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GET /v1/research/project/?format=api&offset=1180&ordering=end_planned
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1200&ordering=end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1160&ordering=end_planned", "results": [ { "id": 6204, "title": { "de": "Der Einfluss pflanzlicher Ernährung auf die Immunmodulation. \r\nEffekte elektiver natürlicher Pflanzenfarbstoffe und der Lebensmittelmatrix auf die Aryl-Hydrocarbon-Rezeptor Aktivität.\r\n", "en": "The impact of plant-based nutrition on Immunmodulation.\r\nSubtitle: Effects of elective natural dyes and food matrix on aryl hydrocarbon receptor interaction.\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-07-01T02:00:00+02:00", "begin_effective": "2020-07-01T02:00:00+02:00", "end_planned": "2020-11-30T01:00:00+01:00", "end_effective": "2022-06-30T02:00:00+02:00", "assignment": "2020-07-15T17:29:13+02:00", "program": null, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 88711, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-53", "ethics_committee": null, "edudract_number": null, "persons": [ "6204-88711-10" ] }, { "id": 5000, "title": { "de": "Veränderungen im intestinalen Mikrobiom als prädiktiver Marker für einen steroid-refraktären Krankheitsverlauf bei Colitis ulzerosa", "en": "Study investigating if specific fecal microbiota alterations can predict a refractory disease course to standard steroid therapy in patients with active ulcerative colitis.\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-07-01T02:00:00+02:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2025-12-31T01:00:00+01:00", "assignment": "2017-07-06T14:47:36+02:00", "program": null, "subprogram": "ÖGGH Wissenschaftspreis", "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 53167, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5000-53167-10" ] }, { "id": 6066, "title": { "de": " Einfluss eines Caspaseinhibitors auf alveoläre Formveränderung nach Zahnextraktion ", "en": "Caspase inhibitor on alveolar shape changes following tooth extraction" }, "short": "caspase inhibitor", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2020-03-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2020-02-24T12:10:22+01:00", "program": null, "subprogram": null, "organization": 14057, "category": 10, "type": 10, "partner_function": 4, "manager": 96335, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6066-96335-10" ] }, { "id": 5108, "title": { "de": "Archaeen auf der Haut", "en": "Archaea on skin" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-02-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2022-07-31T02:00:00+02:00", "assignment": "2017-10-24T15:20:24+02:00", "program": 72, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P30796", "ethics_committee": null, "edudract_number": null, "persons": [ "5108-90021-10", "5108-90618-12", "5108-100035-12" ] }, { "id": 5405, "title": { "de": "Health Literacy und Diversity für SchülerInnen der Sekundarstufe I", "en": "Health Literacy und Diversity" }, "short": "Heli-D", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2018-06-27T15:32:18+02:00", "program": null, "subprogram": null, "organization": 14076, "category": 10, "type": 10, "partner_function": 2, "manager": 80111, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5405-80111-10" ] }, { "id": 5322, "title": { "de": "Zusammensetzung des Mikrobioms in Patienten mit Koronarer Herzerkrankung", "en": "Altered Microbiota in Patients with Coronary Heart Disease:\r\nImpact on Inflammatory Contributors to Atherosclerosis and Ischemic Heart Disease" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2024-05-31T02:00:00+02:00", "assignment": "2018-03-30T12:21:55+02:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 58906, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5322-58906-10", "5322-75758-12", "5322-89154-12", "5322-104482-12" ] }, { "id": 5363, "title": { "de": "Evidenzbasierte Informationen zur Unterstützung von gesundheitskompetenten Entscheidungen", "en": "Evidence-based Information As Support For Health Literate Decisions" }, "short": "EvI", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-05-01T02:00:00+02:00", "begin_effective": "2018-05-01T02:00:00+02:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2021-06-30T02:00:00+02:00", "assignment": "2018-05-15T16:21:00+02:00", "program": null, "subprogram": null, "organization": 27964, "category": 10, "type": 10, "partner_function": 4, "manager": 51117, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5363-51117-10" ] }, { "id": 5225, "title": { "de": "Primäre Imiquimod Therapie versus Chirurgie in der Behandlung der Vulvären Intraepithelialen Neoplasie ", "en": "Primary Imiquimod Treatment versus Surgery for Vulvar Intraepithelial Neoplasia \r\n\r\n" }, "short": "PITVIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-08-01T02:00:00+02:00", "begin_effective": "2018-02-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2021-06-30T02:00:00+02:00", "assignment": "2018-01-31T11:57:04+01:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50853, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5225-50853-10" ] }, { "id": 5639, "title": { "de": "Mikrobiomveränderungen als Indikator für einen steroid-refraktären Verlauf bei Colitis ulzerosa\r\n\r\n\r\n", "en": "Study investigating if specific fecal microbiota alterations can predict a refractory disease course to standard steroid therapy in patients with active ulcerative colitis." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2021-05-31T02:00:00+02:00", "assignment": "2019-01-24T09:45:52+01:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 1, "manager": 53167, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "17936", "ethics_committee": null, "edudract_number": null, "persons": [ "5639-53167-10" ] }, { "id": 4791, "title": { "de": "BioTechMed Leuchtturmprojekt Lipid Signaling", "en": "BioTechMed Leuchtturmprojekt Lipid Signaling" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-02T11:25:35+01:00", "program": 90, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4791-51756-10" ] }, { "id": 5747, "title": { "de": "The relationship between polymorphisms of candidate genes and primary lymphedema", "en": "The relationship between polymorphisms of candidate genes and primary lymphedema" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2022-02-28T01:00:00+01:00", "assignment": "2019-03-28T14:34:58+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 1, "manager": 57932, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "CZ 08/2019", "ethics_committee": null, "edudract_number": null, "persons": [ "5747-57932-10" ] }, { "id": 5748, "title": { "de": "The interaction of Antiretroviral Drugs with the Microbiome: Implications on the development of cardiovascular diseases in HIV+ persons", "en": "The interaction of Antiretroviral Drugs with the Microbiome: Implications on the development of cardiovascular diseases in HIV+ persons" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2022-02-28T01:00:00+01:00", "assignment": "2019-03-28T14:37:22+01:00", "program": null, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 3, "manager": 57932, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": "ZA 05/2019", "ethics_committee": null, "edudract_number": null, "persons": [ "5748-57932-10" ] }, { "id": 5260, "title": { "de": "Entwicklung genetisch kodierter K+-Fluoreszenzsensoren", "en": "Development of genetically encoded fluorescent K+ probes" }, "short": "Shining Light on (sub)cellular K+ fluxes", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2018-02-15T10:36:01+01:00", "program": 64, "subprogram": "I - Internationale Projekte - Joint Project - Austria/Germany", "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50810, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "3716-B27", "ethics_committee": null, "edudract_number": null, "persons": [ "5260-50810-10" ] }, { "id": 4782, "title": { "de": "Bild-basiertes Lernen für prädiktive personalisierte Modelle der Herzfunktion", "en": "Image-based Learning in Predictive Personalized Models of Total Heart Function" }, "short": "ILEARNHEART", "url": null, "abstract": { "de": "The heart is an electrically controlled mechanical pump, which drives blood flow from its cavities into the vascular system through deformation of its walls. Its function emerges from a bidirectional transduction of processes across multiple physical systems as well as spatial and temporal scales. This multiscale-multiphysics nature renders the heart an inherently challenging organ to study through reductionist approaches alone. This fundamental problem can be addressed by using biophysically detailed in silico models. Today in basic sciences such models are considered an indispensable element in any advanced physiology study as they offer the unique ability to mechanistically analyze cause-effect relationships at high spatio-temporal resolutions in the intact organ across scales and physics.\r\n\r\nDriven by recent advances in medical imaging and simulation technologies, a translational trend emerged which is geared towards evolving modeling into a clinical modality. In the clinic image-based analysis of the dynamics of electrophysiological activity, deformation and blood flow is of pivotal importance in the diagnostic assessment of cardiac function. Due to the sparse and noisy nature of medical image data computational analysis tools are essential for providing a more objective quantitative evaluation of a patient's condition. Moreover, relevant biomarkers cannot be measured directly and must be derived from images by computational analysis, a process which is often enriched by PDE models of the underlying physics. To further gain clinical traction such image-informed in silico models must be personalized for a given patient to provide clinically useful biomarkers, which can serve to indicate or stratify disease or allow for virtual testing of treatments and prediction of outcomes acutely and longitudinally. Personalization requires the conception of sophisticated data assimilation procedures to facilitate model adaptation to a patient's cardiac anatomy and function. Such data-model fusion techniques are highly non-trivial to devise for clinical electro-mechano-fluidic (EMF) models due to the large number of and the non-linear relation between model components that must be fit.\r\n\r\nThis project combines expertise in cardiac modeling and simulation, computational image analysis, learning - based data assimilation techniques and high performance computing algorithms to render feasible the development of robust and efficient data-model fusion framework for the image-based personalization of models of total heart function. The long term aim is the development of a clinical assist modality for the optimization and outcome prediction of valve (aortic/mitral) replacement therapies in the left heart. It is anticipated that such personalized EMF models will play an essential role in informing clinical decision making in future precision therapies. ", "en": "The heart is an electrically controlled mechanical pump, which drives blood flow from its cavities into the vascular system through deformation of its walls. Its function emerges from a bidirectional transduction of processes across multiple physical systems as well as spatial and temporal scales. This multiscale-multiphysics nature renders the heart an inherently challenging organ to study through reductionist approaches alone. This fundamental problem can be addressed by using biophysically detailed in silico models. Today in basic sciences such models are considered an indispensable element in any advanced physiology study as they offer the unique ability to mechanistically analyze cause-effect relationships at high spatio-temporal resolutions in the intact organ across scales and physics.\r\n\r\nDriven by recent advances in medical imaging and simulation technologies, a translational trend emerged which is geared towards evolving modeling into a clinical modality. In the clinic image-based analysis of the dynamics of electrophysiological activity, deformation and blood flow is of pivotal importance in the diagnostic assessment of cardiac function. Due to the sparse and noisy nature of medical image data computational analysis tools are essential for providing a more objective quantitative evaluation of a patient's condition. Moreover, relevant biomarkers cannot be measured directly and must be derived from images by computational analysis, a process which is often enriched by PDE models of the underlying physics. To further gain clinical traction such image-informed in silico models must be personalized for a given patient to provide clinically useful biomarkers, which can serve to indicate or stratify disease or allow for virtual testing of treatments and prediction of outcomes acutely and longitudinally. Personalization requires the conception of sophisticated data assimilation procedures to facilitate model adaptation to a patient's cardiac anatomy and function. Such data-model fusion techniques are highly non-trivial to devise for clinical electro-mechano-fluidic (EMF) models due to the large number of and the non-linear relation between model components that must be fit.\r\n\r\nThis project combines expertise in cardiac modeling and simulation, computational image analysis, learning - based data assimilation techniques and high performance computing algorithms to render feasible the development of robust and efficient data-model fusion framework for the image-based personalization of models of total heart function. The long term aim is the development of a clinical assist modality for the optimization and outcome prediction of valve (aortic/mitral) replacement therapies in the left heart. It is anticipated that such personalized EMF models will play an essential role in informing clinical decision making in future precision therapies. " }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2017-01-02T13:42:53+01:00", "program": null, "subprogram": "BioTechMed Flagship Project", "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 50966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4782-50966-10", "4782-96212-12", "4782-98304-12" ] }, { "id": 5223, "title": { "de": "Integrative Strukturelle Charakterisierung von Biopharmazeutika mittels Röntgenkleinwinkelstreuung (SAXS)", "en": "Integrative Strukturelle Charakterisierung von Biopharmazeutika mittels Röntgenkleinwinkelstreuung (SAXS)" }, "short": "BioPharmSAXS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-03-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2021-07-31T02:00:00+02:00", "assignment": "2018-01-31T11:21:43+01:00", "program": 60, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 3, "manager": 91207, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "864690", "ethics_committee": null, "edudract_number": null, "persons": [ "5223-91207-10" ] }, { "id": 6353, "title": { "de": "Impact of UV on skin metabolome and lipidome", "en": "Impact of UV on skin metabolome and lipidome" }, "short": "UVmetabolome", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-06-01T02:00:00+02:00", "begin_effective": "2020-06-01T02:00:00+02:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2020-12-02T17:11:59+01:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 87275, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2471 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6353-87275-10" ] }, { "id": 6064, "title": { "de": "Das Aktin-Zytoskelett und der Transkriptionsfaktor NFkB und IkappaB als prädiktive Faktoren für Leberregeneration und die Entstehung von Leberzellcarcinomen nach Major-Resektionen. ", "en": "The actin cytoskeleton and transkriptionfactor NFkB as predictive factors for liver regeneration and hepatocellular carcinogenesis after hemihepatectomy." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-20T01:00:00+01:00", "begin_effective": "2017-02-20T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2020-02-21T11:45:20+01:00", "program": null, "subprogram": null, "organization": 14108, "category": 10, "type": 10, "partner_function": 2, "manager": 98605, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1170 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6064-98605-10" ] }, { "id": 6236, "title": { "de": "Effekte der Skalpakupunktur auf die Herzratenvariabilität bei Patienten mit Schlafstörungen", "en": "Effects of Scalp Acupuncture on Heart Rate Variability in Patients with Insomnia" }, "short": "Skalp Akupunktur - HRV - EPU2020", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-01-01T01:00:00+01:00", "begin_effective": "2020-07-01T02:00:00+02:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2022-02-28T01:00:00+01:00", "assignment": "2020-08-10T10:39:54+02:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 762 ], "funder_projectcode": "EPU 35/2019", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5111, "title": { "de": "Erforschung des Reinke Ödems mittels Proteom-Analyse", "en": "Exploring Reinke’s Edema by Proteomic Analysis" }, "short": "Reinke Ödem", "url": null, "abstract": { "de": "Das Reinke Ödem (RÖ) ist eine ein- oder beidseitige Schwellung der Stimmlippen, die vor allem bei Nikotinabusus und Stimm-Missbrauch auftritt. Das Reinke Ödem ist durch eine erniedrigten Stimmlage und schlechte Stimmqualität gekennzeichnet, was den beruflichen Alltag vor allem von Personen in Sprechberufen (Lehrer, Call Center Agenten etc.) deutlich erschwert. Bis dato gibt es keine kausale Therapie für das RÖ, auch der Goldstandard der Therapie, Stimmlippenchirurgie, bringt keine zufriedenstellenden Ergebnisse und stellt keine kausale Therapie dar.\r\nIm vorgestellten Projekt wollen wir die zellulären Ursachen des RÖ mittels Protein Analyse (Proteomics) erforschen. Damit werden erstmals die kausalen Ursachen dieser Krankheit erforscht. Aus Schleimhaut Biopsien die während Stimmlippen-OPs betroffener Patienten entnommen werden, sollen spezifische RÖ-Stimmlippenzellen kultiviert und für weitere Analysen und Versuche vorbereitet werden. Die Proteomics Analyse liefert eine Auflistung aller Proteine, die diese Zellen produzieren. Diese sollen mit den Proteinen aus Stimmlippenzellen aus gesundem Gewebe verglichen werden.\r\nIn darauffolgenden funktionellen Experimenten sollen bestimmte Proteine („Kandidaten-Proteine“), die vor allem von RÖ-Fibroblasten produziert werden, auf ihre biologische Relevanz überprüft werden. Mittels Verstärkung oder Blockierung dieser Kandidaten Proteine können wesentliche Rückschlüsse auf die Krankheitsmechanismen von RÖ gezogen werden, die den Weg zu neuen (nicht-chirurgischen) Therapieformen ebnen sollen.\r\n", "en": "Reinke’s edema (RE) is a uni- or bilateral swelling of the vocal folds, occurring in patients with nicotine and voice abuse. Voice of patients is characterized by decreased pitch and detrimental voice quality, making it often difficult for voice professionals who rely on their voices (teacher, call center agents etc.)\r\nSo far treatment is only symptomatic, still the gold standard of therapy, microsurgery of the vocal folds, is far from being satisfactory. \r\nIn the proposed project we seek to explore the cellular mechanisms of RE by protein analysis (proteomics), revealing the true pathophysiology of RE for the first time. During routine vocal fold surgery for RE we will take small mucosa specimens. From these we will extract vocal fold fibroblasts for subsequent analysis. Proteomic analysis will deliver a complete list of proteins produces specifically by these cells. These will be compared with vocal fold cells grown out of healthy laryngeal mucosa. In subsequent functional experiments we will explore certain proteins of interest (aka. candidate proteins) that are produced in a high number by RE fibroblasts for their biological relevance. By enhancing or blocking these candidate proteins we aim to draw conclusions on their role in the development of RE, which should pave to way to new (non-surgical) treatment options.\r\n" }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2022-02-28T01:00:00+01:00", "assignment": "2017-10-30T10:42:53+01:00", "program": 72, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 50670, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P30496", "ethics_committee": null, "edudract_number": null, "persons": [ "5111-50670-10", "5111-50698-12", "5111-51047-12", "5111-69755-12", "5111-77116-12", "5111-82902-12", "5111-51982-12", "5111-88652-12", "5111-103118-12", "5111-104099-12", "5111-58794-12", "5111-57544-12" ] }, { "id": 5380, "title": { "de": "Progressionsbeurteilung bei metastasierenden neuroendokrinen Neoplasien (NEN) mit bildgebenden und biochemischen Verfahren", "en": "Evaluation of tumor progression in metastasised in neuroendocrine neoplasia (NEN) with biochemical and imaging techniques" }, "short": "Registerstudie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-06-10T02:00:00+02:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2027-12-31T01:00:00+01:00", "assignment": "2018-06-06T11:25:43+02:00", "program": null, "subprogram": "MEFOgraz", "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 65139, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-16", "ethics_committee": null, "edudract_number": null, "persons": [ "5380-65139-10" ] } ] }