrankungen, wie z.B. dem Metabolischen Syndrom, Typ-2 Diabetes und Atherosklerose darstellen. Dieses hochgesteckte Ziel ist nur durch eine gemeinsame Anstrengung innerhalb eines dynamischen und interaktiven Konsortiums, die weit über die Möglichkeiten innerhalb von Einzelprojektförderungen hinausgeht, zu erreichen. Durch Einsatz aktueller genomischer, proteomischer und lipidomischer Methoden sollen neue lipotoxische Stoffwechselwege entdeckt werden. Durch Einsatz mutanter Maus- und Hefemodelle werden jene molekulare Mechanismen untersucht, durch die zelluläre Dysfunktion und Zelltod bewirkt werden. Die gewonnenen Erkenntnisse können somit einen wichtigen Beitrag zur Auffindung neuartiger Diagnose- und Behandlungsmethoden leisten." }, "begin_planned": "2007-03-01T01:00:00+01:00", "begin_effective": "2007-03-01T01:00:00+01:00", "end_planned": "2011-02-28T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2006-12-27T15:02:44+01:00", "program": 67, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51705, "contact": 51833, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F30", "ethics_committee": null, "edudract_number": null, "persons": [ "981-51705-10" ] }, { "id": 2758, "title": { "de": "Body Composition and Performance: Relatives Körpergewicht österreichischer Athleten", "en": "Body Composition and Performance" }, "short": "Body Composition", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-01-01T01:00:00+01:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2012-03-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2012-01-19T16:37:18+01:00", "program": 90, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1326 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2197, "title": { "de": "Aufbau eines osteuropäisches Implantationszentrum mit angeschlossenen Rehabilitations- und Trainingszentrum", "en": "Development of an Eastern European implantation center with adjacent Rehabilitation and Trainings center" }, "short": "Osteuropäisches_Implantationszentrum", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-04-01T02:00:00+02:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2011-02-01T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-05-07T10:52:01+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2340, "title": { "de": "Die Bedeutung des gluconeogenetischen Enzyms Phosphoenolpyruvat Carboxykinase (PEPCK) für das Tumorwachstum", "en": "The role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in cancer growth" }, "short": "PEPCK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-11-17T10:58:29+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": 57557, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2340-57557-10" ] }, { "id": 1145, "title": { "de": "Rett Disorder: The Pre-Regression Period", "en": "Rett Disorder: The Pre-Regression Period" }, "short": "RETTDISORDER_FWF07", "url": null, "abstract": { "de": "The main focus of this project is on the motor, behavioural and communicative development in girls with Rett disorder from the age of 6 months to the onset of regression (12 to 18 months). The new results will be discussed in the light of continuity or discontinuity with the findings during the first 6 months of life. In addition, the results of the pre-regression period will be assessed in view of a possible association between genotypes and the severity of phenotypes.", "en": "The main focus of this project is on the motor, behavioural and communicative development in girls with Rett disorder from the age of 6 months to the onset of regression (12 to 18 months). The new results will be discussed in the light of continuity or discontinuity with the findings during the first 6 months of life. In addition, the results of the pre-regression period will be assessed in view of a possible association between genotypes and the severity of phenotypes." }, "begin_planned": "2007-04-01T02:00:00+02:00", "begin_effective": "2007-04-01T02:00:00+02:00", "end_planned": "2010-03-31T02:00:00+02:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2007-03-02T09:43:48+01:00", "program": 72, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P19581", "ethics_committee": null, "edudract_number": null, "persons": [ "1145-58883-12" ] }, { "id": 2390, "title": { "de": "Suche genetischer Faktoren in Neurotrophinen beim primären Offenwinkelglaukom", "en": "Candidate Gene Analysis in Neurotrophins in Primary Open Angle Glaucoma using Haplotype Tagging Single Nucleotide Polymorphisms" }, "short": "CANDIDATE GENE ANALYSIS_GLAUCOMA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-02-01T01:00:00+01:00", "begin_effective": "2011-04-01T02:00:00+02:00", "end_planned": "2013-01-31T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2011-02-04T09:28:08+01:00", "program": 79, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2553, "title": { "de": "Der Einfluss von Dexamethason auf rheumatoide Synoviozyten untersucht anhand einer Gen Chip Transkriptionsanalyse", "en": "The Influence of Dexamethasone on Rheumatoid Fibroblast-Like Synoviocytes based on a Gene CHip Transcription Analysis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-08-09T02:00:00+02:00", "end_planned": "2011-10-31T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-08-10T10:28:02+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2567, "title": { "de": "Die Wirkung eines Konzentrates multipotenter Knochenmarkszellen auf die Knochenregeneration und die Osseointegration von Zahnimplantaten nach Sinusbodenelevation", "en": "Die Wirkung eines Konzentrates multipotenter Knochenmarkszellen auf die Knochenregeneration und die Osseointegration von Zahnimplantaten nach Sinusbodenelevation" }, "short": "Multipotente Knochenmarkszellen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-09-05T17:35:08+02:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 4, "manager": 50792, "contact": 50792, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2567-50792-10" ] } ] }