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GET /v1/research/project/?format=api&offset=1520&ordering=-end_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1540&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1500&ordering=-end_effective", "results": [ { "id": 2954, "title": { "de": "Genetik von Patienten_innen mit Fuchsscher Endotheldystrophie in einer österreichischen Population", "en": "Genetic investigation of Fuchs' endothelial corneal dystrophy in an Austrian population" }, "short": "Genetik bei Fuchsscher Endotheldystroph", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-11-01T01:00:00+01:00", "begin_effective": "2012-10-01T02:00:00+02:00", "end_planned": "2014-11-01T01:00:00+01:00", "end_effective": "2015-09-20T02:00:00+02:00", "assignment": "2012-08-29T10:24:13+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 65638, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135, 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2954-65638-10" ] }, { "id": 2153, "title": { "de": "Prostaglandin Rezeptoren in der Therapie von Allergien", "en": "Prostaglandin Rezeptoren in der Therapie von Allergien" }, "short": "PROSTAGLANDIN_FWF09", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-01T02:00:00+02:00", "begin_effective": "2010-09-15T02:00:00+02:00", "end_planned": "2013-05-31T02:00:00+02:00", "end_effective": "2015-09-14T02:00:00+02:00", "assignment": "2010-03-04T15:00:25+01:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51756, "contact": 51756, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22521", "ethics_committee": null, "edudract_number": null, "persons": [ "2153-51756-10" ] }, { "id": 3581, "title": { "de": "Kortikale Pathologie und periventrikuläre Läsionen bei Multipler Sklerose – Ausdruck identer pathophysiologischer Prozesse?", "en": "An MRI-study to investigate the pathophysiological link between cortical atrophy and periventricular lesions in multiple sclerosis" }, "short": "MS-KORTEX", "url": null, "abstract": { "de": "Die Pathogenese kortikaler Läsionen sowie der Zusammenhang der verschiedenen degenerativen Prozesse im ZNS bei MS sind bis heute weitgehend unklar. Bisherige Studien zeigten, dass meningeale Entzündungen eine wichtige Rolle bei der Entstehung der kortikalen Pathologie spielen können. Aggregierte Lymphozyten und Antikörper (T- und B- Zellen) infiltrieren Meningen und perivaskuläre Bereiche und führen in weiterer Folge zu einer Progression der Erkrankung. Aus dieser Erkenntnis ergibt sich die Fragestellung, ob unmittelbar periventrikuläre (d.h. liquornahe) Marklagerläsionen mit der kortikalen Pathologie in MS in Zusammenhang stehen.Um diese Fragestellung zu untersuchen, sollen in einem interdisziplinären Forschungsprojekt der Universitätsklinik für Neurologie und der klinischen Abteilung für Neuroradiologie (Universitätsklinik für Radiologie) der Medizinischen Universität Graz existierende MRT-Daten einer unizentrischen prospektiven MS-Studie (n=170) analysiert werden. Die kortikale Pathologie wird anhand der Messung der kortikalen Dicke geschätzt. Periventrikuläre Läsionen der weißen Substanz werden halbautomatisiert segmentiert. Die MR-Parameter werden quantifiziert und mittels Korrelationsanalyse wird die Hypothese überprüft, ob verminderte kortikale Dicke (sogenanntes „cortical thinning“ als Ausdruck subpialer kortikaler Läsionen) mit einer Häufung periventrikulärer Läsionen korreliert. Eine Korrelation zwischen diesen MR-Parametern wäre möglicherweise ein Hinweis dafür, dass die Läsionsprogression in MS durch spezifische Faktoren in der zerebrospinalen Flüssigkeit beschleunigt beziehungsweise vielleicht sogar initiiert wird.", "en": null }, "begin_planned": "2014-05-01T02:00:00+02:00", "begin_effective": "2014-03-01T01:00:00+01:00", "end_planned": "2014-11-01T01:00:00+01:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2014-02-27T11:39:15+01:00", "program": null, "subprogram": null, "organization": 14108, "category": 10, "type": 10, "partner_function": 4, "manager": 60744, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3581-60744-10", "3581-51882-11", "3581-50173-11" ] }, { "id": 3031, "title": { "de": "Diagnostik mit partikelplasmon-basierten Biosensoren", "en": "n/a" }, "short": "PP-BioSens", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-09-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-11-06T15:03:34+01:00", "program": null, "subprogram": "Land Steiermark \"HTI:SMApp\"", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3092, "title": { "de": "Erforschung der Abbauprodukte von neuen Implantatmaterialien in der Unfallchirurgie", "en": "Investigation of degradation products of novel implant materials used in accident surgery" }, "short": "degIMMAT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-09-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-12-06T11:35:04+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50785, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1166 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3092-50785-10" ] }, { "id": 3039, "title": { "de": "Evidenzbasierte High-tech Akupunktur und integrative Lasermedizin für Prävention und frühzeitige Intervention bei chronischen Erkrankungen", "en": "Evidence-based high-tech acupuncture and integrative laser medicine for prevention and early intervention of chronic diseases" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-07-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-11-13T13:40:23+01:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 25, 472 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 2957, "title": { "de": "VERHALTENSSTÖRUNGEN NACH VISZERALER IMMUNAKTIVIERUNG", "en": "PSYCHOPHARMACOLOGY OF THE VISCERAL IMMUNE BRAIN AXIS" }, "short": null, "url": null, "abstract": { "de": "Depression ist eine der häufigsten und schwersten affektiven Störungen, welche die Lebensqualität und Arbeitsfähigkeit der betroffenen Patienten massiv einschränkt und damit von enormer sozio-ökonomischer Bedeutung ist. Die Weltgesundheitsorganisation berichtet, dass Depression in der Altersklasse von 15 44 Jahren schon jetzt bei beiden Geschlechtern die zweithäufigste Ursache für disability adjusted life years darstellt und die Zahl der von Depression betroffenen Patienten weiter steigt. Unglücklicherweise sprechen bis zu 40 % der Patienten mit Depression nur unzureichend auf die verfügbaren Antidepressiva an, was mit der Tatsache zusammenhängt, dass die Ätiologie affektiver Störungen nur unvollständig bekannt ist. Abgesehen von genetischen und psychosozialen Risikofaktoren rückt immer mehr auch eine chronische Stimulierung des Immunsystems als eine Ursache für die Entstehung affektiver Störungen in den Blickpunkt. Die Zytokin-Hypothese der Depression postuliert, dass systemische Immunprozesse über erhöhte Blutspiegel proinflammatorischer Zytokine einen Einfluss auf Gehirnfunktionen ausüben, die Ängstlichkeit, Affekt, Stressresistenz und kognitive Prozesse regulieren.\r\nAktivierung des viszeralen Immunsystems und viszerale Entzündung können mit einer Reihe von psychiatrischen Abnormalitäten assoziiert sind. Klinische Beobachtungen sprechen dafür, dass Translokation von Zellwandkomponenten des intestinalen Mikrobioms über eine pathologisch durchlässige Darmschleimhaut zu affektiven Störungen führen kann. Präklinische Befunde belegen, dass gastrointestinale Infektionen, gastrointestinale Entzündungen und intraperitoneale Verabreichung bakteriellen Endotoxins emotional-affektive Verhaltensänderungen auslöst. Vor diesem Hintergrund ist es das Ziel des vorgelegten Projekts, in einem experimentellen Ansatz depressive Verhaltensänderungen nach viszeraler Immunstimulierung in umfassender und innovativer Weise zu analysieren und neue Angriffspunkte für wirksame pharmakologische Interventionen zu identifizieren.\r\nDie wichtigsten Hypothesen, die es zu untersuchen gilt, sind, \r\n\tdass Zellwandkomponenten des intestinalen Mikrobioms (Lipopolysaccharid, Pepidoglycan) und intestinale Hormone unter dem Einfluss des Mikrobioms (Glucagon-Like Peptide, Peptid YY) depressive Verhaltensänderungen hervorrufen,\r\n\tviszerale Immunaktivierung das affektive Verhalten kurz- und langfristig beeinflusst;\r\n\tspezifische Signaltransduktionsmechanismen im Gehirn (Receptor-Activator of Nuclear Factor B Ligand, Cyclooxygenase-2 und Brain-Derived Neurotrophic Factor) von Relevanz für die affektiven Störungen im Gefolge einer peripheren Immunaktivierung sind, und\r\n\tdepressive Verhaltensänderungen nach viszeraler Immunstimulierung mit einer Störung der Hypothalamus-Hypophysen-Nebennieren-Achse, einer Störung des Glukokortikoid-Feedback an das Gehirn und einer Störung der Neurogenese im limbischen System assoziiert sind.", "en": "Being one of the most prevalent and severe mood disorders, major depression is deleterious to the patients quality of life and of enormous socio-economic impact. According to the World Health Organization, depression is the second most frequent cause of disability-adjusted life years in the age category of 15 44 years for both genders, with the number of patients continuing to grow. A proportion of some 40 % of the patients does not satisfactorily respond to the available antidepressant drugs, which reflects the incomplete understanding of the aetiology of affective disorders. Apart from vulnerability and psychosocial factors, chronic immune challenge has emerged as a circumstance relevant to the pathogenesis of mood disorders. The cytokine hypothesis of depression holds that systemic inflammatory processes associated with elevated levels of circulating proinflammatory cytokines disturb several brain mechanisms that control anxiety, mood, stress resilience and cognition.\r\nVisceral immune activation and inflammation are associated with a variety of psychiatric abnormalities, and there is clinical evidence that constituents of the intestinal microbiome across a leaky mucosal barrier may be a factor underlying mood disorders. Preclinical evidence indicates that gastrointestinal infection and inflammation as well as intraperitoneal administration of bacterial lipopolysaccharide induce behavioural disturbances. The current research proposal sets out to specifically examine the visceral immune brain axis in an innovative and comprehensive manner and to identify key mechanisms that are suitable for pharmacological modulation.\r\nThe main hypotheses to be addressed are that\r\n\tfactors derived from the intestinal microbiome (lipopolysaccharide, pepidoglycan) or intestinal hormones under the regulatory influence of the microbiome (glucagon-like peptide, peptide YY) have an impact on the visceral immune brain axis;\r\n\tvisceral immune challenge has a short- and long-term impact on affective behaviour;\r\n\tspecific brain signalling mechanisms involving receptor-activator of nuclear factor B ligand, cyclooxygenase-2 and brain-derived neurotrophic factor play a role in the behavioural effects of peripheral immune challenge; and\r\n\tactivation of the visceral immune brain axis is associated with deranged activity of the hypothalamic-pituitary-adrenal axis, disturbed glucocorticoid feedback on the brain and altered neurogenesis in the limbic system." }, "begin_planned": "2012-05-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2015-04-30T02:00:00+02:00", "end_effective": "2015-08-31T02:00:00+02:00", "assignment": "2012-08-30T10:10:47+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 24618", "ethics_committee": null, "edudract_number": null, "persons": [ "2957-71487-12", "2957-51529-12" ] }, { "id": 2458, "title": { "de": "European Sequencing and Genotyping Infrastructure", "en": "European Sequencing and Genotyping Infrastructure" }, "short": "ESGI", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-01T02:00:00+02:00", "begin_effective": "2011-02-01T01:00:00+01:00", "end_planned": "2014-05-31T02:00:00+02:00", "end_effective": "2015-07-31T02:00:00+02:00", "assignment": "2011-03-31T13:20:58+02:00", "program": 24, "subprogram": "Infrastructures", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "262055", "ethics_committee": null, "edudract_number": null, "persons": [ "2458-51663-10" ] }, { "id": 2743, "title": { "de": "Identifizierung von Früherkennungs- und Progressionsmarkern der Parkinsonkrankheit", "en": "Biomarkers of early Parkinson's disease and disease progression" }, "short": "Parkinson Biomarker", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-02-01T01:00:00+01:00", "begin_effective": "2012-02-01T01:00:00+01:00", "end_planned": "2015-01-31T01:00:00+01:00", "end_effective": "2015-07-31T02:00:00+02:00", "assignment": "2012-01-13T13:36:15+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 50172, "contact": 50172, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2743-50172-10" ] }, { "id": 2927, "title": { "de": "Langzeiteffekte von Gestationsdiabetes führen zu Dysfunktion der feto-plazentaren Endothelzellen", "en": "Long-time effects of gestational diabetes cause feto-placental endothelial dysfunction" }, "short": "Effekte von Schwangerschaftsdiabetes", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-08-01T02:00:00+02:00", "begin_effective": "2012-09-01T02:00:00+02:00", "end_planned": "2014-06-30T02:00:00+02:00", "end_effective": "2015-07-31T02:00:00+02:00", "assignment": "2012-07-25T12:42:08+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 51718, "contact": 51718, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2927-50674-12", "2927-51718-10" ] }, { "id": 3621, "title": { "de": "\"BIPFAT\" - Erforschung der neurobiologischen Zusammenhänge zwischen kardiovaskulären Komorbiditäten als auch Übergewicht und bipolar affektiver Erkrankung", "en": "\"BIPFAT\" - Erforschung der neurobiologischen Zusammenhänge zwischen kardiovaskulären Komorbiditäten als auch Übergewicht und bipolar affektiver Erkrankung" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-03-01T01:00:00+01:00", "begin_effective": "2014-03-01T01:00:00+01:00", "end_planned": "2014-08-31T02:00:00+02:00", "end_effective": "2015-07-31T02:00:00+02:00", "assignment": "2014-03-24T10:57:45+01:00", "program": null, "subprogram": "Österreichische kardiologische Gesellschaft", "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 50654, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3621-50654-10" ] }, { "id": 2405, "title": { "de": "Vergleichende Genomanalyse zweier ökologisch und morphologisch unterschiedlicher Buntbarsche aus dem Tanganyikasee", "en": "Comparative genome analysis of two eco-morphologically divergent Lake Tanganyka cichlid fish" }, "short": "Genomic sequencing of two Lake Tanganyik", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-06-01T02:00:00+02:00", "begin_effective": "2011-03-01T01:00:00+01:00", "end_planned": "2013-06-01T02:00:00+02:00", "end_effective": "2015-07-02T02:00:00+02:00", "assignment": "2011-02-14T11:40:55+01:00", "program": 72, "subprogram": null, "organization": 17235, "category": 10, "type": 10, "partner_function": 2, "manager": 58453, "contact": 58453, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P22737", "ethics_committee": null, "edudract_number": null, "persons": [ "2405-61680-12", "2405-58453-10" ] }, { "id": 2667, "title": { "de": "1.3 The spectrum of vitamin D biomarkers and other secosteroids", "en": "1.3 The spectrum of vitamin D biomarkers and other secosteroids" }, "short": "BioPersMed Project No 1.3", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2015-06-30T02:00:00+02:00", "assignment": "2010-12-12T12:15:40+01:00", "program": 94, "subprogram": "K-Projekt", "organization": 14080, "category": 10, "type": 10, "partner_function": 3, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2667-51831-10" ] }, { "id": 3940, "title": { "de": " 1.8 Metabolomics and proteomics in the search for the Advantage of Online-Hemodiafiltration", "en": " 1.8 Metabolomics and proteomics in the search for the Advantage of Online-Hemodiafiltration" }, "short": "BioPersMed Project No 1.8", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-07-01T02:00:00+02:00", "begin_effective": "2014-07-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2015-06-30T02:00:00+02:00", "assignment": "2015-01-09T16:16:16+01:00", "program": 94, "subprogram": "K-Projekt", "organization": 14084, "category": 10, "type": 10, "partner_function": 3, "manager": 72630, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3940-72630-10" ] }, { "id": 2669, "title": { "de": "1.5 Collagen turnover products as biomarkers of bone remodelling", "en": "1.5 Collagen turnover products as biomarkers of bone remodelling" }, "short": "BioPersMed Project No 1.5", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2015-06-30T02:00:00+02:00", "assignment": "2010-12-12T12:15:40+01:00", "program": 94, "subprogram": "K-Projekt", "organization": 14080, "category": 10, "type": 10, "partner_function": 3, "manager": 51809, "contact": 51809, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "2669-71449-12", "2669-51809-10" ] }, { "id": 2870, "title": { "de": "Entwicklung von biofunktionellen, Kapselfibrose-vermeidenden Barriere-Schutzschichten für das Packaging von in-vivo Sensoren und Aktuatoren", "en": "Development of biofunctional non fibrosis inducing barrier protection layers for in-vivo sensors" }, "short": "HTI:SMApp Sensor Packaging", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-06-01T02:00:00+02:00", "begin_effective": "2012-07-01T02:00:00+02:00", "end_planned": "2014-12-31T01:00:00+01:00", "end_effective": "2015-06-30T02:00:00+02:00", "assignment": "2012-05-21T16:11:32+02:00", "program": null, "subprogram": "Forschung Steiermark Planung, Steuerung, Impulse\r\nHTI-Call Februar 2012", "organization": 17230, "category": 10, "type": 10, "partner_function": 2, "manager": 53900, "contact": 53900, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": "ABT08-35744/2014-3", "ethics_committee": null, "edudract_number": null, "persons": [ "2870-53900-10" ] }, { "id": 2677, "title": { "de": "3.3 Vitamin D, biomarker and regulator of blood pressure", "en": "3.3 Vitamin D, biomarker and regulator of blood pressure" }, "short": "BioPersMed Project No 3.3", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2010-07-01T02:00:00+02:00", "begin_effective": "2010-07-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2015-06-30T02:00:00+02:00", "assignment": "2010-12-12T12:15:40+01:00", "program": 94, "subprogram": "K-Projekt", "organization": 14080, "category": 10, "type": 10, "partner_function": 3, "manager": 51831, "contact": 51831, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2, 1040, 1154 ], "funder_projectcode": null, "ethics_committee": null, 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