List projects.

Fields

id (integer)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

  • organization
  • category
  • type
  • partner_function
  • manager
  • contact
  • status
  • grant
  • research
  • event
  • study
  • language
  • program
  • funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

  • organization
  • category
  • manager
  • contact
  • status
  • grant
  • research
  • study
  • language
  • funders
  • program

For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

  • begin_planned: gt, gte, lt, lte
  • begin_effective: gt, gte, lt, lte
  • end_planned: gt, gte, lt, lte
  • end_effective: gt, gte, lt, lte
GET /v1/research/project/?format=api&offset=1760&ordering=begin_planned
HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2329,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1780&ordering=begin_planned",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1740&ordering=begin_planned",
    "results": [
        {
            "id": 6936,
            "title": {
                "de": "Epigenetische Regulation der Immunantwort nach COVID-19-Impfung",
                "en": "Epigenetic regulation of immune responses following COVID-19 vaccination"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-03-01T01:00:00+01:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2023-12-31T01:00:00+01:00",
            "assignment": "2022-02-28T11:42:52+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14014,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 78952,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2471
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6936-78952-10"
            ]
        },
        {
            "id": 6909,
            "title": {
                "de": "Attraktivierung Allgemeinmedizin ",
                "en": "Attractiveness of general medicine"
            },
            "short": "Attraktivierung AM 2022-2023",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2023-12-31T01:00:00+01:00",
            "end_effective": "2023-12-31T01:00:00+01:00",
            "assignment": "2022-02-08T11:55:39+01:00",
            "program": null,
            "subprogram": null,
            "organization": 27964,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51098,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2160
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6909-51098-10"
            ]
        },
        {
            "id": 6939,
            "title": {
                "de": "Förderung der Lebensspanne durch Mitohormesis induziert durch mitochondriales Kalzium",
                "en": "Promotion of lifespan by mitochondrial Ca2+-induced mitohormesis"
            },
            "short": "Ca2+-induced mitohormesis",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2022-12-31T01:00:00+01:00",
            "assignment": "2022-03-01T12:10:36+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14013,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 85069,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-69",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6939-85069-10"
            ]
        },
        {
            "id": 7013,
            "title": {
                "de": "LncRNAs in triple negativ breast cancer",
                "en": "LncRNAs in triple negative breast cancer"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-07-01T02:00:00+02:00",
            "end_planned": "2025-09-30T02:00:00+02:00",
            "end_effective": "2023-12-31T01:00:00+01:00",
            "assignment": "2022-05-11T11:23:48+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P35975",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 6820,
            "title": {
                "de": "enFaced 2.0 - AR-Tool für die Gesichtschirurgie",
                "en": "enFaced 2.0 - Instant AR Tool for Maxillofacial Surgery"
            },
            "short": "enFaced 2.0",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-04-01T02:00:00+02:00",
            "end_planned": "2024-12-31T01:00:00+01:00",
            "end_effective": "2026-03-31T02:00:00+02:00",
            "assignment": "2021-12-09T10:55:12+01:00",
            "program": 108,
            "subprogram": null,
            "organization": 14112,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 76910,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "KLI1044",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6820-76910-10"
            ]
        },
        {
            "id": 6835,
            "title": {
                "de": "Erforschung des Einflusses der JAK2V617F Gendosis auf den Phänotyp Myeloproliferativer Erkrankungen mittels CRISPR/Cas9 Genome Engineering.",
                "en": "Investigating the effect of JAK2V617F gene dosage on MPN phenotype by\r\nforward and reverse CRISPR/Cas9 genome engineering."
            },
            "short": "JAK2 gene dosage",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2024-12-31T01:00:00+01:00",
            "end_effective": "2024-12-31T01:00:00+01:00",
            "assignment": "2021-12-15T10:41:29+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14082,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50747,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1375
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6835-50747-10",
                "6835-98091-12",
                "6835-97755-12",
                "6835-108881-12",
                "6835-119131-12"
            ]
        },
        {
            "id": 6944,
            "title": {
                "de": "Integriertes Patient*innenmanagement bei Vorhofflimmern: mHealth-Implementierung bis Hybrid-Ablationen",
                "en": "Integrated patient management for atrial fibrillation: implementation of mHealth, hybrid ablations"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-03-01T01:00:00+01:00",
            "end_planned": "2023-12-31T01:00:00+01:00",
            "end_effective": "2024-12-31T01:00:00+01:00",
            "assignment": "2022-03-03T11:52:28+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 63032,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                468
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6944-63032-10"
            ]
        },
        {
            "id": 6972,
            "title": {
                "de": "Terminale Ausreifung erythroider Progenitoren",
                "en": "Terminal maturation of erythroid progenitors"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2024-12-31T01:00:00+01:00",
            "end_effective": "2028-02-29T01:00:00+01:00",
            "assignment": "2022-03-24T09:37:38+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14058,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51164,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P35738",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6972-51164-10"
            ]
        },
        {
            "id": 6760,
            "title": {
                "de": "Apolipoprotein AI(apo-AI) Peptid-Lipid Komplexe",
                "en": "Apolipoprotein AI(apo-AI) Mimetic Peptide Lipid Assemblies"
            },
            "short": "AAMLA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2025-12-31T01:00:00+01:00",
            "end_effective": "2026-11-30T01:00:00+01:00",
            "assignment": "2021-10-22T11:40:29+02:00",
            "program": 111,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 83104,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I5703",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6760-83104-10",
                "6760-83104-12",
                "6760-107231-12"
            ]
        },
        {
            "id": 7333,
            "title": {
                "de": "Serologisches Antikörper Screening zu SARS-CoV-2, Legionellen und Hepatitis unter Zahnmediziner*innen 2022\r\n",
                "en": "Serological antibody screening for SARS-CoV-2, legionella und hepatitis among dental staf 2022"
            },
            "short": "Leg-Hep-S22",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2024-12-31T01:00:00+01:00",
            "end_effective": "2024-12-31T01:00:00+01:00",
            "assignment": "2023-01-16T14:19:57+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14109,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50051,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7333-50051-10"
            ]
        },
        {
            "id": 6857,
            "title": {
                "de": "Predicting Cardiovascular Events Using Machine Learning",
                "en": "Predicting Cardiovascular Events Using Machine Learning"
            },
            "short": "PRE-CARE ML",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2024-12-31T01:00:00+01:00",
            "end_effective": "2027-01-01T01:00:00+01:00",
            "assignment": "2021-12-21T14:20:28+01:00",
            "program": 112,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 58906,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I5898",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6857-58906-10"
            ]
        },
        {
            "id": 6872,
            "title": {
                "de": "Das nasale Mikrobiom in der Therapie der chronischen Rhinosinusitis",
                "en": "The nasal microbiome in the therapy of chronic rhinosinusitis."
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2022-12-31T01:00:00+01:00",
            "assignment": "2022-01-10T08:55:50+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14066,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 82492,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2471
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6872-82492-10"
            ]
        },
        {
            "id": 6891,
            "title": {
                "de": "Assoziation zwischen nicht-invasiver Diagnostik und Endomyokardbiopsie bei Patient*innen mit suspizierter kardialer Amyloidose - eine multizentrische retrospektive Studie",
                "en": "Association between non-invasive diagnostics and results of endomyocardial biopsy in patients with suspected cardiac amyloidosis -  a multicenter retrospective study"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2023-12-31T01:00:00+01:00",
            "end_effective": "2023-12-31T01:00:00+01:00",
            "assignment": "2022-01-24T11:50:17+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 81519,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-66",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6891-81519-10"
            ]
        },
        {
            "id": 6787,
            "title": {
                "de": "Apolipoprotein AI (apo-AI) Mimetische \r\nPeptid-Lipid-Assemblies",
                "en": "Apolipoprotein AI (apo-AI) Mimetic \r\nPeptide Lipid Assemblies"
            },
            "short": "AAMLA",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2025-12-31T01:00:00+01:00",
            "end_effective": "2026-11-30T01:00:00+01:00",
            "assignment": "2021-11-17T15:51:22+01:00",
            "program": 111,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 53252,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I5703",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6787-53252-10"
            ]
        },
        {
            "id": 7025,
            "title": {
                "de": "Die Rolle von Neutrophiler Elastase im Lungenkarzinom",
                "en": "Nuclear function of secreted neutrophil elastase in lung cancer metastasis"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-06-15T02:00:00+02:00",
            "end_planned": "2026-12-31T01:00:00+01:00",
            "end_effective": "2026-06-14T02:00:00+02:00",
            "assignment": "2022-05-18T12:06:31+02:00",
            "program": 121,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 60706,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P35294",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7025-51163-12",
                "7025-60706-10",
                "7025-99558-12",
                "7025-100698-12",
                "7025-112858-12",
                "7025-115261-12"
            ]
        },
        {
            "id": 6884,
            "title": {
                "de": "Einzelzellanalyse in Leberkrebs",
                "en": "Single cell analysis of liver cancer"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-02-01T01:00:00+01:00",
            "begin_effective": "2022-02-01T01:00:00+01:00",
            "end_planned": "2022-08-01T02:00:00+02:00",
            "end_effective": "2023-01-31T01:00:00+01:00",
            "assignment": "2022-01-19T10:14:26+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 89979,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-74",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6884-89979-10"
            ]
        },
        {
            "id": 6892,
            "title": {
                "de": "Anpassung der mitochondrialen Ultrastruktur an die lokale Mikroumgebung in Krebszellen",
                "en": "Adaption of the mitochondrial ultrastructure to the local micro environment in cancer cells"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-02-01T01:00:00+01:00",
            "begin_effective": "2022-02-01T01:00:00+01:00",
            "end_planned": "2022-06-01T02:00:00+02:00",
            "end_effective": "2022-06-30T02:00:00+02:00",
            "assignment": "2022-01-24T12:00:26+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14013,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 90394,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-71",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6892-90394-10"
            ]
        },
        {
            "id": 6900,
            "title": {
                "de": "Präklinische Anwendung von Mg- basiertem bioresorbierbaren Implantatmaterial in der Orbitachirurgie am Schafmodel",
                "en": "Preclinical application of Mg- based bioresorbable material for orbital floor recon-struction in an animal model "
            },
            "short": "OS-MAG",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-02-01T01:00:00+01:00",
            "begin_effective": "2022-02-01T01:00:00+01:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2024-07-31T02:00:00+02:00",
            "assignment": "2022-02-01T14:28:18+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14112,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 87313,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2698
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6900-87313-10"
            ]
        },
        {
            "id": 6899,
            "title": {
                "de": "Wir alle sind Mischwesen: Mikrochimärsimus, Gesundheit und Evolution",
                "en": "We All Are Multitudes: the Microchimerism, Human Health and Evolution"
            },
            "short": "Microchimerism and Evolution",
            "url": "https://www.microchimerism.info/",
            "abstract": {
                "de": "Mikrochimärismus (MC) beschreibt die Existenz einer kleinen Anzahl fremder menschlicher Zellen in einer Person. Dieses Phänomen entsteht unter anderem während der Schwangerschaft durch das Wandern von Zellen zwischen Mutter und Fötus. Das derzeitige Wissen um MC ist unvollständig und teils widersprüchlich, über die Rolle, die mikrochimäre Zellen in der Wirtsphysiologie spielen, ist wenig bekannt.\r\nWas ist der Grund der anscheinend paradoxen Effekte von MC? Welche Mechanismen sind beteiligt oder sogar verantwortlich dafür, dass mikrochimäre Zellen ins Wirtsgewebe wandern, sich dort integrieren und oftmals ein Wirtsleben lang verbleiben? Die Evolutionsbiologie und die maternal-fetale Konflikttheorie können einen Rahmen bieten, um die Persistenz mikrochimärer Zellen zu verstehen und deren Existenz mit einer erhöhten Anfälligkeit für Krankheiten zu verknüpfen.\r\nWir gehen zunächst davon aus, dass MC weiter verbreitet ist als bisher berichtet. Wir nehmen weiters an, dass mikrochimäre Zellen eine adaptive Rolle in der Physiologie des Wirts zu spielen vermögen und Vorteile für Mütter und Nachkommen bieten können, etwa durch Übertragung von Stammzellen und anderen Zelltypen aber auch durch Übertragung von wichtigen Komponenten des und Signalen für das Immunsystem. Jedoch werden sich in manchen Geweben die maternal-fötalen genetischen Interessen nicht zur Deckung bringen lassen, was eine erhöhte Anfälligkeit für Krankheiten zur Folge haben kann. Daher ist es unser Ziel, den Einfluss des MC auf Gesundheit und Krankheit zu studieren und Potential und Effekte des Zelltransfers über Generationengrenzen hinweg zu verstehen.\r\nBasis unseres Projekts ist die Verwendung modernster Technologien zur Analyse des bidirektionalen Transfers mikrochimärer Zellen zwischen Individuen und die Verteilung der mikrochimären Zellen in den Zielgeweben. Weiters widmen wir uns den Effekten, die aus der Interaktion von mikrochimären Zellen und dem Immunsystem des Wirts hervorgehen. Diese Themen studieren wir in mehreren Teilprojekten: Erstellung eines Maus-Mikrochiom-Atlas (Projekt 1), Phänotypisierung von maternalem (Projekt 2) und fetalem (Projekt 3) MC, Charakterisierung von mikrochimären Zellen in plazentanahen, -fernen Geweben und diversen Organen (Projekt 4) sowie den Zusammenhang von MC und Autoimmunerkrankung im Tiermodell (Projekt 5).\r\nUnsere Forschung dient dem Verständnis der Interaktion von mikrochimären Zellen mit dem Wirt und zur Klärung der Fragen, wie die Toleranz von MC während der Schwangerschaft und postpartum bei Müttern gewährleistet und aufrecht erhalten werden kann, welche Auswirkungen MC auf die frühe Entwicklung von Föten hat und ob es während Krankheiten zum Zusammenbruch der Immuntoleranz kommt und welche Ursachen dies hat.",
                "en": "Microchimerism (MC) is the harboring of a small number of cells between two distinct individuals. This transfer of cells is well known to occur between mothers and offspring during gestation, though other avenues of transfer may be possible. The current understanding of MC is puzzling and little is known about the role microchimeric cells play in host physiology.\r\nWhy are the effects of MC paradoxical and what are the mechanisms responsible for maintaining microchimeric cells over an organism’s lifetime? Evolutionary biology and maternal-fetal conflict theory can provide a framework to understand the persistence of microchimeric cells, and how this may lead to disease vulnerability.\r\nWe hypothesize MC is much more common than previously reported and microchimeric cells play an adaptive role in host physiology, providing benefits for both mothers and offspring through transfers of stem and other cell types, and providing key immune system components and signals. However, in certain host tissues the maternal-fetal genetic interests may not align, potentially leading to disease vulnerability.\r\nWe aim to understand the role MC plays in health and disease, and understand the potential for and effects of subsequent generational transfers of microchimeric cells. We will use cutting edge technology to characterize MC cell distribution and trafficking between hosts and the effects of MC-host immune system interactions in various host tissues by creating a mouse Microchiome Atlas (Project 1), phenotyping human maternal MC (mMC) (Project 2), phenotyping human fetal MC (fMC) (Project 3), phenotyping microchimeric cells proximal and distal in terms of distance from the maternal-fetal interface as well as in various other organs (Project 4), and interrogating the context of MC and autoimmune disease in animal models (Project 5).\r\nOur research will determine how microchimeric cells interact with the host system to initiate and maintain tolerance of MC during pregnancy, the postpartum period for mothers and early development in offspring, and uncover if there is a breakdown in immune tolerance during disease states, and what causes it."
            },
            "begin_planned": "2022-02-01T01:00:00+01:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2024-10-31T01:00:00+01:00",
            "end_effective": "2026-08-30T02:00:00+02:00",
            "assignment": "2022-02-01T12:59:33+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 54171,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2575
            ],
            "funder_projectcode": "62214",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6899-104057-12",
                "6899-54171-10",
                "6899-82600-12",
                "6899-104139-12",
                "6899-114270-12",
                "6899-115382-12",
                "6899-116463-12"
            ]
        },
        {
            "id": 6945,
            "title": {
                "de": "Die Rolle von Sirtuin 3 im Rahmen günstiger Behandlungseffekte von Honokiol in myokardialer Ischämie-Reperfusion und Remodeling",
                "en": "The Role of Sirtuin 3 in Beneficial Treatment Effects of Honokiol in Myocardial Ischemia Reperfusion Injury and Remodeling"
            },
            "short": "Sirt3 Honokiol",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-02-01T01:00:00+01:00",
            "begin_effective": "2022-02-01T01:00:00+01:00",
            "end_planned": "2023-08-01T02:00:00+02:00",
            "end_effective": "2024-02-29T01:00:00+01:00",
            "assignment": "2022-03-03T16:32:59+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 99418,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                468
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6945-99418-10",
                "6945-101037-12"
            ]
        }
    ]
}