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GET /v1/research/project/?format=api&offset=1820&ordering=begin_planned
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1840&ordering=begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1800&ordering=begin_planned", "results": [ { "id": 8039, "title": { "de": "Modelling Reproductive Failure with Endometrium-On-A-Chip, acib Projekt ID 98.311 ", "en": "Modelling Reproductive Failure with Endometrium-On-A-Chip, acib Projekt ID 98.311 " }, "short": "Endometrium-On-A-Chip", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2028-12-31T01:00:00+01:00", "assignment": "2024-02-12T12:22:36+01:00", "program": 94, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 3, "manager": 94195, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8039-94195-10" ] }, { "id": 8151, "title": { "de": "Das intestinale Mikrobiom eines orthotopen und eines ektopen Hepatoblastom Mausmodelles", "en": "The Intestinal Microbiome in an Orthotopic and Ectopic Tumor Murine Model of Hepatoblastoma" }, "short": "Microbiome in Hepatoblastoma Mouse Model", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-08-31T02:00:00+02:00", "assignment": "2024-04-24T15:59:17+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 1, "manager": 90375, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8151-50778-12", "8151-90375-10", "8151-97866-12" ] }, { "id": 8133, "title": { "de": "Alterssuizid in Österreich: Eine Niedrig- und Hochrisikopopulationsstudie basierend auf verknüpften personenbezogenen Registerdaten", "en": "Suicide among older adults in Austria: A low- and high-risk population study based on linked individual-level register data" }, "short": "SAOAA", "url": "https://www.oeaw.ac.at/foerderungen/data-research-austria", "abstract": { "de": "Der Suizid eines Menschen ist eine Tragödie auf individueller Ebene und gleichzeitig ein Problem der öffentlichen Gesundheitsfürsorge auf gesellschaftlicher Ebene. Wenig bekannt ist dabei, dass die Suizidraten sowohl in Österreich als auch allen anderen europäischen Ländern stark mit dem Alter ansteigen. Die allerhöchsten Suizidraten finden sich bei hochaltrigen Männern. Österreich hat gegenwärtig eine der höchsten Suizidraten bei Hochaltrigen in ganz Europa und es wird erwartet, dass die absolute Zahl der Suizide bei älteren Menschen in den nächsten Dekaden aufgrund der fortschreitenden Überalterung der Bevölkerung, insbesondere durch das Älterwerden der Babyboomer-Generation, steigen wird. Die zentrale Forschungsfrage dieses Projekts ist daher, welche Risikofaktoren Suizide bei älteren Menschen in Österreich vorhersagen können, was in weiterer Folge dazu beitragen soll, Präventionsmaßnahmen zu verbessern. Vor dem Hintergrund erstmalig zugänglicher und auf individueller Ebene verknüpfbarer Registerdaten in Österreich durch das Austria Micro Data Center (AMDC) soll im Rahmen dieses Projekts untersucht werden, welche älteren Personengruppen ein erhöhtes Risiko für Suizid haben. Konkret planen wir Risikofaktoren in zwei Bevölkerungsgruppen zu untersuchen: (1) die gesamte ältere Allgemeinbevölkerung (Niedrigrisiko-Ansatz) und (2) ältere gerontopsychiatrische Patient*innen (Hochrisiko-Ansatz). Potentielle Risikofaktoren werden demographische und sozioökonomische Faktoren, körperliche und psychische Erkrankungen, Pflegebedürftigkeit und soziale Isolation umfassen. Dabei werden diese Risikofaktoren nicht nur isoliert voneinander betrachtet, sondern auch deren multiplikativer Effekt, d.h. wenn beispielsweise der Verlust eines Partners mit einer neuen Krebsdiagnose zusammenfällt, untersucht. Mit diesem Forschungsprojekt wollen wir den Alterssuizid in Österreich besser verstehen und damit eine bessere Grundlage für Präventionsmaßnahmen schaffen, und nicht zuletzt die Lebensumstände jener älteren Personen besser zu beleuchten, die keinen anderen Ausweg sehen, als sich selbst (oft mit Gewalt) das Leben zu nehmen. ", "en": "Suicide is a tragedy at the individual level and a serious public health problem at the societal level. Although often overlooked, suicide rates in both Austria and other European countries increase rapidly with age, so that the highest suicide rates tend to show among the oldest old, and here, specifically among men. Austria has one of the highest suicide rates among the oldest old within the EU-27 countries. The high number of suicide deaths among older adults in Austria is not only a present-day concern, but also worrying against the background of population ageing, specifically the ageing of the large baby boomer generation, as this will likely lead to an increase in the absolute number of suicides among older adults in the decades ahead. The main research question of this project therefore is what risk factors can predict old age suicides in Austria, which can subsequently inform suicide prevention efforts. Against the background of newly available individual-level register data linkage in Austria within the Austrian Micro Data Center (AMDC), the aim of this project is to provide new and hitherto unavailable evidence on who among the older population is at an elevated risk of suicide death. Specifically, we seek to identify risk factors in two populations: (1) the whole general older population (low-risk setting) and (2) older psychiatric inpatients (high-risk setting). Risk factors will include demographic and socioeconomic factors, physical and mental health problems, disability and social disconnectedness. We will not only look at these factors in isolation, but also assess whether there are multiplicative effects for suicide risk, that is, when multiple risk factors co-occur at the same time, e.g. when the loss of spouse coincides with a cancer diagnosis. With this research project, we aim to better understand old age suicide in Austria, to inform suicide prevention efforts, and to illuminate the life circumstances of those older adults who see no other way but to (often violently) end their own lives." }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-07-01T02:00:00+02:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2024-04-10T11:05:11+02:00", "program": 245, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 1, "manager": 89152, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8133-89152-10", "8133-119651-12", "8133-128434-12" ] }, { "id": 7894, "title": { "de": "Der Einfluss von Typ I Interferon auf die Pathogenese der Riesenzellarteriitis", "en": "Defining the role of the type I interferon pathway in the pathogenesis of giant cell arteritis " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2027-01-01T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2023-11-21T15:06:00+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 117681, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 87 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7894-117681-10" ] }, { "id": 7858, "title": { "de": "Temporal processing in Drosophila melanogaster", "en": "Temporal processing in Drosophila melanogaster" }, "short": "TemProDroMe", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2028-12-31T01:00:00+01:00", "assignment": "2023-10-30T14:30:08+01:00", "program": 208, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 74916, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7858-74916-10", "7858-125334-12", "7858-125735-12", "7858-125877-12" ] }, { "id": 8297, "title": { "de": "LAMB3-DAG1 bei der endoglandulären Trophoblastinvasion", "en": "LAMB3 – DAG1 axis in endoglandular trophoblast invasion" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-10-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-12-31T01:00:00+01:00", "assignment": "2024-07-17T13:08:47+02:00", "program": 72, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 58943, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8297-58943-10" ] }, { "id": 8144, "title": { "de": "Metabolische Signaturen von T-Zell-Untergruppen als neue diagnostische oder therapeutische Angriffspunkte bei Kollagenose-assoziierten interstitiellen Lungenerkrankungen", "en": "Metabolic signatures of T cell subsets as novel diagnostic or therapeutic\r\ntargets in connective tissue disease-associated interstitial lung disease" }, "short": "T cell metabolism in CTD-ILD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2024-04-23T17:42:43+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 3, "manager": 95212, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8144-78952-11", "8144-95212-10", "8144-107391-11" ] }, { "id": 7836, "title": { "de": "Entschlüsselung der Rolle der Nekroptose-induzierten Entzündung in Lungenadenokarzinomen", "en": "Deciphering the role of necroptosis-induced inflammation in lung adenocarcinomas" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2027-01-01T01:00:00+01:00", "end_effective": "2027-12-22T01:00:00+01:00", "assignment": "2023-10-18T12:44:09+02:00", "program": 72, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 107132, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P37275", "ethics_committee": null, "edudract_number": null, "persons": [ "7836-50563-12", "7836-106234-12", "7836-81015-12", "7836-107132-10", "7836-109002-11", "7836-124172-12", "7836-126596-12" ] }, { "id": 7923, "title": { "de": "Die Zukunft im Blick: Alterung des Immunsystems als prädiktiver Marker für Autoimmunerkrankungen in jungen gesunden Individuen\r\n", "en": "The Future in Focus: Aging of the Immune System as a Predictive Marker for Autoimmune Diseases in Young Healthy Individuals" }, "short": "Aging Immune System_Autoimmune Diseases", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2023-12-12T10:50:37+01:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 1, "manager": 97708, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7923-97708-10" ] }, { "id": 7934, "title": { "de": "Maschinelles Hören im Kreißsaal: Pilotstudie zur automatischen Evaluierung der neonatalen Lungenfunktion anhand des ersten Schreis", "en": "Maschinelles Hören im Kreißsaal: Pilotstudie zur automatischen Evaluierung der neonatalen Lungenfunktion anhand des ersten Schreis" }, "short": "Maschinelles Hören im Kreißsaal", "url": null, "abstract": { "de": "Die in den ersten Lebensminuten produzierten Laute von Neugeborenen sorgen dafür, dass ein Teil der Ausatemluft vom Kehlkopf zurückpendelt und so das Fruchtwasser aus der Lunge in das umliegende Gewebe presst. Aufgrund unterschiedlich fortgeschrittener Lungenentwicklung gibt es mitunter hörbare Unterschiede zwischen Termin- und Frühgeborenen. Dieses Projekt evaluiert die Durchführbarkeit von standardisierten Tonaufnahmen in der Geburtssituation. Basierend auf Pilotdaten erfolgt erstmals eine umfassende Beschreibung akustischer Merkmale der ersten Laute von Termin- und Frühgeborenen sowie die Validierung künstlicher Intelligenz zur Einschätzung neonataler Lungenfunktion.", "en": null }, "begin_planned": "2024-01-15T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-01-14T01:00:00+01:00", "end_effective": "2025-05-31T02:00:00+02:00", "assignment": "2023-12-15T12:07:02+01:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 79651, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7934-79651-10", "7934-91531-12", "7934-77049-12" ] }, { "id": 8062, "title": { "de": "Stärkung des schwächelnden Herzens", "en": "Energizing the failing heart" }, "short": "Ener-LIGHT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-05-01T02:00:00+02:00", "end_planned": "2027-01-31T01:00:00+01:00", "end_effective": "2027-04-30T02:00:00+02:00", "assignment": "2024-03-04T08:37:32+01:00", "program": 112, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 3, "manager": 94512, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8062-94512-10", "8062-104482-12", "8062-135812-12" ] }, { "id": 8008, "title": { "de": "Identifizierung neuer Targets in der TP53-vermittelten Therapieresistenz bei akuter myeloischer Leukämie durch CRISPRko-Screens", "en": "Identifying novel targets to combat aberrant TP53 mediated therapeutic resistance in acute myeloid leukemia using CRISPRko screens" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2025-08-01T02:00:00+02:00", "end_effective": "2026-07-31T02:00:00+02:00", "assignment": "2024-02-01T11:43:46+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 1, "manager": 101484, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1564 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8008-103341-12", "8008-101484-10" ] }, { "id": 8252, "title": { "de": "Neonatologischer Lungenultraschall bei Neugeborenen 15 Minuten nach der Geburt, um den Bedarf und Dauer einer Atemunterstützung vorherzusagen", "en": "Neonatologist-performed lung ultrasound (NPLUS) in neonates 15 minutes after birth to predict requirement for respiratory support persisting more than 1 hour" }, "short": "NPLUS in neonates", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-04-01T02:00:00+02:00", "end_planned": "2026-02-01T01:00:00+01:00", "end_effective": "2025-04-30T02:00:00+02:00", "assignment": "2024-06-13T13:19:26+02:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 86558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8252-79516-11", "8252-86558-10" ] }, { "id": 7977, "title": { "de": "Splicing-Faktor Mutationen in myeloischen Neoplasien", "en": "Aberrant innate immune signaling in spliceosome-mutant myeloid neoplasms" }, "short": "Engineering spliceosome mutations", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2026-01-31T01:00:00+01:00", "end_effective": "2026-01-31T01:00:00+01:00", "assignment": "2024-01-17T11:45:23+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 50747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1564 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7977-50747-10" ] }, { "id": 7929, "title": { "de": "Nachhaltige gesunde Ernährung im Pflegeheim", "en": "Sustainable healthy nutrition in nursing homes " }, "short": "SUNRISE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2026-01-31T01:00:00+01:00", "end_effective": "2026-05-31T02:00:00+02:00", "assignment": "2023-12-14T15:30:17+01:00", "program": null, "subprogram": null, "organization": 14509, "category": 10, "type": 10, "partner_function": 4, "manager": 82963, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "TCS00142", "ethics_committee": null, "edudract_number": null, "persons": [ "7929-82963-10" ] }, { "id": 7958, "title": { "de": "Elektrophysiologische Charakterisierung der induzierten Zellalterung zur Krebstherapie", "en": "Electrophysiological characterization of induced cell aging for cancer therapy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-01T01:00:00+01:00", "begin_effective": "2024-02-01T01:00:00+01:00", "end_planned": "2025-01-31T01:00:00+01:00", "end_effective": "2025-07-31T02:00:00+02:00", "assignment": "2023-12-27T17:07:11+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 50615, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7958-50615-10" ] }, { "id": 8375, "title": { "de": "Anpassungsstrategien von Makrophagen in der nährstoffarmen Mikroumgebung von Tumoren ", "en": "Adaptation strategies of macrophages in the nutrient-poor tumor microenvironment \f" }, "short": "Macrophages in nutrient-poor environment", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-12T01:00:00+01:00", "begin_effective": "2024-02-12T01:00:00+01:00", "end_planned": "2024-08-12T02:00:00+02:00", "end_effective": "2024-08-12T02:00:00+02:00", "assignment": "2024-08-28T12:56:10+02:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 102775, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1000 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8375-102775-10" ] }, { "id": 8378, "title": { "de": "Anpassungsstrategien von Makrophagen in der nährstoffarmen Tumormikroumgebung", "en": "Adaptation strategies of macrophages in the nutrient-poor tumor microenvironment (TME)" }, "short": "Macrophages in the TME", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-12T01:00:00+01:00", "begin_effective": "2024-02-12T01:00:00+01:00", "end_planned": "2024-08-12T02:00:00+02:00", "end_effective": "2024-08-12T02:00:00+02:00", "assignment": "2024-08-28T13:04:57+02:00", "program": 220, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 102775, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8378-102775-10" ] }, { "id": 8376, "title": { "de": "Anpassung, Überleben, und Zelltod von Makrophagen und Lungenkrebszellen\r\nunter nährstoffarmen Bedingungen.", "en": "Adaptation, survival, and cell death of macrophages and lung cancer cells to nutrient-poor conditions. " }, "short": "Macrophage and cancer cell adaptation", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-12T01:00:00+01:00", "begin_effective": "2024-02-12T01:00:00+01:00", "end_planned": "2024-08-12T02:00:00+02:00", "end_effective": "2024-08-16T02:00:00+02:00", "assignment": "2024-08-28T13:00:35+02:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 102775, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "MPC-2023-07001", "ethics_committee": null, "edudract_number": null, "persons": [ "8376-102775-10" ] }, { "id": 8140, "title": { "de": "Entschlüsselung von Alzheimer: \r\nTRPC1 als zentrale Figur bei Protein-Entfaltung und Cholesterin-Biosynthese\r\n", "en": "Deciphering Alzheimer's: \r\nTRPC1 as a central player in protein unfolding and cholesterol biosynthesis" }, "short": null, "url": null, "abstract": { "de": "Hintergrund: Die Alzheimer-Krankheit (AD) ist eine irreversible und tödliche Form von Demenz, unterteilt in sporadische (SAD) und familiäre AD (FAD). FAD, mit frühem Beginn aufgrund spezifischer Genmutationen, steht im Gegensatz zu SAD, das einen späten Beginn und eine unklare Ursache aufweist. Die Ca2+-Homöostase- Hypothese von SAD legt nahe, dass eine frühzeitige Ca2+-Dysregulation mit der Fehlfaltung von Proteinen und der Anreicherung von Cholesterin einhergeht. Das endoplasmatische Retikulum (ER) ist entscheidend für die Regulation des intrazellulären Ca2+, die Verarbeitung von Proteinen und die Lipid-Biosynthese. Die Familie der transienten Rezeptorpotenzial-Kanäle (TRPC1-7) umfasst TRPC1, der im Hippocampus stark exprimiert wird. Während TRPC2-7 ausschließlich in der Plasmamembran gefunden werden, befindet sich TRPC1 auch in der ER- Membran.\r\nHypothese: TRPC1 könnte an der Regulation von Ca2+, der Synthese von Proteinen und Cholesterin im ER beteiligt sein.\r\nErgebnisse: Vorläufige Experimente zeigten, dass TRPC1 den Ca2+-Leck aus dem ER signifikant verstärkte, den Cholesterinspiegel in TRPC1-transfizierten HEK293-Zellen erhöhte, den Cholesterinspiegel in den Hippocampi transgener Mäuse im Alter veränderte und die Expression von Transkriptionsfaktoren beeinflusste, die an der Proteinfaltung beteiligt sind.\r\nFazit: Eine weitere Erforschung der Rolle von TRPC1 im ER könnte ihn als potenzielles pharmazeutisches Ziel in der AD-Behandlung etablieren.", "en": "Background: Alzheimer’s disease (AD) is an irreversible and fatal form of dementia, divided into sporadic (SAD) and familial AD (FAD). FAD, with early onset due to specific gene mutations, contrasts SAD, with late onset and an unclear cause. The Ca2+ homeostasis hypothesis of SAD suggests early Ca2+ dyshomeostasis links to protein misfolding and cholesterol accumulation. The endoplasmic reticulum (ER) is crucial, managing intracellular Ca2+, protein processing, and lipid biosynthesis. The transient receptor potential canonical family (TRPC1-7) includes TRPC1, highly expressed in the hippocampus. While TRPC2-7 target the plasma membrane, TRPC1 is also found in the ER membrane.\r\nHypothesis: TRPC1 may be involved in Ca2+ handling, protein, and cholesterol synthesis in the ER.\r\nResults: Preliminary experiments showed TRPC1 increased Ca2+ leak from the ER, elevated cholesterol in TRPC1- transfected HEK293 cells, altered cholesterol levels in hippocampi from aged transgenic mice, and affected expression of transcription factors involved in protein folding.\r\nConclusion: Further exploring TRPC1 role in the ER could establish it as a potential pharmaceutical target in AD treatment." }, "begin_planned": "2024-03-01T01:00:00+01:00", "begin_effective": "2024-03-01T01:00:00+01:00", "end_planned": "2025-02-28T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2024-04-16T14:17:18+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8140-90337-10", "8140-116421-12", "8140-122690-12" ] } ] }