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GET /v1/research/project/?format=api&offset=1620&ordering=-begin_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1640&ordering=-begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1600&ordering=-begin_planned", "results": [ { "id": 2957, "title": { "de": "VERHALTENSSTÖRUNGEN NACH VISZERALER IMMUNAKTIVIERUNG", "en": "PSYCHOPHARMACOLOGY OF THE VISCERAL IMMUNE BRAIN AXIS" }, "short": null, "url": null, "abstract": { "de": "Depression ist eine der häufigsten und schwersten affektiven Störungen, welche die Lebensqualität und Arbeitsfähigkeit der betroffenen Patienten massiv einschränkt und damit von enormer sozio-ökonomischer Bedeutung ist. Die Weltgesundheitsorganisation berichtet, dass Depression in der Altersklasse von 15 44 Jahren schon jetzt bei beiden Geschlechtern die zweithäufigste Ursache für disability adjusted life years darstellt und die Zahl der von Depression betroffenen Patienten weiter steigt. Unglücklicherweise sprechen bis zu 40 % der Patienten mit Depression nur unzureichend auf die verfügbaren Antidepressiva an, was mit der Tatsache zusammenhängt, dass die Ätiologie affektiver Störungen nur unvollständig bekannt ist. Abgesehen von genetischen und psychosozialen Risikofaktoren rückt immer mehr auch eine chronische Stimulierung des Immunsystems als eine Ursache für die Entstehung affektiver Störungen in den Blickpunkt. Die Zytokin-Hypothese der Depression postuliert, dass systemische Immunprozesse über erhöhte Blutspiegel proinflammatorischer Zytokine einen Einfluss auf Gehirnfunktionen ausüben, die Ängstlichkeit, Affekt, Stressresistenz und kognitive Prozesse regulieren.\r\nAktivierung des viszeralen Immunsystems und viszerale Entzündung können mit einer Reihe von psychiatrischen Abnormalitäten assoziiert sind. Klinische Beobachtungen sprechen dafür, dass Translokation von Zellwandkomponenten des intestinalen Mikrobioms über eine pathologisch durchlässige Darmschleimhaut zu affektiven Störungen führen kann. Präklinische Befunde belegen, dass gastrointestinale Infektionen, gastrointestinale Entzündungen und intraperitoneale Verabreichung bakteriellen Endotoxins emotional-affektive Verhaltensänderungen auslöst. Vor diesem Hintergrund ist es das Ziel des vorgelegten Projekts, in einem experimentellen Ansatz depressive Verhaltensänderungen nach viszeraler Immunstimulierung in umfassender und innovativer Weise zu analysieren und neue Angriffspunkte für wirksame pharmakologische Interventionen zu identifizieren.\r\nDie wichtigsten Hypothesen, die es zu untersuchen gilt, sind, \r\n\tdass Zellwandkomponenten des intestinalen Mikrobioms (Lipopolysaccharid, Pepidoglycan) und intestinale Hormone unter dem Einfluss des Mikrobioms (Glucagon-Like Peptide, Peptid YY) depressive Verhaltensänderungen hervorrufen,\r\n\tviszerale Immunaktivierung das affektive Verhalten kurz- und langfristig beeinflusst;\r\n\tspezifische Signaltransduktionsmechanismen im Gehirn (Receptor-Activator of Nuclear Factor B Ligand, Cyclooxygenase-2 und Brain-Derived Neurotrophic Factor) von Relevanz für die affektiven Störungen im Gefolge einer peripheren Immunaktivierung sind, und\r\n\tdepressive Verhaltensänderungen nach viszeraler Immunstimulierung mit einer Störung der Hypothalamus-Hypophysen-Nebennieren-Achse, einer Störung des Glukokortikoid-Feedback an das Gehirn und einer Störung der Neurogenese im limbischen System assoziiert sind.", "en": "Being one of the most prevalent and severe mood disorders, major depression is deleterious to the patients quality of life and of enormous socio-economic impact. According to the World Health Organization, depression is the second most frequent cause of disability-adjusted life years in the age category of 15 44 years for both genders, with the number of patients continuing to grow. A proportion of some 40 % of the patients does not satisfactorily respond to the available antidepressant drugs, which reflects the incomplete understanding of the aetiology of affective disorders. Apart from vulnerability and psychosocial factors, chronic immune challenge has emerged as a circumstance relevant to the pathogenesis of mood disorders. The cytokine hypothesis of depression holds that systemic inflammatory processes associated with elevated levels of circulating proinflammatory cytokines disturb several brain mechanisms that control anxiety, mood, stress resilience and cognition.\r\nVisceral immune activation and inflammation are associated with a variety of psychiatric abnormalities, and there is clinical evidence that constituents of the intestinal microbiome across a leaky mucosal barrier may be a factor underlying mood disorders. Preclinical evidence indicates that gastrointestinal infection and inflammation as well as intraperitoneal administration of bacterial lipopolysaccharide induce behavioural disturbances. The current research proposal sets out to specifically examine the visceral immune brain axis in an innovative and comprehensive manner and to identify key mechanisms that are suitable for pharmacological modulation.\r\nThe main hypotheses to be addressed are that\r\n\tfactors derived from the intestinal microbiome (lipopolysaccharide, pepidoglycan) or intestinal hormones under the regulatory influence of the microbiome (glucagon-like peptide, peptide YY) have an impact on the visceral immune brain axis;\r\n\tvisceral immune challenge has a short- and long-term impact on affective behaviour;\r\n\tspecific brain signalling mechanisms involving receptor-activator of nuclear factor B ligand, cyclooxygenase-2 and brain-derived neurotrophic factor play a role in the behavioural effects of peripheral immune challenge; and\r\n\tactivation of the visceral immune brain axis is associated with deranged activity of the hypothalamic-pituitary-adrenal axis, disturbed glucocorticoid feedback on the brain and altered neurogenesis in the limbic system." }, "begin_planned": "2012-05-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-04-30T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-08-30T10:10:47+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 24618", "ethics_committee": null, "edudract_number": null, "persons": [ "2957-71487-12", "2957-51529-12" ] }, { "id": 2840, "title": { "de": "Kultivierung von glialen Tumoren, insbesondere niedriggradiger Gliome", "en": "Primary cell cultures of glial Tumors, particularely of low grade gliomas." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-05-01T02:00:00+02:00", "begin_effective": "2012-05-01T02:00:00+02:00", "end_planned": "2013-03-30T01:00:00+01:00", "end_effective": "2013-03-30T01:00:00+01:00", "assignment": "2012-04-16T11:38:39+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2820, "title": { "de": "Analyse des RAF Kinase Inhibitor Proteins (RKIP) bei normaler Hämatopoese und myeloischer Leukämogenese in einem murinen in-vivo Modell", "en": "Analysis of the RAF kinase inhibitor protein (RKIP) in normal hematopoiesis and myeloid leukemogenesis in a murine in-vivo model" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-16T02:00:00+02:00", "begin_effective": "2012-04-16T02:00:00+02:00", "end_planned": "2014-04-16T02:00:00+02:00", "end_effective": "2014-04-16T02:00:00+02:00", "assignment": "2012-03-05T11:23:37+01:00", "program": null, "subprogram": "START - Med Uni Graz", "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": 57402, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2820-57402-10", "2820-77371-12" ] }, { "id": 2903, "title": { "de": "Einfluss von Stress auf die Arterielle Gefäßsteifigkeit bei Kindern und Jugendlichen", "en": "Influence of Stress on Arterial Stiffness in Children" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-11T02:00:00+02:00", "begin_effective": "2012-06-25T02:00:00+02:00", "end_planned": "2013-01-31T01:00:00+01:00", "end_effective": "2013-03-30T01:00:00+01:00", "assignment": "2012-06-26T11:45:49+02:00", "program": null, "subprogram": null, "organization": 29447, "category": 10, "type": 10, "partner_function": 1, "manager": 60388, "contact": 60388, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2903-60388-10" ] }, { "id": 3234, "title": { "de": "Morquio Better-Projekt", "en": "Morquio Better Project" }, "short": "Projekt Morquio Better ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2013-04-01T02:00:00+02:00", "end_effective": "2013-04-01T02:00:00+02:00", "assignment": "2013-04-17T09:36:58+02:00", "program": null, "subprogram": null, "organization": 14048, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1002 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2849, "title": { "de": "\"Fettstoffwechselstörungen und anthropometrische Besonderheiten bei PatientInnen mit bipolarer affektiver Störung\"", "en": "\"Disturbed lipid metabolism and anthropometric variants in bipolar disorder\"" }, "short": "FATBIP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2013-01-31T01:00:00+01:00", "end_effective": "2013-04-30T02:00:00+02:00", "assignment": "2012-05-10T13:10:38+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3910, "title": { "de": "Alpha2-Adrenozeptoren bei Colitis", "en": "Alpha-2-adrenoceptors in colitis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2013-03-31T01:00:00+01:00", "end_effective": "2013-03-31T01:00:00+01:00", "assignment": "2015-01-01T12:02:35+01:00", "program": 84, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 51529, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 25, 1028 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3910-51529-10" ] }, { "id": 2893, "title": { "de": "Ischemic Stroke Genome Wide Association Study (IS-GWAS)", "en": "Ischemic Stroke Genome Wide Association Study (IS-GWAS)" }, "short": "IS-GWAS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2013-03-31T01:00:00+01:00", "end_effective": "2013-06-30T02:00:00+02:00", "assignment": "2012-06-19T15:08:13+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3527, "title": { "de": "Genetik und Epigenetik der Uhrengene und Adipositas in der Bipolaren Störung", "en": "Genetics and Epigenetics of Clock Genes and Obesity in Bipolar Disorder" }, "short": "Clock Genes&Obesity in Bipolar Disorder", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2014-08-01T02:00:00+02:00", "end_effective": "2014-08-01T02:00:00+02:00", "assignment": "2014-01-22T12:40:43+01:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 79771, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3527-79771-10" ] }, { "id": 2872, "title": { "de": "Chordom - Charakterisierung der MUG-Chor1 Zelllinie", "en": "Chordoma - Characterizing MUG-Chor1 cell line" }, "short": "Chordoma", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2012-06-30T02:00:00+02:00", "end_effective": "2012-06-30T02:00:00+02:00", "assignment": "2012-05-24T12:00:53+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": 54171, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2872-54171-10" ] }, { "id": 2842, "title": { "de": "Risiko der Entwicklung einer altersabhängigen Makuladegeneration in Abhängigkeit des CFH Tyr402His Genpolymorphismus bei PatientInnen nach Lebertransplantation", "en": "Influence of CFH Tyr402His gene polymorphism on risk for age-related macular degneration in patients after liver transplantation" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-05-01T02:00:00+02:00", "end_planned": "2014-04-01T02:00:00+02:00", "end_effective": "2013-03-30T01:00:00+01:00", "assignment": "2012-04-20T14:57:04+02:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 58323, "contact": 58323, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2842-58323-10" ] }, { "id": 2790, "title": { "de": "GaitBase - Ein interdisciplinären Projekt zur erleichterung von Ganganalyse Datenmanagement bei Kindern mit neuromuskulären Erkrankungen", "en": "GaitBase - An interdisciplinary project to simplify management of gait analysis data in children with neuromuscular disease" }, "short": "GaitBase", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2012-04-01T02:00:00+02:00", "end_planned": "2012-12-31T01:00:00+01:00", "end_effective": "2012-12-31T01:00:00+01:00", "assignment": "2012-02-15T12:31:01+01:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 1, "manager": 65038, "contact": 65038, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1287 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2790-65038-10" ] }, { "id": 2973, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\"", "en": "DK \"Molecular Fundamentals of Inflammation\"" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2016-02-28T01:00:00+01:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2012-09-06T13:04:33+02:00", "program": 66, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51831, "contact": 51831, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "2973-51831-10", "2973-95211-12" ] }, { "id": 2970, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\"", "en": "DK \"Molecular Fundamentals of Inflammation\"" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2016-02-28T01:00:00+01:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2012-09-06T13:03:09+02:00", "program": 66, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51809, "contact": 51809, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "2970-51809-10" ] }, { "id": 2941, "title": { "de": "Kognition bei bipolar affektiver Störung", "en": "cognitive function in bipolar disorder" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2012-05-01T02:00:00+02:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-08-13T15:51:24+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2985, "title": { "de": "Grazer Studie über die hormonellen Ursachen des arteriellen Bluthochdruckes (GECOH Studie)", "en": "Graz Endocrine Causes of Hypertension (GECOH) Study" }, "short": "GECOH Study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-03-01T01:00:00+01:00", "end_planned": "2012-06-01T02:00:00+02:00", "end_effective": "2012-06-01T02:00:00+02:00", "assignment": "2012-09-24T12:56:43+02:00", "program": null, "subprogram": "Land Steiermark: Förderung wissenschaftlicher (Forschungs)Projekte", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 53344, "contact": 53344, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2985-53344-10" ] }, { "id": 2906, "title": { "de": "Der Einfluss der Proteinkinase D2 auf den Glukosemetabolismus von Glioblastomzellen.", "en": "Protein Kinase D2 and its influence on the glucose metabolism of glioblastoma cells." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-07-01T02:00:00+02:00", "end_planned": "2012-05-31T02:00:00+02:00", "end_effective": "2013-09-30T02:00:00+02:00", "assignment": "2012-06-28T10:34:12+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50990, "contact": 50990, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2906-50990-10" ] }, { "id": 2969, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\"", "en": "DK \"Molecular Fundamentals of Inflammation\"" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2016-02-28T01:00:00+01:00", "end_effective": "2017-09-30T02:00:00+02:00", "assignment": "2012-09-06T13:02:47+02:00", "program": 66, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 53252, "contact": 53252, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "2969-53252-10" ] }, { "id": 2750, "title": { "de": "Biostatistisch-genomische Analyse der klinischen Relevanz von Leberkrebsmodellen", "en": "Biostatistical-genomical analysis of the clinical relevance of liver cancer models " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-05-01T02:00:00+02:00", "end_planned": "2013-02-28T01:00:00+01:00", "end_effective": "2013-12-31T01:00:00+01:00", "assignment": "2012-01-18T10:56:20+01:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 51684, "contact": 51684, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1019 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2750-51684-10" ] }, { "id": 2966, "title": { "de": "DK Molecular Fundamentals of Inflammation", "en": "DK Molecular Fundamentals of Inflammation" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-03-01T01:00:00+01:00", "begin_effective": "2012-12-17T01:00:00+01:00", "end_planned": "2016-02-28T01:00:00+01:00", "end_effective": "2017-06-30T02:00:00+02:00", "assignment": "2012-09-06T12:53:37+02:00", "program": 66, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [] } ] }