Project List

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        {
            "id": 6870,
            "title": {
                "de": "Barrierefunktion des Endothels bei Mukopolysaccharidosen",
                "en": "Barrier function of the endothelium in mucopolysaccharidoses"
            },
            "short": null,
            "url": null,
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                "de": null,
                "en": null
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            "organization": 14048,
            "category": 10,
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            "persons": [
                "6870-71568-10"
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        },
        {
            "id": 7009,
            "title": {
                "de": "SARS-CoV-2 Infektion bei Kindern - Epidemiologie und Klinik",
                "en": "SARS-CoV-2 infection in children - epidemiology and clinic"
            },
            "short": "COVIDKINDER",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
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            "begin_planned": "2021-11-01T01:00:00+01:00",
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            "end_planned": "2022-06-30T02:00:00+02:00",
            "end_effective": "2022-12-31T01:00:00+01:00",
            "assignment": "2022-05-05T13:26:09+02:00",
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            "funder_projectcode": null,
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            "persons": [
                "7009-79733-10"
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        },
        {
            "id": 7824,
            "title": {
                "de": "ACKR1 und ACKR4 in der experimentellen Glomerulonephritis",
                "en": "ACKR1 and ACKR4 in experimental kidney diseases"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-11-01T01:00:00+01:00",
            "begin_effective": "2021-11-01T01:00:00+01:00",
            "end_planned": "2023-04-30T02:00:00+02:00",
            "end_effective": "2023-04-30T02:00:00+02:00",
            "assignment": "2023-10-10T10:23:38+02:00",
            "program": 69,
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            "organization": 14084,
            "category": 10,
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            "manager": 86588,
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            "funders": [
                9
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            "funder_projectcode": "J 4606",
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            "edudract_number": null,
            "persons": [
                "7824-86588-10"
            ]
        },
        {
            "id": 6806,
            "title": {
                "de": "Antikörper und Abwehrzellen nach durchgemachter SARS-CoV-2 Infektion bei Kindern und Jugendlichen",
                "en": "Humoral and cellular immunity after SARS-CoV-2 infection in\r\nchildren and adolescents"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-11-01T01:00:00+01:00",
            "begin_effective": "2021-11-01T01:00:00+01:00",
            "end_planned": "2024-12-31T01:00:00+01:00",
            "end_effective": "2024-12-31T01:00:00+01:00",
            "assignment": "2021-11-30T15:49:52+01:00",
            "program": null,
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            "organization": 14095,
            "category": 10,
            "type": 10,
            "partner_function": 4,
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            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
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            "funders": [
                25
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            "funder_projectcode": null,
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            "persons": [
                "6806-56810-10"
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        },
        {
            "id": 6719,
            "title": {
                "de": "Risikopersonen für iatrogene Kiefernekrosen und Knochenbrüche bei Osteoporose- und Krebstherapien frühzeitig identifizieren ",
                "en": "MRONJ and AFF risk identification and prediction in osteoporosis and cancer patients (RIO)"
            },
            "short": "MEFO-RIO",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2021-11-01T01:00:00+01:00",
            "end_planned": "2024-12-31T01:00:00+01:00",
            "end_effective": "2026-12-31T01:00:00+01:00",
            "assignment": "2021-09-30T15:29:09+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 98005,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-65",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6719-50909-12",
                "6719-98005-10"
            ]
        },
        {
            "id": 8268,
            "title": {
                "de": "Standardisierte elektronische Erfassung der Beschwerden und der Lebensqualität von Patienten/Innen mit Kopf/Hals Karzinom unter laufender Radiochemotherapie",
                "en": "Standardized electronic symptom and quality of life tracking of patients with head and neck cancer during radiotherapy."
            },
            "short": "QOLHNC",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-11-01T01:00:00+01:00",
            "begin_effective": "2021-11-01T01:00:00+01:00",
            "end_planned": "2026-11-01T01:00:00+01:00",
            "end_effective": "2026-11-01T01:00:00+01:00",
            "assignment": "2024-06-19T15:15:36+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14066,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 57935,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "8268-57935-10"
            ]
        },
        {
            "id": 6869,
            "title": {
                "de": "Peptidomimetisce INhibitoren für CRAC-Kanal",
                "en": "Light-activatable peptidomimetic inhibitors for CRAC-channel"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-11-01T01:00:00+01:00",
            "begin_effective": "2021-11-01T01:00:00+01:00",
            "end_planned": "2025-10-31T01:00:00+01:00",
            "end_effective": "2027-01-31T01:00:00+01:00",
            "assignment": "2022-01-05T15:23:09+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 86144,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "I5611",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6869-86144-10",
                "6869-116508-12"
            ]
        },
        {
            "id": 6713,
            "title": {
                "de": "Personalized, chronotherapeutic Forest Environment for Delirium Prevention on the ICU",
                "en": "Personalized, chronotherapeutic Forest Environment for Delirium Prevention on the ICU"
            },
            "short": "Forest Environment",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-07-01T02:00:00+02:00",
            "begin_effective": "2021-11-01T01:00:00+01:00",
            "end_planned": "2024-07-01T02:00:00+02:00",
            "end_effective": "2025-10-31T01:00:00+01:00",
            "assignment": "2021-09-27T16:31:58+02:00",
            "program": 60,
            "subprogram": null,
            "organization": 29444,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 79771,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                416
            ],
            "funder_projectcode": "FO999888155",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6713-79771-10"
            ]
        },
        {
            "id": 6818,
            "title": {
                "de": "Isoflavonmessung, Mikrobiom und endokrine Characterisierung",
                "en": "Isoflavone measurement, microbiome and endocrine characterisation"
            },
            "short": "IsoMiEndo",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-12-01T01:00:00+01:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2022-12-01T01:00:00+01:00",
            "end_effective": "2022-12-01T01:00:00+01:00",
            "assignment": "2021-12-07T17:55:45+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51809,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-67",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6818-51809-10",
                "6818-109041-12"
            ]
        },
        {
            "id": 7007,
            "title": {
                "de": "Der Einfluss des Harntrakt-Mikrobioms auf ‚Lower Urinary Tract Symptomes’ (LUTS) bei Männern",
                "en": "The influence of urinary tract microbiome on male lower urinary tract symptomes (LUTS)"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-12-01T01:00:00+01:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2023-12-01T01:00:00+01:00",
            "end_effective": "2026-12-31T01:00:00+01:00",
            "assignment": "2022-05-02T10:13:59+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14056,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 113095,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2471
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7007-113095-10"
            ]
        },
        {
            "id": 6899,
            "title": {
                "de": "Wir alle sind Mischwesen: Mikrochimärsimus, Gesundheit und Evolution",
                "en": "We All Are Multitudes: the Microchimerism, Human Health and Evolution"
            },
            "short": "Microchimerism and Evolution",
            "url": "https://www.microchimerism.info/",
            "abstract": {
                "de": "Mikrochimärismus (MC) beschreibt die Existenz einer kleinen Anzahl fremder menschlicher Zellen in einer Person. Dieses Phänomen entsteht unter anderem während der Schwangerschaft durch das Wandern von Zellen zwischen Mutter und Fötus. Das derzeitige Wissen um MC ist unvollständig und teils widersprüchlich, über die Rolle, die mikrochimäre Zellen in der Wirtsphysiologie spielen, ist wenig bekannt.\r\nWas ist der Grund der anscheinend paradoxen Effekte von MC? Welche Mechanismen sind beteiligt oder sogar verantwortlich dafür, dass mikrochimäre Zellen ins Wirtsgewebe wandern, sich dort integrieren und oftmals ein Wirtsleben lang verbleiben? Die Evolutionsbiologie und die maternal-fetale Konflikttheorie können einen Rahmen bieten, um die Persistenz mikrochimärer Zellen zu verstehen und deren Existenz mit einer erhöhten Anfälligkeit für Krankheiten zu verknüpfen.\r\nWir gehen zunächst davon aus, dass MC weiter verbreitet ist als bisher berichtet. Wir nehmen weiters an, dass mikrochimäre Zellen eine adaptive Rolle in der Physiologie des Wirts zu spielen vermögen und Vorteile für Mütter und Nachkommen bieten können, etwa durch Übertragung von Stammzellen und anderen Zelltypen aber auch durch Übertragung von wichtigen Komponenten des und Signalen für das Immunsystem. Jedoch werden sich in manchen Geweben die maternal-fötalen genetischen Interessen nicht zur Deckung bringen lassen, was eine erhöhte Anfälligkeit für Krankheiten zur Folge haben kann. Daher ist es unser Ziel, den Einfluss des MC auf Gesundheit und Krankheit zu studieren und Potential und Effekte des Zelltransfers über Generationengrenzen hinweg zu verstehen.\r\nBasis unseres Projekts ist die Verwendung modernster Technologien zur Analyse des bidirektionalen Transfers mikrochimärer Zellen zwischen Individuen und die Verteilung der mikrochimären Zellen in den Zielgeweben. Weiters widmen wir uns den Effekten, die aus der Interaktion von mikrochimären Zellen und dem Immunsystem des Wirts hervorgehen. Diese Themen studieren wir in mehreren Teilprojekten: Erstellung eines Maus-Mikrochiom-Atlas (Projekt 1), Phänotypisierung von maternalem (Projekt 2) und fetalem (Projekt 3) MC, Charakterisierung von mikrochimären Zellen in plazentanahen, -fernen Geweben und diversen Organen (Projekt 4) sowie den Zusammenhang von MC und Autoimmunerkrankung im Tiermodell (Projekt 5).\r\nUnsere Forschung dient dem Verständnis der Interaktion von mikrochimären Zellen mit dem Wirt und zur Klärung der Fragen, wie die Toleranz von MC während der Schwangerschaft und postpartum bei Müttern gewährleistet und aufrecht erhalten werden kann, welche Auswirkungen MC auf die frühe Entwicklung von Föten hat und ob es während Krankheiten zum Zusammenbruch der Immuntoleranz kommt und welche Ursachen dies hat.",
                "en": "Microchimerism (MC) is the harboring of a small number of cells between two distinct individuals. This transfer of cells is well known to occur between mothers and offspring during gestation, though other avenues of transfer may be possible. The current understanding of MC is puzzling and little is known about the role microchimeric cells play in host physiology.\r\nWhy are the effects of MC paradoxical and what are the mechanisms responsible for maintaining microchimeric cells over an organism’s lifetime? Evolutionary biology and maternal-fetal conflict theory can provide a framework to understand the persistence of microchimeric cells, and how this may lead to disease vulnerability.\r\nWe hypothesize MC is much more common than previously reported and microchimeric cells play an adaptive role in host physiology, providing benefits for both mothers and offspring through transfers of stem and other cell types, and providing key immune system components and signals. However, in certain host tissues the maternal-fetal genetic interests may not align, potentially leading to disease vulnerability.\r\nWe aim to understand the role MC plays in health and disease, and understand the potential for and effects of subsequent generational transfers of microchimeric cells. We will use cutting edge technology to characterize MC cell distribution and trafficking between hosts and the effects of MC-host immune system interactions in various host tissues by creating a mouse Microchiome Atlas (Project 1), phenotyping human maternal MC (mMC) (Project 2), phenotyping human fetal MC (fMC) (Project 3), phenotyping microchimeric cells proximal and distal in terms of distance from the maternal-fetal interface as well as in various other organs (Project 4), and interrogating the context of MC and autoimmune disease in animal models (Project 5).\r\nOur research will determine how microchimeric cells interact with the host system to initiate and maintain tolerance of MC during pregnancy, the postpartum period for mothers and early development in offspring, and uncover if there is a breakdown in immune tolerance during disease states, and what causes it."
            },
            "begin_planned": "2022-02-01T01:00:00+01:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2024-10-31T01:00:00+01:00",
            "end_effective": "2026-08-30T02:00:00+02:00",
            "assignment": "2022-02-01T12:59:33+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 54171,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2575
            ],
            "funder_projectcode": "62214",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6899-104057-12",
                "6899-54171-10",
                "6899-82600-12",
                "6899-104139-12",
                "6899-114270-12",
                "6899-115382-12",
                "6899-116463-12"
            ]
        },
        {
            "id": 6881,
            "title": {
                "de": "Biomarker für kardiovaskuläre Risiken und neurodegenerative Erkrankungen nach insulininduzierter Hypoglykämie",
                "en": "Biomarkers for cardiovascular risk and neurodegenerative disease following insulin-induced hypoglycaemia"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-12-01T01:00:00+01:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2022-06-30T02:00:00+02:00",
            "end_effective": "2022-06-30T02:00:00+02:00",
            "assignment": "2022-01-17T15:13:04+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 100944,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                151
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6881-78894-11",
                "6881-100944-10"
            ]
        },
        {
            "id": 6830,
            "title": {
                "de": "„Work-Health-Life-Balance 4.0“ ",
                "en": "„Work-Health-Life-Balance 4.0“ "
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-09-30T02:00:00+02:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2022-11-30T01:00:00+01:00",
            "end_effective": "2022-11-30T01:00:00+01:00",
            "assignment": "2021-12-14T08:54:03+01:00",
            "program": null,
            "subprogram": null,
            "organization": 29444,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50887,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                997
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6830-50887-10"
            ]
        },
        {
            "id": 6816,
            "title": {
                "de": "Korrelation von präklinisch erhobenen Laktatwerten mit der Basenabweichung in der Blutgasanalyse von Notfallpatienten*innen",
                "en": "Association of prehospital lactate measurement with base deficit in various emergencies – a retrospective cohort study"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-04-01T02:00:00+02:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2022-01-31T01:00:00+01:00",
            "end_effective": "2024-05-31T02:00:00+02:00",
            "assignment": "2021-12-07T09:31:20+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14069,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 95708,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6816-95708-10"
            ]
        },
        {
            "id": 6949,
            "title": {
                "de": "Alterungsforschung im Fadenwurm",
                "en": "Aging research in Caenorhabditis elegans"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-12-01T01:00:00+01:00",
            "begin_effective": "2021-12-01T01:00:00+01:00",
            "end_planned": "2022-11-30T01:00:00+01:00",
            "end_effective": "2022-11-30T01:00:00+01:00",
            "assignment": "2022-03-07T14:22:38+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14013,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 85069,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6949-85069-10"
            ]
        },
        {
            "id": 6898,
            "title": {
                "de": "FrAmework for ClInicaL trIal participants’ daTA reutilization for a fully Transparent and Ethical\r\necosystem",
                "en": "FrAmework for ClInicaL trIal participants’ daTA reutilization for a fully Transparent and Ethical\r\necosystem"
            },
            "short": "FACILITATE",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2021-10-01T02:00:00+02:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2025-09-30T02:00:00+02:00",
            "end_effective": "2026-06-30T02:00:00+02:00",
            "assignment": "2022-01-27T15:31:30+01:00",
            "program": 109,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51663,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": " 101034366",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6898-51663-10"
            ]
        },
        {
            "id": 7055,
            "title": {
                "de": "Lösung des offenen Rätsels von TRPC3 durch Photopharmakologie",
                "en": "Resolving the open state enigma of TRPC3 by photopharmacology"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg).",
                "en": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg)."
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2025-12-31T01:00:00+01:00",
            "end_effective": "2026-10-31T01:00:00+01:00",
            "assignment": "2022-06-13T15:55:42+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 90337,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": " P 35291",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7055-90337-10",
                "7055-116421-12"
            ]
        },
        {
            "id": 6883,
            "title": {
                "de": "Früherkennung von Therapieresistenzen bei Prostatakrebs - In situ Detektion von Androgen-Rezeptor Splice Varianten",
                "en": "Early detection of therapy resistance in prostate cancer - In situ detection of Androgen receptor splice variants"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2017-07-31T02:00:00+02:00",
            "end_effective": "2023-12-31T01:00:00+01:00",
            "assignment": "2022-01-19T10:08:55+01:00",
            "program": null,
            "subprogram": "MEFO - Diagnostikum Preidler/Szolar-Stipendium",
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 66435,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-70",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "6883-66435-10"
            ]
        },
        {
            "id": 7037,
            "title": {
                "de": "Innovatives Pilotprojekt: Forschung zur Laserakupunktur und Lasermedizin",
                "en": "Innovative Pilot Project: Research on Laser Acupuncture and Laser Medicine"
            },
            "short": "Lasermedizin",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2022-12-31T01:00:00+01:00",
            "assignment": "2022-05-31T11:14:30+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14044,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                762
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 7156,
            "title": {
                "de": "doc.fund BioMolStruct - Zusatzfinanzierung (2. Förderjahr)",
                "en": "doc.fund BioMolStruct - Zusatzfinanzierung (2. Förderjahr)"
            },
            "short": "BioMolStruct - ZF",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2022-01-01T01:00:00+01:00",
            "begin_effective": "2022-01-01T01:00:00+01:00",
            "end_planned": "2022-12-31T01:00:00+01:00",
            "end_effective": "2022-12-31T01:00:00+01:00",
            "assignment": "2022-09-05T15:58:43+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14012,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 91207,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                2471
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "7156-91207-10"
            ]
        }
    ]
}