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GET /v1/research/project/?format=api&offset=1300&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1320&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1280&ordering=-end_effective", "results": [ { "id": 4482, "title": { "de": "Evaluierung der MicroRNA-371 Familie als potentielle Biomarker für den Krankheitsverlauf von Hodenkrebspatienten", "en": "Evaluation of MicroRNA-371 family as potential blood-based biomarkers for disease monitoring in testicular germ cell cancer patients" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-06-01T02:00:00+02:00", "begin_effective": "2016-06-01T02:00:00+02:00", "end_planned": "2016-12-31T01:00:00+01:00", "end_effective": "2018-06-30T02:00:00+02:00", "assignment": "2016-06-07T14:35:19+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 1, "manager": 86226, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 140 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4482-86226-10" ] }, { "id": 3891, "title": { "de": "Doktoratskolleg \"Metabolische und kardiovaskuläre Erkrankungen\" ", "en": "Doktoratskolleg: \"Metabolic and cardiovascular disease\" " }, "short": "DK_METABOL_DISORDERS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-07-01T02:00:00+02:00", "begin_effective": "2014-07-01T02:00:00+02:00", "end_planned": "2018-06-30T02:00:00+02:00", "end_effective": "2018-06-30T02:00:00+02:00", "assignment": "2015-02-04T11:55:15+01:00", "program": 66, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1226", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3882, "title": { "de": "Doktoratskolleg \"Metabolische und kardiovaskuläre Erkrankungen\" ", "en": "Doktoratskolleg: \"Metabolic and cardiovascular disease\"" }, "short": "DK_METABOL_DISORDERS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-07-01T02:00:00+02:00", "begin_effective": "2014-07-01T02:00:00+02:00", "end_planned": "2018-06-30T02:00:00+02:00", "end_effective": "2018-06-30T02:00:00+02:00", "assignment": "2015-02-03T14:23:01+01:00", "program": 66, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51860, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1226", "ethics_committee": null, "edudract_number": null, "persons": [ "3882-51860-10" ] }, { "id": 3890, "title": { "de": "Doktoratskolleg \"Metabolische und kardiovaskuläre Erkrankungen\"", "en": "Doktoratskolleg: \"Metabolic and cardiovascular disease\" " }, "short": "DK_METABOL_DISORDERS ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-07-01T02:00:00+02:00", "begin_effective": "2014-07-01T02:00:00+02:00", "end_planned": "2018-06-30T02:00:00+02:00", "end_effective": "2018-06-30T02:00:00+02:00", "assignment": "2015-02-04T11:20:23+01:00", "program": 66, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1226", "ethics_committee": null, "edudract_number": null, "persons": [ "3890-51904-10" ] }, { "id": 5001, "title": { "de": "organico-typical culture in bone", "en": "organico-typical culture in bone" }, "short": "OCTBone", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-07-01T02:00:00+02:00", "begin_effective": "2017-07-01T02:00:00+02:00", "end_planned": "2018-06-30T02:00:00+02:00", "end_effective": "2018-06-30T02:00:00+02:00", "assignment": "2017-07-06T15:15:42+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50785, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2051 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5001-50785-10" ] }, { "id": 3899, "title": { "de": "Doktoratskolleg \"Metabolische und Kardiovaskuläre Erkrankungen\"", "en": "Doktoratskolleg: \"Metabolic and cardiovascular disease\"" }, "short": "DK_METABOL_DISORDERS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-07-01T02:00:00+02:00", "begin_effective": "2014-07-01T02:00:00+02:00", "end_planned": "2018-06-30T02:00:00+02:00", "end_effective": "2018-06-30T02:00:00+02:00", "assignment": "2015-02-04T14:30:12+01:00", "program": 66, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1226", "ethics_committee": null, "edudract_number": null, "persons": [ "3899-50861-12", "3899-54043-12", "3899-51663-10" ] }, { "id": 5299, "title": { "de": "Entwicklung eines Grazer Notfallventilations- und Metabolismusmonitors", "en": "Development of an Emergency Ventilatory and Metabolic Monitor" }, "short": "VICA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-12-01T01:00:00+01:00", "begin_effective": "2017-12-01T01:00:00+01:00", "end_planned": "2018-06-01T02:00:00+02:00", "end_effective": "2018-06-01T02:00:00+02:00", "assignment": "2018-02-27T13:51:07+01:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 74176, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5299-74176-10" ] }, { "id": 4529, "title": { "de": "ProbioBIP_two- Wirkung von Probiotika bei Menschen mit bipolarer Störung auf Depressionen und Nebenwirkungen der Psychopharmakotherapie\"", "en": "\"ProbioBIP_two- Probiotics in bipolar disorder, effect on depression and side effects of psychopharmacological therapy\"" }, "short": "ProbioBIP_two", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-06-01T02:00:00+02:00", "begin_effective": "2016-06-01T02:00:00+02:00", "end_planned": "2017-06-01T02:00:00+02:00", "end_effective": "2018-06-01T02:00:00+02:00", "assignment": "2016-07-20T15:46:44+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": 50654, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4529-50654-10", "4529-79454-12", "4529-79771-12", "4529-79733-12", "4529-86429-12", "4529-92607-12", "4529-95403-12" ] }, { "id": 5138, "title": { "de": "BioPersMed-Kohorte", "en": "BioPersMed-cohort" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-10-01T02:00:00+02:00", "begin_effective": "2017-10-01T02:00:00+02:00", "end_planned": "2018-02-28T01:00:00+01:00", "end_effective": "2018-05-31T02:00:00+02:00", "assignment": "2017-11-28T09:47:29+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 51809, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5138-51809-10" ] }, { "id": 4414, "title": { "de": "Veränderungen des intestinalen Mikrobioms und der Gallensäuren im Rahmen des Hepatoblastoms", "en": "The Intestinal Microbiome and Bile Acid Profiles in Hepatoblastoma – A Novel Experimental Study" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-06-01T02:00:00+02:00", "begin_effective": "2016-06-01T02:00:00+02:00", "end_planned": "2017-05-31T02:00:00+02:00", "end_effective": "2018-05-31T02:00:00+02:00", "assignment": "2016-05-02T17:04:22+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 82670, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 140 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4414-50778-12", "4414-54087-12", "4414-82670-10" ] }, { "id": 4112, "title": { "de": "SFB: Mathematische Optimierung mit Anwendungen in der biomedizinischen Forschung\r\n3. Förderperiode", "en": "SFB: Mathematical Optimization and Applications in Biomedical Sciences" }, "short": "MOBIS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2015-10-05T12:06:36+02:00", "program": 67, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 1, "manager": 50966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "F32", "ethics_committee": null, "edudract_number": null, "persons": [ "4112-50966-10" ] }, { "id": 3252, "title": { "de": "Rolle von PGE2 und EP Rezeptoren in der pulmonalen Endothelfunktion", "en": "Regulatory role of PGE2 and EP receptors in pulmonary endothelial cell function" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-05-01T02:00:00+02:00", "end_planned": "2015-12-31T01:00:00+01:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2013-04-25T10:48:46+02:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25531", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5029, "title": { "de": "Dynamische MRT bei zerebraler Kleingefäßerkrankung", "en": "Understanding the pathophysiology of cerebral small vessel disease using dynamic MRI techniques" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-11-01T01:00:00+01:00", "begin_effective": "2017-11-01T01:00:00+01:00", "end_planned": "2018-04-30T02:00:00+02:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2017-08-07T16:31:44+02:00", "program": 103, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 70680, "contact": null, "status": 2, "research": 2, "grant": 20, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5029-70680-10" ] }, { "id": 4506, "title": { "de": "Dermal open flow microperfusion for the assessment of cytokine levels in thermal burns", "en": "Dermal open flow microperfusion for the assessment of cytokine levels in thermal burns" }, "short": "Dermal open flow microperfusion ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-05-01T02:00:00+02:00", "begin_effective": "2016-05-01T02:00:00+02:00", "end_planned": "2018-04-30T02:00:00+02:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2016-07-08T14:56:46+02:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 4, "manager": 80111, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1886 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4506-80111-10" ] }, { "id": 4432, "title": { "de": "Aufbau und Etablierung einer Biobank von humanem Stimmlippen-Gewebe.", "en": "Establishing a bio-bank of human vocal fold tissue." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-05-01T02:00:00+02:00", "begin_effective": "2016-05-01T02:00:00+02:00", "end_planned": "2018-04-30T02:00:00+02:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2016-05-10T10:45:16+02:00", "program": null, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 50670, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4432-50670-10" ] }, { "id": 3117, "title": { "de": "Zirkulierende Tumorzellen als Biomarker für Minimal Residual Disease bei Prostatakarzinom", "en": "Circulating Tumor Cells as Biomarker for Minimal Residual Disease in Prostate Cancer" }, "short": "CTC-SCAN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2013-10-01T02:00:00+02:00", "end_planned": "2016-09-30T02:00:00+02:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2012-12-19T12:27:13+01:00", "program": null, "subprogram": "ERA-Net", "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I1220", "ethics_committee": null, "edudract_number": null, "persons": [ "3117-54171-12", "3117-60042-12" ] }, { "id": 3522, "title": { "de": "Endotheliale Indolamin 2,3-dioxygenase-1 in der Regulation des plazentaren Gefäßtonus", "en": "Endothelial indoleamine 2,3-dioxygenase-1 in the regulation of placental vascular tone" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-02-01T01:00:00+01:00", "begin_effective": "2014-01-01T01:00:00+01:00", "end_planned": "2016-07-31T02:00:00+02:00", "end_effective": "2018-04-30T02:00:00+02:00", "assignment": "2014-01-22T09:48:57+01:00", "program": 79, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "15671", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5417, "title": { "de": "Reisestipendium zum EMBO (European Molecular Biology Organization) - Workshop \"Perspectives on Skin Cancer Prevention\" von 08.-11.04.18 in Les Diablerets, Schweiz", "en": "Travel Grant to the EMBO (European Molecular Biology Organization) - Workshop \"Perspectives on Skin Cancer Prevention\" April 08th - 11th, 2018 in Les Diablerets, Switzerland" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-04-08T02:00:00+02:00", "begin_effective": "2018-04-08T02:00:00+02:00", "end_planned": "2018-04-11T02:00:00+02:00", "end_effective": "2018-04-11T02:00:00+02:00", "assignment": "2018-07-12T10:11:40+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 3, "manager": 83662, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5417-83662-10" ] }, { "id": 4661, "title": { "de": "Der Einfluss des Neuroblastoms und dessen Chemotherapie auf die Darmwandbarriere, den Metabolismus und die Entzündungsreaktion. ", "en": "The influence of neuroblastoma and its chemotherapy on gut barrier, inflammation and metabolism." }, "short": "NB Gut barrier", "url": null, "abstract": { "de": "Das Neuroblastom (NB) ist der häufigste extrakranielle solide Tumor im Kindesalter. Obwohl die Kachexie mit Myo- und Lipolyse im Rahmen kindlicher Tumorerkrankungen eine Seltenheit ist, wurden in den letzten Jahren bei vielen verschiedenen Tumorarten Veränderungen des Metabolismus mit signifikantem Einfluss auf Morbidität und Mortalität festgestellt. In diesem Bezug konnten von unserer Arbeitsgruppe erstmalig Störungen des Glukose- und Lipidstoffwechsels beim Neuroblastom Modell in Nacktratten nachgewiesen werden. Die diesen Störungen zugrundeliegenden Pathomechanismen bei NB PatientInnen bleiben jedoch zu einem großen Teil unbekannt. Erste Daten aus anderen Tumormodellen (Leukämie) lassen jedoch einen Zusammenhang zwischen dem intestinalen Mikrobiom – also der Gesamtheit der Darmbakterien – Tumor, Metabolismus und Entzündungssystem erahnen. Dies stellt eine neue Ansatzmöglichkeit in der Tumortherapie dar, da sich das Mikrobiom durch die Gabe von Antibiotika, Bakteriziden, Prä-, Pro- und Synbiotika relativ leicht beeinflussen lässt. Diesbezügliche Daten für solide kindliche Tumore liegen derzeit jedoch nicht vor.\r\nIn diesem Projekt stellen wir die Hypothese, dass das Neuroblastom zu tiefgreifenden Alterationen des intestinalen Mikrobioms mit konsekutiven Veränderungen der Darmbarriere und des Gallensäurenpools mit nachfolgenden pro-inflammatorischem Zustandsbildern und Veränderungen des Lipid- und Kohlenhydratstoffwechsels führt. Damit werden mehrere bisher nicht ausreichend erforschte Themenschwerpunkte aufgegriffen: 1) das Mikrobiom beim NB als solider kindlicher Tumor, 2) das Zusammenspiel Mikrobiom – Gallensäuren – Entzündungskaskade – Metabolismus und 3) der Einfluss der Dysbiose im Rahmen der Tumorerkrankung auf Darmwandbarriere und Entzündungskaskade.\r\nEin etabliertes Modell in Foxn1nu athymischen Nacktmäusen wird zum Anzüchten von Neuroblastommetastasen (Zelllinie MHH-NB11) verwendet. Nach 10 Wochen Tumorwachstum erfolgt eine Analyse des intestinalen Mikrobioms mittels next generation sequencing. Weiters wird der inflammatorische und metabolische Zustand der Tiere (Gallensäuren in Stuhl und Serum, kurzkettige Fettsäuren im Zökum, Zytokin- und Inkretinprofil, Glucosetoleranz, Serumlipide) beurteilt. Zusätzlich wird die Darmwandbarriere mittels Elektronenmikroskopie und Immunhistochemie untersucht und die Lipopolysaccharidspiegel systemisch und im Pfortaderblut bestimmt. Die Daten der Tumortiere werden mit einer Shamgruppe verglichen. Zusätzlich wird der Einfluss der Chemotherapie mit Cyclophosphamid auf die untersuchten Parameter analysiert.\r\nDieser Antrag verwendet neueste mikrobiologische Methoden zur Darstellung der Beziehung zwischen Mikrobiom, Entzündungskaskade und Stoffwechsel beim Neuroblastom. Die Ergebnisse dieser Studie könnten die Krebstherapie der Zukunft erheblich beeinflussen und somit dazu beitragen, die Morbidität und Mortalität von krebskranken Kindern zu verringern.\r\n", "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-03-31T02:00:00+02:00", "assignment": "2016-10-19T11:02:24+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 54087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743, 1950 ], "funder_projectcode": "MEFO-12", "ethics_committee": null, "edudract_number": null, "persons": [ "4661-50778-12", "4661-54087-10", "4661-82670-12", "4661-83445-12" ] }, { "id": 3011, "title": { "de": "Vitamin D und Pharmakogenetik im Glucosestoffwechsel", "en": "VitaminD treatment, pharmacogenetics and glucose metabolism" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-01-01T01:00:00+01:00", "begin_effective": "2013-01-01T01:00:00+01:00", "end_planned": "2016-01-01T01:00:00+01:00", "end_effective": "2018-03-31T02:00:00+02:00", "assignment": "2012-10-22T17:15:49+02:00", "program": 108, "subprogram": "KLIF", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI274", "ethics_committee": null, "edudract_number": null, "persons": [] } ] }