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GET /v1/research/project/?format=api&offset=1680&ordering=begin_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1700&ordering=begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1660&ordering=begin_effective", "results": [ { "id": 6806, "title": { "de": "Antikörper und Abwehrzellen nach durchgemachter SARS-CoV-2 Infektion bei Kindern und Jugendlichen", "en": "Humoral and cellular immunity after SARS-CoV-2 infection in\r\nchildren and adolescents" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-11-01T01:00:00+01:00", "begin_effective": "2021-11-01T01:00:00+01:00", "end_planned": "2024-12-31T01:00:00+01:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2021-11-30T15:49:52+01:00", "program": null, "subprogram": null, "organization": 14095, "category": 10, "type": 10, "partner_function": 4, "manager": 56810, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": 3, "language": null, "funders": [ 25 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6806-56810-10" ] }, { "id": 6713, "title": { "de": "Personalized, chronotherapeutic Forest Environment for Delirium Prevention on the ICU", "en": "Personalized, chronotherapeutic Forest Environment for Delirium Prevention on the ICU" }, "short": "Forest Environment", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-07-01T02:00:00+02:00", "begin_effective": "2021-11-01T01:00:00+01:00", "end_planned": "2024-07-01T02:00:00+02:00", "end_effective": "2025-10-31T01:00:00+01:00", "assignment": "2021-09-27T16:31:58+02:00", "program": 60, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 79771, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999888155", "ethics_committee": null, "edudract_number": null, "persons": [ "6713-79771-10" ] }, { "id": 7824, "title": { "de": "ACKR1 und ACKR4 in der experimentellen Glomerulonephritis", "en": "ACKR1 and ACKR4 in experimental kidney diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-11-01T01:00:00+01:00", "begin_effective": "2021-11-01T01:00:00+01:00", "end_planned": "2023-04-30T02:00:00+02:00", "end_effective": "2023-04-30T02:00:00+02:00", "assignment": "2023-10-10T10:23:38+02:00", "program": 69, "subprogram": null, "organization": 14084, "category": 10, "type": 10, "partner_function": 4, "manager": 86588, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J 4606", "ethics_committee": null, "edudract_number": null, "persons": [ "7824-86588-10" ] }, { "id": 6778, "title": { "de": "Ist die Zusammensetzung der Membranlipide vom Cix-Dux4 \r\nTranskriptionsfaktorfusionssarkomen im Vergleich zum Ewing \r\nSarkom ein Grund für deren Aggressivität und fehlendem \r\nAnsprechen auf Chemotherapeutika im Sinne einer \r\nResistenzbildung?", "en": "Is the membrane lipid composition of the CIC-DUX4 merged sarcoma in comparison to the Ewing sarcoma one reason for their aggressiveness and missing response to a treatment \r\nfor the purpose of an resistence?" }, "short": "Cix-Dux4", "url": null, "abstract": { "de": "Die beiden Mitglieder der Gruppe der klein rund und blauzelligen Sarkome des Binde und Stützgewebes Ewing und CIC-DUX4 sind sich hinsichtlich ihrer Histologie sehr ähnlich. Betrachtet man jedoch molekulare Gesichtspunkte, Alter der PatientInnen und vor allem das Outcome sind diese sehr heterogen.\r\nEwing Sarkome betreffen vor allem Kinder und Jugendliche. Die 5 Jahres Überlebens Wahrscheinlichkeit beträgt ohne Metastasierung über 70% (S1 Leitlinien Ewing Sarkome des Kindes und Jugendalters, Stand 2014, Antonescu et al. beschreibt sogar 82%). Die derzeitige Behandlung erfolgt mit dem VIDE Schema (Vincristin, Ifosfamid, Doxorubicin, Etoposid).\r\nSeltener, aber bösartiger ist das CIC-DUX4 fusionierte Sarkom. Diese Erkrankung trifft PatientInnen im Median von 31 Jahren. Allerdings sind alle Altersgruppen vertreten. CIC und DUX4 sind zwei Genabschnitte, welche fusioniert sind. Aufgrund der Tatsache, dass CIC-DUX4 und Ewing morphologisch ähnlich sind, werden sie gleich therapiert. Obwohl molekulargenetisch bereits festgestellt ist, dass es sich dabei um verschiedene Entitäten handelt. Mit dem Ergebnis, dass die 5-Jahres-Überlebensrate von Patientinnen mit CIC-DUX4 Sarkom bei 43% (Antonescou et al.) liegt.\r\nZiel dieses Projekts ist es, mögliche Resistenzmechanismen der beiden Sarkomentitäten charakterisieren zu können.\r\nDabei handelt es sich um einen Zellkulturversuch.\r\nEin wesentlicher Faktor zur Resistenz gegenüber Chemotherapeutika ist die Zellmembran. Die Zellmembran besteht aus drei Hauptlipiden: Phospholipiden, Sphingolipiden und Cholesterin. Dabei soll die Lipidzusammensetzung der Zellen mittels Massenspektrometrie analysiert werden.\r\nWeiters werden die Sarkome Ultrastrukturell auf Fett Tröpfchen analysiert. Dies kann einen Hinweis auf Resistenzen geben, denn lipophile Therapeutika (wie zum Beispiel das Doxorubicin) könnten darin gefangen werden und dadurch keinen ausreichenden Wirkspiegel im Zellkern ausbilden.\r\nDie funktionale Bestätigung einer möglichen Resistenzbidldung in CIC-DUX4 Sarkomen durch Lipiddetektion mitels Massenspektrometrie und ultrastruktureller Aufklärung in Bezug auf Fett Tröpfchen soll mittels Compound Testing erfolgen.", "en": null }, "begin_planned": "2021-11-05T01:00:00+01:00", "begin_effective": "2021-11-01T01:00:00+01:00", "end_planned": "2022-07-01T02:00:00+02:00", "end_effective": "2022-11-30T01:00:00+01:00", "assignment": "2021-11-04T14:34:16+01:00", "program": null, "subprogram": null, "organization": 27477, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 6899, "title": { "de": "Wir alle sind Mischwesen: Mikrochimärsimus, Gesundheit und Evolution", "en": "We All Are Multitudes: the Microchimerism, Human Health and Evolution" }, "short": "Microchimerism and Evolution", "url": "https://www.microchimerism.info/", "abstract": { "de": "Mikrochimärismus (MC) beschreibt die Existenz einer kleinen Anzahl fremder menschlicher Zellen in einer Person. Dieses Phänomen entsteht unter anderem während der Schwangerschaft durch das Wandern von Zellen zwischen Mutter und Fötus. Das derzeitige Wissen um MC ist unvollständig und teils widersprüchlich, über die Rolle, die mikrochimäre Zellen in der Wirtsphysiologie spielen, ist wenig bekannt.\r\nWas ist der Grund der anscheinend paradoxen Effekte von MC? Welche Mechanismen sind beteiligt oder sogar verantwortlich dafür, dass mikrochimäre Zellen ins Wirtsgewebe wandern, sich dort integrieren und oftmals ein Wirtsleben lang verbleiben? Die Evolutionsbiologie und die maternal-fetale Konflikttheorie können einen Rahmen bieten, um die Persistenz mikrochimärer Zellen zu verstehen und deren Existenz mit einer erhöhten Anfälligkeit für Krankheiten zu verknüpfen.\r\nWir gehen zunächst davon aus, dass MC weiter verbreitet ist als bisher berichtet. Wir nehmen weiters an, dass mikrochimäre Zellen eine adaptive Rolle in der Physiologie des Wirts zu spielen vermögen und Vorteile für Mütter und Nachkommen bieten können, etwa durch Übertragung von Stammzellen und anderen Zelltypen aber auch durch Übertragung von wichtigen Komponenten des und Signalen für das Immunsystem. Jedoch werden sich in manchen Geweben die maternal-fötalen genetischen Interessen nicht zur Deckung bringen lassen, was eine erhöhte Anfälligkeit für Krankheiten zur Folge haben kann. Daher ist es unser Ziel, den Einfluss des MC auf Gesundheit und Krankheit zu studieren und Potential und Effekte des Zelltransfers über Generationengrenzen hinweg zu verstehen.\r\nBasis unseres Projekts ist die Verwendung modernster Technologien zur Analyse des bidirektionalen Transfers mikrochimärer Zellen zwischen Individuen und die Verteilung der mikrochimären Zellen in den Zielgeweben. Weiters widmen wir uns den Effekten, die aus der Interaktion von mikrochimären Zellen und dem Immunsystem des Wirts hervorgehen. Diese Themen studieren wir in mehreren Teilprojekten: Erstellung eines Maus-Mikrochiom-Atlas (Projekt 1), Phänotypisierung von maternalem (Projekt 2) und fetalem (Projekt 3) MC, Charakterisierung von mikrochimären Zellen in plazentanahen, -fernen Geweben und diversen Organen (Projekt 4) sowie den Zusammenhang von MC und Autoimmunerkrankung im Tiermodell (Projekt 5).\r\nUnsere Forschung dient dem Verständnis der Interaktion von mikrochimären Zellen mit dem Wirt und zur Klärung der Fragen, wie die Toleranz von MC während der Schwangerschaft und postpartum bei Müttern gewährleistet und aufrecht erhalten werden kann, welche Auswirkungen MC auf die frühe Entwicklung von Föten hat und ob es während Krankheiten zum Zusammenbruch der Immuntoleranz kommt und welche Ursachen dies hat.", "en": "Microchimerism (MC) is the harboring of a small number of cells between two distinct individuals. This transfer of cells is well known to occur between mothers and offspring during gestation, though other avenues of transfer may be possible. The current understanding of MC is puzzling and little is known about the role microchimeric cells play in host physiology.\r\nWhy are the effects of MC paradoxical and what are the mechanisms responsible for maintaining microchimeric cells over an organism’s lifetime? Evolutionary biology and maternal-fetal conflict theory can provide a framework to understand the persistence of microchimeric cells, and how this may lead to disease vulnerability.\r\nWe hypothesize MC is much more common than previously reported and microchimeric cells play an adaptive role in host physiology, providing benefits for both mothers and offspring through transfers of stem and other cell types, and providing key immune system components and signals. However, in certain host tissues the maternal-fetal genetic interests may not align, potentially leading to disease vulnerability.\r\nWe aim to understand the role MC plays in health and disease, and understand the potential for and effects of subsequent generational transfers of microchimeric cells. We will use cutting edge technology to characterize MC cell distribution and trafficking between hosts and the effects of MC-host immune system interactions in various host tissues by creating a mouse Microchiome Atlas (Project 1), phenotyping human maternal MC (mMC) (Project 2), phenotyping human fetal MC (fMC) (Project 3), phenotyping microchimeric cells proximal and distal in terms of distance from the maternal-fetal interface as well as in various other organs (Project 4), and interrogating the context of MC and autoimmune disease in animal models (Project 5).\r\nOur research will determine how microchimeric cells interact with the host system to initiate and maintain tolerance of MC during pregnancy, the postpartum period for mothers and early development in offspring, and uncover if there is a breakdown in immune tolerance during disease states, and what causes it." }, "begin_planned": "2022-02-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2024-10-31T01:00:00+01:00", "end_effective": "2026-08-30T02:00:00+02:00", "assignment": "2022-02-01T12:59:33+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 3, "manager": 54171, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2575 ], "funder_projectcode": "62214", "ethics_committee": null, "edudract_number": null, "persons": [ "6899-104057-12", "6899-54171-10", "6899-82600-12", "6899-104139-12", "6899-114270-12", "6899-115382-12", "6899-116463-12" ] }, { "id": 6818, "title": { "de": "Isoflavonmessung, Mikrobiom und endokrine Characterisierung", "en": "Isoflavone measurement, microbiome and endocrine characterisation" }, "short": "IsoMiEndo", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-12-01T01:00:00+01:00", "end_effective": "2022-12-01T01:00:00+01:00", "assignment": "2021-12-07T17:55:45+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51809, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-67", "ethics_committee": null, "edudract_number": null, "persons": [ "6818-51809-10", "6818-109041-12" ] }, { "id": 6881, "title": { "de": "Biomarker für kardiovaskuläre Risiken und neurodegenerative Erkrankungen nach insulininduzierter Hypoglykämie", "en": "Biomarkers for cardiovascular risk and neurodegenerative disease following insulin-induced hypoglycaemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-06-30T02:00:00+02:00", "end_effective": "2022-06-30T02:00:00+02:00", "assignment": "2022-01-17T15:13:04+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 1, "manager": 100944, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 151 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6881-78894-11", "6881-100944-10" ] }, { "id": 7007, "title": { "de": "Der Einfluss des Harntrakt-Mikrobioms auf ‚Lower Urinary Tract Symptomes’ (LUTS) bei Männern", "en": "The influence of urinary tract microbiome on male lower urinary tract symptomes (LUTS)" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2023-12-01T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2022-05-02T10:13:59+02:00", "program": null, "subprogram": null, "organization": 14056, "category": 10, "type": 10, "partner_function": 4, "manager": 113095, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7007-113095-10" ] }, { "id": 6816, "title": { "de": "Korrelation von präklinisch erhobenen Laktatwerten mit der Basenabweichung in der Blutgasanalyse von Notfallpatienten*innen", "en": "Association of prehospital lactate measurement with base deficit in various emergencies – a retrospective cohort study" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-04-01T02:00:00+02:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-01-31T01:00:00+01:00", "end_effective": "2024-05-31T02:00:00+02:00", "assignment": "2021-12-07T09:31:20+01:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 95708, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6816-95708-10" ] }, { "id": 6949, "title": { "de": "Alterungsforschung im Fadenwurm", "en": "Aging research in Caenorhabditis elegans" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-11-30T01:00:00+01:00", "end_effective": "2022-11-30T01:00:00+01:00", "assignment": "2022-03-07T14:22:38+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6949-85069-10" ] }, { "id": 6830, "title": { "de": "„Work-Health-Life-Balance 4.0“ ", "en": "„Work-Health-Life-Balance 4.0“ " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-09-30T02:00:00+02:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-11-30T01:00:00+01:00", "end_effective": "2022-11-30T01:00:00+01:00", "assignment": "2021-12-14T08:54:03+01:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 50887, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 997 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6830-50887-10" ] }, { "id": 6852, "title": { "de": "Anomalien im Fettstoffwechsel von PEMT-Knockout Mäusen", "en": "Abnormalities in lipid metabolism of PEMT knockout mice." }, "short": "PEMT-KO-Mäuse", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-17T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2023-04-30T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2021-12-20T09:49:08+01:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 4, "manager": 50712, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6852-50712-10" ] }, { "id": 6909, "title": { "de": "Attraktivierung Allgemeinmedizin ", "en": "Attractiveness of general medicine" }, "short": "Attraktivierung AM 2022-2023", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2023-12-31T01:00:00+01:00", "end_effective": "2023-12-31T01:00:00+01:00", "assignment": "2022-02-08T11:55:39+01:00", "program": null, "subprogram": null, "organization": 27964, "category": 10, "type": 10, "partner_function": 4, "manager": 51098, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6909-51098-10" ] }, { "id": 7037, "title": { "de": "Innovatives Pilotprojekt: Forschung zur Laserakupunktur und Lasermedizin", "en": "Innovative Pilot Project: Research on Laser Acupuncture and Laser Medicine" }, "short": "Lasermedizin", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-01-01T01:00:00+01:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2022-05-31T11:14:30+02:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 762 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 7156, "title": { "de": "doc.fund BioMolStruct - Zusatzfinanzierung (2. Förderjahr)", "en": "doc.fund BioMolStruct - Zusatzfinanzierung (2. 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