Project List
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GET /v1/research/project/?format=api&offset=1480&ordering=-begin_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1500&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1460&ordering=-begin_effective", "results": [ { "id": 3376, "title": { "de": "Netzwerk für Innovation, Transfer und Verwertung von Medizinprodukten", "en": "Dynamic Network Arranged for Medical Device Innovation, Transfer & Exploitation" }, "short": "DYNAMITE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2013-09-18T13:27:30+02:00", "program": 104, "subprogram": "Kooperation und Netzwerke", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840131", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3353, "title": { "de": "Vermeidung arterieller Hypotonie bei Frühgeborenen", "en": "Avoiding hypotension in preterm neonates (AHIP) - A randomised controlled study on near infrared spectroscopy monitoring of peripheral-muscle and cerebral oxygenation with defined interventions versus routine monitoring and treatment in preterm neonates" }, "short": "AHIP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-08-31T02:00:00+02:00", "assignment": "2013-08-14T16:35:13+02:00", "program": 79, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3353-50907-10" ] }, { "id": 3325, "title": { "de": "Neue Biomarker für die Voraussage der Wirkung von Krebsmedikamenten bei Dickdarmkrebs [Charakterisierung von neuen prädiktiven Biomarkern bei Kolorektalkarzinom]", "en": "Characterization of novel predictive biomarkers in colorectal cancer patients treated with EGFR-targeting therapies" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-30T02:00:00+02:00", "end_effective": "2017-04-30T02:00:00+02:00", "assignment": "2013-07-10T15:42:33+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 58814, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3325-58814-10" ] }, { "id": 3558, "title": { "de": "Entwicklung von bioresorbierbaren Implantaten für Kinder", "en": "Development of bioresorbable implants for children with special regards to fracture healing and patient requirements" }, "short": "BRIC Phase 2", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-31T02:00:00+02:00", "end_effective": "2017-06-30T02:00:00+02:00", "assignment": "2014-02-07T10:34:22+01:00", "program": 95, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 3, "manager": 50785, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "840286", "ethics_committee": null, "edudract_number": null, "persons": [ "3558-50785-10" ] }, { "id": 3340, "title": { "de": "Methylierungsanalysen von zirkulierenden Tumorzellen und weißen Blutzellen bei Brustkrebspatientinnen", "en": "Methylation analysis of circulating tumor cells and white blood cells in breast cancer patients" }, "short": null, "url": null, "abstract": { "de": "Die Identifizierung von zirkulierenden Tumorzellen (CTCs) spielt eine zunehmende Rolle in der effektiven und zielgerichteten Behandlung von Mammakarzinom Patientinnen. CTCs kommen im Blut sehr selten vor, sodass ihr Nachweis und ihre Charakterisierung eine tech- nologische Herausforderung darstellen. Molekulare Charakterisierung, wie die DNA Methylierung von CTCs, ist wichtig um neue biologische Informationen zu bekommen.\r\nWir beabsichtigen einen neuen Filter zur größenbasierten Anreicherung und Methylierungs- analyse von CTCs einzusetzen, um zu prüfen ob dieser Mikrofilter geeignet ist, sowohl CTCs und parallel beim gleichen Patienten weißen Blutzellen epigenetisch zu charakterisieren.", "en": "Identification of circulating tumor cells (CTCs) is increasingly playing an important role in the effective and targeted treatment of breast cancer patients. CTCs are very rare in the blood stream, making their isolation and characterization a major technological challenge. Molecular characterization, such as DNA methylation analysis of CTCs, is important to help extract information about their biology.\r\nWe propose to use a novel size-based microfilter to enrich for CTCs and analyze methylation in CTCs, thus evaluating the microfilter platform for its applicability to epigenetically characterize both CTCs and white blood cells from the same patient." }, "begin_planned": "2013-09-01T02:00:00+02:00", "begin_effective": "2013-09-01T02:00:00+02:00", "end_planned": "2016-08-31T02:00:00+02:00", "end_effective": "2016-08-31T02:00:00+02:00", "assignment": "2013-07-22T10:39:23+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 50563, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3340-105079-12", "3340-110608-12", "3340-50563-10", "3340-88082-12", "3340-59188-12" ] }, { "id": 3264, "title": { "de": "Molekulare Mechanismen in der frühen Entwicklung von dendritischen Zellen", "en": "Regulatory mechanisms in early dendritic cell development" }, "short": null, "url": null, "abstract": { "de": null, "en": "Dendritic cells (DCs) are essential immune cells for antigen presentation and are responsible for the initiation of T-cell responses. With the exception of Langerhans cells, all subtypes of DCs are derived from bone marrow-resident hematopoietic stem cells (HSCs). DCs develop from HSCs via several specification steps and intermediate progenitor stages including common myeloid progenitor (CMP) and the monocyte/DC progenitor (MDPs) stages. \r\nThe transcription factor C/EBPa (CCAAT/enhancer binding protein alpha) is known to play an important role in early hematopoiesis. Mice with a homozygous deletion of the Cebpa gene have normal to elevated numbers of CMPs but completely lack granulocytic/monocytic progenitors (GMPs) and all subsequent granulocytic stages indicating that C/EBPa is essential for transition of early myeloid to late myeloid progenitors. Despite its critical role in early myeloid and hence DC progenitors little is known about C/EBPa in early DC development. \r\nPreliminary results from our lab using an inducible bone marrow-specific Cebpa knock-out mouse model (Mx1-Cre CebpaF/F) suggest that C/EBPa indeed has an important role in early DC development. Mice lacking Cebpa in the bone marrow display reduced numbers of both subtypes of conventional DCs (cDCs) in spleen, and even more prominent in lymph nodes and thymus, while plasmacytoid DCs are not affected. The fact that cDCs are formed albeit at reduced numbers indicates that C/EBPa is dispensable for cDC formation but is crucially involved in proliferation and/or inhibition of apoptosis in cDC precursors. In addition, it is currently not known whether cDCs formed in the absence of C/EBPa display full functional activity. Using gene expression profiling we have identified a number of C/EBPa target genes in early DC progenitors including other transcription factors, inflammatory cytokines, genes of the NF-kB-pathway, genes associated with DC maturation and distinct anti-apoptotic factors. Based on these results the aim of this project is to identify critical factors involved in differentiation, proliferation and/or inhibition of apoptosis in early DC progenitors affected by C/EBPa. To experimentally approach this goal we will use Mx1-Cre CebpaF/F experimental and Mx1-Cre Cebpawt/wt control mice and analyze DCs in spleen, lymph nodes and thymus for expression of various DC-specific surface antigens and - after isolation characterize their function. In addition, isolated FLT3+ myeloid progenitors of these mice will be stimulated with FLT3L and monitored in vitro for changes in gene expression and functionality at critical steps during DC formation. \r\n" }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2013-05-08T09:53:08+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51911, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3264-94653-12", "3264-51911-10", "3264-103865-12" ] }, { "id": 3338, "title": { "de": "Rolle von Tumorstammzell-assoziierten non-coding RNAs beim hepatozellulären Karzinom", "en": "Role of stem cell-associated non-coding RNAs in hepatocellular carcinoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-08-31T02:00:00+02:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2013-07-18T16:36:18+02:00", "program": 81, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3342, "title": { "de": "Klinisches Decision Support System (DSS) für molekulare Pathologie - Research Studios Austria - ProjektNr. 841246", "en": "Klinisches Decision Support System (DSS) für molekulare Pathologie" }, "short": "kDSSMP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2015-09-30T02:00:00+02:00", "assignment": "2013-08-02T15:02:02+02:00", "program": 107, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 3, "manager": 51663, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "841246", "ethics_committee": null, "edudract_number": null, "persons": [ "3342-51663-10" ] }, { "id": 3350, "title": { "de": "Etablierung eines in-vitro Modells zur Stimmlippenvernarbung", "en": "Establishment of an in-vitro model for vocal fold scarring" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2014-07-31T02:00:00+02:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2013-08-14T11:38:53+02:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 50670, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3350-50562-12", "3350-50464-12", "3350-50670-10" ] }, { "id": 3327, "title": { "de": "Bedeutung von Autophagy in chronischer Cholestase und mögliche Modulierung durch Kernrezeptoren", "en": "Role of autophagy in chronic cholestasis in humans and its modulation by nuclear receptors" }, "short": "Autophagy and Cholestasis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2015-12-31T01:00:00+01:00", "assignment": "2013-07-12T10:53:15+02:00", "program": 79, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 57377, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3327-50593-12", "3327-57377-10" ] }, { "id": 3527, "title": { "de": "Genetik und Epigenetik der Uhrengene und Adipositas in der Bipolaren Störung", "en": "Genetics and Epigenetics of Clock Genes and Obesity in Bipolar Disorder" }, "short": "Clock Genes&Obesity in Bipolar Disorder", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-04-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2014-08-01T02:00:00+02:00", "end_effective": "2014-08-01T02:00:00+02:00", "assignment": "2014-01-22T12:40:43+01:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 79771, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3527-79771-10" ] }, { "id": 3309, "title": { "de": "Biomarker ErKennenLernen, Projektnr: 839728", "en": "Biomarker ErKennenLernen" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2014-09-30T02:00:00+02:00", "end_effective": "2014-07-31T02:00:00+02:00", "assignment": "2013-06-21T10:07:47+02:00", "program": null, "subprogram": null, "organization": 28394, "category": 10, "type": 10, "partner_function": 2, "manager": 58453, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "839728 ", "ethics_committee": null, "edudract_number": null, "persons": [ "3309-58453-10" ] }, { "id": 3312, "title": { "de": "Anti-atherosclerotic Effects of Ligustrazine", "en": "Anti-atherosclerotic Effects of Ligustrazine" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-07-28T02:00:00+02:00", "begin_effective": "2013-07-28T02:00:00+02:00", "end_planned": "2014-06-28T02:00:00+02:00", "end_effective": "2014-12-31T01:00:00+01:00", "assignment": "2013-06-27T11:34:02+02:00", "program": 92, "subprogram": "Eurasia Pacific Uninet", "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 57932, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3312-57932-10" ] }, { "id": 3442, "title": { "de": "Evaluierung der Häufigkeit, Biologie und therapeutischer Relevanz von Fusionskinasen beim Melanom", "en": "Evaluating the frequency, biology, and therapeutic relevance of kinase fusions in melanoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-07-01T02:00:00+02:00", "begin_effective": "2013-07-01T02:00:00+02:00", "end_planned": "2015-06-30T02:00:00+02:00", "end_effective": "2016-06-30T02:00:00+02:00", "assignment": "2013-11-21T14:01:52+01:00", "program": 79, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3292, "title": { "de": "Leitbilder zur Gestaltung des Lebensendes Einstellungen zur Begleitung und Versorgung von Menschen am Lebensende und zur Hospizidee in der Steiermark", "en": "Attitudes toward end-of-life decisions and the hospice idea in Styria " }, "short": "Leitbilder zur Gestaltung des Lebensende", "url": "http://www.medunigraz.at/sozialmedizin/projekte/leitbilder_lebensende.html", "abstract": { "de": "Fragen der Gestaltung es Lebensendes sind europaweit zunehmend Gegenstand von öffentlichen Debatten sowie von politischen Initiativen. Es zeichnet sich in Europa jedoch kein einheitlicher Zugang zum Thema ab, sondern je nach nationaler Kultur und weltanschaulicher Prägung eines Landes entstehen variierende Leitbilder und institutionelle Lösungen.\r\n\r\nFür Österreich steht ein Reflexionsprozess zum Thema Gestaltung des Lebensendes bislang aus und es besteht daher die Gefahr, dass diese Leerstelle in der Zukunft durch einfache Übernahme von Leitbildern aus anderen Ländern gefüllt wird.\r\nAn dieser Stelle möchte das geplante Projekt die Grundlagen für eine eigenständige und innovative, der soziokulturellen Identität und den Traditionen des Landes entsprechende, Leitbildentwicklung schaffen.\r\n\t", "en": null }, "begin_planned": "2013-04-01T02:00:00+02:00", "begin_effective": "2013-07-01T02:00:00+02:00", "end_planned": "2014-06-30T02:00:00+02:00", "end_effective": "2015-03-31T02:00:00+02:00", "assignment": "2013-05-29T11:50:24+02:00", "program": 75, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 4, "manager": 51741, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3292-66488-12", "3292-51741-10" ] }, { "id": 3323, "title": { "de": "Gealterte T Zellen und Knochenabbau bei Rheumatoider Arthritis und Osteoporose ", "en": "T cells and bone loss in rheumatoid arthritis and primary osteoporosis" }, "short": "T cell senescence and bone loss", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-07-01T02:00:00+02:00", "begin_effective": "2013-07-01T02:00:00+02:00", "end_planned": "2016-06-30T02:00:00+02:00", "end_effective": "2017-01-31T01:00:00+01:00", "assignment": "2013-07-10T10:43:13+02:00", "program": 79, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 66227, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3323-53560-12", "3323-78952-12", "3323-89855-12", "3323-66227-10" ] }, { "id": 3337, "title": { "de": "Analyse des Darm-Mikrobioms bei affektiven Erkrankungen", "en": "Gut microbiome analyses in affective disorders" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-07-01T02:00:00+02:00", "begin_effective": "2013-07-01T02:00:00+02:00", "end_planned": "2014-07-01T02:00:00+02:00", "end_effective": "2014-03-31T02:00:00+02:00", "assignment": "2013-07-18T16:33:48+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 54165, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3337-54165-10" ] }, { "id": 3433, "title": { "de": "Antibiotikaresistenz von E. coli von Spielplatzsandproben in Österreich", "en": "Antimicrobial resistance of E. coli isolates from playground sand in Austria" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-07-01T02:00:00+02:00", "begin_effective": "2013-07-01T02:00:00+02:00", "end_planned": "2015-07-01T02:00:00+02:00", "end_effective": "2016-06-30T02:00:00+02:00", "assignment": "2013-11-15T13:50:51+01:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 50521, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 895 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3433-50521-10" ] }, { "id": 3329, "title": { "de": " Molekulare Wirkungsweise von therapeutische Antikörper in der Lymphomtherapie ", "en": " Molecular Mechanism of therapeutic Antibodies in Lymphomatherapy " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-02-01T01:00:00+01:00", "begin_effective": "2013-07-01T02:00:00+02:00", "end_planned": "2013-10-31T01:00:00+01:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2013-07-15T12:59:46+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3329-59183-10" ] }, { "id": 3294, "title": { "de": "Spontaneous Movements at 3-5 Months Postterm Age: Are Sporadic Fidgety Movements of Clinical Relevance?", "en": "Spontaneous Movements at 3-5 Months Postterm Age: Are Sporadic Fidgety Movements of Clinical Relevance?" }, "short": "Sporadic Fidgety Movements", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-07-01T02:00:00+02:00", "begin_effective": "2013-07-01T02:00:00+02:00", "end_planned": "2014-06-30T02:00:00+02:00", "end_effective": "2014-06-30T02:00:00+02:00", "assignment": "2013-06-06T15:43:30+02:00", "program": 92, "subprogram": "EURASIA-PACIFIC UNINET ", "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3294-58883-11" ] } ] }