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GET /v1/research/project/?format=api&offset=1800&ordering=-begin_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1820&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1780&ordering=-begin_effective", "results": [ { "id": 2351, "title": { "de": "Effekte einer Vitamin D Supplementierung auf die arterielle Gefäßsteifigkeit in Vitamin D deffzienten Patienten mit Typ 2 Diabetes (EVITDAS-DM) - eine randomisierte doppelblinde Studie", "en": "Effects of Vitamin D supplementation on arterial stiffness in Vitamin D defficient patients with type 2 diabetes mellitus (EVITDAS-DM) - a randomized double-blind placebo controlled trial" }, "short": "EVITDAS-DM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-08-01T02:00:00+02:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2013-08-31T02:00:00+02:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2010-12-06T11:49:18+01:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50877, "contact": 50877, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2351-50877-10" ] }, { "id": 2448, "title": { "de": "Onco Track - Methods for systematic next generation oncology biomarker development", "en": "Onco Track - Methods for systematic next generation oncology biomarker development" }, "short": "OncoTrack", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2015-12-31T01:00:00+01:00", "end_effective": "2016-12-31T01:00:00+01:00", "assignment": "2011-03-22T10:18:00+01:00", "program": 24, "subprogram": "IMI_FP7-Health.2010.4.2.9-6:Integrated data analyses and servicing.", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "115234", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2662, "title": { "de": "Die Orai Aktivierungs-Maschinerie", "en": "Key determinants of the Orai activation machinery - evaluated by a STIM1 conformational sensor" }, "short": "The Orai Activation Machinery", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-12-06T13:47:03+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 78591, "contact": 78591, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22565", "ethics_committee": null, "edudract_number": null, "persons": [ "2662-78591-10" ] }, { "id": 2353, "title": { "de": "Wirkung einer postoperativen Gabe von Prednisolon auf Sensibilitätsstörungen nach oralchirurgischen Eingriffen im Unterkiefer", "en": "Effect of postoperative application of Prednisolone on disturbances of sensitivity following oral surgery interventions" }, "short": "Postoperative Gabe von Prednisolon ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2011-01-01T01:00:00+01:00", "end_planned": "2014-05-01T02:00:00+02:00", "end_effective": "2014-05-31T02:00:00+02:00", "assignment": "2010-12-10T10:16:14+01:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 1, "manager": 50792, "contact": 50792, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2353-50792-10" ] }, { "id": 2442, "title": { "de": "CD-Labor für Forschung an biologischen Proben und Biobanktechnologien", "en": "CD-Laboratory for Advanced Biospecimen Research and Biobanking Technologies" }, "short": "CDLabBRBT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2017-10-30T01:00:00+01:00", "end_effective": "2017-11-30T01:00:00+01:00", "assignment": "2011-03-03T17:53:09+01:00", "program": 97, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 3, "manager": 51663, "contact": 50828, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 23 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2442-51663-10" ] }, { "id": 2306, "title": { "de": "Zellbasierte nichtinvasive Pränataldiagnostik", "en": "Cell-based non-invasive prenatal diagnosis" }, "short": "ZELLBAS NICHTINV PRAENATALDIAG", "url": null, "abstract": { "de": "Genetische Pränataldiagostik erfordert die Gewinnung von Zellen des Kindes. Dies erfolgt durch invasive Methoden wie Amniozentese oder Chorionzottenbiopsie. Das Risiko, daß es durch diese Eingriffe zu einem Abort kommt, ist nicht vernachlässigbar und liegt bei 0,5 1%. Aus diesem Grund ist genetische Pränataldiagnostik auf Schwangerschaften mit einem erhöhten Risiko einer genetischen Krankheit des Fetus beschränkt, wie z. B. einem Alter der Schwangeren von über 35 Jahren. Tatsächlich wird aber die Mehrzahl von Kindern mit genetischen Krankheiten nach Schwangerschaften geboren, die nicht primär als mit erhöhtem Risiko behaftet eingestuft werden können und bei denen das Risiko einer invasive Diagnostik in keinem vertretbaren Verhältnis zum Risiko durch den Eingriff steht.\r\nAusgehend von einer von uns entwickelten Methode zur geschlechtsunabhängigen Analyse der fötalen Identität von Zellen wollen wir in dem vorgeschlagenen Projekt ein Verfahren etablieren, das auf der Basis der Analyse von Einzelzellen eine nicht-invasive pränatale Diagnostik numerischer Chromosomenaberrationen und monogenetisch bedingter Krankheiten ermöglicht. Wir vergleichen die Effizienz etablierter Protokolle zur Anreicherung fetaler Zellen aus dem peripheren Blut schwangerer Frauen. Weiters etablieren wir die Amplifikation des gesamten Genoms von Einzelzellen, kombinieren die Analyse der fetalen Identität mittels array comparative genomic hybridization zur Analyse von Trisomien und analysieren als Beispiel der prinzipiellen Machbarkeit Mutationen des CFTR Gens.\r\nAuf Basis dieser Arbeiten wollen wir unter Nutzung von Ressourcen der Medizinischen Universität Graz im Sinn einer kommerziellen Anwendung ein überregionales Zentrum zur zellbasierten nichtinvasiven Pränataldiagnostik etablieren.\r\n", "en": "Genetic prenatal diagnosis is dependent on procurement of fetal cells. This is done my invasive methods such as amniocentesis and chorionic villous sampling. These methods are associated to a risk of 0.5 1% of subsequent abortus. For this reason genetic prenatal diagnosis is restricted to pregnancies with are associated with an increased risk of renetik disease of the fetus, such as age of the pregnant women higher than 35 years. In fact the majority of children with genetic diseases is born at the end of pregnancies which have not abeen associated with an increased risk, where the risk of invasive procedures cannot be justified.\r\nBased on a method which we developed previously for sex-independent analysis of the fetal identity of cells in a fetal microchimeric setting, we plan to establish a technique allowing for non-invasive prenatal diagnosis of both numeric chromosomal aberrations and monogenetic hereditary diseases, using analysis of single cells. We will compare the efficiency of established protocols for enrichment of fetal cells from the peripheral blood of pregnant women. Furthermore, we will establish whole genome amplification of single cells and combine the analysis of fetal identity with analysis of trisomy by means of array comparative genomic hybridization. As a proof of principle for feasibility of analysis of monogenic hereditary diseases using the preamplified genome of single cells we will analyze mutations of the CFTR gene.\r\nThe results of this work will be commercially exploited as we plan to establish an supra-regional center for cell-based non-invasive prenatal diagnosis by using the facilities of the Medical University of Graz.\r\n" }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2013-02-28T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2010-09-17T13:41:38+02:00", "program": 71, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "TRP17 ", "ethics_committee": null, "edudract_number": null, "persons": [ "2306-54171-12" ] }, { "id": 2340, "title": { "de": "Die Bedeutung des gluconeogenetischen Enzyms Phosphoenolpyruvat Carboxykinase (PEPCK) für das Tumorwachstum", "en": "The role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in cancer growth" }, "short": "PEPCK", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-03-31T02:00:00+02:00", "assignment": "2010-11-17T10:58:29+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": 57557, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2340-57557-10" ] }, { "id": 2335, "title": { "de": "Steirische Vitamin D Bluthochdruck Studie", "en": "Styrian Vitamin D Hypertension Study" }, "short": "STEIRISCHE_BLUTHOCHDRUCK_STUDIE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-08-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2013-07-31T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2010-11-10T10:05:48+01:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 53344, "contact": 53344, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2335-53344-10" ] }, { "id": 2341, "title": { "de": "Einzelzellanalyse in der forensischen Medizin", "en": "Single cell analysis in forensic medicine" }, "short": "Single cell analysis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-05-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-04-30T02:00:00+02:00", "end_effective": "2011-12-31T01:00:00+01:00", "assignment": "2010-11-17T11:21:30+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": 54171, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2341-54171-10" ] }, { "id": 2342, "title": { "de": "Quantifizierung der orthostatischen Kapazität", "en": "Orthocap - Use of galanin and adrenomedullin responses to quantify orthostatic capacity" }, "short": "Orthocap", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2009-07-31T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2010-11-22T12:56:50+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 51683, "contact": 51683, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2342-51683-10" ] }, { "id": 2360, "title": { "de": "Klinisches System für die Aufzeichnung von metabolischen Profilen", "en": "Clinical application for metabolic profiling" }, "short": "EU-CLAMP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-09-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2012-08-31T02:00:00+02:00", "end_effective": "2015-04-30T02:00:00+02:00", "assignment": "2010-12-15T14:17:14+01:00", "program": 24, "subprogram": "Research for SMEs FP7-SME-2010-01", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "262007", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2387, "title": { "de": "BioSHaRE_Biobank Standardisation and Harmonization for Research", "en": "BioSHaRE_Biobank Standardisation and Harmonization for Research" }, "short": "Bio_SHaRE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2015-05-31T02:00:00+02:00", "end_effective": "2015-11-30T01:00:00+01:00", "assignment": "2011-02-01T14:20:10+01:00", "program": 24, "subprogram": "HEALTH", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "261433", "ethics_committee": null, "edudract_number": null, "persons": [ "2387-51663-10" ] }, { "id": 2482, "title": { "de": "Experience-oriented Sharing of Health Knowledge via Information and Communication Technology", "en": "Experience-oriented Sharing of Health Knowledge via Information and Communication Technology" }, "short": "ESICT", "url": null, "abstract": { "de": "Die ESICT-Konsortium (Experience-oriented Sharing of health knowledge via Information and Communication Technology) wird von dem dänischen Strategic Research Council finanziert. ESICT konzentriert sich auf die wissenschaftliche Untersuchung und Entwicklung von Methoden und Technologien, welche Bürgern mittels eines innovativen Informationssystems über chronische Erkrankungen aufklärt, unter Verwendung von Sprachtechnologien und medizinischen Wissensbasen. Das Ziel von ESICT ist die computergestützte Beantwortung von natürlichsprachigen Benutzeranfragen.", "en": "The ESICT consortium (Experience-oriented Sharing of health knowledge via Information and Communication Technology) is funded by the Danish Strategic Research Council. ESICT focuses on research in methods and development of technologies providing citizens with an innovative information system on chronic diseases based on language technology and formalized medical knowledge. The goal of ESICT is to allow users to ask questions in natural language. " }, "begin_planned": "2010-12-01T01:00:00+01:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2012-11-30T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-05-19T18:33:42+02:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 2, "manager": 72306, "contact": 72306, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2482-72306-10" ] }, { "id": 2463, "title": { "de": "European High Security BSL4 Laboratories", "en": "European High Security BSL4 Laboratories" }, "short": "ERINHA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-01T02:00:00+02:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2013-05-31T02:00:00+02:00", "end_effective": "2014-08-31T02:00:00+02:00", "assignment": "2011-04-12T14:42:14+02:00", "program": 24, "subprogram": "Infrastructures\r\nINFRA-2010-2.2.8", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2463-51663-10" ] }, { "id": 2318, "title": { "de": "Der Einfluss von molekulargenetischen Veränderungen in TGFß1 auf den Schweregrad von strahlentherapiebedingten Toxizitäten bei Prostatakarzinompatienten.", "en": "The association between genetic variants in TGFß1 and radiation induced side effects in prostate cancer patients." }, "short": "MOLECULAR GENETIC VARIANTS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2010-11-30T01:00:00+01:00", "end_effective": "2011-06-30T02:00:00+02:00", "assignment": "2010-09-29T12:46:53+02:00", "program": null, "subprogram": null, "organization": 14060, "category": 10, "type": 10, "partner_function": 4, "manager": 50495, "contact": 50495, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2318-50495-10" ] }, { "id": 2321, "title": { "de": "Die Rolle der intestinalen ATGL in Lipidabsorption und metabolischen Erkrankungen", "en": "Role of intestinal ATGL in lipid absorption and metabolic disorders" }, "short": "Intestinal ATGL ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2015-10-31T01:00:00+01:00", "assignment": "2010-10-04T15:54:28+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22832", "ethics_committee": null, "edudract_number": null, "persons": [ "2321-51904-10" ] }, { "id": 2400, "title": { "de": "Etablierung einer Forschungsinfrastruktur für Biobanken und biologische Ressourcen an der Medizinischen Universität Graz", "en": "-" }, "short": "Biobank der MUG ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2014-06-30T02:00:00+02:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2011-02-08T09:39:21+01:00", "program": 75, "subprogram": null, "organization": 28392, "category": 10, "type": 10, "partner_function": 4, "manager": 54033, "contact": 54033, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 55 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2400-54033-10" ] }, { "id": 2319, "title": { "de": "Mechanische Stimulierung von Humanen Synoviozyten in der Zellkultur - Pilotstudie", "en": "Mechanical Stimulation of Human Synoviocytes in vitro" }, "short": "Mechanische Stimulierung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-04-01T02:00:00+02:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2010-06-30T02:00:00+02:00", "end_effective": "2011-03-31T02:00:00+02:00", "assignment": "2010-09-29T12:49:43+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": 50696, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2319-50696-10" ] }, { "id": 2381, "title": { "de": "EUTRAF - THE EUROPEAN NETWORK FOR TRANSLATIONAL RESEARCH IN ATRIAL FIBRILLATION", "en": "EUTRAF - THE EUROPEAN NETWORK FOR TRANSLATIONAL RESEARCH IN ATRIAL FIBRILLATION" }, "short": "EUTRAF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2015-12-31T01:00:00+01:00", "end_effective": "2015-10-31T01:00:00+01:00", "assignment": "2011-01-19T10:52:22+01:00", "program": 24, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": 50168, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "261057", "ethics_committee": null, "edudract_number": null, "persons": [ "2381-60041-12", "2381-66430-12", "2381-79173-12", "2381-50168-10" ] }, { "id": 2403, "title": { "de": "Maßgeschneiderte Therapien für Chordome: Bietet IGF-IR-Targeting neue Behandlungsoptionen?", "en": "Targeted Therapies for Chordomas: Does IGF-IR-Targeting Provide New Treatment Options?" }, "short": "Chordoma Targeted Therapies", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-11-01T01:00:00+01:00", "begin_effective": "2010-11-01T01:00:00+01:00", "end_planned": "2011-11-01T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2011-02-09T14:17:52+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 1, "manager": 50448, "contact": 50448, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1091 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2403-50448-10" ] } ] }