Project List
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GET /v1/research/project/?format=api&offset=1380&ordering=-end_planned
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1400&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1360&ordering=-end_planned", "results": [ { "id": 3738, "title": { "de": "Potentielle positive Effekte von intestinaler ATGL Überexpression", "en": "Potential beneficial effects of intestinal ATGL overexpression" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2014-08-07T12:28:43+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 27070", "ethics_committee": null, "edudract_number": null, "persons": [ "3738-51904-10" ] }, { "id": 4759, "title": { "de": "Die Rolle langer, nicht-kodierender RNS in Tumorstammzellen des Nierenzellkarzinoms.", "en": "Role of long non-coding RNAs in renal cancer stem cells." }, "short": "longncRNA in RCC-CSC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-11T10:02:18+01:00", "program": 103, "subprogram": null, "organization": 14056, "category": 10, "type": 10, "partner_function": 4, "manager": 59858, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4759-59858-10" ] }, { "id": 3144, "title": { "de": "Nanomedizin für molekulares Imaging und Behandlung von Atherosklerose: Entwicklung und Analyse klinischer Machbarkeit", "en": "Nanomedicine for target-specific imaging and treatment of atherothrombosis : development and initial clinical feasibility" }, "short": "NanoAthero", "url": null, "abstract": { "de": null, "en": "NanoAthero is a European-funded project under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. \r\n\r\nFacts & Figures\r\n- Total project volume: EUR 12.8 million \r\n- Project time: five years (1026 person-months)\r\n- Start of the project: 1 February 2013\r\n- 16 partners from 10 countries\r\n\r\nObjectives: \r\n\r\nNanoAthero aims to demonstrate initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented and provided evidence of efficacy of carriers and ligands. \r\nOver 5 years, NanoAthero will integrate GMP production, the initiation of clinical investigations in high-risk patients, including the preparation of regulatory dossiers, risk and ethical assessments, and the evaluation of the performance of optimized diagnostic and therapeutic compounds. NanoAthero offers a unique opportunity for combining in-depth knowledge of nanocarrier bioengineering and production with state-of the art expertise in imaging and treatment of cardiovascular patients providing a full bench-to-bedside framework within one collaborative consortium of 16 partners. \r\nNanoAthero gathers together leading chemists, engineers, pharmacists, biologists, toxicologists, clinicians, analysts, ethicists and key-opinion leaders in the field of cardiovascular medicine and early drug development, a European association, 3 SMEs and a large pharmaceutical company (i.e.Bracco). \r\nPhase I clinical trials targeting pivotal pathways in atherothrombosis will be performed with nanosystems for diagnosis and treatment of carotid atheroma and stroke. NanoAthero aims to complete phase I evaluation of two nanosystems: thrombus imaging and plaque stabilization in high-risk patients. Preclinical studies for two nanosystems (one to dissolve blood clots in stroke and one for plaque imaging) will be collaboratively completed and collection of clinical data will be launched. \r\n\r\n" }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-01-31T01:00:00+01:00", "assignment": "2013-01-21T11:07:13+01:00", "program": 24, "subprogram": "NMP.2012.1.2-2: Development and phase-I clinical trials of novel therapeutic nanotechnology-enabled systems for the diagnosis and treatment of atherosclerosis.", "organization": 14028, "category": 10, "type": 10, "partner_function": 2, "manager": 52854, "contact": 52854, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "309820", "ethics_committee": null, "edudract_number": null, "persons": [ "3144-50464-12", "3144-52854-10", "3144-56571-12", "3144-88042-12" ] }, { "id": 5035, "title": { "de": "Anschubfinanzierung BioPersMed-Kohorte", "en": "Anschubfinanzierung BioPersMed-Kohorte" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-09-01T02:00:00+02:00", "begin_effective": "2017-09-01T02:00:00+02:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-08-17T14:06:03+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51809, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1519 ], "funder_projectcode": "MEFO-24", "ethics_committee": null, "edudract_number": null, "persons": [ "5035-51809-10" ] }, { "id": 4697, "title": { "de": "Untersuchungen zur tumorsuppressiven Funktion von Nr4a3 in der cMYC induzierten Lymphomentstehung", "en": "Investigating the role of nuclear orphan receptor NR4A3 in Myc-driven lymphomagenesis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-01-01T01:00:00+01:00", "begin_effective": "2016-12-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2019-06-30T02:00:00+02:00", "assignment": "2016-11-21T14:35:22+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4697-100134-12", "4697-59183-10", "4697-59496-12", "4697-51930-12", "4697-106234-12" ] }, { "id": 4214, "title": { "de": "Vitamin D und Nebennierenrinde- Der Einfluss des Calciumstoffwechsels auf die adrenale Steroidregulation in vitro und in vivo", "en": "Vitamin D and adrenocortical hypertension\r\nThe impact of calcium metabolism on adrenal steroid regulation\r\n" }, "short": "ViDAH Study", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-01-01T01:00:00+01:00", "begin_effective": "2016-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2016-01-04T15:09:43+01:00", "program": 79, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4742, "title": { "de": "Laserakupunktur zur Schmerzprävention bei gesunden Neugeborenen\r\n", "en": "Laser acupuncture for the prevention of pain in healthy newborns" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-15T02:00:00+02:00", "begin_effective": "2016-10-15T02:00:00+02:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2016-12-20T14:54:00+01:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1864 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4779, "title": { "de": "Panobinostat reduziert Hypoxie-induzierte Cisplatin Resistenz in nicht-kleinzelligen Lungenkarzinom Zellen durch Destabilisierung vom HIF-1alpha", "en": "Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1alpha destabilization" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-23T13:50:46+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 50610, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-21", "ethics_committee": null, "edudract_number": null, "persons": [ "4779-50610-10" ] }, { "id": 4060, "title": { "de": "Genetische Basis der sekundär sklerosierenden Cholangitis* nach kritischer Krankheit", "en": "Secondary Sclerosing Cholangitis in Critically Ill Patients (SSC-CIP): Possible genetic basis of the disease" }, "short": "SSC Genetik", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2015-07-14T13:53:55+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 50989, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1748 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4060-62756-12", "4060-81091-12", "4060-50989-10" ] }, { "id": 4766, "title": { "de": "Die Rolle von SIRT1 in der Pathogenese der Spondyloarthritiden", "en": "The role of SIRT1 in the pathogenesis of Spondyloarthritides" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-11T14:04:18+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 78952, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 87 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4766-78952-10" ] }, { "id": 4178, "title": { "de": "Untersuchungen zur Rolle von NR4A3 in lymphatischen Malignitäten", "en": "Investigating the role of nuclear orphan receptor NR4A3 in lymphoid malignancies" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-01-01T01:00:00+01:00", "begin_effective": "2016-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2015-12-02T09:50:15+01:00", "program": null, "subprogram": "Förderprogramm „GESUNDHEIT3000“ der MEFOgraz Vereinigung Forschungsförderung Medizinischen Universität Graz", "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-09", "ethics_committee": null, "edudract_number": null, "persons": [ "4178-100134-12", "4178-59183-10" ] }, { "id": 4661, "title": { "de": "Der Einfluss des Neuroblastoms und dessen Chemotherapie auf die Darmwandbarriere, den Metabolismus und die Entzündungsreaktion. ", "en": "The influence of neuroblastoma and its chemotherapy on gut barrier, inflammation and metabolism." }, "short": "NB Gut barrier", "url": null, "abstract": { "de": "Das Neuroblastom (NB) ist der häufigste extrakranielle solide Tumor im Kindesalter. Obwohl die Kachexie mit Myo- und Lipolyse im Rahmen kindlicher Tumorerkrankungen eine Seltenheit ist, wurden in den letzten Jahren bei vielen verschiedenen Tumorarten Veränderungen des Metabolismus mit signifikantem Einfluss auf Morbidität und Mortalität festgestellt. In diesem Bezug konnten von unserer Arbeitsgruppe erstmalig Störungen des Glukose- und Lipidstoffwechsels beim Neuroblastom Modell in Nacktratten nachgewiesen werden. Die diesen Störungen zugrundeliegenden Pathomechanismen bei NB PatientInnen bleiben jedoch zu einem großen Teil unbekannt. Erste Daten aus anderen Tumormodellen (Leukämie) lassen jedoch einen Zusammenhang zwischen dem intestinalen Mikrobiom – also der Gesamtheit der Darmbakterien – Tumor, Metabolismus und Entzündungssystem erahnen. Dies stellt eine neue Ansatzmöglichkeit in der Tumortherapie dar, da sich das Mikrobiom durch die Gabe von Antibiotika, Bakteriziden, Prä-, Pro- und Synbiotika relativ leicht beeinflussen lässt. Diesbezügliche Daten für solide kindliche Tumore liegen derzeit jedoch nicht vor.\r\nIn diesem Projekt stellen wir die Hypothese, dass das Neuroblastom zu tiefgreifenden Alterationen des intestinalen Mikrobioms mit konsekutiven Veränderungen der Darmbarriere und des Gallensäurenpools mit nachfolgenden pro-inflammatorischem Zustandsbildern und Veränderungen des Lipid- und Kohlenhydratstoffwechsels führt. Damit werden mehrere bisher nicht ausreichend erforschte Themenschwerpunkte aufgegriffen: 1) das Mikrobiom beim NB als solider kindlicher Tumor, 2) das Zusammenspiel Mikrobiom – Gallensäuren – Entzündungskaskade – Metabolismus und 3) der Einfluss der Dysbiose im Rahmen der Tumorerkrankung auf Darmwandbarriere und Entzündungskaskade.\r\nEin etabliertes Modell in Foxn1nu athymischen Nacktmäusen wird zum Anzüchten von Neuroblastommetastasen (Zelllinie MHH-NB11) verwendet. Nach 10 Wochen Tumorwachstum erfolgt eine Analyse des intestinalen Mikrobioms mittels next generation sequencing. Weiters wird der inflammatorische und metabolische Zustand der Tiere (Gallensäuren in Stuhl und Serum, kurzkettige Fettsäuren im Zökum, Zytokin- und Inkretinprofil, Glucosetoleranz, Serumlipide) beurteilt. Zusätzlich wird die Darmwandbarriere mittels Elektronenmikroskopie und Immunhistochemie untersucht und die Lipopolysaccharidspiegel systemisch und im Pfortaderblut bestimmt. Die Daten der Tumortiere werden mit einer Shamgruppe verglichen. Zusätzlich wird der Einfluss der Chemotherapie mit Cyclophosphamid auf die untersuchten Parameter analysiert.\r\nDieser Antrag verwendet neueste mikrobiologische Methoden zur Darstellung der Beziehung zwischen Mikrobiom, Entzündungskaskade und Stoffwechsel beim Neuroblastom. Die Ergebnisse dieser Studie könnten die Krebstherapie der Zukunft erheblich beeinflussen und somit dazu beitragen, die Morbidität und Mortalität von krebskranken Kindern zu verringern.\r\n", "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-03-31T02:00:00+02:00", "assignment": "2016-10-19T11:02:24+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 54087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743, 1950 ], "funder_projectcode": "MEFO-12", "ethics_committee": null, "edudract_number": null, "persons": [ "4661-50778-12", "4661-54087-10", "4661-82670-12", "4661-83445-12" ] }, { "id": 3180, "title": { "de": "Spiegelbestimmung ausgewählter antimikrobieller Substanzen im Liquor cerebrospinalis bei pädiatrischen, hämato-/onkologischen Patienten", "en": "Levels of selected antimicrobial agents in cerebrospinal fluid (CSF) of paediatric haemato-/oncologic patients" }, "short": "Antimicrobials in CSF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2013-03-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-03-31T02:00:00+02:00", "assignment": "2013-02-20T09:59:20+01:00", "program": null, "subprogram": "Land Steiermark < 5.000,- Euro", "organization": 14092, "category": 10, "type": 10, "partner_function": 4, "manager": 56810, "contact": 56810, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3180-56810-10" ] }, { "id": 4378, "title": { "de": "EULAR Empfehlungen für die Anwendung der Bildgebung in der Diagnose und im Management der Groß Gefäßvaskulitis in der klinischen Praxis", "en": "EULAR recommendations for the use of imaging in the diagnosis and management of large vessel vasculitis in clinical practice " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-07-01T02:00:00+02:00", "begin_effective": "2016-07-01T02:00:00+02:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2016-03-30T16:05:51+02:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 66227, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4378-66227-10" ] }, { "id": 4849, "title": { "de": "Assessing the Role of Circadian Alterations, Cardio-postrual Interactions and Vascular Changes in Cognitive Functional Decline", "en": "Assessing the Role of Circadian Alterations, Cardio-postrual Interactions and Vascular Changes in Cognitive Functional Decline" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-10-31T01:00:00+01:00", "assignment": "2017-02-21T14:53:59+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 57932, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4849-57932-10" ] }, { "id": 3794, "title": { "de": "Entwicklungsgrundlagen der Mediaverkalkung", "en": "Developmental Basis of Media Calcification" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-10-31T01:00:00+01:00", "assignment": "2014-10-24T12:16:43+02:00", "program": 72, "subprogram": null, "organization": 14079, "category": 10, "type": 10, "partner_function": 4, "manager": 74175, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 27537", "ethics_committee": null, "edudract_number": null, "persons": [ "3794-74174-12", "3794-74175-10", "3794-75657-12", "3794-86124-12", "3794-86588-12" ] }, { "id": 3849, "title": { "de": "Chronische Elektro-Stimulation zur Therapie altersbedingter Stimmveränderungen.", "en": "Chronic electrical stimulation for treatment of age-related voice changes." }, "short": "Altersstimme", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-05T01:00:00+01:00", "end_planned": "2017-12-21T01:00:00+01:00", "end_effective": "2018-07-31T02:00:00+02:00", "assignment": "2015-01-08T13:25:58+01:00", "program": null, "subprogram": "BRIDGE", "organization": 14068, "category": 10, "type": 10, "partner_function": 1, "manager": 50670, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "848458", "ethics_committee": null, "edudract_number": null, "persons": [ "3849-50670-10", "3849-50698-12", "3849-77116-12", "3849-88652-12" ] }, { "id": 4080, "title": { "de": "Die Rolle der microRNA-199a in diffus großzelligen B-Zell Lymphomen", "en": "Elucidating the role of microRNA-199a in diffuse large B cell lymphom" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-12-01T01:00:00+01:00", "begin_effective": "2016-01-01T01:00:00+01:00", "end_planned": "2017-11-30T01:00:00+01:00", 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