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GET /v1/research/project/?format=api&offset=1200&ordering=begin_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1220&ordering=begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1180&ordering=begin_effective", "results": [ { "id": 4874, "title": { "de": "Analyse des RAS/MAPK-ERK Signalweges bei der akuten myeloischen Leukämie", "en": "Analysis of the RAS/MAPK-ERK signal transduction cascade in acute myeloid leukemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-15T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-04-14T02:00:00+02:00", "end_effective": "2028-06-30T02:00:00+02:00", "assignment": "2017-03-09T11:45:45+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4874-80093-12", "4874-57402-10", "4874-97430-12", "4874-104139-12", "4874-126117-12" ] }, { "id": 4709, "title": { "de": "DNA-seq Biomarker-Identifikation in Subgruppen von Stadium II Kolon-Adenokarzinomen", "en": "DNA-seq biomarker identification in subgroups of stage II colon adenocarcinoma" }, "short": "BmarkerCOAD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-03-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2016-11-29T12:41:23+01:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 51684, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1019 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4709-51684-10" ] }, { "id": 4764, "title": { "de": "Bedeutung von microRNAs in Chemotherapie-resistenten hypoxischen Lungenadenokarzinomen", "en": "RELEVANCE OF MicroRNAs IN CHEMOTHERAPY-RESISTANT\r\nHYPOXIC LUNG ADENOCARCINOMA" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2020-03-31T02:00:00+02:00", "assignment": "2017-01-11T12:26:16+01:00", "program": 79, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 50610, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4764-50593-12", "4764-50610-10", "4764-81608-12", "4764-101018-12" ] }, { "id": 4894, "title": { "de": "Postmortale Validatierung von Quantitative Susceptibility Mapping", "en": "Postmortem Validation of Quantitative Susceptibility Mapping" }, "short": "pmQSM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2022-06-30T02:00:00+02:00", "assignment": "2017-03-23T14:45:33+01:00", "program": 72, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 60116, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P30134", "ethics_committee": null, "edudract_number": null, "persons": [ "4894-60116-10" ] }, { "id": 4896, "title": { "de": "Zerebrale Sauerstoffsättigung zur Steuerung der Versorgung", "en": "Cerebral tissue Oxygen Saturation to Guide Oxygen Delivery \r\nin preterm neonates during immediate transition after birth\r\n" }, "short": "COSGOD III", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2022-02-28T01:00:00+01:00", "assignment": "2017-03-23T15:27:42+01:00", "program": 108, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 3, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI615", "ethics_committee": null, "edudract_number": null, "persons": [ "4896-50907-10" ] }, { "id": 4762, "title": { "de": "Hochauflösende In Silico Modelle der Gesamten Herzfunktion", "en": "High-resolution In Silico Models of Total Heart Function" }, "short": "INSILICARDIO", "url": null, "abstract": { "de": "Fortschritte bei der Entwicklung von tomographischen Verfahren ermöglichen in beispielloser Weise die Anatomie des Herzens abzubilden. Allerdings hatten diese Technologien bisher einen relativ geringen Einfluss auf die Entwicklung von medizinischen Implantaten oder die Verbesserung von klinischen Behandlungsmethoden.\r\nDer Einsatz von bildgebenden Verfahren zur Extraktion von wichtigen funktionellen Informationen und der Kopplung von Bildinformationen mit physiologischen Aspekten, die nicht durch Bildgebung allein verstanden werden können, stellt eine große Herausforderung dar. In silico Modelle, also computerunterstützte Simulationen, bergen enormes Potenzial zur Bewältigung dieser Herausforderungen und können zu einem besseren Verständnis der Herzfunktion, sei es im gesunden oder auch im erkrankten Zustand, führen. Ein entscheidender Vorteil ist hierbei die Möglichkeit diagnostische und therapeutische Methoden zu optimieren ohne dabei Patienten zusätzlichen Risiken oder Schmerzen auszusetzen. In silico Experimente können somit bei der Untersuchung von klinisch relevanten Problemen, wie zum Beispiel Herzklappenchirurgie, Ballon-Angioplastie oder Stenting, äußerst hilfreich sein.\r\nDie Herzfunktion ergibt sich aus der Interaktion verschiedener Physiken, unter anderem der Elektrophysiologie, der Strukturmechanik und der Strömungsmechanik. Während die beteiligten Physiken klar bidirektional wechselwirken, werden sie in praktisch allen Studien isoliert betrachtet. Dies ist zu einem guten Teil auf die Komplexität von Multiphysik-Modellen und den Schwierigkeiten, die bei der Entwicklung von modernen numerischen Methoden und deren effizienten Implementierung auf modernen Rechnerarchitekturen auftauchen, zurückzuführen. Die Bewältigung dieser Herausforderungen ist das zentrale Themas dieses Projektes und die Durchführung setzt auf die Kombination der Expertisen der Antragsteller: Christoph Augustin und Gernot Plank in der Modellierung der Elektrophysiologie und der Strukturmechanik und Shawn Shadden in der Computermodellierung des Blutflusses.\r\nDieses ambitionierte Unterfangen geht weit über den aktuellen Stand der Technik hinaus. Kombinierte Modelle von Herz und Blutgefäßen ermöglichen die Berechnung von natürlichen Randbedingungen für die Simulation des Blutflusses und das Studium von Rückkopplungsmechanismen die die Pumpleistung des Herzens beeinflussen können. Im Endeffekt wird dieses Modell eines der modernsten Werkzeuge der Grundlagenforschung sein, das einen mechanistischen Einblick in die Herzpumpfunktion gewährt. Von wesentlicher Bedeutung ist in diesem Kontext auch die Überprüfung, Parametrisierung und Validierung dieses Modells mit klinischen Datensätzen, die von klinischen Partnern zur Verfügung gestellt werden.\r\nDas Ziel dieser Forschung ist ein innovatives Multiphysik-Computermodell der gesamten Herzfunktion um eine biophysikalisch detaillierte und bidirektional gekoppelte Erforschung der elektromechanischen Funktion des Herzens im gesunden wie im kranken Zustand zu ermöglichen.", "en": "Advances in tomographic imaging have enabled unprecedented ability to image cardiac anatomy. However, these technologies have had relatively modest clinical impact. Key challenge have been the use of imaging to extract important functional information and to understand how image-derived information couples with other physiological aspects that cannot be understood through imaging alone. In-silico models hold vast potential to address these challenges by enabling the integration of imaging data into quantitative frameworks that can aid in better understanding cardiac function in health and disease, and developing optimal treatment strategies.\r\nCardiac function arises from interactions between different physics, including electrophysiology, structural mechanics and fluid dynamics. While these physics are bidirectionally linked, virtually all reported modeling studies have considered them in isolation. In no small part this is due to the complexity of multiphysics models and the difficulties in devising advanced numerical methods and their efficient implementation on modern computing architectures. Addressing these challenges as we propose is key to keep model execution and analysis cycles tractable and, thus, to leverage modeling in a translational context. The proposed work goes beyond the state-of-the-art in many regards. Combined models of both heart and attached outflow vessels will be used to provide natural inflow boundary conditions for simulating blood flow and to facilitate studying feedback mechanisms between flow and pressure in the outflow vessels and pumping performance. This set of novel features and the parallel efficiency of the implemented methods will provide a unique platform for translational research. At the fundamental level, this model will be among the most advanced basic research tools for gaining mechanistic insight into cardiac pumping function. This challenging endeavor is feasible only as it builds upon combining the expertise of the applicant Christoph Augustin (Medical University of Graz) in modeling electrophysiology and soft tissue mechanics, and the host Shawn Shadden (UC Berkeley) in computational modeling of blood flow. Clinical datasets for model parametrization and validation are provided by Titus Kühne at the German Heart Centre Berlin, as well as by clinical collaborators of Prof. Shadden at the University of California San Francisco.Technical challenges to be addressed relate to multiphysics coupling methods which converge robustly and scale efficiently. While such methods have been developed recently for single physics cardiac simulations, this has not been the case for coupled multiphysics models of total heart function. This will be addressed by massively parallel implementations which are based on domain decomposition and strongly scalable iterative methods using appropriate preconditioning and stabilization techniques. In summary, the overall objective is to develop the most advanced in-silico model of total heart function, to facilitate biophysically detailed studies of electro-mechano-fluidic function of the heart. This model will be parametrized, verified and employed to study bidirectional cause-effect relationships between flow and pressure in the outflow vessels and pumping performance." }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-03-31T02:00:00+02:00", "end_effective": "2017-04-01T02:00:00+02:00", "assignment": "2017-01-11T11:38:59+01:00", "program": 101, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 79791, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4762-79791-10" ] }, { "id": 4935, "title": { "de": "EFSD - Albert Renold Travel Fellowship", "en": "EFSD - Albert Renold Travel Fellowship" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-05-01T02:00:00+02:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2017-10-31T01:00:00+01:00", "end_effective": "2017-10-31T01:00:00+01:00", "assignment": "2017-04-25T16:33:52+02:00", "program": 103, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4940, "title": { "de": "Double hit und double expressor Lymphome - Eine Entität oder nicht?", "en": "Double hit and double expressor lymphoma – Same but different?" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-05-01T02:00:00+02:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2017-05-02T16:31:20+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51930, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4940-51930-10" ] }, { "id": 4664, "title": { "de": "Stoffwechsel-basierte Therapie gegen diastolische Herzinsuffizienz", "en": "Metabolic Therapy for Managing Diastolic Heart Failure" }, "short": "MINOTAUR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2020-01-31T01:00:00+01:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2016-10-19T15:00:07+02:00", "program": 64, "subprogram": "ERA-Net", "organization": 14083, "category": 10, "type": 10, "partner_function": 3, "manager": 60041, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I3301", "ethics_committee": null, "edudract_number": null, "persons": [ "4664-60041-10", "4664-59941-12", "4664-94512-12", "4664-107389-12" ] }, { "id": 4830, "title": { "de": "Neue therapeutische Agentien für die Kombinationstherapie von Chordomen", "en": "Novel therapeutic agents for chordoma combination treatment" }, "short": "Chordom Kombinationstherapie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-05-01T02:00:00+02:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2017-02-14T11:23:52+01:00", "program": null, "subprogram": "ISNK: Ingrid Shaker Nessmann Krebsforschungsvereinigung", "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50448, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1765 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4830-50448-10" ] }, { "id": 4962, "title": { "de": "Die Funktion des Enzyms Phosphatidylethanolamine N‐Methyltransferase (PEMT) für die Chylomicronen-Biosynthese. ", "en": "Establishment of in vitro models for primary mouse enterocytes to study chylomicron biosynthesis: Role of the enzyme phosphatidylethanolamine N‐methyltransferase (PEMT)" }, "short": "PEMT und Chylomicronen-Biosynthese", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2021-04-30T02:00:00+02:00", "assignment": "2017-05-22T12:39:11+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51817, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 25 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4962-51817-10" ] }, { "id": 4899, "title": { "de": "Prognostische Wertigkeit der PD-L1 Expression in der Weichteilsarkommikroumgebung", "en": "Prognostic impact of PD-L1 expression in soft tissue sarcoma microenvironment" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-06-01T02:00:00+02:00", "begin_effective": "2017-06-01T02:00:00+02:00", "end_planned": "2019-06-01T02:00:00+02:00", "end_effective": "2025-05-31T02:00:00+02:00", "assignment": "2017-03-27T17:41:39+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 69234, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1888 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4899-69234-10" ] }, { "id": 5155, "title": { "de": "Einfluss von Myelin auf die diamagnetische Suszeptibilitzät im gesunden Gehirn und bei Multipler Sklerose", "en": "Contribution of Myelin to the Diamagnetic Susceptibility of Normal and Multiple Sclerosis Brain" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-06-01T02:00:00+02:00", "begin_effective": "2017-06-01T02:00:00+02:00", "end_planned": "2020-05-31T02:00:00+02:00", "end_effective": "2019-10-15T02:00:00+02:00", "assignment": "2017-12-07T11:58:22+01:00", "program": 69, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "MEFO-52", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4981, "title": { "de": "Hautnah - TeleHaut", "en": "Skin close and tele" }, "short": "Hautnah - TeleHaut", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-06-01T02:00:00+02:00", "end_planned": "2019-10-01T02:00:00+02:00", "end_effective": "2019-11-30T01:00:00+01:00", "assignment": "2017-06-13T14:35:07+02:00", "program": null, "subprogram": "FFG Talente Praktika für Schülerinnen und Schüler", "organization": 14047, "category": 10, "type": 10, "partner_function": 3, "manager": 51711, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "860148", "ethics_committee": null, "edudract_number": null, "persons": [ "4981-51711-10" ] }, { "id": 4891, "title": { "de": "Entwicklungsgen-Evolution und Adaptation der Kopf-Anatomie von Buntbarschen", "en": "Developmental gene evolution shaping the head morphology of cichlid fishes" }, "short": "Head morphology of cichlid fishes", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-06-01T02:00:00+02:00", "begin_effective": "2017-06-01T02:00:00+02:00", "end_planned": "2019-05-31T02:00:00+02:00", "end_effective": "2021-10-31T02:00:00+02:00", "assignment": "2017-03-23T10:36:03+01:00", "program": 72, "subprogram": "Nationaler Forschungspartner", "organization": 28394, "category": 10, "type": 10, "partner_function": 2, "manager": 58453, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI615", "ethics_committee": null, "edudract_number": null, "persons": [ "4891-58453-10" ] }, { "id": 5226, "title": { "de": "Aufbau eines breiten teledermatologischen Netzwerks in Uganda", "en": "Organisation of a broad teledermatologic network in Uganda" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-07-01T02:00:00+02:00", "begin_effective": "2017-06-01T02:00:00+02:00", "end_planned": "2017-06-30T02:00:00+02:00", "end_effective": "2019-05-31T02:00:00+02:00", "assignment": "2018-01-31T14:22:37+01:00", "program": null, "subprogram": "Fair Styria", "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 51711, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5226-51711-10" ] }, { "id": 6755, "title": { "de": "Implementierung eines neuen Ausbildungskonzeptes für das Spezialgebiet „Polytraumamanagement“", "en": "Implementation of new Training Concept in Poyltrauma Management" }, "short": "Training Poyltrauma", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-07-01T02:00:00+02:00", "begin_effective": "2017-07-01T02:00:00+02:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2021-10-21T10:43:27+02:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 62925, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6755-62925-10", "6755-72835-12", "6755-59379-11" ] }, { "id": 5027, "title": { "de": "Evaluierung der post-thymischen Stabilität der FOXP3 Expression zur Aufrechterhaltung der Immuntoleranz", "en": "Evaluation of the post-thymic stability of FOXP3 expression in the maintenance of immune tolerance" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-07-01T02:00:00+02:00", "begin_effective": "2017-07-01T02:00:00+02:00", "end_planned": "2019-06-30T02:00:00+02:00", "end_effective": "2019-06-30T02:00:00+02:00", "assignment": "2017-08-07T13:36:01+02:00", "program": 92, "subprogram": "Internationale Kooperation/Wissenschaftlich-Technische Zusammenarbeit Bulgarien-Österreich", "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5027-54171-10" ] }, { "id": 5000, "title": { "de": "Veränderungen im intestinalen Mikrobiom als prädiktiver Marker für einen steroid-refraktären Krankheitsverlauf bei Colitis ulzerosa", "en": "Study investigating if specific fecal microbiota alterations can predict a refractory disease course to standard steroid therapy in patients with active ulcerative colitis.\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-07-01T02:00:00+02:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2017-07-06T14:47:36+02:00", "program": null, "subprogram": "ÖGGH Wissenschaftspreis", "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 53167, "contact": null, "status": 2, "research": 2, 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