Project List
List projects.
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GET /v1/research/project/?format=api&offset=1180&ordering=-end_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1200&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1160&ordering=-end_effective", "results": [ { "id": 5449, "title": { "de": "Lysophosphatidsäure als Aktivator des MAPK Wegs in Mikroglia", "en": "Lysophospatidic acid induced signaling in microglia: the role of MAPK pathways" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2019-03-31T01:00:00+01:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2018-08-20T12:02:08+02:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4796, "title": { "de": "Algorithmengestützte Diabetestherapie für ältere Menschen zu Hause", "en": "Algorithm-based diabetes therapy for geriatric patients at home" }, "short": "DiabetesTherapy@Home", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-12-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-11-30T01:00:00+01:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2017-01-30T11:03:05+01:00", "program": 75, "subprogram": "HumanTechnologyInterface: Healthy Ageing–Assisted Living\r\n", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 65558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4796-65558-10" ] }, { "id": 4188, "title": { "de": "implementAtion anD OPeration of the gaTeway for health into the Biobanking and BioMolecular resources Research Infrastructure – European Research Infrastructure Consortium.", "en": "implementAtion anD OPeration of the gaTeway for health into the Biobanking and BioMolecular resources Research Infrastructure – European Research Infrastructure Consortium." }, "short": "Adopt BBMRI-ERIC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-10-01T02:00:00+02:00", "begin_effective": "2015-10-01T02:00:00+02:00", "end_planned": "2018-09-30T02:00:00+02:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2015-12-10T12:10:09+01:00", "program": 109, "subprogram": "INFRADEV-3-2015", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "676550", "ethics_committee": null, "edudract_number": null, "persons": [ "4188-51663-10" ] }, { "id": 5330, "title": { "de": "Zellkultur mit Zelllinien der akuten myeloischen Leukämie", "en": "Tissue culture in acute myeloid leukemia cell lines" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-03-06T01:00:00+01:00", "begin_effective": "2018-04-01T02:00:00+02:00", "end_planned": "2019-03-06T01:00:00+01:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2018-04-09T14:57:43+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-29", "ethics_committee": null, "edudract_number": null, "persons": [ "5330-57402-10" ] }, { "id": 4858, "title": { "de": "Das Mikrobiom der Lunge im Kindesalter", "en": "The SPAM –Project \r\n(Studying the Paediatric Airway Microbiome)\r\nA Prospective Multicentric Clinical Study\r\n" }, "short": "SPAM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2019-03-01T01:00:00+01:00", "end_effective": "2019-03-01T01:00:00+01:00", "assignment": "2017-02-28T09:34:51+01:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 83445, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 550 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4858-83445-10" ] }, { "id": 3489, "title": { "de": "BIOBANKING AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE AUSTRIA", "en": "BIOBANKING AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE AUSTRIA" }, "short": "BBMRI.AT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-12-01T01:00:00+01:00", "begin_effective": "2013-12-01T01:00:00+01:00", "end_planned": "2018-11-30T01:00:00+01:00", "end_effective": "2019-02-28T01:00:00+01:00", "assignment": "2014-01-07T14:19:47+01:00", "program": 90, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 54142, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 25 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3489-54142-10" ] }, { "id": 3691, "title": { "de": "Placenta Perfusion Studio", "en": "Placenta Perfusion Studio" }, "short": "Plazentatox", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-09-01T02:00:00+02:00", "begin_effective": "2014-09-01T02:00:00+02:00", "end_planned": "2018-08-30T02:00:00+02:00", "end_effective": "2019-02-28T01:00:00+01:00", "assignment": "2014-06-26T13:30:26+02:00", "program": 107, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50442, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "844741", "ethics_committee": null, "edudract_number": null, "persons": [ "3691-88993-12", "3691-50442-10", "3691-56938-12", "3691-83661-12", "3691-89898-12", "3691-90214-12", "3691-51632-12", "3691-100813-12" ] }, { "id": 4793, "title": { "de": "Lipasen und Lipidsignaling ", "en": "Lipases and Lipid Signaling" }, "short": "BioTechMed", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2019-02-28T01:00:00+01:00", "end_effective": "2019-02-28T01:00:00+01:00", "assignment": "2017-01-02T11:28:55+01:00", "program": null, "subprogram": "BioTechMed Flagship Project", "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4793-50442-10" ] }, { "id": 3809, "title": { "de": "Funktionalität ex vivo generierter Retikulozyten aus humanen Stammzellen", "en": "Functional quality of reticulocytes generated ex vivo from human stem cells" }, "short": "Ex vivo generated Reticulocytes", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-01T01:00:00+01:00", "end_planned": "2019-02-28T01:00:00+01:00", "end_effective": "2019-02-08T01:00:00+01:00", "assignment": "2014-11-14T14:34:34+01:00", "program": null, "subprogram": null, "organization": 14058, "category": 10, "type": 10, "partner_function": 4, "manager": 88593, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1586 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3809-51164-12", "3809-88593-10", "3809-93640-12", "3809-51910-12", "3809-50131-12" ] }, { "id": 4512, "title": { "de": "Kontrolle des Ansprechens auf neoadjuvante Therapie bei Brustkrebspatientinnen anhand von Plasma-DNA", "en": "Clinical utility of plasma-DNA to monitor response to neoadjuvant therapy in breast cancer patients\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-08-01T02:00:00+02:00", "begin_effective": "2016-08-01T02:00:00+02:00", "end_planned": "2019-01-31T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2016-07-11T16:41:21+02:00", "program": 79, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": 50899, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4512-50899-10" ] }, { "id": 3265, "title": { "de": "HOMAGE", "en": "HOMAGE" }, "short": "HOMAGE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2012-11-01T01:00:00+01:00", "begin_effective": "2013-02-01T01:00:00+01:00", "end_planned": "2017-10-30T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2013-05-13T17:29:05+02:00", "program": 24, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "305507", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4256, "title": { "de": "The functional role of HDL in the tumor microenvironment", "en": "The functional role of HDL in the tumor microenvironment" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-02-01T01:00:00+01:00", "begin_effective": "2015-02-01T01:00:00+01:00", "end_planned": "2018-01-31T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2016-01-28T12:53:45+01:00", "program": 69, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J3664-B19", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3413, "title": { "de": "Verhaltensstörungen nach viszeraler Immunaktivierung", "en": "Psychopharmacology of the Visceral Immune Brain Axis" }, "short": "Immune-Brain Axis", "url": null, "abstract": { "de": "Depression ist eine der häufigsten und schwersten affektiven Störungen, welche die Lebensqualität und Arbeitsfähigkeit der betroffenen Patienten massiv einschränkt und damit von enormer sozio-ökonomischer Bedeutung ist. Die Weltgesundheitsorganisation berichtet, dass Depression in der Altersklasse von 15 44 Jahren schon jetzt bei beiden Geschlechtern die zweithäufigste Ursache für disability adjusted life years darstellt und die Zahl der von Depression betroffenen Patienten weiter steigt. Unglücklicherweise sprechen bis zu 40 % der Patienten mit Depression nur unzureichend auf die verfügbaren Antidepressiva an, was mit der Tatsache zusammenhängt, dass die Ätiologie affektiver Störungen nur unvollständig bekannt ist. Abgesehen von genetischen und psychosozialen Risikofaktoren rückt immer mehr auch eine chronische Stimulierung des Immunsystems als eine Ursache für die Entstehung affektiver Störungen in den Blickpunkt. Die Zytokin-Hypothese der Depression postuliert, dass systemische Immunprozesse über erhöhte Blutspiegel proinflammatorischer Zytokine einen Einfluss auf Gehirnfunktionen ausüben, die Ängstlichkeit, Affekt, Stressresistenz und kognitive Prozesse regulieren.\r\nAktivierung des viszeralen Immunsystems und viszerale Entzündung können mit einer Reihe von psychiatrischen Abnormalitäten assoziiert sind. Klinische Beobachtungen sprechen dafür, dass Translokation von Zellwandkomponenten des intestinalen Mikrobioms über eine pathologisch durchlässige Darmschleimhaut zu affektiven Störungen führen kann. Präklinische Befunde belegen, dass gastrointestinale Infektionen, gastrointestinale Entzündungen und intraperitoneale Verabreichung bakteriellen Endotoxins emotional-affektive Verhaltensänderungen auslöst. Vor diesem Hintergrund ist es das Ziel des vorgelegten Projekts, in einem experimentellen Ansatz depressive Verhaltensänderungen nach viszeraler Immunstimulierung in umfassender und innovativer Weise zu analysieren und neue Angriffspunkte für wirksame pharmakologische Interventionen zu identifizieren.\r\nDie wichtigsten Hypothesen, die es zu untersuchen gilt, sind, \r\n\tdass Zellwandkomponenten des intestinalen Mikrobioms (Lipopolysaccharid, Pepidoglycan) und intestinale Hormone unter dem Einfluss des Mikrobioms (Glucagon-Like Peptide, Peptid YY) depressive Verhaltensänderungen hervorrufen,\r\n\tviszerale Immunaktivierung das affektive Verhalten kurz- und langfristig beeinflusst;\r\n\tspezifische Signaltransduktionsmechanismen im Gehirn (Receptor-Activator of Nuclear Factor B Ligand, Cyclooxygenase-2 und Brain-Derived Neurotrophic Factor) von Relevanz für die affektiven Störungen im Gefolge einer peripheren Immunaktivierung sind, und\r\n\tdepressive Verhaltensänderungen nach viszeraler Immunstimulierung mit einer Störung der Hypothalamus-Hypophysen-Nebennieren-Achse, einer Störung des Glukokortikoid-Feedback an das Gehirn und einer Störung der Neurogenese im limbischen System assoziiert sind.", "en": "Being one of the most prevalent and severe mood disorders, major depression is deleterious to the patients quality of life and of enormous socio-economic impact. According to the World Health Organization, depression is the second most frequent cause of disability-adjusted life years in the age category of 15 44 years for both genders, with the number of patients continuing to grow. A proportion of some 40 % of the patients does not satisfactorily respond to the available antidepressant drugs, which reflects the incomplete understanding of the aetiology of affective disorders. Apart from vulnerability and psychosocial factors, chronic immune challenge has emerged as a circumstance relevant to the pathogenesis of mood disorders. The cytokine hypothesis of depression holds that systemic inflammatory processes associated with elevated levels of circulating proinflammatory cytokines disturb several brain mechanisms that control anxiety, mood, stress resilience and cognition.\r\nVisceral immune activation and inflammation are associated with a variety of psychiatric abnormalities, and there is clinical evidence that constituents of the intestinal microbiota across a leaky mucosal barrier may be a factor underlying mood disorders. Preclinical evidence indicates that gastrointestinal infection and inflammation as well as intraperitoneal administration of bacterial lipopolysaccharide induce behavioural disturbances. The current research proposal sets out to specifically examine the visceral immune brain axis in an innovative and comprehensive manner and to identify key mechanisms that are suitable for pharmacological modulation.\r\nThe main hypotheses to be addressed are that\r\n\tfactors derived from the intestinal microbiota (lipopolysaccharide, pepidoglycan) or intestinal hormones under the regulatory influence of the microbiota (glucagon-like peptide, peptide YY) have an impact on the visceral immune brain axis;\r\n\tvisceral immune challenge has a short- and long-term impact on affective behaviour;\r\n\tspecific brain signalling mechanisms involving receptor-activator of nuclear factor B ligand, cyclooxygenase-2 and brain-derived neurotrophic factor play a role in the behavioural effects of peripheral immune challenge; and\r\n\tactivation of the visceral immune brain axis is associated with deranged activity of the hypothalamic-pituitary-adrenal axis, disturbed glucocorticoid feedback on the brain and altered neurogenesis in the limbic system." }, "begin_planned": "2013-10-01T02:00:00+02:00", "begin_effective": "2014-02-01T01:00:00+01:00", "end_planned": "2016-09-30T02:00:00+02:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2013-10-25T11:06:48+02:00", "program": 72, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 51529, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P25912", "ethics_committee": null, "edudract_number": null, "persons": [ "3413-71386-12", "3413-71487-12", "3413-77692-12", "3413-51529-10" ] }, { "id": 4316, "title": { "de": "Relaxin", "en": "Relaxin" }, "short": "RELAXIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-05-01T02:00:00+02:00", "begin_effective": "2016-08-01T02:00:00+02:00", "end_planned": "2018-04-30T02:00:00+02:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2016-02-17T10:16:51+01:00", "program": 60, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 50874, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "853276", "ethics_committee": null, "edudract_number": null, "persons": [ "4316-98584-12", "4316-50874-10", "4316-62756-12", "4316-81091-12", "4316-108983-12" ] }, { "id": 3738, "title": { "de": "Potentielle positive Effekte von intestinaler ATGL Überexpression", "en": "Potential beneficial effects of intestinal ATGL overexpression" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2014-08-07T12:28:43+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 27070", "ethics_committee": null, "edudract_number": null, "persons": [ "3738-51904-10" ] }, { "id": 3854, "title": { "de": "Die Prävalenz von FHH bei PatientInnen mit einem primären Hyperparathyreoidismus", "en": "The Prevalence of FHH in Patients with Primary Hyperparathyroidism" }, "short": "EPATH-FHH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-07-01T02:00:00+02:00", "begin_effective": "2015-02-01T01:00:00+01:00", "end_planned": "2014-02-01T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2015-01-13T10:13:03+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 81519, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1565 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3854-81519-10" ] }, { "id": 3852, "title": { "de": "Aufklärung der spezifischen Zytotoxizität von Dimethylacrylshikonin in Melanomzellen", "en": "Elucidation of specific cytotoxic effects of dimethylacrylshikonin in melanoma cells" }, "short": "SpeDiMel", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-01-01T01:00:00+01:00", "begin_effective": "2015-01-28T01:00:00+01:00", "end_planned": "2018-01-01T01:00:00+01:00", "end_effective": "2019-01-27T01:00:00+01:00", "assignment": "2015-01-09T09:19:54+01:00", "program": 72, "subprogram": null, "organization": 17218, "category": 10, "type": 10, "partner_function": 2, "manager": 50826, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P27505", "ethics_committee": null, "edudract_number": null, "persons": [ "3852-50826-10" ] }, { "id": 4830, "title": { "de": "Neue therapeutische Agentien für die Kombinationstherapie von Chordomen", "en": "Novel therapeutic agents for chordoma combination treatment" }, "short": "Chordom Kombinationstherapie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-05-01T02:00:00+02:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2017-02-14T11:23:52+01:00", "program": null, "subprogram": "ISNK: Ingrid Shaker Nessmann Krebsforschungsvereinigung", "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50448, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1765 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4830-50448-10" ] }, { "id": 4445, "title": { "de": "1.1 - Clinical information systems for biobanks - CBmed", "en": "1.1 - Clinical information systems for biobanks - CBmed" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-07-01T02:00:00+02:00", "begin_effective": "2015-07-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2016-05-13T13:29:26+02:00", "program": null, "subprogram": null, "organization": 23613, "category": 10, "type": 10, "partner_function": 4, "manager": 54142, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4445-54142-10" ] }, { "id": 4122, "title": { "de": "3.3 - Biosensoren für kurzlebige Biomarker - CBmed", "en": "3.3 - Biosensors for short-living biomarkers - 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