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GET /v1/research/project/?format=api&offset=1620&ordering=end_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1640&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1600&ordering=end_effective", "results": [ { "id": 8378, "title": { "de": "Anpassungsstrategien von Makrophagen in der nährstoffarmen Tumormikroumgebung", "en": "Adaptation strategies of macrophages in the nutrient-poor tumor microenvironment (TME)" }, "short": "Macrophages in the TME", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-12T01:00:00+01:00", "begin_effective": "2024-02-12T01:00:00+01:00", "end_planned": "2024-08-12T02:00:00+02:00", "end_effective": "2024-08-12T02:00:00+02:00", "assignment": "2024-08-28T13:04:57+02:00", "program": 220, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 102775, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8378-102775-10" ] }, { "id": 8375, "title": { "de": "Anpassungsstrategien von Makrophagen in der nährstoffarmen Mikroumgebung von Tumoren ", "en": "Adaptation strategies of macrophages in the nutrient-poor tumor microenvironment \f" }, "short": "Macrophages in nutrient-poor environment", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-12T01:00:00+01:00", "begin_effective": "2024-02-12T01:00:00+01:00", "end_planned": "2024-08-12T02:00:00+02:00", "end_effective": "2024-08-12T02:00:00+02:00", "assignment": "2024-08-28T12:56:10+02:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 102775, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1000 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8375-102775-10" ] }, { "id": 8376, "title": { "de": "Anpassung, Überleben, und Zelltod von Makrophagen und Lungenkrebszellen\r\nunter nährstoffarmen Bedingungen.", "en": "Adaptation, survival, and cell death of macrophages and lung cancer cells to nutrient-poor conditions. " }, "short": "Macrophage and cancer cell adaptation", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-02-12T01:00:00+01:00", "begin_effective": "2024-02-12T01:00:00+01:00", "end_planned": "2024-08-12T02:00:00+02:00", "end_effective": "2024-08-16T02:00:00+02:00", "assignment": "2024-08-28T13:00:35+02:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 102775, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "MPC-2023-07001", "ethics_committee": null, "edudract_number": null, "persons": [ "8376-102775-10" ] }, { "id": 6773, "title": { "de": "Die Wirkung von Nr4a1 auf die immunologische Synapse in aggressiven Lymphomen", "en": "Investigating the impact of Nr4a1 on immune synapse in lymphoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-09-01T02:00:00+02:00", "begin_effective": "2021-09-01T02:00:00+02:00", "end_planned": "2024-08-31T02:00:00+02:00", "end_effective": "2024-08-31T02:00:00+02:00", "assignment": "2021-11-02T09:20:25+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 100134, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": 8, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6773-100134-10", "6773-59183-12", "6773-111069-12" ] }, { "id": 6081, "title": { "de": "Ein quantitatives Konzept zur Untersuchung von human-assoziierten Antibiotikaresistenzen in Flüsse", "en": "A quantitative concept to study the distribution of human-derived antibiotic resistance in rivers" }, "short": "RIVAR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-01-01T01:00:00+01:00", "begin_effective": "2020-04-01T02:00:00+02:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2024-08-31T02:00:00+02:00", "assignment": "2020-03-04T10:12:35+01:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 58733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6081-58733-10", "6081-103077-12", "6081-113950-12" ] }, { "id": 5941, "title": { "de": "Multiskalen-Modellierung von Herzklappenerkrankungen", "en": "Multiscale Modeling of Valvular Heart Diseases - Understanding the Mechanisms of Adverse Remodeling to Improve Precision Medicine." }, "short": "SICVALVES", "url": null, "abstract": { "de": "SICVALVES – Multiskalen-Modellierung von Herzklappenerkrankungen\r\n\r\nMotivation: Herzklappenerkrankungen sind eine zunehmende gesundheitliche Belastung für die alternde Bevölkerung, bei der allein die Aortenklappenstenose bei mehr als 12% der Patienten >70 Jahre vorherrscht. Es ist eine chronisch-progressive Erkrankung, die mit Geschlecht und Alter variiert. Bestehende Leitlinien für die Behandlungsplanung verwenden jedoch nur grobe Funktionsparameter, die die interindividuelle Variabilität nicht berücksichtigen und weit von den Anforderungen der Präzisionsmedizin entfernt sind. Im Zeitalter der digitalen Medizin haben Computermodelle das Potenzial, wichtige pathophysiologische Mechanismen zu entschlüsseln und zur personalisierten Präzisionsmedizin beizutragen.\r\nZiele: Die Nutzung fortgeschrittener Modelle auf Zell-, Gewebe- und Organebene, um mechanistische Erkenntnisse über Auslöser von ventrikulären Arrhythmien, diastolischer und systolischer Dysfunktion und myokardialen metabolischen Veränderungen zu gewinnen und zu untersuchen wie sich diese Prozesse gegenseitig verstärken. Geschlechtsspezifische Unterschiede müssen systematisch berücksichtigt werden. Letztlich sollen die Modelle zur Verbesserung der Diagnostik, Risikobewertung und Behandlungsplanung von Herzklappenerkrankungen beitragen.\r\nMethoden: Basierend auf unseren bisherigen Arbeiten werden wir bestehende computergestützte Modelle der Biomechanik, Elektrophysiologie und der Hämodynamik technologisch weiterentwickeln, testen und validieren. Zur Modellparametrisierung verwenden wir bestehende multidimensionale klinische Daten (Bildgebung, Sensortechnik, Systembiologie) aus eigenen früheren Untersuchungen bei Patienten mit Herzklappenerkrankungen. Die Validierung der Genauigkeit der Modelle zur Vorhersage von mechanistischen Veränderungen erfolgt anhand von Daten, die vor und nach dem Einsatz von künstlichen Klappenprothesen gewonnen werden.\r\nInnovation: Fortgeschrittene computergestützte Werkzeuge werden dafür genutzt, um personalisierte Modelle zu erstellen und diese zur quantitativen Bewertung von hypertropischem Remodeling und der Neigung zu Arrhythmien zu verwenden. Es werden vollständig neue Methoden entwickelt um zugrunde liegenden Mechanismen, Verlauf und Symptome die bei Herzklappenerkrankungen auftreten zu verstehen. Des Weiteren wird ein virtueller Simulator für die patientenspezifische Planung der Therapie von Herzklappenerkrankungen entwickelt, der die Wirksamkeit der künstlichen Klappenprothesen verbessert und die Sterblichkeit bei Patienten reduziert.", "en": "SICVALVES – Multiscale modeling of Valvular Heart Diseases\r\nUnderstanding the mechanisms of adverse remodeling to improve precision medicine\r\n\r\nBackground: Valvular Heart Diseases (VHD) are a detrimental health burden to the aging population where aortic valve stenosis alone has reached an incidence of more than 12% of patients >70y. It is a chronic-progressive disease that varies with gender and age. If left untreated, VHDs can cause malignant arrhythmias and severe heart failure. However, existing guidelines for treatment planning are using only rough function parameters that fail to account for inter-individual variability and are far away from the demands of precision medicine. In the age of digital medicine, computational modeling has the potential to unveil important pathophysiological mechanisms and to contribution towards personalized precision medicine.\r\nObjectives: To use advanced models of the cell, tissue, and organ level in VHD to gain mechanistic insights about triggers of ventricular arrhythmias, diastolic, and systolic dysfunction and myocardial metabolic alterations and how these processes reinforce each other. Gender differences will be systematically taken into account. Ultimately, models shall contribute to improve diagnostics, risk assessment, and treatment planning of VHDs.\r\nMethods: Based on our previous work, we will technologically advance, test, and validate existing computational models of biomechanics, electrophysiology, and hemodynamics. For model parameterization we use existing multidimensional clinical data (imaging, sensors, omics) from own previous research in patients with VHD (obtained before and after valve replacement). Validation of the model's accuracy to predict mechanistic changes will be done with data obtained before and after aortic valve replacement.\r\nInnovation: Advanced computational models will be leveraged to build personalized models and use these for quantitative assessment of hypertrophic remodeling and propensity for arrhythmias. Novel methodologies will be developed to understand important mechanisms of adverse remodeling in VHDs, as well as to improve patient care by optimizing patient selection and precision treatment planning in valve disease." }, "begin_planned": "2020-01-01T01:00:00+01:00", "begin_effective": "2020-05-01T02:00:00+02:00", "end_planned": "2022-12-31T01:00:00+01:00", "end_effective": "2024-08-31T02:00:00+02:00", "assignment": "2019-10-28T13:38:14+01:00", "program": 112, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 79791, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I4652", "ethics_committee": null, "edudract_number": null, "persons": [ "5941-79791-10", "5941-91352-12", "5941-119147-12", "5941-122514-12" ] }, { "id": 7129, "title": { "de": "BlueBerry - Mitgestaltung eines Entwurfs für die Erstellung eines nachhaltigen, effektiven und anpassbaren Euracan Registers für seltene Tumorerkrankungen", "en": "BlueBerry – Co-creating a Blueprint for Building a sustainable, effective and scalable Euracan Rare cancer Registry" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-09-01T02:00:00+02:00", "begin_effective": "2022-09-01T02:00:00+02:00", "end_planned": "2024-08-31T02:00:00+02:00", "end_effective": "2024-08-31T02:00:00+02:00", "assignment": "2022-08-16T10:13:43+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 69234, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7129-69234-10" ] }, { "id": 5987, "title": { "de": "Licht-vermittelte Kontrolle der TRPC3Funktion", "en": "Illuminating the TRPC3 signaling machinery" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-04-01T02:00:00+02:00", "begin_effective": "2020-03-01T01:00:00+01:00", "end_planned": "2023-03-30T02:00:00+02:00", "end_effective": "2024-08-31T02:00:00+02:00", "assignment": "2019-12-09T11:13:45+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 78591, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P33263", "ethics_committee": null, "edudract_number": null, "persons": [ "5987-78591-10" ] }, { "id": 6227, "title": { "de": "Therapeutisches Potenzial der Autophagie-Aktivierung bei Bluthochdruck", "en": "Therapeutic potential of autophagy activation in hypertension" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-08-01T02:00:00+02:00", "begin_effective": "2020-09-01T02:00:00+02:00", "end_planned": "2022-08-01T02:00:00+02:00", "end_effective": "2024-08-31T02:00:00+02:00", "assignment": "2020-08-06T13:32:13+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 94512, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6227-75758-12", "6227-94512-10" ] }, { "id": 5562, "title": { "de": "European Joint Programme on Rare Diseases", "en": "European Joint Programme on Rare Diseases" }, "short": "EJP RD", "url": null, "abstract": { "de": null, "en": "As recognized by the Council Recommendation 2009/C 151/02, rare diseases (RD) are a prime example of a research area that can strongly profit from coordination on a European and international scale. RD research should be improved to overcome fragmentation, leading to efficacious use of data and resources, faster scientific progress and competitiveness, and most importantly to decrease unnecessary hardship and prolonged suffering of RD patients. In the specific context of the massive generation, need for reuse and efficient interpretation of data, introduction of omics into care practice and the structuration of RD care centers in European Reference Networks, it appears crucial and timely to maximize the potential of already funded tools and programmes by supporting them further, scaling up, linking, and most importantly, adapting them to the needs of end- users through implementation tests in real settings. Such a concerted effort is necessary to develop a sustainable ecosystem allowing a virtuous circle between RD care, research and medical innovation. To achieve this goal, the European Joint Programme on RD (EJP RD) has two major objectives: (i) To improve the integration, the efficacy, the production and the social impact of research on RD through the development, demonstration and promotion of Europe/world-wide sharing of research and clinical data, materials, processes, knowledge and know-how; (ii) To implement and further develop an efficient model of financial support for all types of research on RD (fundamental, clinical, epidemiological, social, economic, health service) coupled with accelerated exploitation of research results for benefit of patients. To this end, the EJP RD actions will be organized within four major Pillars assisted by the central coordination: (P1): Funding of research; (P2): Coordinated access to data and services; (P3) Capacity building; (P4): Accelerated translation of research projects and improvement outcomes of clinical studies. " }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2019-01-01T01:00:00+01:00", "end_planned": "2023-09-30T02:00:00+02:00", "end_effective": "2024-08-31T02:00:00+02:00", "assignment": "2018-11-30T13:21:57+01:00", "program": 109, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51449, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "825575", "ethics_committee": null, "edudract_number": null, "persons": [ "5562-51449-10" ] }, { "id": 7183, "title": { "de": "Optimierung des Katheterwechsels bei der Therapie mit Insulinpumpen mittels Messung des Gewebewiderstands", "en": "Optimising the timing of infusion set replacement in insulin pump therapy using tissue flow resistance monitoring" }, "short": "Opt-INFUSE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2022-01-01T01:00:00+01:00", "begin_effective": "2022-09-05T02:00:00+02:00", "end_planned": "2023-12-31T01:00:00+01:00", "end_effective": "2024-09-04T02:00:00+02:00", "assignment": "2022-09-26T16:37:02+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51831, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2689 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7183-51831-10", "7183-50452-12", "7183-103585-12" ] }, { "id": 6504, "title": { "de": "Prävention von Adipositas, Sarkopenie und sarkopener Adipositas bei Personen im Pensionsalter - digitale personalisierte Interventionen für gesunde Ernährung und körperliche Bewegung für SeniorInnen", "en": "Preventing obesity, sarcopenia, and Sarcopenic Obesity in retirement – digital personalized interventions for healthy NUTrition and physical activity for Seniors" }, "short": "SO-NUTS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-04-01T02:00:00+02:00", "begin_effective": "2021-04-01T02:00:00+02:00", "end_planned": "2024-03-31T01:00:00+01:00", "end_effective": "2024-09-30T02:00:00+02:00", "assignment": "2021-03-23T13:35:18+01:00", "program": null, "subprogram": null, "organization": 14509, "category": 10, "type": 10, "partner_function": 2, "manager": 82963, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "883211", "ethics_committee": null, "edudract_number": null, "persons": [ "6504-82963-10" ] }, { "id": 5742, "title": { "de": "Untersuchungen zur Rolle von cholestase-induzierter Thrombozytenaktivierung in der Pathogenese cholestatischer Lebererkrankungen", "en": "Investigating the role of cholestasis induced platelet activation in the pathogenesis of cholestatic liver injury. " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-02-01T01:00:00+01:00", "begin_effective": "2019-02-01T01:00:00+01:00", "end_planned": "2020-01-31T01:00:00+01:00", "end_effective": "2024-09-30T02:00:00+02:00", "assignment": "2019-03-25T09:23:29+01:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": 62201, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-40", "ethics_committee": null, "edudract_number": null, "persons": [ "5742-62201-10" ] }, { "id": 6488, "title": { "de": "Umwidmung von Xenobiotika-Rezeptor Liganden fuer die Behandlung von A1AT Mangel", "en": "Repurposing of xenobiotic receptor ligands to treat A1AT deficient liver disease" }, "short": "drug repurposing", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-03-01T01:00:00+01:00", "begin_effective": "2021-03-01T01:00:00+01:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2024-09-30T02:00:00+02:00", "assignment": "2021-03-10T11:43:57+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50593, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-62", "ethics_committee": null, "edudract_number": null, "persons": [ "6488-50593-10" ] }, { "id": 7367, "title": { "de": "Krebs und Alterung Flüssigchromatindiagnostik", "en": "Cancer and Aging Liquid Chromatin Diagnostics" }, "short": "CALC Dx", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-04-01T02:00:00+02:00", "begin_effective": "2023-04-01T02:00:00+02:00", "end_planned": "2024-07-04T02:00:00+02:00", "end_effective": "2024-09-30T02:00:00+02:00", "assignment": "2023-02-02T10:09:22+01:00", "program": 117, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 77970, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999899093", "ethics_committee": null, "edudract_number": null, "persons": [ "7367-77970-10" ] }, { "id": 6550, "title": { "de": "Gedruckte Aktiv-Matrix-Sensoren im Textilverbund für medizinische Anwendungen", "en": "Printed in-textile active matrix sensors for medical applications " }, "short": "MedSens", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-01-01T01:00:00+01:00", "begin_effective": "2021-05-01T02:00:00+02:00", "end_planned": "2023-12-31T01:00:00+01:00", "end_effective": "2024-09-30T02:00:00+02:00", "assignment": "2021-04-30T09:20:05+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 50448, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "883840", "ethics_committee": null, "edudract_number": null, "persons": [ "6550-50448-10", "6550-50877-12", "6550-97866-12" ] }, { "id": 5271, "title": { "de": "Liquid Biopsies for early Detection of Cancer - 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