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GET /v1/research/project/?format=api&offset=1640&ordering=-end_planned
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1660&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1620&ordering=-end_planned", "results": [ { "id": 3436, "title": { "de": "Quantitatives Modeling von Ca2+ Nanodomänen (QuMoCa)", "en": "Quantitative Modeling of Ca2+ Nanodomains" }, "short": "QuMoCa", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-06-01T02:00:00+02:00", "begin_effective": "2014-02-10T01:00:00+01:00", "end_planned": "2015-05-31T02:00:00+02:00", "end_effective": "2016-02-09T01:00:00+01:00", "assignment": "2013-11-19T11:43:39+01:00", "program": 24, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "330657", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2387, "title": { "de": "BioSHaRE_Biobank Standardisation and Harmonization for Research", "en": "BioSHaRE_Biobank Standardisation and Harmonization for Research" }, "short": "Bio_SHaRE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-01T02:00:00+02:00", "begin_effective": "2010-12-01T01:00:00+01:00", "end_planned": "2015-05-31T02:00:00+02:00", "end_effective": "2015-11-30T01:00:00+01:00", "assignment": "2011-02-01T14:20:10+01:00", "program": 24, "subprogram": "HEALTH", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "261433", "ethics_committee": null, "edudract_number": null, "persons": [ "2387-51663-10" ] }, { "id": 3776, "title": { "de": "EFSD Albert Renold Travel Fellowship", "en": "EFSD Albert Renold Travel Fellowship" }, "short": "Visiting Scientist Philadelphia", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-11-01T01:00:00+01:00", "begin_effective": "2014-11-01T01:00:00+01:00", "end_planned": "2015-05-01T02:00:00+02:00", "end_effective": "2015-05-01T02:00:00+02:00", "assignment": "2014-09-24T11:25:02+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2957, "title": { "de": "VERHALTENSSTÖRUNGEN NACH VISZERALER IMMUNAKTIVIERUNG", "en": "PSYCHOPHARMACOLOGY OF THE VISCERAL IMMUNE BRAIN AXIS" }, "short": null, "url": null, "abstract": { "de": "Depression ist eine der häufigsten und schwersten affektiven Störungen, welche die Lebensqualität und Arbeitsfähigkeit der betroffenen Patienten massiv einschränkt und damit von enormer sozio-ökonomischer Bedeutung ist. Die Weltgesundheitsorganisation berichtet, dass Depression in der Altersklasse von 15 44 Jahren schon jetzt bei beiden Geschlechtern die zweithäufigste Ursache für disability adjusted life years darstellt und die Zahl der von Depression betroffenen Patienten weiter steigt. Unglücklicherweise sprechen bis zu 40 % der Patienten mit Depression nur unzureichend auf die verfügbaren Antidepressiva an, was mit der Tatsache zusammenhängt, dass die Ätiologie affektiver Störungen nur unvollständig bekannt ist. Abgesehen von genetischen und psychosozialen Risikofaktoren rückt immer mehr auch eine chronische Stimulierung des Immunsystems als eine Ursache für die Entstehung affektiver Störungen in den Blickpunkt. Die Zytokin-Hypothese der Depression postuliert, dass systemische Immunprozesse über erhöhte Blutspiegel proinflammatorischer Zytokine einen Einfluss auf Gehirnfunktionen ausüben, die Ängstlichkeit, Affekt, Stressresistenz und kognitive Prozesse regulieren.\r\nAktivierung des viszeralen Immunsystems und viszerale Entzündung können mit einer Reihe von psychiatrischen Abnormalitäten assoziiert sind. Klinische Beobachtungen sprechen dafür, dass Translokation von Zellwandkomponenten des intestinalen Mikrobioms über eine pathologisch durchlässige Darmschleimhaut zu affektiven Störungen führen kann. Präklinische Befunde belegen, dass gastrointestinale Infektionen, gastrointestinale Entzündungen und intraperitoneale Verabreichung bakteriellen Endotoxins emotional-affektive Verhaltensänderungen auslöst. Vor diesem Hintergrund ist es das Ziel des vorgelegten Projekts, in einem experimentellen Ansatz depressive Verhaltensänderungen nach viszeraler Immunstimulierung in umfassender und innovativer Weise zu analysieren und neue Angriffspunkte für wirksame pharmakologische Interventionen zu identifizieren.\r\nDie wichtigsten Hypothesen, die es zu untersuchen gilt, sind, \r\n\tdass Zellwandkomponenten des intestinalen Mikrobioms (Lipopolysaccharid, Pepidoglycan) und intestinale Hormone unter dem Einfluss des Mikrobioms (Glucagon-Like Peptide, Peptid YY) depressive Verhaltensänderungen hervorrufen,\r\n\tviszerale Immunaktivierung das affektive Verhalten kurz- und langfristig beeinflusst;\r\n\tspezifische Signaltransduktionsmechanismen im Gehirn (Receptor-Activator of Nuclear Factor B Ligand, Cyclooxygenase-2 und Brain-Derived Neurotrophic Factor) von Relevanz für die affektiven Störungen im Gefolge einer peripheren Immunaktivierung sind, und\r\n\tdepressive Verhaltensänderungen nach viszeraler Immunstimulierung mit einer Störung der Hypothalamus-Hypophysen-Nebennieren-Achse, einer Störung des Glukokortikoid-Feedback an das Gehirn und einer Störung der Neurogenese im limbischen System assoziiert sind.", "en": "Being one of the most prevalent and severe mood disorders, major depression is deleterious to the patients quality of life and of enormous socio-economic impact. According to the World Health Organization, depression is the second most frequent cause of disability-adjusted life years in the age category of 15 44 years for both genders, with the number of patients continuing to grow. A proportion of some 40 % of the patients does not satisfactorily respond to the available antidepressant drugs, which reflects the incomplete understanding of the aetiology of affective disorders. Apart from vulnerability and psychosocial factors, chronic immune challenge has emerged as a circumstance relevant to the pathogenesis of mood disorders. The cytokine hypothesis of depression holds that systemic inflammatory processes associated with elevated levels of circulating proinflammatory cytokines disturb several brain mechanisms that control anxiety, mood, stress resilience and cognition.\r\nVisceral immune activation and inflammation are associated with a variety of psychiatric abnormalities, and there is clinical evidence that constituents of the intestinal microbiome across a leaky mucosal barrier may be a factor underlying mood disorders. Preclinical evidence indicates that gastrointestinal infection and inflammation as well as intraperitoneal administration of bacterial lipopolysaccharide induce behavioural disturbances. The current research proposal sets out to specifically examine the visceral immune brain axis in an innovative and comprehensive manner and to identify key mechanisms that are suitable for pharmacological modulation.\r\nThe main hypotheses to be addressed are that\r\n\tfactors derived from the intestinal microbiome (lipopolysaccharide, pepidoglycan) or intestinal hormones under the regulatory influence of the microbiome (glucagon-like peptide, peptide YY) have an impact on the visceral immune brain axis;\r\n\tvisceral immune challenge has a short- and long-term impact on affective behaviour;\r\n\tspecific brain signalling mechanisms involving receptor-activator of nuclear factor B ligand, cyclooxygenase-2 and brain-derived neurotrophic factor play a role in the behavioural effects of peripheral immune challenge; and\r\n\tactivation of the visceral immune brain axis is associated with deranged activity of the hypothalamic-pituitary-adrenal axis, disturbed glucocorticoid feedback on the brain and altered neurogenesis in the limbic system." }, "begin_planned": "2012-05-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-04-30T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-08-30T10:10:47+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 24618", "ethics_committee": null, "edudract_number": null, "persons": [ "2957-71487-12", "2957-51529-12" ] }, { "id": 3205, "title": { "de": "Analyse von RAS Mutationen in einem murinen in vivo Modell der akuten myeloischen Leukämie", "en": "Analysis of RAS mutations in a murine in vivo model of acute myeloid leukemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-04-15T02:00:00+02:00", "begin_effective": "2013-04-15T02:00:00+02:00", "end_planned": "2015-04-15T02:00:00+02:00", "end_effective": "2016-04-15T02:00:00+02:00", "assignment": "2013-03-08T14:51:46+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3205-57402-10", "3205-77371-12", "3205-94596-12" ] }, { "id": 3596, "title": { "de": "Interleukin-6 signal transduction pathways in glial cells", "en": "Interleukin-6 signal transduction pathways in glial cells" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-04-01T02:00:00+02:00", "begin_effective": "2014-04-01T02:00:00+02:00", "end_planned": "2015-03-31T02:00:00+02:00", "end_effective": "2015-03-14T01:00:00+01:00", "assignment": "2014-03-07T10:54:06+01:00", "program": 69, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 69755, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J 3081 ", "ethics_committee": null, "edudract_number": null, "persons": [ "3596-69755-10" ] }, { "id": 3579, "title": { "de": "Die Rolle von Autophagie bei cholämischer Nephropathie", "en": "The Role of Autophagy in Cholemic Nephropathy" }, "short": "Cholemic Nephropathy", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-01-01T01:00:00+01:00", "begin_effective": "2014-01-01T01:00:00+01:00", "end_planned": "2015-03-31T02:00:00+02:00", "end_effective": "2015-03-31T02:00:00+02:00", "assignment": "2014-02-24T13:59:53+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 66467, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3579-66467-10" ] }, { "id": 3355, "title": { "de": "Schwangerschaftserkrankungen - Die Rolle von Metalloproteinasen und Endothelin ", "en": "The role of placental metalloproteinases in inflammation-associated pregnancy diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-04-01T02:00:00+02:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2015-03-31T02:00:00+02:00", "end_effective": "2014-07-31T02:00:00+02:00", "assignment": "2013-08-20T15:17:51+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3431, "title": { "de": "Serum Mannan/ Anti-Mannan EIA und Serum Galactomannan EIA zur Früherkennung von Invasiven Pilzinfektionen in Patienten mit hämato-onkologischen Grundkrankheiten", "en": "Serum Mannan/ Anti-Mannan EIA and Galactomannan EIA Screening for early diagnosis of Invasive Fungal Infections among patients with hematological malignancies" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-03-01T01:00:00+01:00", "begin_effective": "2014-01-10T01:00:00+01:00", "end_planned": "2015-03-30T02:00:00+02:00", "end_effective": "2015-01-09T01:00:00+01:00", "assignment": "2013-11-15T12:23:23+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 895 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3684, "title": { "de": "Adipositas und Bipolar affektive Störung", "en": "Adipositas and Bipolar Disorder" }, "short": "BIPFAT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-03-20T01:00:00+01:00", "begin_effective": "2014-03-20T01:00:00+01:00", "end_planned": "2015-03-20T01:00:00+01:00", "end_effective": "2015-03-20T01:00:00+01:00", "assignment": "2014-06-13T14:50:24+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3166, "title": { "de": "Zusammenhang zwischen IQ und Biofeedbackstrategien unter Berücksichtigung des körperlichen Aktivitätsniveaus Gibt es psychosomatische Intelligenz?", "en": "Association between IQ and biofeedback strategies with consideration of bodily activity: is there evidence for psychosomatic intelligence?" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-03-01T01:00:00+01:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2015-03-01T01:00:00+01:00", "end_effective": "2013-12-30T01:00:00+01:00", "assignment": "2013-02-06T16:32:49+01:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 4, "manager": 50774, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3166-50774-10" ] }, { "id": 3455, "title": { "de": "Dyslexie und Strabismus: Vision und Perzeption", "en": "Dyslexie und Strabismus: Vision und Perzeption" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-02-28T01:00:00+01:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2013-12-03T12:45:45+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 77049, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3455-58883-11", "3455-77049-10" ] }, { "id": 2725, "title": { "de": "Mechanismen von Kleingefäßerkrangung bedingter Hirnschädigung und kognitiver Beeinträchtigung", "en": "Mechanisms of Small Vessel Related Brain Damage and Cognitive Impairment" }, "short": "MESCOG", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-03-01T01:00:00+01:00", "end_planned": "2015-02-28T01:00:00+01:00", "end_effective": "2016-02-29T01:00:00+01:00", "assignment": "2012-01-12T12:39:48+01:00", "program": 72, "subprogram": "ERA-Net", "organization": 14051, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I904", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3112, "title": { "de": "Entwicklung eines Fragebogens zur sexuellen Gesundheit von KrebspatientInnen", "en": "Development of a questionnaire for assessing sexual health in cancer patients" }, "short": "Sx Health", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-02-01T01:00:00+01:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2015-01-31T01:00:00+01:00", "end_effective": "2015-03-31T02:00:00+02:00", "assignment": "2012-12-17T11:17:51+01:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 442 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3161, "title": { "de": "Die Rolle von NR4A1 in hämatologischen Neoplasien", "en": "Investigating the role of nuclear orphan receptor NR4A1 in hematologic malignancies" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-02-01T01:00:00+01:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2015-01-31T01:00:00+01:00", "end_effective": "2015-01-31T01:00:00+01:00", "assignment": "2013-01-30T11:01:06+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3161-59183-10" ] }, { "id": 3697, "title": { "de": "Weiterentwicklung und Validierung der Offenen Mikroperfusion zur kliniktauglichen Technologien für die Medikamentenevaluierung", "en": "Development und validation off open flow microperfusion towards suitable clinical technology for drug evaluation" }, "short": "OFM clinical", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-02-01T01:00:00+01:00", "begin_effective": "2014-02-01T01:00:00+01:00", "end_planned": "2015-01-31T01:00:00+01:00", "end_effective": "2015-01-31T01:00:00+01:00", "assignment": "2014-07-01T16:10:02+02:00", "program": null, "subprogram": "HTI", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3697-51831-10" ] }, { "id": 2743, "title": { "de": "Identifizierung von Früherkennungs- und Progressionsmarkern der Parkinsonkrankheit", "en": "Biomarkers of early Parkinson's disease and disease progression" }, "short": "Parkinson Biomarker", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-02-01T01:00:00+01:00", "begin_effective": "2012-02-01T01:00:00+01:00", "end_planned": "2015-01-31T01:00:00+01:00", "end_effective": "2015-07-31T02:00:00+02:00", "assignment": "2012-01-13T13:36:15+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 50172, "contact": 50172, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2743-50172-10" ] }, { "id": 4624, "title": { "de": "DTI und RS-MRT als Prädiktoren von Kognition in NF1", "en": "DTI and RS-fMRI as predictors of cognition in NF1" }, "short": "DTI and RS-fMRI in NF1", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-01-06T01:00:00+01:00", "begin_effective": "2014-01-06T01:00:00+01:00", "end_planned": "2015-01-06T01:00:00+01:00", "end_effective": "2015-01-06T01:00:00+01:00", "assignment": "2016-01-20T16:18:28+01:00", "program": 69, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 59566, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J 3500-B23", "ethics_committee": null, "edudract_number": null, "persons": [ "4624-59566-10" ] }, { "id": 3487, "title": { "de": "Österreichweite Auswertung über die Prävalenz von Komorbiditäten und möglichen prädiktiven Faktoren bei Patienten mit Psoriasis - Datenanalyse des Psoriasis Registry Austria (PsoRA)", "en": "Nationwide assessment for Austria on the prevalence of comorbidities and potential predictive factors in patients with psoriasis: Analysis of the Psoriasis Registry Austria (PsoRA)" }, "short": "PsoRA-Komorbiditäten", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-12-01T01:00:00+01:00", "begin_effective": "2013-12-01T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2016-12-31T01:00:00+01:00", "assignment": "2014-01-07T10:54:03+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1161 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3137, "title": { "de": "Überwachung von Patienten mit colorektalen Karzinomen durch serielle Plasma DNA Untersuchungen", "en": "Monitoring colorectal cancer by serial plasma DNA analyses" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2015-01-31T01:00:00+01:00", "assignment": "2013-01-16T10:11:09+01:00", "program": 79, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] } ] }