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GET /v1/research/project/?format=api&offset=120
{ "count": 2194, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=140", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=100", "results": [ { "id": 4164, "title": { "de": "Regulation der Eosinophilen Funktion durch kurzkettige Fettsäuren und deren Rezeptoren FFA2 und FFA3", "en": "Regulation of eosinophil function by short chain fatty acids and their receptors FFA2 and FFA3" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-01-01T01:00:00+01:00", "begin_effective": "2016-01-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2015-11-23T12:06:05+01:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3165, "title": { "de": "Phenotyping Fragile X Syndrome for the first two years of life", "en": "Phenotyping Fragile X Syndrome for the first two years of life" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-12-01T01:00:00+01:00", "begin_effective": "2012-12-01T01:00:00+01:00", "end_planned": "2014-11-30T01:00:00+01:00", "end_effective": "2014-11-30T01:00:00+01:00", "assignment": "2013-02-06T14:50:06+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3222, "title": { "de": "GPR55 in der Entwicklung des Kolonkarzinoms", "en": "GPR55 in tumorigenesis and metastasis of colon cancer" }, "short": null, "url": null, "abstract": { "de": "GPR55 in der Entwicklung des Kolonkarzinoms\r\nG Protein gekoppelte Rezeptoren spielen eine wichtige Rolle im Tumorwachstum und in der Metastasierung von Krebszellen und stellen somit ein wichtiges pharmakologisches Target für die Krebstherapie dar. Auf Grund seiner fördernden Wirkung in der Proliferation und Invasion von Tumorzellen, aber auch in der Angiogenese, ist der G Protein gekoppelte Rezeptor 55 (GPR55) in jüngster Zeit als ein mögliches neues Target in Erscheinung getreten. Das bioaktive Phospholipid Lysophosphatidylinositol (LPI) ist seit längerem als der endogene Ligand des GPR55 Rezeptors bekannt. Erhöhte LPI Werte wurden im Ovarialkarzinom nachgewiesen und lassen auf einen Zusammenhang zwischen der LPI/GPR55 Achse und Krebswachstum schließen.\r\nGPR55 ist auch in Epithelzellen des Darmtrakts vorhanden, was auf eine mögliche Rolle in der Entwicklung des Kolonkarzinoms vermuten läßt. Im vorliegenden Projekt untersuchen wir die Funktion von GPR55 und LPI in der Tumorgenese und in der Metastasierung des Kolonkarzinoms zuerst an Hand der Kolonkarzinom Zelllinien HCT116 und SW480. Dabei werden Proliferations-, Apoptose-, Migration- und Invasionsassays verwendet ebenso wie molekularbiologische Methoden, um LPI-induzierte Signaltransduktionswege zu untersuchen. In einem Kolitis-assoziierten Kolonkarzinom Modell der Maus soll die Bedeutung von GPR55 in der Tumorentstehung in vivo untersucht werden, insbesondere ob GPR55 an der Proliferation von malignen Zellen und der Expression von onkogenen Transkriptionsfaktoren, wie NF-kappa B und STAT3, beteiligt ist. Die Rolle von GPR55 in der Verbreitung der Kolonkarzinomzellen in Sekundärorgane soll in einem in vivo Metastasierungsmodell untersucht werden. An Hand von histologischen Schnitten und Biopsien von humanem Kolonkarzinomgewebe wollen wir schließlich noch die Bedeutung von GPR55 und LPI in der Entstehung des Kolonkarzinoms beim Menschen untersuchen. Das Projekt sollte wesentliche Aussagen bezüglich einer möglichen pharmakologischen Therapie gegen Dickdarmkrebs basierend auf GPR55 geben. Weiters soll es eine Aussage liefern, ob LPI als möglicher Biomarker bei Dickdarmkrebs Verwendung finden könnte. \r\n", "en": null }, "begin_planned": "2013-06-01T02:00:00+02:00", "begin_effective": "2013-04-01T02:00:00+02:00", "end_planned": "2016-05-31T02:00:00+02:00", "end_effective": "2016-10-31T01:00:00+01:00", "assignment": "2013-03-26T10:24:55+01:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25633", "ethics_committee": null, "edudract_number": null, "persons": [ "3222-56687-10" ] }, { "id": 4895, "title": { "de": "Eosinophile in der Entstehung des Dickdarmkarzinoms", "en": "Eosinophils and colon cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-08-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2019-07-31T02:00:00+02:00", "end_effective": "2021-05-31T02:00:00+02:00", "assignment": "2017-03-23T14:46:43+01:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P30144", "ethics_committee": null, "edudract_number": null, "persons": [ "4895-56687-10" ] }, { "id": 4051, "title": { "de": "Schwangerschaftskomplikationen: eine Chance zur Früherkennung von Herz-Kreislauf-Erkrankungen?", "en": "Pregnancy complications: challenge and/or chance for further cardiovascular risk in later life?" }, "short": "RiChLife", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-10-01T02:00:00+02:00", "begin_effective": "2015-10-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-09-30T02:00:00+02:00", "assignment": "2015-07-08T16:50:25+02:00", "program": 79, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 64295, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4051-64295-10" ] }, { "id": 4978, "title": { "de": "Kardiovaskuläre Folgen von Schwangerschaftskomplikationen", "en": "Cardiovascular Consequences of Preeclampsia and Pregnancy Induced Hypertension\r\n" }, "short": "CaCoPE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-01-31T01:00:00+01:00", "end_effective": "2018-01-31T01:00:00+01:00", "assignment": "2017-06-07T15:24:18+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 64295, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4978-64295-10" ] }, { "id": 4977, "title": { "de": "Stressinduzierte kardiovaskuläre Reaktivität bei Jugendlichen – Vergleich von Früh- zu Normalgeborenen.", "en": "Stress-related cardiovascular reactivity in adolescents" }, "short": "ReaJu", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-01-31T01:00:00+01:00", "end_effective": "2018-01-31T01:00:00+01:00", "assignment": "2017-06-07T14:58:02+02:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 64295, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4977-64295-10" ] }, { "id": 3712, "title": { "de": "Domäneninteraktion zur Kontrolle der STIM1 Aktivierung von Orai1 Kanälen", "en": "Domain interactions controlling STIM1 activation of Orai1 channels " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-10-01T02:00:00+02:00", "begin_effective": "2014-10-01T02:00:00+02:00", "end_planned": "2017-10-01T02:00:00+02:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2014-07-17T13:01:43+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 78591, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P27263", "ethics_committee": null, "edudract_number": null, "persons": [ "3712-78591-10" ] }, { "id": 4243, "title": { "de": "Synthese licht-aktiver Modulatoren/Marker von TRPC3/6-Kanälen", "en": "Synthesis of light-responsive modulators/labels of TRPC3/6-channels" }, "short": null, "url": null, "abstract": { "de": null, "en": "Novel light-responsive modulators/labels of TRPC3/6-channels\r\nMammalian Transient Receptor Potential (TRP) channels include six related protein\r\nfamilies. Members of the human TRP Canonical (TRPC) subfamily\r\n(TRPC1/3/4/5/6/7), form channels that mediate Ca2+- and Na+-ion entry and are\r\nexpressed in many mammalian cell types to serve a broad-range of important\r\nphysiological processes. Recently, TRPC3/6 channels have been implicated in the\r\npathogenesis of cardiovascular disorders including heart failure, arrhythmias, and\r\nsudden death. Consequently, TRPC channels have emerged as highly promising\r\ntargets for drug development, while, at the same time, their exact cellular function and\r\nprinciples of pharmacologic modulation are still incompletely understood and require\r\nbetter understanding. For this, novel strategies to experimentally control channel\r\nfunction are urgently needed. These channels are endogenously controlled by plasma\r\nmembrane lipid metabolites, which are difficult to administer in most experimental\r\nsettings. Novel modulating or blocking ligands with potentially suitable selectivity for\r\nexact experimental control of TRPC3/6 channel have just recently been reported. One\r\nobjective of this proposal is therefore the synthesis of small modulators\r\n(inhibitors/activators) of TRPC3/6-channels that response to light, allowing the\r\ncontrol of biological events with unparalleled spatial and temporal precision – so\r\ncalled “photoswitches” (e.g. azobenzens). Taking advantage of our experience in the\r\nsynthesis of pyrazole-based inhibitors of TRPC3/6-channels and benzimidazolonebased\r\nactivators as well as our expertise in microwave and continuous-flow\r\nchemistry, we aim to generate and explore various photoswitchable ligands in\r\nconnection to the emerging pharmacology of TRPC3/6-channels. Another objective\r\nof ours, involving small photoresponsive molecules, is the synthesis of photoaffinity\r\nlabels to help in the elucidation of potential ligand-binding sites in the TRPC3/6-\r\nchannels as well as on the structure elucidation of TRPC3/6-channels.\r\nThe research proposed herein is meant to become a significant contribution to\r\na thrilling and rapidly growing field for optoregulation of biological functions in\r\nmammalian cells and for better understanding on the TRPC3/6-channel machinery. If\r\npositive results are obtained, the arising pharmacology will importantly aid\r\ninvestigations of the physiological and pathophysiological roles of TRPC channels,\r\nfacilitate the validation of TRPCs as potential therapeutic targets in different\r\nchannelopathies, and possibly provide foundations for drug discovery and\r\ndevelopment." }, "begin_planned": "2015-05-01T02:00:00+02:00", "begin_effective": "2015-05-01T02:00:00+02:00", "end_planned": "2018-04-30T02:00:00+02:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2016-01-22T13:09:43+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 78591, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 28243-B27 ", "ethics_committee": null, "edudract_number": null, "persons": [ "4243-78591-10" ] }, { "id": 8217, "title": { "de": "Regulation von TRPV6 durch PIP2 im Membranparalipidom", "en": "Towards understanding the regulation of TRPV6 channels by sensing PIP2 in the functional paralipidome\r\n\r\nKurztitel: TRPV6 regulation by sensing PIP2 in the paralipidome" }, "short": "NA", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-05-01T02:00:00+02:00", "begin_effective": "2024-05-01T02:00:00+02:00", "end_planned": "2027-04-30T02:00:00+02:00", "end_effective": "2027-04-30T02:00:00+02:00", "assignment": "2024-05-16T14:13:14+02:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 2, "manager": 78591, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT9543223", "ethics_committee": null, "edudract_number": null, "persons": [ "8217-78591-10" ] }, { "id": 4740, "title": { "de": "Magnesium und dessen Einfluss auf die Entstehung einer nicht-alkoholischen Fettleber (NAFLD)", "en": "Magnesium and the Development of Fatty Liver Disease (NAFLD)\r\n" }, "short": "Magnesium und NAFLD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-06-30T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2016-12-20T09:23:53+01:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-14", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3052, "title": { "de": "Adrenerge Regulation der CaV1.2 L-Typ Kalziumkanäle Dynamik in Neuronen", "en": "Adrenergic regulation of CaV1.2 L-type calcium channel dynamics in neurons" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-10-01T02:00:00+02:00", "begin_effective": "2012-11-01T01:00:00+01:00", "end_planned": "2015-09-30T02:00:00+02:00", "end_effective": "2016-09-30T02:00:00+02:00", "assignment": "2012-11-26T15:44:00+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25085", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5449, "title": { "de": "Lysophosphatidsäure als Aktivator des MAPK Wegs in Mikroglia", "en": "Lysophospatidic acid induced signaling in microglia: the role of MAPK pathways" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2019-03-31T01:00:00+01:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2018-08-20T12:02:08+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4141, "title": { "de": "Verbesserung der Studiendesigns von Beobachtungsstudien bei Infektionskrankheiten mittels mathematischer Modelle", "en": "Enhancing observational study designs of infectious disease surveys using mathematical modelling techniques" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-05-01T02:00:00+02:00", "begin_effective": "2016-05-01T02:00:00+02:00", "end_planned": "2016-07-31T02:00:00+02:00", "end_effective": "2016-07-31T02:00:00+02:00", "assignment": "2015-11-05T13:28:54+01:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 83644, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4141-83644-10" ] }, { "id": 4433, "title": { "de": "Methodik zur Detektion von Hämoxygenase 1 - Albert Renold Fellowship", "en": "Methodology for detection of heme oxygenase 1 activity - Albert Renold Fellowship" }, "short": "HO-1 detection", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-06-27T02:00:00+02:00", "begin_effective": "2016-06-27T02:00:00+02:00", "end_planned": "2016-09-26T02:00:00+02:00", "end_effective": "2016-09-26T02:00:00+02:00", "assignment": "2016-05-10T11:54:47+02:00", "program": 103, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4256, "title": { "de": "The functional role of HDL in the tumor microenvironment", "en": "The functional role of HDL in the tumor microenvironment" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-02-01T01:00:00+01:00", "begin_effective": "2015-02-01T01:00:00+01:00", "end_planned": "2018-01-31T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2016-01-28T12:53:45+01:00", "program": 69, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J3664-B19", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3436, "title": { "de": "Quantitatives Modeling von Ca2+ Nanodomänen (QuMoCa)", "en": "Quantitative Modeling of Ca2+ Nanodomains" }, "short": "QuMoCa", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-06-01T02:00:00+02:00", "begin_effective": "2014-02-10T01:00:00+01:00", "end_planned": "2015-05-31T02:00:00+02:00", "end_effective": "2016-02-09T01:00:00+01:00", "assignment": "2013-11-19T11:43:39+01:00", "program": 24, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "330657", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 8111, "title": { "de": "Voice Analysis & Pattern Recognition in Patients with Acute Speech Problems suspected to have a Brainstem Stroke", "en": "Voice Analysis & Pattern Recognition in Patients with Acute Speech Problems suspected to have a Brainstem Stroke" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-07-01T02:00:00+02:00", "begin_effective": "2015-07-14T02:00:00+02:00", "end_planned": "2016-06-30T02:00:00+02:00", "end_effective": "2017-01-10T01:00:00+01:00", "assignment": "2024-03-22T13:59:30+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 79651, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8111-79651-10" ] }, { "id": 5567, "title": { "de": "Entschluesselung des komplizierten Interaktionsnetzwerkes im β-Catenin Destruktion Komplex - Das Axin-1 Paradigma", "en": "Deciphering the Intricate Interaction Network in the β-Catenin Destruktion Complex - The Axin-1 Paradigm" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-12-01T01:00:00+01:00", "begin_effective": "2018-12-01T01:00:00+01:00", "end_planned": "2020-11-30T01:00:00+01:00", "end_effective": "2020-11-30T01:00:00+01:00", "assignment": "2018-12-05T10:51:12+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 6204, "title": { "de": "Der Einfluss pflanzlicher Ernährung auf die Immunmodulation. \r\nEffekte elektiver natürlicher Pflanzenfarbstoffe und der Lebensmittelmatrix auf die Aryl-Hydrocarbon-Rezeptor Aktivität.\r\n", "en": "The impact of plant-based nutrition on Immunmodulation.\r\nSubtitle: Effects of elective natural dyes and food matrix on aryl hydrocarbon receptor interaction.\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-07-01T02:00:00+02:00", "begin_effective": "2020-07-01T02:00:00+02:00", "end_planned": "2020-11-30T01:00:00+01:00", "end_effective": "2022-06-30T02:00:00+02:00", "assignment": "2020-07-15T17:29:13+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 88711, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-53", "ethics_committee": null, "edudract_number": null, "persons": [ "6204-88711-10" ] } ] }