Project List
List projects.
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GET /v1/research/project/?format=api&offset=1180&ordering=-end_planned
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1200&ordering=-end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1160&ordering=-end_planned", "results": [ { "id": 4722, "title": { "de": "Transplant Check", "en": "Non-Invasive Transplant Check" }, "short": "Transplant Check", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-02T01:00:00+01:00", "begin_effective": "2016-09-01T02:00:00+02:00", "end_planned": "2018-12-30T01:00:00+01:00", "end_effective": "2019-06-30T02:00:00+02:00", "assignment": "2016-12-02T14:01:40+01:00", "program": 105, "subprogram": null, "organization": 28392, "category": 10, "type": 10, "partner_function": 4, "manager": 54033, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "857831", "ethics_committee": null, "edudract_number": null, "persons": [ "4722-50874-12", "4722-54142-12", "4722-54033-10" ] }, { "id": 5328, "title": { "de": "Das Mikrobiom der Harnblase bei Frühgeburtlichkeit – Eine Pilotstudie", "en": "The urine microbiome and preterm complications - a pilot study" }, "short": "UMIC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-05-01T02:00:00+02:00", "begin_effective": "2018-05-01T02:00:00+02:00", "end_planned": "2018-12-01T01:00:00+01:00", "end_effective": "2018-12-01T01:00:00+01:00", "assignment": "2018-04-05T17:30:45+02:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5328-90021-10" ] }, { "id": 4155, "title": { "de": "Dynamik klinischer, morphologischer und biochemischer Marker in unterschiedlichen Krankheitsstadien bei multipler Sklerose (MS)", "en": "Clinical, morphologic and biochemical markers at different stages of multiple sclerosis (MS) and their dynamics over time" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-12-01T01:00:00+01:00", "begin_effective": "2015-12-01T01:00:00+01:00", "end_planned": "2018-11-30T01:00:00+01:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2015-11-17T11:14:47+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 1, "manager": 57435, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4155-57435-10" ] }, { "id": 3552, "title": { "de": "Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior", "en": "Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior" }, "short": "MYNEWGUT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-12-01T01:00:00+01:00", "begin_effective": "2013-12-01T01:00:00+01:00", "end_planned": "2018-11-30T01:00:00+01:00", "end_effective": "2018-11-30T01:00:00+01:00", "assignment": "2014-02-03T13:02:28+01:00", "program": 24, "subprogram": "KBBE.2013.2.2-02: Factors influencing the human gut\r\nmicrobiome and its effect on the development of diet-related diseases and brain development", "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 51529, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "613979", "ethics_committee": null, "edudract_number": null, "persons": [ "3552-71386-12", "3552-71487-12", "3552-77692-12", "3552-51529-10" ] }, { "id": 3489, "title": { "de": "BIOBANKING AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE AUSTRIA", "en": "BIOBANKING AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE AUSTRIA" }, "short": "BBMRI.AT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-12-01T01:00:00+01:00", "begin_effective": "2013-12-01T01:00:00+01:00", "end_planned": "2018-11-30T01:00:00+01:00", "end_effective": "2019-02-28T01:00:00+01:00", "assignment": "2014-01-07T14:19:47+01:00", "program": 90, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 54142, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 25 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3489-54142-10" ] }, { "id": 4796, "title": { "de": "Algorithmengestützte Diabetestherapie für ältere Menschen zu Hause", "en": "Algorithm-based diabetes therapy for geriatric patients at home" }, "short": "DiabetesTherapy@Home", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-12-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-11-30T01:00:00+01:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2017-01-30T11:03:05+01:00", "program": 75, "subprogram": "HumanTechnologyInterface: Healthy Ageing–Assisted Living\r\n", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 65558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4796-65558-10" ] }, { "id": 5193, "title": { "de": "Polymorphismen im NLRP3-Inflammasom bei Patienten/-innen mit Uveitis", "en": "Gene Polymorphisms of the NLRP3-Inflammasome in Uveitis" }, "short": "NLRP3-Inflammasom und Uveitis", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-11-01T01:00:00+01:00", "begin_effective": "2017-11-01T01:00:00+01:00", "end_planned": "2018-11-01T01:00:00+01:00", "end_effective": "2018-03-31T02:00:00+02:00", "assignment": "2018-01-10T10:21:36+01:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 1, "manager": 93387, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5193-93387-10" ] }, { "id": 4194, "title": { "de": "PCK2 in Lungentumoren: Rolle für Metabolismus und Wachstum", "en": "The role of PCK2 in lung cancer metabolism and growth" }, "short": "PCK2 in Lungentumoren", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-11-01T01:00:00+01:00", "begin_effective": "2016-02-01T01:00:00+01:00", "end_planned": "2018-10-31T01:00:00+01:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2015-12-15T11:22:27+01:00", "program": 72, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P28692", "ethics_committee": null, "edudract_number": null, "persons": [ "4194-58591-12", "4194-71794-12", "4194-81608-12", "4194-105621-12", "4194-57557-10" ] }, { "id": 4616, "title": { "de": "Langzeit-biozide Beschichtungen zur Verhinderung von Schmier-Infektionen in\r\nöffentlichen Verkehrsmitteln", "en": "Long-lasting biocide coatings to prevent smear infections of people in public transportion" }, "short": "protectedTOUCH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-09-01T02:00:00+02:00", "begin_effective": "2016-09-01T02:00:00+02:00", "end_planned": "2018-10-30T01:00:00+01:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2016-09-15T15:30:52+02:00", "program": null, "subprogram": null, "organization": 17230, "category": 10, "type": 10, "partner_function": 2, "manager": 53900, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "855307", "ethics_committee": null, "edudract_number": null, "persons": [ "4616-53900-10" ] }, { "id": 4848, "title": { "de": "Sarkopenie und physische Gebrechlichkeit bei alten Menschen: \r\nEine multidimensionale Behandlungsstrategie", "en": "Sarcopenia and Physical fRailty IN older people:\r\nmulti-componenT Treatment strategies " }, "short": "SPRINTT_IMI_FP7", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-07-15T02:00:00+02:00", "begin_effective": "2016-07-01T02:00:00+02:00", "end_planned": "2018-10-30T01:00:00+01:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2017-02-21T11:10:59+01:00", "program": null, "subprogram": "IMI", "organization": 14046, "category": 10, "type": 10, "partner_function": 2, "manager": 51745, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "115621", "ethics_committee": null, "edudract_number": null, "persons": [ "4848-51745-10", "4848-99239-12" ] }, { "id": 4668, "title": { "de": "Verbesserung der Aktivität, Spezifität und Stabilität von Antitumor Peptiden gegen humanes malignes Melanom", "en": "Improvement of activity, specificity and stability of antitumor peptides against human malignant melanoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2016-10-01T02:00:00+02:00", "end_planned": "2018-10-01T02:00:00+02:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2016-10-24T13:25:23+02:00", "program": 60, "subprogram": null, "organization": 27477, "category": 10, "type": 10, "partner_function": 2, "manager": 50826, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "855671", "ethics_committee": null, "edudract_number": null, "persons": [ "4668-106294-12", "4668-117943-12", "4668-50826-10" ] }, { "id": 5174, "title": { "de": "Wird die Osteogenese in osteoporotischen Tiermodell durch Einsatz von Magnesiumimplantaten unterstützt?", "en": "Do magnesium implants support osteogenesis in an ovariectomy\r\ninduced osteoporotic animal model? " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-01-01T01:00:00+01:00", "begin_effective": "2018-01-01T01:00:00+01:00", "end_planned": "2018-10-01T02:00:00+02:00", "end_effective": "2018-10-01T02:00:00+02:00", "assignment": "2017-12-20T11:03:06+01:00", "program": 103, "subprogram": "ÖGKM Projektpreis", "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 98087, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1565 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5174-98087-10" ] }, { "id": 3478, "title": { "de": "Proposal for Establishing a National Hub of the European Biobanking and Biomolecular Resources Research Infrastructure BBMRI-ERIC", "en": "Antrag zur Etablierung eines Nationalen Knotens der Europäischen Forschungsinfrastruktur für Biobanken und Biomolekulare Ressourcen" }, "short": "BBMRI.AT", "url": null, "abstract": { "de": "Die systematische Analyse von biologischen Proben und medizinischen Daten bildet seit\r\nJahrhunderten die Grundlage unseres Wissens über Krankheitsursachen und der Entwicklung neuer\r\nDiagnosemethoden, Medikamente und Therapien. Biologische Proben und Daten werden daher auch\r\nals die Schlüsselressource für den Fortschritt in Medizin und Biotechnologie gesehen (OECD 2001).\r\nDie nachhaltige Erschließung dieser Schlüsselressourcen soll durch die pan‐europäische\r\nForschungsinfrastruktur BBMRI‐ERIC mit dem Hauptquartier in Graz/Österreich sichergestellt\r\nwerden. Die österreichische wissenschaftliche Beteiligung an BBMRI‐ERIC erfolgt durch ein nationales\r\nNetzwerk (BBMRI.AT), das eng mit dem europäischen Hauptquartier zusammenarbeiten soll und die\r\nöffentlichen medizinischen Universitäten Österreichs, die Alpen Adria Universität Klagenfurt, die\r\nveterinärmedizinische Universität Wien und das Wiener Life Science Governance Institute als\r\nPartner vorsieht.\r\nDas Arbeitsprogramm von BBMRI.AT wird sich auf folgende Bereiche konzentrieren:\r\n Etablierung des österreichischen nationalen Knotens und die Vertretung des Knotens im BBMRIERIC\r\nManagement Komitee entsprechend den Statuten und des Businessplans von BBMRI‐ERIC;\r\n Optimale Harmonisierung der Prozesse innerhalb von BBMRI.AT, um die bestehenden Biobanken\r\nin eine nationale Forschungsinfrastruktur zu integrieren;\r\n Optimale Harmonisierung der Prozesse von BBMRI.AT mit denen von BBMRI‐ERIC, um die\r\ninternationale Sichtbarkeit und Bedeutung der österreichischen Biobanken und damit\r\nzusammenhängender Forschung zu erhöhen;\r\n Weiterentwicklung der österreichischen Stärken im Bereich von im Gesundheitssystem\r\nintegrierten Biobanken, um ein führender Partner für akademische und industrielle Forschung zu\r\nwerden.\r\n Verankerung von BBMRI.AT im gesellschaftlichen Umfeld unter Einbeziehung der öffentlichen\r\nErwartungshaltungen und ethisch/rechtliche Gegebenheiten.", "en": "Since centuries the systematic investigation of biological samples and medical data provides the\r\nfoundation for our knowledge on diseases and the development of new diagnostic procedures,\r\nmedications, and therapies. Therefore, biological samples are considered as the key resource for the\r\nadvancement of medicine and biotechnology (OECD 2001). The sustainable exploration of this key\r\nresource should be assured by the pan‐European research infrastructure BBMRI‐ERIC with its\r\nstatutory seat and executive management office in Graz/Austria. The scientific participation of\r\nAustria in BBMRI‐ERIC is exerted by a national node (BBMRI.AT) which should closely collaborate\r\nwith the central executive management office, and involves the Austrian public medical universities,\r\nthe Alpen Adria University Klagenfurt, the University of Veterinary Medicine Vienna, and the Life\r\nScience Governance Institute.\r\nThe work programme will focus on the following topics:\r\n Establishment of the Austrian national node and representation of the national node in the\r\nBBMRI‐ERIC management committee according to the statutes and business plan of BBMRI‐ERIC;\r\n Optimal harmonization of procedures within BBMRI.AT to integrate existing biobanks into a\r\nnational research infrastructure;\r\n Optimal harmonization of BBMRI.AT procedures with BBMRI‐ERIC to increase international\r\nvisibility and the role of Austrian biobanks and related research;\r\n Further development of the Austrian strengths in health care integrated biobanking to become a\r\nleading partner for academic and industrial research.\r\n Embedding BBMRI.AT into the societal framework by relating BBMRI.AT to societal expectations\r\nand ethical/legal requirements" }, "begin_planned": "2013-11-01T01:00:00+01:00", "begin_effective": "2013-12-01T01:00:00+01:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2013-12-19T16:17:04+01:00", "program": 90, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 3, "manager": 51663, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 25 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3478-51870-12", "3478-51663-10" ] }, { "id": 4125, "title": { "de": "Die Energieversorgung des Endoplasmatischen Retikulums", "en": "The Energy Supply of the Endoplasmic Reticulum" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-10-01T02:00:00+02:00", "begin_effective": "2016-01-01T01:00:00+01:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-09-30T02:00:00+02:00", "assignment": "2015-10-15T12:04:23+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 50810, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 28529", "ethics_committee": null, "edudract_number": null, "persons": [ "4125-50810-10" ] }, { "id": 4188, "title": { "de": "implementAtion anD OPeration of the gaTeway for health into the Biobanking and BioMolecular resources Research Infrastructure – European Research Infrastructure Consortium.", "en": "implementAtion anD OPeration of the gaTeway for health into the Biobanking and BioMolecular resources Research Infrastructure – European Research Infrastructure Consortium." }, "short": "Adopt BBMRI-ERIC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-10-01T02:00:00+02:00", "begin_effective": "2015-10-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2015-12-10T12:10:09+01:00", "program": 109, "subprogram": "INFRADEV-3-2015", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "676550", "ethics_committee": null, "edudract_number": null, "persons": [ "4188-51663-10" ] }, { "id": 5359, "title": { "de": "Humanmilch Oligosaccharide im ersten Schwangerschaftstrimester ", "en": "First Trimester Human Milk Oligosaccharides" }, "short": "FirstHMOs", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-04-01T02:00:00+02:00", "begin_effective": "2018-05-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-09-13T02:00:00+02:00", "assignment": "2018-05-03T12:13:57+02:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 88993, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5359-88993-10" ] }, { "id": 4051, "title": { "de": "Schwangerschaftskomplikationen: eine Chance zur Früherkennung von Herz-Kreislauf-Erkrankungen?", "en": "Pregnancy complications: challenge and/or chance for further cardiovascular risk in later life?" }, "short": "RiChLife", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-10-01T02:00:00+02:00", "begin_effective": "2015-10-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-09-30T02:00:00+02:00", "assignment": "2015-07-08T16:50:25+02:00", "program": 79, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 64295, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4051-64295-10" ] }, { "id": 4609, "title": { "de": "Die Gehirnzentrale - Neuronenwelt verständlich erklärt", "en": "Brain Center - Comprehensible explaination of the Neurons' World" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-07-01T02:00:00+02:00", "begin_effective": "2016-07-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2018-09-30T02:00:00+02:00", "assignment": "2016-09-08T11:14:17+02:00", "program": null, "subprogram": "FFG Talente Praktika für Schülerinnen und Schüler", "organization": 14050, "category": 10, "type": 10, "partner_function": 4, "manager": 61927, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "854227", "ethics_committee": null, "edudract_number": null, "persons": [ "4609-61927-10" ] }, { "id": 4032, "title": { "de": "Imaging mit Nuclear Quadrupole Enhanced Relaxation", "en": "Contrast by Nuclear Quadrupole Enhanced Relaxation" }, "short": "CONQUER_Horizon2020", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-10-01T02:00:00+02:00", "begin_effective": "2015-09-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2018-08-31T02:00:00+02:00", "assignment": "2015-05-29T12:07:42+02:00", "program": 109, "subprogram": "FET Open", "organization": 17230, "category": 10, "type": 10, "partner_function": 2, "manager": 53900, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "665172", "ethics_committee": null, "edudract_number": null, "persons": [ "4032-53900-10" ] }, { "id": 4220, "title": { "de": "Phospholipide und deren Rezeptoren in Erkrankungen des Kolons", "en": "Phospholipids and their receptors in diseases of the colon" }, "short": null, "url": null, "abstract": { "de": "Phospholipide und deren Rezeptoren: mögliche Rolle in entzündlichen Darmerkrankungen und im Dickdarmkrebs \r\nLipidmoleküle sind nicht nur wichtige Spieler im Energiestoffwechsel, sondern dienen auch als Botenstoffe zur Signalübertragung. Mehrere neue Arten solcher Lipidmoleküle, welche die Funktion von Krebszellen beeinflussen können, wurden in den letzten Jahren entdeckt. Unter ihnen befinden sich die sogenannten Endocannabinoide, die ähnliche Wirkung haben wie die Inhaltsstoffe von Cannabis sativa, aber im Organismus selbst gebildet werden. Diese Lipide sind Botenstoffe an Krebszellen, wo sie an Rezeptoren binden und die Funktion der Zellen beeinflussen.\r\nIm vorliegenden Projekt wollen wir einen sogenannten atypischen Cannabinoid Rezeptor mit dem Namen GPR55, der an Dickdarmkrebszellen vorkommt, untersuchen. Dieser Rezeptor besitzt als aktivierenden Botenstoff nicht nur Endocannabinoide, sondern auch ein Phospholipidmolekül, genannt LPI (Lysophophatidylinositol). LPI und GPR55 bilden zusammen eine Achse, von der man glaubt, dass sie eine treibende Rolle im Dickdarmkrebs und in entzündlichen Darmerkrankungen spielt. Diese Hypothese wird durch die Tatsache untermauert, dass GPR55 sowohl in Dickdarmkrebszellen als auch im gesunden Darm vorhanden ist und in experimentellen Modellen die Entzündung und das Krebswachstum fördert. Zur Klärung der Frage, ob diese molekulare Achse auch in Darmentzündungen und im Dickdarmkrebs des Menschen Bedeutung hat, wird der Gehalt an GPR55 Rezeptoren im Tumorgewebe von Kolonkarzinompatienten und in Darmbiopsien von Patienten mit entzündlichen Darmerkrankungen mittels geeigneten biochemischen und histologischen Methoden nachgewiesen. LPI wird im Serum mittels hochauflösender Massenspektrometrie gemessen. \r\nDie wenig erforschte Rolle von GPR55 in diesen Erkrankungen wird in diesem Projekt erstmals in humanen Proben untersucht. Es wird vermutet, dass GPR55 als Bestandteil des Endocannabinoidsystems an wichtigen Schaltstellen zur Entstehung dieser Erkrankungen sitzt. Diese Tatsache macht GPR55 zu einem wichtigen Angriffspunkt einer pharmakologischen Therapie. Schließlich wird in diesem Projekt auch die Möglichkeit erforscht, ob LPI als Biomarker zur Bestimmung dieser Krankheiten geeignet ist.\r\n", "en": null }, "begin_planned": "2015-10-01T02:00:00+02:00", "begin_effective": "2016-05-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-10-31T01:00:00+01:00", "assignment": "2016-01-11T13:59:08+01:00", "program": 108, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 56687, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI521", "ethics_committee": null, "edudract_number": null, "persons": [ "4220-56687-10" ] } ] }