Project List

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            "id": 3603,
            "title": {
                "de": "Die Rolle von RKIP in myeloischer Leukämogenese",
                "en": "The role of RKIP in myeloid leukemogenesis"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
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            "begin_planned": "2014-04-15T02:00:00+02:00",
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            "end_planned": "2017-04-14T02:00:00+02:00",
            "end_effective": "2019-09-30T02:00:00+02:00",
            "assignment": "2014-03-11T09:55:02+01:00",
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                "3603-99630-12",
                "3603-50747-12",
                "3603-57402-10",
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                "3603-99621-12"
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        {
            "id": 4790,
            "title": {
                "de": "Lipasen und Lipid-Signaltransduktion",
                "en": "Lipases and Lipid Signaling"
            },
            "short": null,
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                "de": null,
                "en": null
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            "id": 4051,
            "title": {
                "de": "Schwangerschaftskomplikationen: eine Chance zur Früherkennung von Herz-Kreislauf-Erkrankungen?",
                "en": "Pregnancy complications: challenge and/or chance for further cardiovascular risk in later life?"
            },
            "short": "RiChLife",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
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            "begin_planned": "2015-10-01T02:00:00+02:00",
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            "end_effective": "2019-09-30T02:00:00+02:00",
            "assignment": "2015-07-08T16:50:25+02:00",
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                12
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            "persons": [
                "4051-64295-10"
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        {
            "id": 3602,
            "title": {
                "de": "Imatinib als neues Prostaglandin freisetzendes Arzneimittel",
                "en": "Imatinib as a novel prostaglandin releasing drug"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
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            "begin_planned": "2013-07-01T02:00:00+02:00",
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            "end_planned": "2016-07-01T02:00:00+02:00",
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            "assignment": "2014-03-11T09:48:51+01:00",
            "program": 72,
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            "funder_projectcode": "P 26185",
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        {
            "id": 5060,
            "title": {
                "de": "Effekt von  Acetazolamid auf die Expression von Prion Protein auf T regulatorischen Zellen\r\n",
                "en": "Effect of Acetazolamide on the expression of Prion Protein on T regulatory cells\r\n"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
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            "begin_planned": "2017-09-01T02:00:00+02:00",
            "begin_effective": "2017-09-01T02:00:00+02:00",
            "end_planned": "2018-03-01T01:00:00+01:00",
            "end_effective": "2019-09-30T02:00:00+02:00",
            "assignment": "2017-09-14T12:49:18+02:00",
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            "organization": 14043,
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            "funder_projectcode": null,
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            "persons": [
                "5060-89577-10"
            ]
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        {
            "id": 4347,
            "title": {
                "de": "Therapiemonitoring in Plasma DNA bei PatientInnen mit mRCC",
                "en": "Therapy monitoring in plasma DNA of patients with mRCC"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-01-01T01:00:00+01:00",
            "begin_effective": "2016-01-01T01:00:00+01:00",
            "end_planned": "2018-12-31T01:00:00+01:00",
            "end_effective": "2019-09-30T02:00:00+02:00",
            "assignment": "2016-03-07T14:18:24+01:00",
            "program": 72,
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            "organization": 14021,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50899,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
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            "funders": [
                9
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            "funder_projectcode": "P 28949-B28",
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            "persons": [
                "4347-50899-10"
            ]
        },
        {
            "id": 5359,
            "title": {
                "de": "Humanmilch Oligosaccharide im ersten Schwangerschaftstrimester ",
                "en": "First Trimester Human Milk Oligosaccharides"
            },
            "short": "FirstHMOs",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2018-04-01T02:00:00+02:00",
            "begin_effective": "2018-05-01T02:00:00+02:00",
            "end_planned": "2018-09-30T02:00:00+02:00",
            "end_effective": "2019-09-13T02:00:00+02:00",
            "assignment": "2018-05-03T12:13:57+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 88993,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
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                457
            ],
            "funder_projectcode": null,
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            "persons": [
                "5359-88993-10"
            ]
        },
        {
            "id": 3834,
            "title": {
                "de": "Komplexe Schwingungssysteme: Modellierung und Analyse ",
                "en": "Complex Oscillatory Systems: Modelling and Analysis"
            },
            "short": "COSMOS_HORIZON",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2015-01-01T01:00:00+01:00",
            "begin_effective": "2015-01-01T01:00:00+01:00",
            "end_planned": "2018-12-31T01:00:00+01:00",
            "end_effective": "2019-08-31T02:00:00+02:00",
            "assignment": "2014-12-12T09:24:46+01:00",
            "program": 109,
            "subprogram": "Innovative Training Network /European Joint Doctorate",
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51671,
            "contact": null,
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            "research": 1,
            "grant": 10,
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            "funders": [
                10
            ],
            "funder_projectcode": "642563",
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            "edudract_number": null,
            "persons": [
                "3834-51671-10"
            ]
        },
        {
            "id": 4792,
            "title": {
                "de": "Lipasen und Lipid-Signaltransduktion",
                "en": "Lipases and lipid signaling"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-09-01T02:00:00+02:00",
            "begin_effective": "2017-09-01T02:00:00+02:00",
            "end_planned": "2019-08-31T02:00:00+02:00",
            "end_effective": "2019-08-31T02:00:00+02:00",
            "assignment": "2017-01-02T11:27:47+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 56687,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
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                2325
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            "funder_projectcode": null,
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            "persons": [
                "4792-56687-10"
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        },
        {
            "id": 4847,
            "title": {
                "de": "Hochauflösende In-silico Modelle der Gesamten Herzfunktion",
                "en": "High-resolution In Silico Models of Total Heart Function"
            },
            "short": "InsiliCardio",
            "url": null,
            "abstract": {
                "de": "Fortschritte bei der Entwicklung von tomographischen Verfahren ermöglichen in beispielloser Weise die Anatomie des Herzens abzubilden. Allerdings hatten diese Technologien bisher einen relativ geringen Einfluss auf die Entwicklung von medizinischen Implantaten oder die Verbesserung von klinischen Behandlungsmethoden. \r\nDer Einsatz von bildgebenden Verfahren zur Extraktion von wichtigen funktionellen Informationen und der Kopplung von Bildinformationen mit physiologischen Aspekten, die nicht durch Bildgebung allein verstanden werden können, stellt eine große Herausforderung dar. In silico Modelle, also computerunterstützte Simulationen, bergen enormes Potenzial zur Bewältigung dieser Herausforderungen und können zu einem besseren Verständnis der Herzfunktion, sei es im gesunden oder auch im erkrankten Zustand, führen. Ein entscheidender Vorteil ist hierbei die Möglichkeit diagnostische und therapeutische Methoden zu optimieren ohne dabei Patienten zusätzlichen Risiken oder Schmerzen auszusetzen. In silico Experimente können somit bei der Untersuchung von klinisch relevanten Problemen, wie zum Beispiel Herzklappenchirurgie, Ballon-Angioplastie oder Stenting, äußerst hilfreich sein. \r\nDie Herzfunktion ergibt sich aus der Interaktion verschiedener Physiken, unter anderem der Elektrophysiologie, der Strukturmechanik und der Strömungsmechanik. Während die beteiligten Physiken klar bidirektional wechselwirken, werden sie in praktisch allen Studien isoliert betrachtet. Dies ist zu einem guten Teil auf die Komplexität von Multiphysik-Modellen und den Schwierigkeiten, die bei der Entwicklung von modernen numerischen Methoden und deren effizienten Implementierung auf modernen Rechnerarchitekturen auftauchen, zurückzuführen. Die Bewältigung dieser Herausforderungen ist das zentrale Themas dieses Projektes und die Durchführung setzt auf die Kombination der Expertisen der Antragsteller: Christoph Augustin und Gernot Plank in der Modellierung der Elektrophysiologie und der Strukturmechanik und Shawn Shadden in der Computermodellierung des Blutflusses. \r\nDieses ambitionierte Unterfangen geht weit über den aktuellen Stand der Technik hinaus. Kombinierte Modelle von Herz und Blutgefäßen ermöglichen die Berechnung von natürlichen Randbedingungen für die Simulation des Blutflusses und das Studium von Rückkopplungsmechanismen die die Pumpleistung des Herzens beeinflussen können. Im Endeffekt wird dieses Modell eines der modernsten Werkzeuge der Grundlagenforschung sein, das einen mechanistischen Einblick in die Herzpumpfunktion gewährt. Von wesentlicher Bedeutung ist in diesem Kontext auch die Überprüfung, Parametrisierung und Validierung dieses Modells mit klinischen Datensätzen, die von klinischen Partnern zur Verfügung gestellt werden. \r\nDas Ziel dieser Forschung ist ein innovatives Multiphysik-Computermodell der gesamten Herzfunktion um eine biophysikalisch detaillierte und bidirektional gekoppelte Erforschung der elektromechanischen Funktion des Herzens im gesunden wie im kranken Zustand zu ermöglichen.",
                "en": "Advances in medical imaging have enabled unprecedented ability to image cardiac anatomy and function. So far these technologies have had relatively modest clinical impact as the analysis of such rich multi-modal datasets has proven challenging. In silico models hold vast potential to better harness such datasets by enabling their integration into quantitative frameworks that can aid in gaining better mechanistic insight into cardiac function in health and disease, and thus paving the way towards optimal therapeutic strategies.\r\nOur objective is to develop the most advanced biophysically detailed in-silico model of total electro-mechano-fluidic function of the heart. This model will be parametrized, verified and used to study cause-effect relationships between flow and pressure and their impact upon pumping performance. A novel set of features such as combined models of both heart and attached outflow vessels and the computational efficiency will provide a unique platform for translational research.\r\nThis ambitious endeavor is feasible only by combining the expertise of the applicant in modeling soft tissue mechanics and his supervisors in modeling electrophysiology (Gernot Plank, MUG) and blood flow (Shawn Shadden, UC Berkeley). Clinical input and datasets for model parametrization and validation are provided by Titus Kühne (DHZ Berlin) and by clinical collaborators of Prof. Shadden at UCSF. During the return-phase, the applicant will use the infrastructure of Prof. Plank’s lab and the large network of academic and industrial collaborations as an incubator for building up his own research group in computational hemodynamics. This is ideal in many regards, as the expertise of the applicant's group will be entirely orthogonal to the expertise in Prof. Plank's lab, thus promoting a fast pathway towards full indepence, and core expertise necessary for further developing and maintaining a highly complex computing environment is synergistically shared between the labs."
            },
            "begin_planned": "2017-06-01T02:00:00+02:00",
            "begin_effective": "2017-03-01T01:00:00+01:00",
            "end_planned": "2020-05-31T02:00:00+02:00",
            "end_effective": "2019-08-31T02:00:00+02:00",
            "assignment": "2017-02-20T09:41:41+01:00",
            "program": 109,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 79791,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
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            "funders": [
                10
            ],
            "funder_projectcode": "750835",
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            "edudract_number": null,
            "persons": [
                "4847-79791-10"
            ]
        },
        {
            "id": 5750,
            "title": {
                "de": "Albert Renold Travel Fellowship: Einfluss von mütterlichem Übergewicht auf epigenetische Programmierung der humanen Plazenta des ersten Schwangerschaftstrimesters",
                "en": "Albert Renold Travel Fellowship: Effect of maternal obesity on epigenetic programming of the early human early placenta"
            },
            "short": "Epigenetics in FT",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2019-04-01T02:00:00+02:00",
            "begin_effective": "2019-04-01T02:00:00+02:00",
            "end_planned": "2019-08-16T02:00:00+02:00",
            "end_effective": "2019-08-16T02:00:00+02:00",
            "assignment": "2019-03-28T15:26:58+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
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            "funders": [
                431
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 5046,
            "title": {
                "de": "Untersuchung der Rolle von mitochondrieller Ca2+-Homöostase der Podozyten in diabetischer Nephropathie",
                "en": "Investigating the role of podocyte mitochondrial Ca2+-signalling in diabetic nephropathy"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-08-01T02:00:00+02:00",
            "begin_effective": "2017-08-01T02:00:00+02:00",
            "end_planned": "2019-08-01T02:00:00+02:00",
            "end_effective": "2019-08-01T02:00:00+02:00",
            "assignment": "2017-08-24T10:42:36+02:00",
            "program": null,
            "subprogram": "START - Med Uni Graz",
            "organization": 14084,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 76689,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
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            "funders": [
                894
            ],
            "funder_projectcode": null,
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            "edudract_number": null,
            "persons": [
                "5046-76689-10",
                "5046-85976-12"
            ]
        },
        {
            "id": 5420,
            "title": {
                "de": "Pilotstudie zur Evaluierung der Korrelation von Tumor mutational Burden mit der Überlebensdauer von Krebspatienten",
                "en": "Pilot study for the evaluation of the correlation of tumor mutational burden and overall survival"
            },
            "short": "TMB",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2018-07-01T02:00:00+02:00",
            "begin_effective": "2018-07-01T02:00:00+02:00",
            "end_planned": "2019-07-31T02:00:00+02:00",
            "end_effective": "2019-07-31T02:00:00+02:00",
            "assignment": "2018-07-20T15:27:52+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57386,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-32",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5420-57386-10"
            ]
        },
        {
            "id": 5078,
            "title": {
                "de": "Basalzellkarzinom Studie",
                "en": "BCC – basal cell carcinoma study"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-11-01T01:00:00+01:00",
            "begin_effective": "2017-11-01T01:00:00+01:00",
            "end_planned": "2018-05-01T02:00:00+02:00",
            "end_effective": "2019-07-31T02:00:00+02:00",
            "assignment": "2017-09-28T17:10:48+02:00",
            "program": null,
            "subprogram": null,
            "organization": 27477,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50826,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
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            "persons": [
                "5078-50826-10"
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        },
        {
            "id": 5004,
            "title": {
                "de": "Blickbewegungen im Fokus: Visuelle Prozesse im klinischen Kontext",
                "en": "Blickbewegungen im Fokus: Visuelle Prozesse im klinischen Kontext"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
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            "begin_planned": "2017-07-01T02:00:00+02:00",
            "begin_effective": "2017-07-01T02:00:00+02:00",
            "end_planned": "2018-12-31T01:00:00+01:00",
            "end_effective": "2019-07-31T02:00:00+02:00",
            "assignment": "2017-07-10T11:59:38+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14068,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 89272,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
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                457
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            "funder_projectcode": null,
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                "5004-89272-10"
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        },
        {
            "id": 5208,
            "title": {
                "de": "KRYO–SEM Präparationssystem",
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