Project List
List projects.
Fields
id (integer)
Primary key.
Expansions
To activate relation expansion add the desired fields as a comma separated
list to the expand query parameter like this:
?expand=<field>,<field>,<field>,...
The following relational fields can be expanded:
organizationcategorytypepartner_functionmanagercontactstatusgrantresearcheventstudylanguageprogramfunders
Filters
To filter for exact value matches:
?<fieldname>=<value>
Possible exact filters:
organizationcategorymanagercontactstatusgrantresearchstudylanguagefundersprogram
For advanced filtering use lookups:
?<fieldname>__<lookup>=<value>
All fields with advanced lookups can also be used for exact value matches as described above.
Possible advanced lookups:
begin_planned:gt,gte,lt,ltebegin_effective:gt,gte,lt,lteend_planned:gt,gte,lt,lteend_effective:gt,gte,lt,lte
GET /v1/research/project/?format=api&offset=1760&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1780&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1740&ordering=-end_effective", "results": [ { "id": 1577, "title": { "de": "Identification of specific endothelial binding-sites for inflammatory carbamylated low-density lipoproteins", "en": "Identification of specific endothelial binding-sites for inflammatory carbamylated low-density lipoproteins" }, "short": "CARBAMYL_LDL_FWF08", "url": null, "abstract": { "de": "In renal disease, elevated levels of urea lead to an increased concentration of cyanate that reacts irreversible with amino groups of proteins through carbamylation reactions. High concentrations of carbamylated low-density-lipoproteins (cLDL) have recently been reported to accumulate in plasma of pateints with chronic renal failure, indicating that cLDL is by far the most abundant modified LDL found in human plasa. Of importance, carbamylated proteins may also be formed directly at sites of inflammation - even in the absence of renal disease- via the phagocyte derived inflammatory mediator myeloperoxidase (MPO). Active MPO is present in human atherosclerotic lesion material and has been shown to bind to low- and high-density lipoproteins. Thus, it can be assumed that MPO derived cyanate contributes to lipoprotein carbamylation at sites of inflammation. Recent clinical studies demonstrated that carbamylated proteins predict increased risk of coronary artery disease, future myocardial infarction, stroke and death.\r\n\r\nNo endothelial receptors of binding proteins that might trigger the potent pro-atherosclerotic effects of carbamylated LDL have yet been identified. Therefore, the aim of the proposed project is to identify endothelial receptors for carbamylated LDL and to systemically examine the impact of carbamylated LDL on the expression of inflammatory genes in human derived vascular endothelial cells.", "en": "In renal disease, elevated levels of urea lead to an increased concentration of cyanate that reacts irreversible with amino groups of proteins through carbamylation reactions. High concentrations of carbamylated low-density-lipoproteins (cLDL) have recently been reported to accumulate in plasma of pateints with chronic renal failure, indicating that cLDL is by far the most abundant modified LDL found in human plasa. Of importance, carbamylated proteins may also be formed directly at sites of inflammation - even in the absence of renal disease- via the phagocyte derived inflammatory mediator myeloperoxidase (MPO). Active MPO is present in human atherosclerotic lesion material and has been shown to bind to low- and high-density lipoproteins. Thus, it can be assumed that MPO derived cyanate contributes to lipoprotein carbamylation at sites of inflammation. Recent clinical studies demonstrated that carbamylated proteins predict increased risk of coronary artery disease, future myocardial infarction, stroke and death.\r\n\r\nNo endothelial receptors of binding proteins that might trigger the potent pro-atherosclerotic effects of carbamylated LDL have yet been identified. Therefore, the aim of the proposed project is to identify endothelial receptors for carbamylated LDL and to systemically examine the impact of carbamylated LDL on the expression of inflammatory genes in human derived vascular endothelial cells." }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2008-10-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2008-07-14T14:41:55+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 53252, "contact": 53252, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P21004", "ethics_committee": null, "edudract_number": null, "persons": [ "1577-53252-10" ] }, { "id": 2253, "title": { "de": "Stickstoffmonoxid und Schilddrüsen Studie - NOTHYS", "en": "Nitric Oxide Thyroid Study - NOTHYS" }, "short": "NOTHYS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-06-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2010-07-14T12:58:34+02:00", "program": 72, "subprogram": null, "organization": 14028, "category": 10, "type": 10, "partner_function": 4, "manager": 50562, "contact": 50562, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22694", "ethics_committee": null, "edudract_number": null, "persons": [ "2253-50562-10", "2253-50464-12", "2253-51263-12", "2253-51809-12" ] }, { "id": 1940, "title": { "de": "Altered prostaglandin receptor function in patients with aspirin intolerance", "en": "Altered prostaglandin receptor function in patients with aspirin intolerance" }, "short": "Prostaglandin receptor function", "url": null, "abstract": { "de": "Prostaglandin E2 (PGE2) limitiert in der Lunge immunologische und entzündliche Prozesse. Eosinophile Granulozyten spielen eine entscheidende Rolle bei der Pathogenese von Asthma bronchiale. Etwa 10% der Asthmapatienten vertragen keine Analgetika vom Typ der nichtsteroidalen Antirheumatika (z.B. Aspirin). Daher ist eine effektive Schmerz- und Entzündungstherapie bei diesen Patienten schwierig. Wir konnten zeigen, dass PGE2 hemmende Effekte an eosinophilen Granulozyten hat. Die Effekte von PGE2 werden durch vier Rezeptoren vermittelt. Wir untersuchen, inwieweit die Wirkungen von PGE2 auf Eosinophile von Patienten mit Aspirin-Unverträglichkeit verändert sind und welche Rolle die PGE2 Rezeptoren spielen. Als Vergleich dienen gesunde Probanden, allergische Patienten ohne Asthma und Asthmatiker ohne Aspirin-Unverträglichkeit. Diese Studie soll das Verständnis der Rolle von PGE2 bei Asthma und Aspirin-Unverträglichkeit erweitern, und möglicherweise neue therapeutische Optionen eröffen.", "en": "Prostaglandin E2 (PGE2) limitiert in der Lunge immunologische und entzündliche Prozesse. Eosinophile Granulozyten spielen eine entscheidende Rolle bei der Pathogenese von Asthma bronchiale. Etwa 10% der Asthmapatienten vertragen keine Analgetika vom Typ der nichtsteroidalen Antirheumatika (z.B. Aspirin). Daher ist eine effektive Schmerz- und Entzündungstherapie bei diesen Patienten schwierig. Wir konnten zeigen, dass PGE2 hemmende Effekte an eosinophilen Granulozyten hat. Die Effekte von PGE2 werden durch vier Rezeptoren vermittelt. Wir untersuchen, inwieweit die Wirkungen von PGE2 auf Eosinophile von Patienten mit Aspirin-Unverträglichkeit verändert sind und welche Rolle die PGE2 Rezeptoren spielen. Als Vergleich dienen gesunde Probanden, allergische Patienten ohne Asthma und Asthmatiker ohne Aspirin-Unverträglichkeit. Diese Studie soll das Verständnis der Rolle von PGE2 bei Asthma und Aspirin-Unverträglichkeit erweitern, und möglicherweise neue therapeutische Optionen eröffen." }, "begin_planned": "2009-04-01T02:00:00+02:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-03-31T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2009-10-01T18:22:11+02:00", "program": 79, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2254, "title": { "de": "Nanoelectronics for Mobile Ambient Assisted Living (AAL) Systems - Technology Platform for AAL Applications - MAS", "en": "Nanoelectronics for Mobile Ambient Assisted Living (AAL) Systems - Technology Platform for AAL Applications - MAS" }, "short": "MAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-04-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2010-07-15T12:58:37+02:00", "program": 24, "subprogram": "ENIAC", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10, 416 ], "funder_projectcode": "120228", "ethics_committee": null, "edudract_number": null, "persons": [ "2254-51831-10" ] }, { "id": 2886, "title": { "de": "Kardioposturale Interaktionen und Endothelfunktion in Abhängigkeit vom Menstruationszyklus", "en": "Cardiopostural interactions and endothelial function chagnes across the menstural cycle" }, "short": "KARPEM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-05-20T02:00:00+02:00", "begin_effective": "2012-06-01T02:00:00+02:00", "end_planned": "2012-08-20T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2012-06-14T13:45:08+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 1, "manager": 57932, "contact": 57932, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2886-57932-10" ] }, { "id": 2906, "title": { "de": "Der Einfluss der Proteinkinase D2 auf den Glukosemetabolismus von Glioblastomzellen.", "en": "Protein Kinase D2 and its influence on the glucose metabolism of glioblastoma cells." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-07-01T02:00:00+02:00", "end_planned": "2012-05-31T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2012-06-28T10:34:12+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50990, "contact": 50990, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2906-50990-10" ] }, { "id": 2376, "title": { "de": "GATIB II - Subprojekt 4", "en": "GATIB II - Subproject 4" }, "short": "GATIB II - Subprojekt 4", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2011-01-10T14:46:48+01:00", "program": 73, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 51344, "contact": 51344, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2376-51344-10" ] }, { "id": 2643, "title": { "de": "Einfluß der diabetischen Neuropathie auf die Stimulationsparameter der peripheren Nervenstimulation in der peripheren Nervenstimulation", "en": "The influence of diabetic neuropathy on the current settings during peripheral nerve stimulation for peripheral regional anesthesia" }, "short": "DIABETIC NEUROPATHY PERIPHAL NERVES", "url": "http://www.fwf.ac.at/de/abstracts/abstract.asp?L=D&PROJ=KLI135", "abstract": { "de": "Die Prävalenz von Diabetes Mellitus (DM) wird in industrialisierten Ländern auf ungefähr 7,3% geschätzt, wobei die Inzidenz in den letzten Jahren gestiegen ist. Die Prävalenz der diabetischen Neuropathie in dieser Population wird mit bis zu 50% angegeben. Wegen der vielen Komorbiditäten von diabetischen Patienten, geht man davon aus, dass speziell diese Patientengruppe von regionalanästhesiologischen Verfahren profitieren könnte. Andererseits wird die periphere Regionalanästhesie (RA) bei Patienten mit bereits vorbestehender Neuropathie nicht empfohlen, da man eine Verschlechterung der Erkrankung durch eine Nervenverletzung beim regionalanästhesiologischen Verfahren befürchtet. Die periphere Nervenstimulation (PNS) ist das Standardverfahren in der Regionalanästhesie, bei der man den zu blockierenden Nerven mit Hilfe von Stromimpulsen, die eine motorische Reizantwort verursachen, aufsucht. Es wird davon ausgegangen, dass bei Verschwinden der motorischen Reizantwort bei 0,3 mA ein ausreichender Sicherheitsabstand vorhanden ist, um eine schädliche intraneurale Injektion des Lokalanästhetikums zu verhindern. Ob nun die diabetische Neuropathie diese Stimulationsparameter beeinflusst, ist bis heute nicht ausreichend untersucht und könnte daher ein Risiko für diese Patienten darstellen.\r\n\r\nDas beantragte Projekt untersucht die Hypothese, ob die Nerven von Patienten mit DM weniger empfindlich auf Stromimpulse reagieren und daher die unteren Grenzwerte für die PNS in dieser Patientenpopulation deutlich höher gewählt werden müssen um eine intraneurale Injektion sicher zu verhindern. Wir möchten den Einfluss von DM auf die Erregbarkeit von peripheren Nerven anhand einer prospektiven, geblindeten, fallkontrollierten Observationsstudie untersuchen. Dementsprechend haben wir folgende Ziele definiert.\r\n\r\nZiel 1:\tDie benötigte Stimulationsstromstärke bei Patienten mit und ohne Diabetes mellitus zu definieren.\r\nZiel 2:\tZu überprüfen ob es bei diabetischen Patienten zu einer höheren Inzidenz von neurologischen Verletzungen gibt. \r\nZiel 3:\tVon den Ergebnissen geleitete Empfehlungen für die Durchführung von regionalanästhesiologischen Verfahren bei diabetischen Patienten zu generieren. \r\n\r\nDie Ergebnisse dieser Studie werden das Verständnis von der Nadel-Strom-Nerven-Beziehung bei peripherer Nervenstimulation deutlich verbessern und dadurch einen immensen Einfluss auf die Patientensicherheit während regionalanästhesiologischer Verfahren haben, besonders in der Patientenpopulation mit bereits vorbestehender Neuropathie. \r\n", "en": "The prevalence of diabetes mellitus (DM) in industrialized countries is estimated to be about 7.3% and its incidence has been growing in recent years. The prevalence of diabetic neuropathy in the diabetic patient population is up to 50%. When limb surgery is necessary, it is reasonable to assume that diabetic patients will benefit from a regional anesthetic because of the severe comorbidities associated with DM. On the other hand, the use of regional anesthesia (RA) has generally not been recommended in patients with preexisting neuropathies mainly because of medical liability issues, as worsening neuropathy could be attributed to nerve damage caused by the regional anesthetic. The current state of the art of peripheral regional anesthesia for the identification of correct placement of an injection needle suitably close to the target nerve is to elicit a motor response by current injection through the needle. Constant reduction of the current as the nerve is approached ensures close proximity so that an effective nerve block is obtained when the local anesthetic is delivered through the needle, and absence of a motor response at 0.3 mA is generally accepted as a safety marker to avoid harmful intraneural injection. An important deficit in our understanding is whether diabetic neuropathy influences the stimulation parameters for peripheral nerve stimulation (PNS), possibly decreasing safety.\r\n\r\nThe currently proposed research is guided by the hypothesis that nerves in patients with DM are resistant to stimulation and, as a consequence, the current thresholds for PNS have to be set much higher to prevent injections from occurring within the epineurium. We will examine this the effect of DM on nerve excitability in a blinded, prospective, observational case control trial. Accordingly, we have defined following aims:\r\n\r\nAim 1: \tTo characterize the required stimulation current in patients with and without diabetes mellitus. \r\nAim 2: \tFollow-up to examine if the rate of adverse neurologic events is higher in diabetic patients.\r\nAim 3: \tGuided by the results, formulate recommendations for the performance of regional anesthesia in patients with a history of DM.\r\n\r\nThese experiments will provide better understanding of the needle-current-nerve relationship during peripheral nerve stimulation. Findings from this proposed study will have a major impact on patient safety, especially in the subgroup with preexisting neuropathy, undergoing regional anesthesia\r\n" }, "begin_planned": "2011-08-01T02:00:00+02:00", "begin_effective": "2012-01-01T01:00:00+01:00", "end_planned": "2013-01-31T01:00:00+01:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2011-11-18T14:50:50+01:00", "program": 108, "subprogram": "KLIF", "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI135", "ethics_committee": null, "edudract_number": null, "persons": [ "2643-50869-11", "2643-67711-11", "2643-75117-12", "2643-50731-12" ] }, { "id": 2489, "title": { "de": "Etablierung eines künstlichen Blutgefäßmodells zur Entwicklung von Gefäßprothesen", "en": "Artifical blood vessel model for the development of vascular protheses" }, "short": "Artifical blood vessel model", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-04T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2012-12-04T01:00:00+01:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2011-05-30T18:05:42+02:00", "program": null, "subprogram": "Human Technology Interface", "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 51718, "contact": 51718, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2489-76930-12", "2489-51718-10" ] }, { "id": 1878, "title": { "de": "Anandamide/LPI signaling & function in endothelial cells", "en": "Anandamide/LPI signaling & function in endothelial cells" }, "short": "Anandamide/LPI", "url": null, "abstract": { "de": "Anandamide (ANA), also known as N-arachidonoylethanolamine, is a prominent substance of endocannabinoids, and exhibits multiple physiological functions in the brain, the immune system and the cardiovasculature. Although ANA is well known to contribute to human behavior, like eating and sleeping, and pain relief, evidence accumulated that ANA is an important vascular mediator that is released during tissue stress. LPI (lysophosphatidylinositol is another putatively important lipid mediator in the vessel wall.\r\nThe overall aim of this project is to explore ANA/LPI as important vascular mediators, to characterize their respective signal transduction, their interrelation and consequences to endothelial cell functions. In the end, our proposal aims to provide the scientific basis of consideration of the ANA/LPI system as therapeutic target for vascular-related medicine.", "en": "Anandamide (ANA), also known as N-arachidonoylethanolamine, is a prominent substance of endocannabinoids, and exhibits multiple physiological functions in the brain, the immune system and the cardiovasculature. Although ANA is well known to contribute to human behavior, like eating and sleeping, and pain relief, evidence accumulated that ANA is an important vascular mediator that is released during tissue stress. LPI (lysophosphatidylinositol is another putatively important lipid mediator in the vessel wall.\r\nThe overall aim of this project is to explore ANA/LPI as important vascular mediators, to characterize their respective signal transduction, their interrelation and consequences to endothelial cell functions. In the end, our proposal aims to provide the scientific basis of consideration of the ANA/LPI system as therapeutic target for vascular-related medicine." }, "begin_planned": "2009-07-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2009-07-30T13:21:16+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51860, "contact": 51860, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P21857", "ethics_committee": null, "edudract_number": null, "persons": [ "1878-50810-11", "1878-51860-10" ] }, { "id": 2546, "title": { "de": "MSc in Migrant Health: Adressing New Challenges in Europe", "en": "MSc in Migrant Health: Adressing New Challenges in Europe" }, "short": "MSC IN MIGRANT HEALTH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-01-01T01:00:00+01:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2011-07-28T12:19:44+02:00", "program": null, "subprogram": "Erasmus", "organization": 29447, "category": 10, "type": 10, "partner_function": 2, "manager": 51521, "contact": 51521, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2546-51521-10" ] }, { "id": 2980, "title": { "de": "Gewebedatenbank zur Erforschung der stadienabhängigen Herzinsuffizienz Graz", "en": "Tissue database Graz for the investigation of stage-dependent heart failure" }, "short": "GESHG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2014-09-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2012-09-20T11:36:28+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 59941, "contact": 59941, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2980-59941-10" ] }, { "id": 1640, "title": { "de": "Effect of ivabradine, a novel If-blocker, on human atrial myocytes under elevated endotoxin levels", "en": "Effect of ivabradine, a novel If-blocker, on human atrial myocytes under elevated endotoxin levels" }, "short": "IVABRADINE_FWF08", "url": null, "abstract": { "de": "Endotoxine (Lipopolysaccharide, LPSe), die Auslöser von gram-negativer Sepsis, führen durch Interaktion mit den Wirtszellen zu einer Vielzahl von biologischen Reaktionen. Kürzlich konnten wir in einer Publikation zeigen, dass LPS den Schrittmacherstrom If in humanen Vorhofzellen, nach 6-stündiger Inkubation hemmt, ein Ereignis, das für das Verständnis der bei Sepsis auftretenden Reduktion der Herzfrequenzvariabilität von großer Relevanz ist.\r\nAusgehend von der hemmenden LPS-Wirkung auf If sollen 2 große Themenschwerpunkte untersucht werden:\r\n*Interaktion von Ivabradine und Endotoxin auf den humanen If\r\n*Mechanismus der Endotoxinwirkung", "en": "Endotoxine (Lipopolysaccharide, LPSe), die Auslöser von gram-negativer Sepsis, führen durch Interaktion mit den Wirtszellen zu einer Vielzahl von biologischen Reaktionen. Kürzlich konnten wir in einer Publikation zeigen, dass LPS den Schrittmacherstrom If in humanen Vorhofzellen, nach 6-stündiger Inkubation hemmt, ein Ereignis, das für das Verständnis der bei Sepsis auftretenden Reduktion der Herzfrequenzvariabilität von großer Relevanz ist.\r\nAusgehend von der hemmenden LPS-Wirkung auf If sollen 2 große Themenschwerpunkte untersucht werden:\r\n*Interaktion von Ivabradine und Endotoxin auf den humanen If\r\n*Mechanismus der Endotoxinwirkung" }, "begin_planned": "2008-10-01T02:00:00+02:00", "begin_effective": "2009-10-01T02:00:00+02:00", "end_planned": "2011-09-30T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2008-10-13T14:02:42+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 50615, "contact": 50615, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P21159", "ethics_committee": null, "edudract_number": null, "persons": [ "1640-50615-10", "1640-50417-12", "1640-50969-12", "1640-51592-12" ] }, { "id": 2904, "title": { "de": "Prognostische und therapeutische Relevanz von steatohepatitischen Veränderungen beim Hepatozellulären Karzinom", "en": "Prognostic and therapeutic relevance of steatohepatitic features in hepatocellular carinoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-08-01T02:00:00+02:00", "begin_effective": "2012-08-01T02:00:00+02:00", "end_planned": "2013-08-01T02:00:00+02:00", "end_effective": "2013-08-31T02:00:00+02:00", "assignment": "2012-06-27T13:08:00+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 50871, "contact": 50871, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2904-50871-10" ] }, { "id": 3053, "title": { "de": "Genetische Charakterisierung einer steirischen Familie mit einem familiären kolorektalen Syndrom X", "en": "Genetic characterization of a Styrian family with colorectal cancer type X" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-11-01T01:00:00+01:00", "begin_effective": "2012-11-01T01:00:00+01:00", "end_planned": "2013-11-01T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2012-11-27T13:32:52+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 77615, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3053-77615-10" ] }, { "id": 2119, "title": { "de": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)", "en": "Alzheimer drugs incorporated in nanoparticles for specific transport over the blood brain barrier (NanoBrain)" }, "short": "NanoBrain", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-10-01T02:00:00+02:00", "end_planned": "2013-12-31T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2010-02-12T14:34:51+01:00", "program": 64, "subprogram": "ERA-Net", "organization": 14051, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I453", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 1777, "title": { "de": "The role of C/EBPa on the development of monocyte subsets", "en": "The role of C/EBPa on the development of monocyte subsets" }, "short": "C/EBPa", "url": null, "abstract": { "de": "The integrity of the hematopoietic system depends on a large number of blood cell lineages being continuously replenished from a rare population of pluripotent heatopoietic stem cells(HSC), representing a paradigm for how multilineage diversity can be achieved from a common stem cell through lineage commitment and subsequent differentiation.\r\nMonocytes are mononuclear cells and represent about 10% of leukocytes in human blood and 4% of leukocytes in mouse blood. The best known function of monocytes is their role as accessory cells, which link inflammation and the innate defense system against microorganisms to adaptive immune response.\r\nMany factors are involved in monocyte differentiation like PU.1, IRF8, KLF-4, MafB, c-maf and C/EBPalpha. C/EBPalpha (CCAAT/enhancer binding protein alpha) is a basic region-leucine zipper transcription factor and indispensable for formation of mature neutrophils and eosinophils. It is expressed at low levels in HSC, and is up-regulated to its highest levels in GMP(granulocyte/monocyte progenitors), whereas it is not expressed in precursors of lymphoid cells and is downregulated as CMP differentiate to MEP(megakaryocyte/erythrocyte progenitors). Mice-studies indicate that C/EBPalpha is essential for transition of CMP to GMP.\r\n\r\nWe hypothesize that C/EBPalpha positive and C/EBPalpha negative monocytes represent distinct subgroups of monocytes, which also differ in their function. In addition, we speculate that they are derived from different progenitors. To experimentally approach this hypothesis we want to use the C/EBPalphaCRE EYFP reporter mouse model.", "en": "The integrity of the hematopoietic system depends on a large number of blood cell lineages being continuously replenished from a rare population of pluripotent heatopoietic stem cells(HSC), representing a paradigm for how multilineage diversity can be achieved from a common stem cell through lineage commitment and subsequent differentiation.\r\nMonocytes are mononuclear cells and represent about 10% of leukocytes in human blood and 4% of leukocytes in mouse blood. The best known function of monocytes is their role as accessory cells, which link inflammation and the innate defense system against microorganisms to adaptive immune response.\r\nMany factors are involved in monocyte differentiation like PU.1, IRF8, KLF-4, MafB, c-maf and C/EBPalpha. C/EBPalpha (CCAAT/enhancer binding protein alpha) is a basic region-leucine zipper transcription factor and indispensable for formation of mature neutrophils and eosinophils. It is expressed at low levels in HSC, and is up-regulated to its highest levels in GMP(granulocyte/monocyte progenitors), whereas it is not expressed in precursors of lymphoid cells and is downregulated as CMP differentiate to MEP(megakaryocyte/erythrocyte progenitors). Mice-studies indicate that C/EBPalpha is essential for transition of CMP to GMP.\r\n\r\nWe hypothesize that C/EBPalpha positive and C/EBPalpha negative monocytes represent distinct subgroups of monocytes, which also differ in their function. In addition, we speculate that they are derived from different progenitors. To experimentally approach this hypothesis we want to use the C/EBPalphaCRE EYFP reporter mouse model." }, "begin_planned": "2009-05-01T02:00:00+02:00", "begin_effective": "2009-08-01T02:00:00+02:00", "end_planned": "2010-04-30T02:00:00+02:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2009-04-07T10:52:48+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51911, "contact": 51911, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "1777-58889-12", "1777-51911-10" ] }, { "id": 3018, "title": { "de": "Automatisierte Erkennung eines Herzgeräusches (Systolikums) mittels Phonokardiographie", "en": "Automated analysis of cardial murmurs with phonocardiography" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-08-01T02:00:00+02:00", "begin_effective": "2012-08-01T02:00:00+02:00", "end_planned": "2013-07-31T02:00:00+02:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2012-10-31T11:54:12+01:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": 50907, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3018-50907-10" ] }, { "id": 2526, "title": { "de": "Rezeptoren und Metabolite von Prostaglandinen im Morbus Crohn und der ulzerösen Kolitis", "en": "DP receptors and their prostaglandin metabolite ligands: a good or bad match for human IBD?" }, "short": "DP receptors in IBD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-08-01T02:00:00+02:00", "begin_effective": "2011-08-01T02:00:00+02:00", "end_planned": "2013-07-31T02:00:00+02:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2011-07-12T16:34:21+02:00", "program": 79, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": 56687, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2526-56687-10" ] }, { "id": 2431, "title": { "de": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?", "en": "Genetic predisposition to therapy-related myeloid neoplasms: involvement of the Fanconi anemia/BRCA pathway?" }, "short": "FANCONI ANEMIA BRCA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-01-01T01:00:00+01:00", "begin_effective": "2010-01-01T01:00:00+01:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2013-07-31T02:00:00+02:00", "assignment": "2011-02-28T11:28:49+01:00", "program": 79, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51857, "contact": 51857, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2431-77371-12", "2431-77615-12", "2431-51857-10", "2431-50116-12" ] } ] }