API @ Medical University of Graz

List projects.

Fields

`id` (`integer`)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

organization
category
type
partner_function
manager
contact
status
grant
research
event
study
language
program
funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

organization
category
manager
contact
status
grant
research
study
language
funders
program

For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

begin_planned: gt, gte, lt, lte
begin_effective: gt, gte, lt, lte
end_planned: gt, gte, lt, lte
end_effective: gt, gte, lt, lte

GET /v1/research/project/?format=api&offset=1260&ordering=-end_planned

HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2329,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1280&ordering=-end_planned",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1240&ordering=-end_planned",
    "results": [
        {
            "id": 4513,
            "title": {
                "de": "Einfluss pränataler Humanmilch Oligosaccharide auf feto-plazentare Angiogenese in Gestationsdiabetes",
                "en": "Prenatal Human Milk Oligosaccharides Alter Feto-placental Angiogenesis in Gestational Diabetes"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-08-01T02:00:00+02:00",
            "begin_effective": "2016-08-01T02:00:00+02:00",
            "end_planned": "2018-01-31T01:00:00+01:00",
            "end_effective": "2018-11-30T01:00:00+01:00",
            "assignment": "2016-07-11T16:42:14+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 88993,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": "16927",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4513-88993-10"
            ]
        },
        {
            "id": 3852,
            "title": {
                "de": "Aufklärung der spezifischen Zytotoxizität von Dimethylacrylshikonin in Melanomzellen",
                "en": "Elucidation of specific cytotoxic effects of dimethylacrylshikonin in melanoma cells"
            },
            "short": "SpeDiMel",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2015-01-01T01:00:00+01:00",
            "begin_effective": "2015-01-28T01:00:00+01:00",
            "end_planned": "2018-01-01T01:00:00+01:00",
            "end_effective": "2019-01-27T01:00:00+01:00",
            "assignment": "2015-01-09T09:19:54+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 17218,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 50826,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P27505",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3852-50826-10"
            ]
        },
        {
            "id": 4779,
            "title": {
                "de": "Panobinostat reduziert Hypoxie-induzierte Cisplatin Resistenz in nicht-kleinzelligen Lungenkarzinom Zellen durch Destabilisierung vom HIF-1alpha",
                "en": "Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1alpha destabilization"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-02-01T01:00:00+01:00",
            "begin_effective": "2017-02-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2017-01-23T13:50:46+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14087,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50610,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-21",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4779-50610-10"
            ]
        },
        {
            "id": 5085,
            "title": {
                "de": "Mikrobiom Graz",
                "en": "Microbiome Graz"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-09-01T02:00:00+02:00",
            "begin_effective": "2017-09-01T02:00:00+02:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2017-10-11T10:52:53+02:00",
            "program": null,
            "subprogram": "Subvention Kulturamt Graz",
            "organization": 14023,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 90021,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5085-90021-10"
            ]
        },
        {
            "id": 4940,
            "title": {
                "de": "Double hit und double expressor Lymphome - Eine Entität oder nicht?",
                "en": "Double hit and double expressor lymphoma – Same but different?"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-05-01T02:00:00+02:00",
            "begin_effective": "2017-05-01T02:00:00+02:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2020-04-30T02:00:00+02:00",
            "assignment": "2017-05-02T16:31:20+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14082,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 51930,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1375
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4940-51930-10"
            ]
        },
        {
            "id": 4783,
            "title": {
                "de": "Entwicklung eines Konzepts zur Charakterisierung und dem Deployment einer einer integrativen\r\nHealthy Ageing Region unter Berücksichtigung von Active und Assisted-Living Technologien\r\nund Smart City –Komponenten.\r\n",
                "en": "Integrative Strategies for Healthy Ageing Regions"
            },
            "short": "i-Share",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-02-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2017-01-24T13:55:59+01:00",
            "program": 75,
            "subprogram": "HumanTechnologyInterface:\r\nHealthy Ageing–Assisted Living\r\nProjekttitel:",
            "organization": 14046,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51745,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                55
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4783-51745-10"
            ]
        },
        {
            "id": 4849,
            "title": {
                "de": "Assessing the Role of Circadian Alterations, Cardio-postrual Interactions and Vascular Changes in Cognitive Functional Decline",
                "en": "Assessing the Role of Circadian Alterations, Cardio-postrual Interactions and Vascular Changes in Cognitive Functional Decline"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-10-31T01:00:00+01:00",
            "assignment": "2017-02-21T14:53:59+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57932,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                15
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4849-57932-10"
            ]
        },
        {
            "id": 4214,
            "title": {
                "de": "Vitamin D und Nebennierenrinde- Der Einfluss des Calciumstoffwechsels auf die adrenale Steroidregulation in vitro und in vivo",
                "en": "Vitamin D and adrenocortical hypertension\r\nThe impact of calcium metabolism on adrenal steroid regulation\r\n"
            },
            "short": "ViDAH Study",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-01-01T01:00:00+01:00",
            "begin_effective": "2016-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2016-01-04T15:09:43+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14080,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 4234,
            "title": {
                "de": "Die Interaktion von p53 und Wnt-Signalpfaden in mesenchymalen Stammzellen",
                "en": "THE INTERACTION OF P53 AND WNT SIGNALING IN THE STEMNESS OF MESENCHYMAL STEM CELLS"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-01-01T01:00:00+01:00",
            "begin_effective": "2016-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2016-01-19T11:43:48+01:00",
            "program": 92,
            "subprogram": "Wissenschaftlich-technische Zusammenarbeit Österr.-Serbien",
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 89979,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                20
            ],
            "funder_projectcode": "SRB 02/2016",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4234-89979-10"
            ]
        },
        {
            "id": 4729,
            "title": {
                "de": "ETABLIERUNG EINER NEUEN METHODE ZUR BEURTEILUNG DER DARMWANDBARRIERE",
                "en": "ESTABLISHING A NEW METHOD FOR FUNCTIONAL ANALYSIS OF THE GUT BARRIER"
            },
            "short": "Darmwand SAXS",
            "url": null,
            "abstract": {
                "de": "Hintergrund: Die Darmwand stellt eine essentielle Barriere des Körpers gegen Invasion von Bakterien und bakteriellen Toxinen dar. Verschiedene Erkrankungen wie Sepsis, Tumorkachexie, Adipositas oder chronisch entzündliche Darmerkrankungen führen zu einer Störung der Darmwandbarriere mit erhöhter Durchlässigkeit für bakterielle Toxine und konsekutiver Entzündungsreaktion. Aus diesem Grund ist die Beurteilung der Darmwanddurchlässigkeit essentieller Bestandteil verschiedener Grundlagenforschungsprojekte. Bisherige Methoden erlauben jedoch keine vollständige und zufriedenstellende Analyse der Darmwandbarriere. \r\nZiel: Ziel dieser Untersuchung ist es die Technik des small angle x-ray-scattering (SAXS) an einem Sepsismodell zu erproben, damit neue Erkenntnisse über die Darmwand zu erlangen und eine neue Technik zu etablieren.\u2028Tiere: 16 wild type Mäuse werden in 2 Gruppen geteilt. Die Kontrollgruppe erhält nur FITC Dextran per Sonde und wird 16h später euthanasiert. Bei den Tieren der zweiten Gruppe wird mittels CLP (cecal ligation and puncture) eine Sepsis erzeugt. Auch diese Tiere erhalten FITC dextran per Sonde. \r\nMethodik: Bei der Euthanasie wird Blut gewonnen und daraus der Serumgehalt von FITC als funktioneller Parameter der Darmdurchlässigkeit spektrophotometrisch bestimmt. Zusätzlich wird die Entzündung der Darmwand in HE Schnitten quantifiziert und der Darm elektronenmikroskopisch untersucht. Zusätzlich werden Ileumabschnitte mittels SAXS untersucht. Die Permeabilitätsparameter zwischen den Gruppen werden verglichen. Zusätzlich werden die Ergebnisse der Standardmethoden mit denen des SAXS korreliert. \r\nDissemination: Bisher gibt es keine Daten zur Darmwandanalyse mittels SAXS in der medizinischen Literatur. Die Ergebnisse sollen hochwertig veröffentlicht und auf internationalen Kongressen präsentiert werden. Zudem legen sie die Basis für weitere Forschungsanträge. Da unzählige Pathologien mit gestörter Darmwandbarriere vergesellschaftet sind und diese Technik auch bei der Versuchstierreduktion hilft, könnte mit dieser Methode durch die Kooperation zwischen Medizinischer Universität Graz und Universität für Bodenkultur Wien wissenschaftliches Neuland ergründet und neue Standards gelegt werden. \r\n\r\n",
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-03-31T02:00:00+02:00",
            "assignment": "2016-12-12T11:48:08+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 54087,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-20",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4729-50778-12",
                "4729-54087-10",
                "4729-82670-12"
            ]
        },
        {
            "id": 3144,
            "title": {
                "de": "Nanomedizin für molekulares Imaging und Behandlung von Atherosklerose: Entwicklung und Analyse klinischer Machbarkeit",
                "en": "Nanomedicine for target-specific imaging and treatment of atherothrombosis : development and initial clinical feasibility"
            },
            "short": "NanoAthero",
            "url": null,
            "abstract": {
                "de": null,
                "en": "NanoAthero is a European-funded project under the 7th Framework Programme for Research. The main objective of this project is to address more in depth prospects of improved diagnosis and treatment of atherosclerosis by means of nanotechnology. \r\n\r\nFacts & Figures\r\n- Total project volume: EUR 12.8 million \r\n- Project time: five years (1026 person-months)\r\n- Start of the project: 1 February 2013\r\n- 16 partners from 10 countries\r\n\r\nObjectives: \r\n\r\nNanoAthero aims to demonstrate initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented and provided evidence of efficacy of carriers and ligands. \r\nOver 5 years, NanoAthero will integrate GMP production, the initiation of clinical investigations in high-risk patients, including the preparation of regulatory dossiers, risk and ethical assessments, and the evaluation of the performance of optimized diagnostic and therapeutic compounds. NanoAthero offers a unique opportunity for combining in-depth knowledge of nanocarrier bioengineering and production with state-of the art expertise in imaging and treatment of cardiovascular patients providing a full bench-to-bedside framework within one collaborative consortium of 16 partners. \r\nNanoAthero gathers together leading chemists, engineers, pharmacists, biologists, toxicologists, clinicians, analysts, ethicists and key-opinion leaders in the field of cardiovascular medicine and early drug development, a European association, 3 SMEs and a large pharmaceutical company (i.e.Bracco). \r\nPhase I clinical trials targeting pivotal pathways in atherothrombosis will be performed with nanosystems for diagnosis and treatment of carotid atheroma and stroke. NanoAthero aims to complete phase I evaluation of two nanosystems: thrombus imaging and plaque stabilization in high-risk patients. Preclinical studies for two nanosystems (one to dissolve blood clots in stroke and one for plaque imaging) will be collaboratively completed and collection of clinical data will be launched. \r\n\r\n"
            },
            "begin_planned": "2013-01-01T01:00:00+01:00",
            "begin_effective": "2013-02-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-01-31T01:00:00+01:00",
            "assignment": "2013-01-21T11:07:13+01:00",
            "program": 24,
            "subprogram": "NMP.2012.1.2-2: Development and phase-I clinical trials of novel therapeutic nanotechnology-enabled systems for the diagnosis and treatment of atherosclerosis.",
            "organization": 14028,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 52854,
            "contact": 52854,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "309820",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3144-50464-12",
                "3144-52854-10",
                "3144-56571-12",
                "3144-88042-12"
            ]
        },
        {
            "id": 3180,
            "title": {
                "de": "Spiegelbestimmung ausgewählter antimikrobieller Substanzen im Liquor cerebrospinalis bei pädiatrischen, hämato-/onkologischen Patienten",
                "en": "Levels of selected antimicrobial agents in cerebrospinal fluid (CSF) of paediatric haemato-/oncologic patients"
            },
            "short": "Antimicrobials in CSF",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2012-10-01T02:00:00+02:00",
            "begin_effective": "2013-03-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-03-31T02:00:00+02:00",
            "assignment": "2013-02-20T09:59:20+01:00",
            "program": null,
            "subprogram": "Land Steiermark < 5.000,- Euro",
            "organization": 14092,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 56810,
            "contact": 56810,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                135
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3180-56810-10"
            ]
        },
        {
            "id": 4491,
            "title": {
                "de": "Early Detection of Trastuzumab induced Cardiotoxicity with novel Biomarkers and Identification of protective Co-treatments",
                "en": "Early Detection of Trastuzumab induced Cardiotoxicity with novel Biomarkers and Identification of protective Co-treatments"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-06-01T02:00:00+02:00",
            "begin_effective": "2016-06-01T02:00:00+02:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-12-31T01:00:00+01:00",
            "assignment": "2016-06-15T14:41:57+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14083,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 58906,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                140
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4491-96882-12",
                "4491-58906-10"
            ]
        },
        {
            "id": 4378,
            "title": {
                "de": "EULAR Empfehlungen für die Anwendung der Bildgebung in der Diagnose und im Management der Groß Gefäßvaskulitis in der klinischen Praxis",
                "en": "EULAR recommendations for the use of imaging in the diagnosis and management of large vessel vasculitis in clinical practice "
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-07-01T02:00:00+02:00",
            "begin_effective": "2016-07-01T02:00:00+02:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2016-03-30T16:05:51+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14086,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 66227,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4378-66227-10"
            ]
        },
        {
            "id": 4766,
            "title": {
                "de": "Die Rolle von SIRT1 in der Pathogenese der Spondyloarthritiden",
                "en": "The role of SIRT1 in the pathogenesis of Spondyloarthritides"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2017-01-11T14:04:18+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14086,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 78952,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                87
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4766-78952-10"
            ]
        },
        {
            "id": 3794,
            "title": {
                "de": "Entwicklungsgrundlagen der Mediaverkalkung",
                "en": "Developmental Basis of Media Calcification"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2015-01-01T01:00:00+01:00",
            "begin_effective": "2015-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-10-31T01:00:00+01:00",
            "assignment": "2014-10-24T12:16:43+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14079,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 74175,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P 27537",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3794-74174-12",
                "3794-74175-10",
                "3794-75657-12",
                "3794-86124-12",
                "3794-86588-12"
            ]
        },
        {
            "id": 4331,
            "title": {
                "de": "Mikrobiom interstitieller Pneumonien",
                "en": "Microbiome of interstitial Pneumonias"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-06-01T02:00:00+02:00",
            "begin_effective": "2016-06-01T02:00:00+02:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-10-08T02:00:00+02:00",
            "assignment": "2016-02-29T14:55:11+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 4661,
            "title": {
                "de": "Der Einfluss des Neuroblastoms und dessen Chemotherapie auf die Darmwandbarriere, den Metabolismus und die Entzündungsreaktion. ",
                "en": "The influence of neuroblastoma and its chemotherapy on gut barrier, inflammation and metabolism."
            },
            "short": "NB Gut barrier",
            "url": null,
            "abstract": {
                "de": "Das Neuroblastom (NB) ist der häufigste extrakranielle solide Tumor im Kindesalter. Obwohl die Kachexie mit Myo- und Lipolyse im Rahmen kindlicher Tumorerkrankungen eine Seltenheit ist, wurden in den letzten Jahren bei vielen verschiedenen Tumorarten Veränderungen des Metabolismus mit signifikantem Einfluss auf Morbidität und Mortalität festgestellt. In diesem Bezug konnten von unserer Arbeitsgruppe erstmalig Störungen des Glukose- und Lipidstoffwechsels beim Neuroblastom Modell in Nacktratten nachgewiesen werden. Die diesen Störungen zugrundeliegenden Pathomechanismen bei NB PatientInnen bleiben jedoch zu einem großen Teil unbekannt. Erste Daten aus anderen Tumormodellen (Leukämie) lassen jedoch einen Zusammenhang zwischen dem intestinalen Mikrobiom – also der Gesamtheit der Darmbakterien – Tumor, Metabolismus und Entzündungssystem erahnen. Dies stellt eine neue Ansatzmöglichkeit in der Tumortherapie dar, da sich das Mikrobiom durch die Gabe von Antibiotika, Bakteriziden, Prä-, Pro- und Synbiotika relativ leicht beeinflussen lässt. Diesbezügliche Daten für solide kindliche Tumore liegen derzeit jedoch nicht vor.\r\nIn diesem Projekt stellen wir die Hypothese, dass das Neuroblastom zu tiefgreifenden Alterationen des intestinalen Mikrobioms mit konsekutiven Veränderungen der Darmbarriere und des Gallensäurenpools mit nachfolgenden pro-inflammatorischem Zustandsbildern und Veränderungen des Lipid- und Kohlenhydratstoffwechsels führt. Damit werden mehrere bisher nicht ausreichend erforschte Themenschwerpunkte aufgegriffen: 1) das Mikrobiom beim NB als solider kindlicher Tumor, 2) das Zusammenspiel Mikrobiom – Gallensäuren – Entzündungskaskade – Metabolismus und 3) der Einfluss der Dysbiose im Rahmen der Tumorerkrankung auf Darmwandbarriere und Entzündungskaskade.\r\nEin etabliertes Modell in Foxn1nu athymischen Nacktmäusen wird zum Anzüchten von Neuroblastommetastasen (Zelllinie MHH-NB11) verwendet. Nach 10 Wochen Tumorwachstum erfolgt eine Analyse des intestinalen Mikrobioms mittels next generation sequencing. Weiters wird der inflammatorische und metabolische Zustand der Tiere (Gallensäuren in Stuhl und Serum, kurzkettige Fettsäuren im Zökum, Zytokin- und Inkretinprofil, Glucosetoleranz, Serumlipide) beurteilt. Zusätzlich wird die Darmwandbarriere mittels Elektronenmikroskopie und Immunhistochemie untersucht und die Lipopolysaccharidspiegel systemisch und im Pfortaderblut bestimmt. Die Daten der Tumortiere werden mit einer Shamgruppe verglichen. Zusätzlich wird der Einfluss der Chemotherapie mit Cyclophosphamid auf die untersuchten Parameter analysiert.\r\nDieser Antrag verwendet neueste mikrobiologische Methoden zur Darstellung der Beziehung zwischen Mikrobiom, Entzündungskaskade und Stoffwechsel beim Neuroblastom. Die Ergebnisse dieser Studie könnten die Krebstherapie der Zukunft erheblich beeinflussen und somit dazu beitragen, die Morbidität und Mortalität von krebskranken Kindern zu verringern.\r\n",
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-03-31T02:00:00+02:00",
            "assignment": "2016-10-19T11:02:24+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 54087,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743,
                1950
            ],
            "funder_projectcode": "MEFO-12",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4661-50778-12",
                "4661-54087-10",
                "4661-82670-12",
                "4661-83445-12"
            ]
        },
        {
            "id": 4784,
            "title": {
                "de": "Schmerzmittelreduktion in der Neurochirurgie durch perioperative Behandlung mit transkutaner Vagusnervstimulation.",
                "en": "Transcutaneous vagus stimulation for reduction of analgetics in neurosurgery"
            },
            "short": "SchTraV",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-06-01T02:00:00+02:00",
            "begin_effective": "2016-06-01T02:00:00+02:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2020-12-31T01:00:00+01:00",
            "assignment": "2017-01-24T16:15:28+01:00",
            "program": null,
            "subprogram": "Kulturamt Stadt Graz",
            "organization": 14050,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50845,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4784-50845-10"
            ]
        },
        {
            "id": 4183,
            "title": {
                "de": "CCAT beim Triple negativen Brustkrebs",
                "en": "Characterization of CCAT2 in triple negative breast cancer patients"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-01-01T01:00:00+01:00",
            "begin_effective": "2016-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2017-12-31T01:00:00+01:00",
            "assignment": "2015-12-09T09:44:06+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 65726,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                122
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4183-65726-10"
            ]
        }
    ]
}

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