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GET /v1/research/project/?format=api&offset=1700&ordering=begin_effective
{ "count": 2266, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1720&ordering=begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1680&ordering=begin_effective", "results": [ { "id": 6931, "title": { "de": "Überwindung von Resistenzen in der Krebstherapie - Identifizierung neuer therapeutischer Angriffspunkte mittels dualen CRISPRko und CRISPRa Screens", "en": "Using dual CRISPRko and CRISPRa screens to identify novel\r\ntargets to overcome cancer drug resistance" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2022-02-17T11:44:31+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 109002, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6931-98327-12", "6931-109501-12", "6931-109002-10" ] }, { "id": 6836, "title": { "de": "Erforschung zellulärer Mechanismen der progredienten Multiplen Sklerose mit Hilfe eines experimentellen Rattenmodells.", "en": "Exploration of cellular mechanisms behind progressive multiple sclerosis via an experimental rat model." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-06-01T02:00:00+02:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2023-04-01T02:00:00+02:00", "end_effective": "2023-12-31T01:00:00+01:00", "assignment": "2021-12-15T10:42:21+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 70759, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-68", "ethics_committee": null, "edudract_number": null, "persons": [ "6836-70759-10" ] }, { "id": 6928, "title": { "de": "Apoptose als therapeutischer Angriffspunkt bei behandlungsresistentem Lungenkrebs", "en": "Targeting the apoptotic pathway to overcome therapy resistance in lung cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2023-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2022-02-15T13:14:17+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 109002, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-75", "ethics_committee": null, "edudract_number": null, "persons": [ "6928-109002-10" ] }, { "id": 6898, "title": { "de": "FrAmework for ClInicaL trIal participants’ daTA reutilization for a fully Transparent and Ethical\r\necosystem", "en": "FrAmework for ClInicaL trIal participants’ daTA reutilization for a fully Transparent and Ethical\r\necosystem" }, "short": "FACILITATE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-10-01T02:00:00+02:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-09-30T02:00:00+02:00", "end_effective": "2026-06-30T02:00:00+02:00", "assignment": "2022-01-27T15:31:30+01:00", "program": 109, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": " 101034366", "ethics_committee": null, "edudract_number": null, "persons": [ "6898-51663-10" ] }, { "id": 7055, "title": { "de": "Lösung des offenen Rätsels von TRPC3 durch Photopharmakologie", "en": "Resolving the open state enigma of TRPC3 by photopharmacology" }, "short": null, "url": null, "abstract": { "de": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg).", "en": "• Wider research context / theoretical framework: TRPC3 is a distinct member of TRPC family. This channel is expressed in excitable and non-excitable cells. By non-selectively conducting cations even at its resting state, TRPC3 promotes cellular processes in both health and disease. However, there are only a few modulators of this channel available. To precisely design new therapeutic ligands, it is of high importance to gain knowledge about TRPC3 protein structure and, consequently, its gating mechanism. Recently, two TRPC3 structures were revealed by cryo electron microscopy (cryo-EM). Nonetheless, neither of them captured open pore architecture. Hence, the open conformations is the critical missing piece of information to solve the TRPC3 gating puzzle. This knowledge is essential for comprehension of the molecular function of TRPC3 and definition of possible ligand binding sites to control this channel is health and, especially, disease.\r\n• Hypotheses / research questions / objectives: Here, we propose to succeed in capturing open pore structures of TRPC3 by stabilizing and synchronizing the channels at a high open probability using photochromic ligands and in addition by preserving their lipid environment during the protein preparation for cryo-EM.\r\n• Approach / methods: We will screen two expression systems for suitability to maintain TRPC3 in open conformation. We will utilize photopharmacological tools for a temporal control over TRPC3 gating during protein extraction and cryo-EM. Structural details obtained from cryo-EM will be followed by structure-guided mutagenesis and evaluated in a multifunctional live cell approach combining Ca2+ imaging and electrophysiology.\r\n• Level of originality / innovation: With our project, we will introduce a novel approach to control protein conformations during cryo-EM by photoswitchable ligands. Our work will unravel TRPC3 open architecture and promote the development of new concepts for therapeutic targeting of these channels.\r\n• Primary researchers involved: The research team will include profound experts in TRPC3 electrophysiology and Ca2+ signaling Dr. Oleksandra Tiapko and Dr. Klaus Groschner (Medical University of Graz, Austria), experts in membrane lipids Dr. Anita Emmerstorfer-Augustin (Graz University of Technology) and in structural biology and electron microscopy Dr. Christine Ziegler (University of Regensburg)." }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-10-31T01:00:00+01:00", "assignment": "2022-06-13T15:55:42+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 90337, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": " P 35291", "ethics_committee": null, "edudract_number": null, "persons": [ "7055-90337-10", "7055-116421-12" ] }, { "id": 6857, "title": { "de": "Predicting Cardiovascular Events Using Machine Learning", "en": "Predicting Cardiovascular Events Using Machine Learning" }, "short": "PRE-CARE ML", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2026-05-01T02:00:00+02:00", "assignment": "2021-12-21T14:20:28+01:00", "program": 112, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 3, "manager": 58906, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I5898", "ethics_committee": null, "edudract_number": null, "persons": [ "6857-58906-10" ] }, { "id": 6872, "title": { "de": "Das nasale Mikrobiom in der Therapie der chronischen Rhinosinusitis", "en": "The nasal microbiome in the therapy of chronic rhinosinusitis." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2022-01-10T08:55:50+01:00", "program": null, "subprogram": null, "organization": 14066, "category": 10, "type": 10, "partner_function": 4, "manager": 82492, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6872-82492-10" ] }, { "id": 7333, "title": { "de": "Serologisches Antikörper Screening zu SARS-CoV-2, Legionellen und Hepatitis unter Zahnmediziner*innen 2022\r\n", "en": "Serological antibody screening for SARS-CoV-2, legionella und hepatitis among dental staf 2022" }, "short": "Leg-Hep-S22", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2023-01-16T14:19:57+01:00", "program": null, "subprogram": null, "organization": 14109, "category": 10, "type": 10, "partner_function": 4, "manager": 50051, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7333-50051-10" ] }, { "id": 6909, "title": { "de": "Attraktivierung Allgemeinmedizin ", "en": "Attractiveness of general medicine" }, "short": "Attraktivierung AM 2022-2023", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2023-12-31T01:00:00+01:00", "end_effective": "2023-12-31T01:00:00+01:00", "assignment": "2022-02-08T11:55:39+01:00", "program": null, "subprogram": null, "organization": 27964, "category": 10, "type": 10, "partner_function": 4, "manager": 51098, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6909-51098-10" ] }, { "id": 6787, "title": { "de": "Apolipoprotein AI (apo-AI) Mimetische \r\nPeptid-Lipid-Assemblies", "en": "Apolipoprotein AI (apo-AI) Mimetic \r\nPeptide Lipid Assemblies" }, "short": "AAMLA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2025-12-31T01:00:00+01:00", "end_effective": "2026-11-30T01:00:00+01:00", "assignment": "2021-11-17T15:51:22+01:00", "program": 111, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 53252, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I5703", "ethics_committee": null, "edudract_number": null, "persons": [ "6787-53252-10" ] }, { "id": 6939, "title": { "de": "Förderung der Lebensspanne durch Mitohormesis induziert durch mitochondriales Kalzium", "en": "Promotion of lifespan by mitochondrial Ca2+-induced mitohormesis" }, "short": "Ca2+-induced mitohormesis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2022-03-01T12:10:36+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-69", "ethics_committee": null, "edudract_number": null, "persons": [ "6939-85069-10" ] }, { "id": 6907, "title": { "de": "Strategies for Safety Evaluation of Food Contact Materials\r\n", "en": "Strategien zur Sicherheitsbewertung Food Contact Material" }, "short": "Fit4Food", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-07-01T02:00:00+02:00", "begin_effective": "2022-01-03T01:00:00+01:00", "end_planned": "2024-06-30T02:00:00+02:00", "end_effective": "2025-04-02T02:00:00+02:00", "assignment": "2022-02-08T10:18:53+01:00", "program": 60, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 54018, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999891100", "ethics_committee": null, "edudract_number": null, "persons": [ "6907-54018-10", "6907-99824-12" ] }, { "id": 6947, "title": { "de": "Integrated Services for Infectious Disease Outbreak Research", "en": "Integrated Services for Infectious Disease Outbreak Research" }, "short": "ISIDORe", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-09-01T02:00:00+02:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2024-08-30T02:00:00+02:00", "end_effective": "2025-07-31T02:00:00+02:00", "assignment": "2022-03-04T11:47:38+01:00", "program": 210, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101046133", "ethics_committee": null, "edudract_number": null, "persons": [ "6947-51663-10" ] }, { "id": 6890, "title": { "de": "Kontinuierliche Bestimmung der Leberfunktion während simulierter Transplantation durch Maschinenperfusion", "en": "Continuous measurement of liver function during simulated transplantation by machine perfusion" }, "short": "CorLab_MP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2023-02-01T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2022-01-24T11:47:45+01:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 50144, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-73", "ethics_committee": null, "edudract_number": null, "persons": [ "6890-50144-10" ] }, { "id": 6884, "title": { "de": "Einzelzellanalyse in Leberkrebs", "en": "Single cell analysis of liver cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2022-08-01T02:00:00+02:00", "end_effective": "2023-01-31T01:00:00+01:00", "assignment": "2022-01-19T10:14:26+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 89979, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-74", "ethics_committee": null, "edudract_number": null, "persons": [ "6884-89979-10" ] }, { "id": 6900, "title": { "de": "Präklinische Anwendung von Mg- basiertem bioresorbierbaren Implantatmaterial in der Orbitachirurgie am Schafmodel", "en": "Preclinical application of Mg- based bioresorbable material for orbital floor recon-struction in an animal model " }, "short": "OS-MAG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2024-07-31T02:00:00+02:00", "assignment": "2022-02-01T14:28:18+01:00", "program": null, "subprogram": null, "organization": 14112, "category": 10, "type": 10, "partner_function": 1, "manager": 87313, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2698 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6900-87313-10" ] }, { "id": 6919, "title": { "de": "Energiestoffwechsel während der Bronchiolarepithel Regeneration", "en": "Energy Metabolism of Bronchiolar Epithelial Regeneration" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2023-12-31T01:00:00+01:00", "assignment": "2022-02-11T13:41:37+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 57409, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-76", "ethics_committee": null, "edudract_number": null, "persons": [ "6919-57409-10" ] }, { "id": 6945, "title": { "de": "Die Rolle von Sirtuin 3 im Rahmen günstiger Behandlungseffekte von Honokiol in myokardialer Ischämie-Reperfusion und Remodeling", "en": "The Role of Sirtuin 3 in Beneficial Treatment Effects of Honokiol in Myocardial Ischemia Reperfusion Injury and Remodeling" }, "short": "Sirt3 Honokiol", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2023-08-01T02:00:00+02:00", "end_effective": "2024-02-29T01:00:00+01:00", "assignment": "2022-03-03T16:32:59+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 99418, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6945-99418-10", "6945-101037-12" ] }, { "id": 6927, "title": { "de": "Charakterisierung der therapierelevanten epigenetischen Grundlagen des fortgeschrittenen Lungenkarzinom ", "en": "Characterizing the epigenetics of lung cancer progression to inform\r\npersonalized treatment" }, "short": "epiLUAD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2023-12-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2022-02-15T12:48:51+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 109087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-77", "ethics_committee": null, "edudract_number": null, "persons": [ "6927-109087-10" ] }, { "id": 6956, "title": { "de": "Immunantwort bei Puumala und anderen Orthohantavirusinfektionen und Generierung von Antikörpern aus peripheren mononuklären Zellen infizierter Individuen", "en": "Immune response to Puumala and related Orthohantavirus infections and generation of antibodies from peripheral blood mononuclear cells (PBMCs) of infected individuals" }, "short": "Puumala/Hanta Virus Immune response", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2022-02-01T01:00:00+01:00", "end_planned": "2023-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2022-03-10T13:53:28+01:00", "program": null, "subprogram": null, "organization": 29164, "category": 10, "type": 10, "partner_function": 1, "manager": 51976, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": "33-329 ex 20/21", "edudract_number": null, "persons": [ "6956-51976-10" ] } ] }