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GET /v1/research/project/?format=api&offset=1440&ordering=end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1460&ordering=end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1420&ordering=end_effective", "results": [ { "id": 5487, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:36:55+02:00", "program": 114, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5487-51904-10" ] }, { "id": 5829, "title": { "de": "Bestimmung von altersbedingten kognitiven Einschränkungen", "en": "Quantifying ageing related cognitive decline and mild cognitive impairment" }, "short": "COGDEC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-10-01T02:00:00+02:00", "begin_effective": "2019-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2019-06-17T12:03:54+02:00", "program": 109, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 1, "manager": 51279, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "857375", "ethics_committee": null, "edudract_number": null, "persons": [ "5829-51279-10" ] }, { "id": 5485, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:34:58+02:00", "program": 114, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 54142, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5485-54142-10" ] }, { "id": 5486, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:35:48+02:00", "program": 114, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 2, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5486-90021-10", "5486-100806-12" ] }, { "id": 5830, "title": { "de": "Metrologie der automatisierten Datenanalyse für das Management von kardialen Arrhythmien", "en": "Metrology of Automated Data Analysis for Cardiac Arrhythmia Management" }, "short": "MEDAL-CARE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-07-01T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2019-06-19T14:45:53+02:00", "program": 109, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 50966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "18HLT0", "ethics_committee": null, "edudract_number": null, "persons": [ "5830-50966-10" ] }, { "id": 5484, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Inflammatory Disorders in Pregnancy\r\n\r\n" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:33:55+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 51632, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5484-59816-12", "5484-68413-12", "5484-95608-12", "5484-51632-10", "5484-109041-12", "5484-100803-12" ] }, { "id": 6725, "title": { "de": "Biomolekulare Strukturen und Interaktionen (Förderjahr 1)", "en": "Biomolecular Structures and Interactions" }, "short": "BioMolStruct", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-10-01T02:00:00+02:00", "begin_effective": "2021-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2021-10-04T11:49:58+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 3, "manager": 91207, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6725-91207-10" ] }, { "id": 5990, "title": { "de": "Entschlüsselung des Zusammenspiels zwischen der langen nicht-kodierenden RNA NORAD und PARP Inhibitoren in dreifach negativem Brustkrebs.", "en": "Dissecting the interplay of the long non-coding RNA NORAD and PARP inhibitors in triple negative breast cancer allowing optimization of treatment concepts" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-10-01T02:00:00+02:00", "begin_effective": "2020-02-01T01:00:00+01:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2019-12-10T14:25:53+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 122 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5990-100665-12" ] }, { "id": 5431, "title": { "de": "Koordination des Doktoratsprogramms: Inflammatorische Erkrankungen in der Schwangerschaft", "en": "Coordination of the Doctoral Program: Inflammatory Disorders in Pregnancy " }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-26T15:31:56+02:00", "program": 114, "subprogram": "doc.funds", "organization": 14038, "category": 10, "type": 10, "partner_function": 3, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5431-50442-10", "5431-56938-12", "5431-59816-12", "5431-83661-12", "5431-90214-12", "5431-95608-12", "5431-100813-12", "5431-100803-12", "5431-105059-12" ] }, { "id": 5480, "title": { "de": "Inflammatorische Erkrankungen in der Schwangerschaft.\r\nNuclear Rezeptor - vermittelte Regulation metabolischer und inflammatorischer Mediatoren in fetoplazentaren Endothelzellen", "en": "Inflammatory Disorders in Pregnancy.\r\nNuclear receptors regulating metabolism and inflammatory mediators in fetoplacental endothelial cells" }, "short": "DP-iDP", "url": "https://www.medunigraz.at/phd-inflammatory-disorders-in-pregnancy/", "abstract": { "de": null, "en": "Rising evidence suggests that Gestational diabetes mellitus (GDM) modulates the placental endothelium to an altered metabolic state causing vascular dysfunction and altered fetal programming. GDM is associated with oxidative stress which may contribute to endothelial dysfunction. Oxysterols, generated from cholesterol oxidation either by CYP-450 reductase or by reactive oxygen species (ROS), are endogenous activators of liver-X receptors (LXRs), nuclear transcription factors centrally involved in important biological processes, including lipid/cholesterol and glucose metabolism (1). \r\nLXRs promote high-density lipoprotein (HDL) formation by activating several target genes of reverse cholesterol transport. We earlier reported that LXR target genes (ABCA1, ABCG1 and PLTP) are centrally involved in HDL mediated cholesterol efflux from fetoplacental endothelial cells (HPEC) (2-4). \r\nA current focus of our laboratory is to define the impact of oxysterols and pharmacological activators of LXRs on cholesterol-metabolic and inflammatory functions in the GDM feto-placental vasculature. Unpublished results of our group strongly suggest that the GDM environment modulates cholesterol homeostasis by enhancing cholesterol biosynthesis and cholesterol efflux in fetoplacental endothelial cells while cellular cholesterol homeostasis is largely maintained. Thus, GDM may affect placental cholesterol metabolism via LXR activation due to increased oxysterol levels in cells and/or in the fetal circulation. \r\nWhile HDL itself exerts anti-inflammatory actions on endothelial cells, LXRs are also involved in immune regulatory functions and can reduce inflammation by sumoylation-dependent and -independent mechanisms (1). Upon activation, LXRs can be sumoylated and as a monomer can stabilize repressor complexes present on the promoter sequence of proinflammatory pathways such as activator protein 1 (AP-1) and nuclear factor kB (NF-kB), thereby preventing the expression of proinflammatory factors. In brain endothelial cells, LXR activation by oxysterols or synthetic agonist TO901317 significantly reduced expression of inflammatory genes COX-II and TNF along with modulating cellular cholesterol metabolism (5). We hypothesize that endogenous and/or pharmacologic activation of LXRs may improve fetoplacental endothelial function in conditions of GDM and other pregnancy complications related to metabolic diseases.\r\n\r\nReferences:\r\n1.\tGuillemot-Legris O, Mutemberezi V, Muccioli GG. Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids. Trends Mol Med. 2016; 22(7):594-614.\r\n2.\tStefulj J, Panzenboeck U1, Becker T, Hirschmugl B, Schweinzer C, Lang I, Marsche G, Sadjak A, Lang U, Desoye G, and Wadsack C. Human Endothelial Cells of the Placental Barrier Efficiently Deliver Cholesterol to the Fetal Circulation via ABCA1 and ABCG1. Circ Res. 2009; 104:600-608.\r\n4.\tScholler M, Wadsack C, Metso J, Chirackal Manavalan AP, Sreckovic I, Schweinzer C, Hiden U, Jauhiainen M, Desoye G, Panzenboeck U. Phospholipid transfer protein is differentially expressed in human arterial and venous placental endothelial cells and enhances cholesterol efflux to fetal HDL. J Clin Endocrinol Metab. 2012; 97:2466-74.\r\n5.\tScholler M, Wadsack C, Lang I, Etschmaier K, Schweinzer C, Marsche G, Dieber-Rotheneder M, Desoye G, Panzenboeck U. Phospholipid Transfer Protein in the Placental Endothelium Is Affected by Gestational Diabetes Mellitus. J Clin Endocrinol Metab. 2012; 97:437-45.\r\n7.\tSchweinzer C, Kober A, Lang I, Etschmaier K, Scholler M, Kresse A, Sattler W, Panzenboeck U. Processing of Endogenous AβPP in Blood-Brain Barrier Endothelial Cells is Modulated by Liver-X Receptor Agonists and Altered Cellular Cholesterol Homeostasis. J Alzheimers Dis. 2011; 27(2):341-360.\r\n" }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2018-09-19T11:18:44+02:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "Doc 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "5480-50442-10", "5480-61645-12" ] }, { "id": 6841, "title": { "de": "Der Effekt von Hydroxychloroquin auf Plazentafunktion bei Frauen mit Präeklampsie", "en": "Effect of hydroxychloroquine on human placental function in severe preeclampsia" }, "short": "DP-iDP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2021-10-01T02:00:00+02:00", "end_planned": "2022-09-30T02:00:00+02:00", "end_effective": "2022-09-30T02:00:00+02:00", "assignment": "2021-12-15T16:30:47+01:00", "program": 114, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 74840, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "DOC 31-B26", "ethics_committee": null, "edudract_number": null, "persons": [ "6841-74840-10" ] }, { "id": 6055, "title": { "de": "COST: Internationales Netzwerk für translationale Forschung an perinatalen Derivaten für therapeutische Applikationen", "en": "COST: International Network for Translating Research on Perinatal Derivatives into Therapeutic Approaches" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-16T02:00:00+02:00", "begin_effective": "2018-10-16T02:00:00+02:00", "end_planned": "2022-10-15T02:00:00+02:00", "end_effective": "2022-10-15T02:00:00+02:00", "assignment": "2020-02-12T16:36:06+01:00", "program": 22, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 51718, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6055-51718-10" ] }, { "id": 5471, "title": { "de": "Klinische Anwendbarkeit ex vivo generierter Erythrozyten mit Fokus auf biomechanische Eigenschaften", "en": "Clinical translation of ex vivo cultured erythrocytes – biomechanical properties of manufactured red blood cells\r\n\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-09-01T02:00:00+02:00", "begin_effective": "2018-09-01T02:00:00+02:00", "end_planned": "2020-08-31T02:00:00+02:00", "end_effective": "2022-10-31T01:00:00+01:00", "assignment": "2018-09-11T18:08:07+02:00", "program": null, "subprogram": null, "organization": 14058, "category": 10, "type": 10, "partner_function": 4, "manager": 51164, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5471-51164-10" ] }, { "id": 6510, "title": { "de": "Identifizierung von Antigen-spezifischen T-Zellen über Ca2+ - NFAT-Aktivierung bei Lungenkrebs", "en": "Identification of antigen-specific T cells via Ca2+ - NFAT signaling in non-small cell lung cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-04-01T02:00:00+02:00", "begin_effective": "2021-04-01T02:00:00+02:00", "end_planned": "2022-10-31T01:00:00+01:00", "end_effective": "2022-10-31T01:00:00+01:00", "assignment": "2021-03-30T10:44:48+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 60706, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-60", "ethics_committee": null, "edudract_number": null, "persons": [ "6510-60706-10" ] }, { "id": 5505, "title": { "de": "Spielgestützte multimodale Intervention, Monitoring und Decision Support zur Aktivierung bei Alzheimer-Demenz", "en": "Game-based multimodal intervention, monitoring and decision support for activation in Alzheimer's disease" }, "short": "multimodAAL", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-04-18T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2022-10-31T01:00:00+01:00", "assignment": "2018-10-02T16:51:06+02:00", "program": null, "subprogram": null, "organization": 14509, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "875345", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5508, "title": { "de": "Spielgestützte Multimodale Intervention, Monitoring und Decision Support zur Aktivierung bei Alzheimer-Demenz", "en": "multimodAAL" }, "short": "multimodAAL", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-04-18T02:00:00+02:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2022-10-31T01:00:00+01:00", "assignment": "2018-10-08T11:13:54+02:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 59566, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": 8, "language": null, "funders": [ 416 ], "funder_projectcode": "875345 ", "ethics_committee": null, "edudract_number": null, "persons": [ "5508-59566-10" ] }, { "id": 6417, "title": { "de": "Herz-Sache -- Unser Herz soll uns am Herzen liegen", "en": "Heart Matter - Our Heart should lie close to our Heart" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-02-01T01:00:00+01:00", "begin_effective": "2021-05-01T02:00:00+02:00", "end_planned": "2022-01-31T01:00:00+01:00", "end_effective": "2022-10-31T01:00:00+01:00", "assignment": "2021-01-19T14:08:40+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 79755, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "WKP00157", "ethics_committee": null, "edudract_number": null, "persons": [ "6417-79755-10" ] }, { "id": 6830, "title": { "de": "„Work-Health-Life-Balance 4.0“ ", "en": "„Work-Health-Life-Balance 4.0“ " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-09-30T02:00:00+02:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-11-30T01:00:00+01:00", "end_effective": "2022-11-30T01:00:00+01:00", "assignment": "2021-12-14T08:54:03+01:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 50887, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 997 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6830-50887-10" ] }, { "id": 6949, "title": { "de": "Alterungsforschung im Fadenwurm", "en": "Aging research in Caenorhabditis elegans" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2021-12-01T01:00:00+01:00", "begin_effective": "2021-12-01T01:00:00+01:00", "end_planned": "2022-11-30T01:00:00+01:00", "end_effective": "2022-11-30T01:00:00+01:00", "assignment": "2022-03-07T14:22:38+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 85069, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6949-85069-10" ] }, { "id": 6778, "title": { "de": "Ist die Zusammensetzung der Membranlipide vom Cix-Dux4 \r\nTranskriptionsfaktorfusionssarkomen im Vergleich zum Ewing \r\nSarkom ein Grund für deren Aggressivität und fehlendem \r\nAnsprechen auf Chemotherapeutika im Sinne einer \r\nResistenzbildung?", "en": "Is the membrane lipid composition of the CIC-DUX4 merged sarcoma in comparison to the Ewing sarcoma one reason for their aggressiveness and missing response to a treatment \r\nfor the purpose of an resistence?" }, "short": "Cix-Dux4", "url": null, "abstract": { "de": "Die beiden Mitglieder der Gruppe der klein rund und blauzelligen Sarkome des Binde und Stützgewebes Ewing und CIC-DUX4 sind sich hinsichtlich ihrer Histologie sehr ähnlich. Betrachtet man jedoch molekulare Gesichtspunkte, Alter der PatientInnen und vor allem das Outcome sind diese sehr heterogen.\r\nEwing Sarkome betreffen vor allem Kinder und Jugendliche. Die 5 Jahres Überlebens Wahrscheinlichkeit beträgt ohne Metastasierung über 70% (S1 Leitlinien Ewing Sarkome des Kindes und Jugendalters, Stand 2014, Antonescu et al. beschreibt sogar 82%). Die derzeitige Behandlung erfolgt mit dem VIDE Schema (Vincristin, Ifosfamid, Doxorubicin, Etoposid).\r\nSeltener, aber bösartiger ist das CIC-DUX4 fusionierte Sarkom. Diese Erkrankung trifft PatientInnen im Median von 31 Jahren. Allerdings sind alle Altersgruppen vertreten. CIC und DUX4 sind zwei Genabschnitte, welche fusioniert sind. Aufgrund der Tatsache, dass CIC-DUX4 und Ewing morphologisch ähnlich sind, werden sie gleich therapiert. Obwohl molekulargenetisch bereits festgestellt ist, dass es sich dabei um verschiedene Entitäten handelt. Mit dem Ergebnis, dass die 5-Jahres-Überlebensrate von Patientinnen mit CIC-DUX4 Sarkom bei 43% (Antonescou et al.) liegt.\r\nZiel dieses Projekts ist es, mögliche Resistenzmechanismen der beiden Sarkomentitäten charakterisieren zu können.\r\nDabei handelt es sich um einen Zellkulturversuch.\r\nEin wesentlicher Faktor zur Resistenz gegenüber Chemotherapeutika ist die Zellmembran. Die Zellmembran besteht aus drei Hauptlipiden: Phospholipiden, Sphingolipiden und Cholesterin. Dabei soll die Lipidzusammensetzung der Zellen mittels Massenspektrometrie analysiert werden.\r\nWeiters werden die Sarkome Ultrastrukturell auf Fett Tröpfchen analysiert. Dies kann einen Hinweis auf Resistenzen geben, denn lipophile Therapeutika (wie zum Beispiel das Doxorubicin) könnten darin gefangen werden und dadurch keinen ausreichenden Wirkspiegel im Zellkern ausbilden.\r\nDie funktionale Bestätigung einer möglichen Resistenzbidldung in CIC-DUX4 Sarkomen durch Lipiddetektion mitels Massenspektrometrie und ultrastruktureller Aufklärung in Bezug auf Fett Tröpfchen soll mittels Compound Testing erfolgen.", "en": null }, "begin_planned": "2021-11-05T01:00:00+01:00", "begin_effective": "2021-11-01T01:00:00+01:00", "end_planned": "2022-07-01T02:00:00+02:00", "end_effective": "2022-11-30T01:00:00+01:00", "assignment": "2021-11-04T14:34:16+01:00", "program": null, "subprogram": null, "organization": 27477, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] } ] }