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GET /v1/research/project/?format=api&offset=1660&ordering=-begin_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1680&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1640&ordering=-begin_effective", "results": [ { "id": 2650, "title": { "de": "Schwanger in die Höhe - Untersuchungen im in vitro Modellsystem", "en": "Pregnancy at high altitudes - Investigations with an in vitro model system" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-11-01T01:00:00+01:00", "begin_effective": "2011-11-01T01:00:00+01:00", "end_planned": "2013-10-31T01:00:00+01:00", "end_effective": "2017-04-30T02:00:00+02:00", "assignment": "2011-11-25T12:21:37+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 58943, "contact": 58943, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2650-58943-10" ] }, { "id": 2602, "title": { "de": "Verlust des RAF Kinase Inhibitor Proteins bei der akuten myeloischen Leukämie", "en": "Loss of RAF Kinase Inhibitor Protein in acute myeloid leukemia" }, "short": "RKIP Verlust bei AML", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-15T02:00:00+02:00", "begin_effective": "2011-10-15T02:00:00+02:00", "end_planned": "2012-04-15T02:00:00+02:00", "end_effective": "2012-10-15T02:00:00+02:00", "assignment": "2011-10-03T13:18:57+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": 57402, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2602-57402-10" ] }, { "id": 2614, "title": { "de": "Mechanismen der Kalzium-getriggerten Arrhythmien", "en": "Mechanisms of Ca2+-triggered arrhythmias" }, "short": "Buchkapitel", "url": null, "abstract": { "de": null, "en": "Calcium (Ca2+) - the simplest and most versatile intracellular messenger - couples an action potential with the contraction in cardiac myocytes. Abnormal changes in intracellular Ca2+ homeostasis may cause contractile dysfunction, subcellular Ca2+ alternans and oscillations of the myocyte membrane potential, such as early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs), both of which may evoke a number of triggered arrhythmias that cause sudden cardiac death. EAD occurs during excessive action potential prolongation mainly due to the reactivation of L-type Ca2+ channels. DAD, on the other hand, typically results from the increased diastolic SR Ca2+ release, which is caused by either defective regulation of the sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR2), increased SR Ca2+ load or a combination of both. Sufficient cytosolic Ca2+ elevation propagates along myocytes as Ca2+ waves, which may activate an arrhythmogenic depolarizing current largely carried by inward Na+/Ca2+ exchanger. DADs need to reach threshold potential for voltage-gated Na+ channels to evoke premature beats (ectopic activity). Ca2+-dependent triggered arrhythmias occur both in acquired (e.g. heart failure, atrial fibrillation) and in congenital cardiac diseases (e.g. cathecholaminergic polymorphic ventricular tachycardia, CPVT). CPVT is an inherited arrhythmia syndrome associated with mutations in either RyR2 or calsequestrin, SR Ca2+-binding protein. Both mutations destabilize the RyR2 Ca2+ release complex implying increased diastolic SR Ca2+ leak through RyR2 in the presence of beta-adrenergic stimulation (e.g. physical exercise or emotional stress). Several mechanisms underlying the increased diastolic Ca2+ leak in heart failure and CPVT have been proposed, including excessive RyR2 phosphorylation, altered Ca2+ sensitivity of the RyR2 at luminal or cytosolic sites, weaker interdomain interaction and lower threshold for store-overload-induced Ca2+ release. A better understanding of the similarities and differences between the mechanisms underlying triggered arrhythmias in acquired and inherited cardiac diseases, holds the promise to develop new specific diagnostic and therapeutic approaches for effective treatment of defective ion handling in these lethal arrhythmias. \r\nThis chapter will review common mechanisms that cause the susceptibility to, and initiation of, Ca2+-dependent arrhythmias with a focus on increased SR Ca2+ release due to congenital or acquired RyR2 dysfunction and increased SR Ca2+ load. Finally, RyR2 stabilizers (e.g. JTV-519, flecainide, dantrolene) and RyR2 phosphorylation inhibitors (e.g. CaMKII inhibitors) as novel therapeutic targets will be discussed. \t\t\r\n" }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2011-10-15T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-14T16:07:01+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 60041, "contact": 60041, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2614-60041-10" ] }, { "id": 2799, "title": { "de": "Effekte einer Vitamin D-Supplementation bei PatientInnen mit koronarer Herzkrankheit, Postbelastungshyperglykaemie und Vitamin D Mangel.", "en": "Effects of a vitamin D supplementation in patients with coronary artery disease, postchallenge hyperglycaemia and vitamin D deficiency" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-06-01T02:00:00+02:00", "end_effective": "2014-10-30T01:00:00+01:00", "assignment": "2012-02-20T11:04:51+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50838, "contact": 50838, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2799-50838-10" ] }, { "id": 2609, "title": { "de": "Hepcidin im Rahmen von Sepsis und Adipositas", "en": "The Role of Hepcidin in Sepsis and Obesity" }, "short": "HEPCIDIN_SEPSIS_ADIPOSITAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2011-12-31T01:00:00+01:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2011-10-06T15:38:08+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50778, "contact": 50778, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2609-50778-10" ] }, { "id": 2697, "title": { "de": "Herzinsuffizienzforschung an der Medizinischen Universität Graz", "en": "Herzinsuffizienzforschung an der Medizinischen Universität Graz" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2011-12-19T10:48:05+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2697-58906-12", "2697-60041-12", "2697-60377-12", "2697-60390-12", "2697-62075-12", "2697-62747-12", "2697-59941-12", "2697-75758-12", "2697-78591-12", "2697-83082-12", "2697-89052-12" ] }, { "id": 2489, "title": { "de": "Etablierung eines künstlichen Blutgefäßmodells zur Entwicklung von Gefäßprothesen", "en": "Artifical blood vessel model for the development of vascular protheses" }, "short": "Artifical blood vessel model", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-04T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2012-12-04T01:00:00+01:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2011-05-30T18:05:42+02:00", "program": null, "subprogram": "Human Technology Interface", "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 51718, "contact": 51718, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2489-76930-12", "2489-51718-10" ] }, { "id": 2618, "title": { "de": "Wirkung des neuen Lipidsenkers Niacin/Laropiprant (Tredaptive®) auf Funktion humaner Blutplättchen", "en": "Effect of the novel lipid-lowering therapy niacin plus laropiprant (Tredaptive®) on platelet function: Benefit or hazard?" }, "short": "LIPIDSENKER NIACIN/LAROPIPRANT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2011-10-19T13:21:31+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": 51756, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2618-51756-10" ] }, { "id": 2483, "title": { "de": "PSYCHOPHARMAKOLOGISCHE MODELLE CHRONISCHER BAUCHSCHMERZEN", "en": "Psychopharmacological modelling of ongoing visceral pain" }, "short": "Chron Bauchschmerzen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-06-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2014-05-31T02:00:00+02:00", "end_effective": "2015-04-30T02:00:00+02:00", "assignment": "2011-05-23T12:56:33+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51529, "contact": 51529, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P23097", "ethics_committee": null, "edudract_number": null, "persons": [ "2483-51529-10" ] }, { "id": 2538, "title": { "de": "Expression und Funktion von Prostaglandin D2 Rezeptoren bei allergischen und asthmatischen Erkrankungen", "en": "Enhanced expression and function of prostaglandin D2 receptors in monocytes, macrophages and eosinophils of patients with allergy and bronchial asthma" }, "short": "PGD2 receptors in allergic and asthmatic", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2011-07-19T12:42:10+02:00", "program": 79, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 50791, "contact": 50791, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2538-50791-10" ] }, { "id": 2388, "title": { "de": "Carbamyliertes HDL und Atherosklerose", "en": "Effect(s) of protein carbamylation on anti-atherogenic properties of high-density lipoprotein" }, "short": "HDL und Atherosklerose", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-10-01T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2011-02-02T13:57:11+01:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 53252, "contact": 53252, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22976", "ethics_committee": null, "edudract_number": null, "persons": [ "2388-53252-10" ] }, { "id": 2528, "title": { "de": "Pilze als Indikatoren für pathogeninaktivierende Eigenschaften eines neuen Fixativs für die Gewebekonservierung", "en": "Fungi as indicators for pathogen inactivating capacity of a novel fixative employed on tissue preservation" }, "short": "3P", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-03-31T01:00:00+01:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2011-07-13T15:48:48+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 50828, "contact": 50828, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 895 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2528-50828-10" ] }, { "id": 2615, "title": { "de": "Tailored biodegradable magnesium implant materials", "en": "Tailored biodegradable magnesium implant materials" }, "short": "MagnIM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2014-09-30T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2011-10-18T11:42:58+02:00", "program": 24, "subprogram": "Marie Curie Initial Training Network (ITN)", "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50785, "contact": 50785, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "289163", "ethics_committee": null, "edudract_number": null, "persons": [ "2615-50785-10" ] }, { "id": 2834, "title": { "de": "Vitamin D3 Supplementierung bei polymorpher Lichtdermatose: Randomisierte doppelblinde plazebo-kontrollierte Studie", "en": "Vitamin D3 supplementation in polymorphic light eruption: Randomized double-blinded placebo-controlled trial" }, "short": "Vitamin D und polymorphe Lichtdermatose", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-10-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2014-09-30T02:00:00+02:00", "end_effective": "2015-03-31T02:00:00+02:00", "assignment": "2012-04-04T13:19:59+02:00", "program": 108, "subprogram": "KLIF", "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51618, "contact": 51618, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI132", "ethics_committee": null, "edudract_number": null, "persons": [ "2834-62056-12", "2834-51618-10" ] }, { "id": 2649, "title": { "de": "Identifizierung von Biomarkern aus zirkulierenden Tumorzellen", "en": "Identification of biomarkers from circulating tumor cells" }, "short": "CTC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-05-01T02:00:00+02:00", "begin_effective": "2011-10-01T02:00:00+02:00", "end_planned": "2013-04-30T02:00:00+02:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2011-11-25T11:07:38+01:00", "program": 72, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P23284", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2568, "title": { "de": "Akustisches Interface zur Tremoranalyse", "en": "Acoustic interface for tremoranalysis" }, "short": "ACOUSTIC INTERFACE TREMORANALYSIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2011-11-30T01:00:00+01:00", "end_effective": "2012-10-31T01:00:00+01:00", "assignment": "2011-09-06T12:41:59+02:00", "program": null, "subprogram": "Forschung Steiermark - Planung, Steuerung, Impulse\r\nHTI", "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2549, "title": { "de": "Postoperative altersentsprechende Akutschmerzerfassung bei Kindern und Jugendlichen", "en": "postoperative age-related assessment of acute pain in children and adolescents" }, "short": "POSTOPERATIVE AGE-RELATED ACUTE PAIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2013-06-30T02:00:00+02:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2011-07-29T11:15:50+02:00", "program": 79, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 50785, "contact": 50785, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2549-50785-10" ] }, { "id": 2686, "title": { "de": "Disseminierende Tumorzellen in primär metastasierten Brustkrebspatientinnen mit Chirurgie des Primärtumors ", "en": "Disseminating tumor cells in primary metastasized breast cancer patients undergoing surgery of primary tumor" }, "short": "DISSEMINATING TUMOR CELLS_BREAST CANCER", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-07-01T02:00:00+02:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2014-07-01T02:00:00+02:00", "end_effective": "2016-06-30T02:00:00+02:00", "assignment": "2011-12-14T13:04:08+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 59188, "contact": 59188, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2686-80692-12", "2686-97797-12", "2686-50539-12", "2686-50563-12", "2686-59188-10" ] }, { "id": 2567, "title": { "de": "Die Wirkung eines Konzentrates multipotenter Knochenmarkszellen auf die Knochenregeneration und die Osseointegration von Zahnimplantaten nach Sinusbodenelevation", "en": "Die Wirkung eines Konzentrates multipotenter Knochenmarkszellen auf die Knochenregeneration und die Osseointegration von Zahnimplantaten nach Sinusbodenelevation" }, "short": "Multipotente Knochenmarkszellen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-03-01T01:00:00+01:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-03-30T02:00:00+02:00", "assignment": "2011-09-05T17:35:08+02:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 4, "manager": 50792, "contact": 50792, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2567-50792-10" ] }, { "id": 2486, "title": { "de": "Eiseneinlagerung und mikrostrukturelle Gewebsveränderungen bei amyotropher Lateralsklerose", "en": "Longitudinal Assessment of Iron Deposition and Microstructural Tissue Changes in Amyotrophic Lateral Sclerosis" }, "short": "Quantitative MRI in ALS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2011-09-01T02:00:00+02:00", "begin_effective": "2011-09-01T02:00:00+02:00", "end_planned": "2014-08-31T02:00:00+02:00", "end_effective": "2015-02-28T01:00:00+01:00", "assignment": "2011-05-26T16:57:51+02:00", "program": 72, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 51279, "contact": 51279, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P23576", "ethics_committee": null, "edudract_number": null, "persons": [ "2486-51279-10" ] } ] }