Project List

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        {
            "id": 4729,
            "title": {
                "de": "ETABLIERUNG EINER NEUEN METHODE ZUR BEURTEILUNG DER DARMWANDBARRIERE",
                "en": "ESTABLISHING A NEW METHOD FOR FUNCTIONAL ANALYSIS OF THE GUT BARRIER"
            },
            "short": "Darmwand SAXS",
            "url": null,
            "abstract": {
                "de": "Hintergrund: Die Darmwand stellt eine essentielle Barriere des Körpers gegen Invasion von Bakterien und bakteriellen Toxinen dar. Verschiedene Erkrankungen wie Sepsis, Tumorkachexie, Adipositas oder chronisch entzündliche Darmerkrankungen führen zu einer Störung der Darmwandbarriere mit erhöhter Durchlässigkeit für bakterielle Toxine und konsekutiver Entzündungsreaktion. Aus diesem Grund ist die Beurteilung der Darmwanddurchlässigkeit essentieller Bestandteil verschiedener Grundlagenforschungsprojekte. Bisherige Methoden erlauben jedoch keine vollständige und zufriedenstellende Analyse der Darmwandbarriere. \r\nZiel: Ziel dieser Untersuchung ist es die Technik des small angle x-ray-scattering (SAXS) an einem Sepsismodell zu erproben, damit neue Erkenntnisse über die Darmwand zu erlangen und eine neue Technik zu etablieren.\u2028Tiere: 16 wild type Mäuse werden in 2 Gruppen geteilt. Die Kontrollgruppe erhält nur FITC Dextran per Sonde und wird 16h später euthanasiert. Bei den Tieren der zweiten Gruppe wird mittels CLP (cecal ligation and puncture) eine Sepsis erzeugt. Auch diese Tiere erhalten FITC dextran per Sonde. \r\nMethodik: Bei der Euthanasie wird Blut gewonnen und daraus der Serumgehalt von FITC als funktioneller Parameter der Darmdurchlässigkeit spektrophotometrisch bestimmt. Zusätzlich wird die Entzündung der Darmwand in HE Schnitten quantifiziert und der Darm elektronenmikroskopisch untersucht. Zusätzlich werden Ileumabschnitte mittels SAXS untersucht. Die Permeabilitätsparameter zwischen den Gruppen werden verglichen. Zusätzlich werden die Ergebnisse der Standardmethoden mit denen des SAXS korreliert. \r\nDissemination: Bisher gibt es keine Daten zur Darmwandanalyse mittels SAXS in der medizinischen Literatur. Die Ergebnisse sollen hochwertig veröffentlicht und auf internationalen Kongressen präsentiert werden. Zudem legen sie die Basis für weitere Forschungsanträge. Da unzählige Pathologien mit gestörter Darmwandbarriere vergesellschaftet sind und diese Technik auch bei der Versuchstierreduktion hilft, könnte mit dieser Methode durch die Kooperation zwischen Medizinischer Universität Graz und Universität für Bodenkultur Wien wissenschaftliches Neuland ergründet und neue Standards gelegt werden. \r\n\r\n",
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-03-31T02:00:00+02:00",
            "assignment": "2016-12-12T11:48:08+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 54087,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-20",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4729-50778-12",
                "4729-54087-10",
                "4729-82670-12"
            ]
        },
        {
            "id": 5193,
            "title": {
                "de": "Polymorphismen im NLRP3-Inflammasom bei Patienten/-innen mit Uveitis",
                "en": "Gene Polymorphisms of the NLRP3-Inflammasome in Uveitis"
            },
            "short": "NLRP3-Inflammasom und Uveitis",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-11-01T01:00:00+01:00",
            "begin_effective": "2017-11-01T01:00:00+01:00",
            "end_planned": "2018-11-01T01:00:00+01:00",
            "end_effective": "2018-03-31T02:00:00+02:00",
            "assignment": "2018-01-10T10:21:36+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14043,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 93387,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                938
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5193-93387-10"
            ]
        },
        {
            "id": 4053,
            "title": {
                "de": "Einfluss proinflammatorischer Zytokine auf plazentales Fraktalkin und die Interaktion mit Monozyten",
                "en": "The role of pro-inflammatory cytokines on placental fractalkine and its interaction with monocytes"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2015-07-01T02:00:00+02:00",
            "begin_effective": "2015-07-01T02:00:00+02:00",
            "end_planned": "2017-06-30T02:00:00+02:00",
            "end_effective": "2018-03-31T02:00:00+02:00",
            "assignment": "2015-07-08T16:58:48+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 53232,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4053-53232-10"
            ]
        },
        {
            "id": 4071,
            "title": {
                "de": "Duodenal-jejunal bypass liner bei Patienten mit Typ 2 Diabetes mellitus: Einfluss auf die Pankreasfunktion, Insulinresistenz, Darmpeptide und Darmpermeabilität ",
                "en": "Duodenal-jejunal bypass liner in obese subjects with type 2 diabetes: Impact on pancreatic function, insulin resistance, gut peptides and gut permeability"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2015-09-01T02:00:00+02:00",
            "begin_effective": "2015-09-01T02:00:00+02:00",
            "end_planned": "2017-09-30T02:00:00+02:00",
            "end_effective": "2018-03-31T02:00:00+02:00",
            "assignment": "2015-08-07T14:31:23+02:00",
            "program": null,
            "subprogram": "Skoda Preis 2015",
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50838,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                204
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4071-50838-10"
            ]
        },
        {
            "id": 3695,
            "title": {
                "de": "Ultrakonservierte Gene und deren Rolle im Metastasierungsprozeß bei Nierenkrebs",
                "en": "Metastases-associated ultraconserved genes in renal cell carcinoma patients"
            },
            "short": "Ultraconserved genes in mRCC",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-10-01T02:00:00+02:00",
            "begin_effective": "2014-10-01T02:00:00+02:00",
            "end_planned": "2016-09-30T02:00:00+02:00",
            "end_effective": "2018-02-28T01:00:00+01:00",
            "assignment": "2014-07-01T13:10:13+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14056,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50839,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3695-110608-12",
                "3695-100192-12",
                "3695-50229-12",
                "3695-50839-10"
            ]
        },
        {
            "id": 4312,
            "title": {
                "de": "Analyse falsch positiver ß-D-Glucan-Werte nach Verabreichung von intravenösen Immunglobulin-Präparaten und anderen Blutprodukten",
                "en": "False positive ß-D-Glucan levels after intravenous administration of immunoglobuline preparations and other blodd products"
            },
            "short": "BDG nach IVIG",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-03-01T01:00:00+01:00",
            "begin_effective": "2016-03-01T01:00:00+01:00",
            "end_planned": "2018-02-28T01:00:00+01:00",
            "end_effective": "2018-02-28T01:00:00+01:00",
            "assignment": "2016-02-12T12:12:08+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14092,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 56810,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1550
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4312-56810-10"
            ]
        },
        {
            "id": 2916,
            "title": {
                "de": "ApoA-I und ApoJ beeinflussen den Amyloid-beta Metabolismus an der Blut-Hirn-Schranke",
                "en": "Implications of apoA-I and apoJ as modulators of amyloid beta metabolism in brain capillary endothelial cells of the blood-brain barrier"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2012-10-01T02:00:00+02:00",
            "begin_effective": "2013-03-01T01:00:00+01:00",
            "end_planned": "2015-09-30T02:00:00+02:00",
            "end_effective": "2018-02-28T01:00:00+01:00",
            "assignment": "2012-07-17T12:22:27+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14014,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P24783",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 4235,
            "title": {
                "de": "CB2 Cannabinoid-Rezeptoren als neues therapeutisches Target für Eosinophilie-assoziierte Erkrankungen",
                "en": "Cannabinoid Receptor CB2 as a novel Target for Eosinophilic Diseases"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-01-01T01:00:00+01:00",
            "begin_effective": "2016-01-01T01:00:00+01:00",
            "end_planned": "2016-12-31T01:00:00+01:00",
            "end_effective": "2018-02-28T01:00:00+01:00",
            "assignment": "2016-01-19T12:19:01+01:00",
            "program": null,
            "subprogram": "Diagnostikum Preidler/Szolar Stipendium ",
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50791,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-08",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4235-50791-10"
            ]
        },
        {
            "id": 4780,
            "title": {
                "de": "Folatmetabolismus limitiert Krebswachstum",
                "en": "Folate metabolism limits cancer cell proliferation"
            },
            "short": "Folate metabolism in cancer",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-11-01T01:00:00+01:00",
            "begin_effective": "2016-11-01T01:00:00+01:00",
            "end_planned": "2018-02-27T01:00:00+01:00",
            "end_effective": "2018-02-27T01:00:00+01:00",
            "assignment": "2017-01-23T15:24:53+01:00",
            "program": 69,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "J 3983",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 3144,
            "title": {
                "de": "Nanomedizin für molekulares Imaging und Behandlung von Atherosklerose: Entwicklung und Analyse klinischer Machbarkeit",
                "en": "Nanomedicine for target-specific imaging and treatment of atherothrombosis : development and initial clinical feasibility"
            },
            "short": "NanoAthero",
            "url": null,
            "abstract": {
                "de": null,
                "en": "NanoAthero is a European-funded project under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. \r\n\r\nFacts & Figures\r\n- Total project volume: EUR 12.8 million \r\n- Project time: five years (1026 person-months)\r\n- Start of the project: 1 February 2013\r\n- 16 partners from 10 countries\r\n\r\nObjectives: \r\n\r\nNanoAthero aims to demonstrate initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented and provided evidence of efficacy of carriers and ligands. \r\nOver 5 years, NanoAthero will integrate GMP production, the initiation of clinical investigations in high-risk patients, including the preparation of regulatory dossiers, risk and ethical assessments, and the evaluation of the performance of optimized diagnostic and therapeutic compounds. NanoAthero offers a unique opportunity for combining in-depth knowledge of nanocarrier bioengineering and production with state-of the art expertise in imaging and treatment of cardiovascular patients providing a full bench-to-bedside framework within one collaborative consortium of 16 partners. \r\nNanoAthero gathers together leading chemists, engineers, pharmacists, biologists, toxicologists, clinicians, analysts, ethicists and key-opinion leaders in the field of cardiovascular medicine and early drug development, a European association, 3 SMEs and a large pharmaceutical company (i.e.Bracco). \r\nPhase I clinical trials targeting pivotal pathways in atherothrombosis will be performed with nanosystems for diagnosis and treatment of carotid atheroma and stroke. NanoAthero aims to complete phase I evaluation of two nanosystems: thrombus imaging and plaque stabilization in high-risk patients. Preclinical studies for two nanosystems (one to dissolve blood clots in stroke and one for plaque imaging) will be collaboratively completed and collection of clinical data will be launched. \r\n\r\n"
            },
            "begin_planned": "2013-01-01T01:00:00+01:00",
            "begin_effective": "2013-02-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-01-31T01:00:00+01:00",
            "assignment": "2013-01-21T11:07:13+01:00",
            "program": 24,
            "subprogram": "NMP.2012.1.2-2: Development and phase-I clinical trials of novel therapeutic nanotechnology-enabled systems for the diagnosis and treatment of atherosclerosis.",
            "organization": 14028,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 52854,
            "contact": 52854,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "309820",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3144-50464-12",
                "3144-52854-10",
                "3144-56571-12",
                "3144-88042-12"
            ]
        },
        {
            "id": 4800,
            "title": {
                "de": "Mitochondrien-Forschung: Je sanfter desto besser!\r\n",
                "en": "Mitochondria-research"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-02-01T01:00:00+01:00",
            "begin_effective": "2017-02-01T01:00:00+01:00",
            "end_planned": "2018-01-31T01:00:00+01:00",
            "end_effective": "2018-01-31T01:00:00+01:00",
            "assignment": "2017-02-01T15:06:11+01:00",
            "program": null,
            "subprogram": null,
            "organization": 28392,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-02",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 4977,
            "title": {
                "de": "Stressinduzierte kardiovaskuläre Reaktivität bei Jugendlichen – Vergleich von Früh- zu Normalgeborenen.",
                "en": "Stress-related cardiovascular reactivity in adolescents"
            },
            "short": "ReaJu",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2018-01-31T01:00:00+01:00",
            "end_effective": "2018-01-31T01:00:00+01:00",
            "assignment": "2017-06-07T14:58:02+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 64295,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                530
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4977-64295-10"
            ]
        },
        {
            "id": 4978,
            "title": {
                "de": "Kardiovaskuläre Folgen von Schwangerschaftskomplikationen",
                "en": "Cardiovascular Consequences of Preeclampsia and Pregnancy Induced Hypertension\r\n"
            },
            "short": "CaCoPE",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2018-01-31T01:00:00+01:00",
            "end_effective": "2018-01-31T01:00:00+01:00",
            "assignment": "2017-06-07T15:24:18+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 64295,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                530
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4978-64295-10"
            ]
        },
        {
            "id": 3483,
            "title": {
                "de": "Systembiologie zur Identifizierung neuer Targets in der Therapie von Gefässerkrankungen",
                "en": "Systems Biology to Identify Molecular Targets for Vascular Disease Treatment"
            },
            "short": "SysVasc",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-09-01T02:00:00+02:00",
            "begin_effective": "2014-02-01T01:00:00+01:00",
            "end_planned": "2018-09-01T02:00:00+02:00",
            "end_effective": "2018-01-31T01:00:00+01:00",
            "assignment": "2013-12-20T11:31:45+01:00",
            "program": 24,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 3,
            "manager": 59317,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "603288",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3483-59941-12",
                "3483-91349-12"
            ]
        },
        {
            "id": 3099,
            "title": {
                "de": "Parodontale Therapie und Reduktion der Gefäßinflammation bei Patienten mit peripherer arterieller Verschlusskrankheit",
                "en": "Periodontal treatment and reduction of vascular inflammation in patients with peripheral arterial disease"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2012-11-01T01:00:00+01:00",
            "begin_effective": "2013-01-01T01:00:00+01:00",
            "end_planned": "2015-10-31T01:00:00+01:00",
            "end_effective": "2018-01-01T01:00:00+01:00",
            "assignment": "2012-12-10T11:16:43+01:00",
            "program": 108,
            "subprogram": "KLIF",
            "organization": 14079,
            "category": 10,
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