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GET /v1/research/project/?format=api&offset=1140&ordering=-begin_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1160&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1120&ordering=-begin_effective", "results": [ { "id": 4865, "title": { "de": "Kalziumdomäne in Orai1 reguliert NFAT abhängige Gene", "en": "Calcium domain in Orai1 regulates NFAT dependent genes" }, "short": null, "url": null, "abstract": { "de": "Kalziumdomäne in Orai1 reguliert Gene im Immunsystem\r\nKalzium steuert das Immunsystem vielseitig, etwa indem es spezielle Gene aktiviert. Diese Gen-regulation führt zur raschen Teilung von Immunzellen oder zur Abwehr eindringender Bakterien. Für diese zellulären Prozesse strömt Kalzium über eine Pore, den sogenannte Ionenkanal Orai1, in die Immunzelle ein. Orai1 wirkt somit wie ein Schalter, den die Immunzelle entweder oszillatorisch oder langanhaltend öffnen kann. Mutationen in Orai1 können zu schweren Immunkrankheiten führen. In diesem Projekt möchten Dr. Rainer Schindl und seine Mitarbeiter herausfinden, wie die Genregulation der Immunzellen durch molekulare Strukturen des Kalziumtransports gesteuert wird. In Vorexperimenten konnten wir bereits mit Supercomputern eine Bindung von Kalzium an den Ionenkanal Orai1 simulieren. Unsere Hypothese ist, dass diese Kalzium Bindedomäne den Kalzium Einstrom reguliert, und für die Genregulation von entscheidender Bedeutung ist. Zur experimentellen Untersuchung wird die Kalzium Bindestruktur genetisch verändert und mit dem ursprünglichen Orai1 Ionenkanal verglichen. Sowohl der Einstrom von Kalzium in die Zelle, die Aktivierung von Genen als auch die anschließende Produktion von Proteinen werden gemessen. Diese Methoden erlauben es eine mechanistische Verbindung von molekularen Orai1 Strukturen über Kalzium Transportwege bis hin zur Produktion von Proteinen herzustellen. Die Charakterisierung der Kalzium Bindestruktur im Orai1 Kanal verspricht fundamental neue Erkenntnisse über den Kalziumtransport in die Immunzelle. Die Regulation des Kalzium Einstroms wird klären wie Gene effizient aktiviert werden können.\r\n", "en": "Calcium domain in Orai1 regulates genes in the immune system\r\nCalcium is a main trigger for the immune system due to its regulation of gene expression. This signaling process controls both the proliferation of immune cells and the defense against bacteria. To mediate these cellular processes, calcium influx occurs via special pores, termed the Orai1 ion channel. Orai1 acts like a trigger that can be oscillatory or sustained opened by an immune cell. Mutations within Orai1 can result in severe immune diseases. Within this project, Dr. Rainer Schindl and his team aim to resolve which molecular structures are required for the calcium transport into immune cells and subsequent gene regulation. In preliminary experiments, we used super computers to simulate the binding of calcium with the ion channel Orai1. We hypothesize that this calcium binding domain is crucial for gene regulation. Hence the calcium binding structure will be genetically modified and compared experimentally with the function of the original Orai1 ion channel. We will record the influx of calcium into the cell, the activation of genes and the production of proteins. These methods allow to mechanistically link the molecular Orai1 structures, with calcium transport pathways and the production of proteins. The characterization of Orai1 calcium binding structure aims to provide fundamental insight into calcium transport in immune cells. Regulation of calcium influx will determine how genes are activated efficiently. \r\n" }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2020-02-29T01:00:00+01:00", "end_effective": "2021-03-31T02:00:00+02:00", "assignment": "2017-03-02T14:37:06+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 98848, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 28701", "ethics_committee": null, "edudract_number": null, "persons": [ "4865-98848-10" ] }, { "id": 4793, "title": { "de": "Lipasen und Lipidsignaling ", "en": "Lipases and Lipid Signaling" }, "short": "BioTechMed", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2019-02-28T01:00:00+01:00", "end_effective": "2019-02-28T01:00:00+01:00", "assignment": "2017-01-02T11:28:55+01:00", "program": null, "subprogram": "BioTechMed Flagship Project", "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4793-50442-10" ] }, { "id": 4829, "title": { "de": "Non-coding RNAs in colorectal cancer", "en": "Non-coding RNAs in colorectal cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2017-02-13T13:39:16+01:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-18", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4886, "title": { "de": "Darm-Metabotypen als Biomarker für Ernährung und Gesundheit", "en": "Gut Metabotypes as Biomarkers for Nutrition and Health" }, "short": "BioNUGUT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2020-08-31T02:00:00+02:00", "assignment": "2017-03-22T09:48:23+01:00", "program": null, "subprogram": null, "organization": 17225, "category": 10, "type": 10, "partner_function": 4, "manager": 58455, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4886-87300-12", "4886-58455-10", "4886-58451-12" ] }, { "id": 4603, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" (2. funding period)", "en": "DK \"Molecular Fundamentals of Inflammation\" (2. funding period)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-12-01T01:00:00+01:00", "assignment": "2016-09-06T12:09:49+02:00", "program": 66, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 2, "manager": 51618, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4603-54011-12", "4603-83662-12", "4603-84167-12", "4603-88082-12", "4603-98990-12", "4603-51618-10", "4603-100552-12", "4603-107955-12" ] }, { "id": 6064, "title": { "de": "Das Aktin-Zytoskelett und der Transkriptionsfaktor NFkB und IkappaB als prädiktive Faktoren für Leberregeneration und die Entstehung von Leberzellcarcinomen nach Major-Resektionen. ", "en": "The actin cytoskeleton and transkriptionfactor NFkB as predictive factors for liver regeneration and hepatocellular carcinogenesis after hemihepatectomy." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-20T01:00:00+01:00", "begin_effective": "2017-02-20T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2020-02-21T11:45:20+01:00", "program": null, "subprogram": null, "organization": 14108, "category": 10, "type": 10, "partner_function": 2, "manager": 98605, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1170 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6064-98605-10" ] }, { "id": 4760, "title": { "de": "Segmentale Akupunktur zur Prophylaxe von rezidivierenden Harnwegsinfekten", "en": "Segmental Acupuncture for prevention of Recurrent Urinary Tract Infections" }, "short": "SARUTI Studie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-08-01T02:00:00+02:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2017-06-01T02:00:00+02:00", "end_effective": "2021-12-31T01:00:00+01:00", "assignment": "2017-01-11T11:08:23+01:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50853, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": 1, "language": null, "funders": [ 1864 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4760-50853-10" ] }, { "id": 4593, "title": { "de": "Magnetische Eigenschaften weißer Gehirnsubstanz bei Multipler Sklerose Patienten", "en": "Magnetic Properties of Normal Appearing Brain White Matter in Multiple Sclerosis" }, "short": "QMTinMS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-07-01T02:00:00+02:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2019-06-30T02:00:00+02:00", "end_effective": "2021-01-31T01:00:00+01:00", "assignment": "2016-09-06T10:24:56+02:00", "program": 64, "subprogram": "DACH", "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 51279, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I3001", "ethics_committee": null, "edudract_number": null, "persons": [ "4593-51279-10" ] }, { "id": 4802, "title": { "de": "Sarkomforschung", "en": "sarcoma research" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-01-31T01:00:00+01:00", "end_effective": "2026-12-31T01:00:00+01:00", "assignment": "2017-02-02T12:27:48+01:00", "program": null, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50696, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-17", "ethics_committee": null, "edudract_number": null, "persons": [ "4802-50696-10" ] }, { "id": 4653, "title": { "de": "Flexibilität in der Organforschung", "en": "Flexibility in Organ Research" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2019-09-30T02:00:00+02:00", "end_effective": "2021-01-31T01:00:00+01:00", "assignment": "2016-10-14T13:09:27+02:00", "program": 64, "subprogram": "Partnership in Research", "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 76930, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9, 23 ], "funder_projectcode": "PIR00007", "ethics_committee": null, "edudract_number": null, "persons": [ "4653-50394-12", "4653-76930-10", "4653-51718-12", "4653-128875-12" ] }, { "id": 4790, "title": { "de": "Lipasen und Lipid-Signaltransduktion", "en": "Lipases and Lipid Signaling" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2019-09-30T02:00:00+02:00", "end_effective": "2019-09-30T02:00:00+02:00", "assignment": "2017-01-02T11:24:13+01:00", "program": null, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 53252, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4790-53252-10" ] }, { "id": 4765, "title": { "de": "Nicht-Protein Kodierende RNA und deren klinische Relevanz in Bauchspeicheldrüsenkrebs ", "en": "Non-coding RNA networks and their role in pancreatic cancer patients" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2020-01-31T01:00:00+01:00", "end_effective": "2020-01-31T01:00:00+01:00", "assignment": "2017-01-11T12:26:52+01:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 66005, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4765-66005-10" ] }, { "id": 4758, "title": { "de": "Invasive Druckmessung unter laufender Reanimation", "en": "Invasive Blood Pressure Measurement during Cardio-Pulmonary Resuscitation" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2017-01-11T10:01:43+01:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 91898, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-13", "ethics_committee": null, "edudract_number": null, "persons": [ "4758-91898-10", "4758-51986-10" ] }, { "id": 4800, "title": { "de": "Mitochondrien-Forschung: Je sanfter desto besser!\r\n", "en": "Mitochondria-research" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-01-31T01:00:00+01:00", "end_effective": "2018-01-31T01:00:00+01:00", "assignment": "2017-02-01T15:06:11+01:00", "program": null, "subprogram": null, "organization": 28392, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-02", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4763, "title": { "de": "Mütterliches Übergewicht vermindert Neprilysin im Plazentaendothel: Funktionelle Auswirkungen?", "en": "Maternal overweight reduces neprilysin in placental endothelium:\r\nImplication on endothelial function\r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-07-31T02:00:00+02:00", "end_effective": "2019-06-30T02:00:00+02:00", "assignment": "2017-01-11T12:25:24+01:00", "program": 79, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50674, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4763-50674-10" ] }, { "id": 4779, "title": { "de": "Panobinostat reduziert Hypoxie-induzierte Cisplatin Resistenz in nicht-kleinzelligen Lungenkarzinom Zellen durch Destabilisierung vom HIF-1alpha", "en": "Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1alpha destabilization" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-23T13:50:46+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 50610, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-21", "ethics_committee": null, "edudract_number": null, "persons": [ "4779-50610-10" ] }, { "id": 4796, "title": { "de": "Algorithmengestützte Diabetestherapie für ältere Menschen zu Hause", "en": "Algorithm-based diabetes therapy for geriatric patients at home" }, "short": "DiabetesTherapy@Home", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-12-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-11-30T01:00:00+01:00", "end_effective": "2019-03-31T01:00:00+01:00", "assignment": "2017-01-30T11:03:05+01:00", "program": 75, "subprogram": "HumanTechnologyInterface: Healthy Ageing–Assisted Living\r\n", "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 65558, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4796-65558-10" ] }, { "id": 4783, "title": { "de": "Entwicklung eines Konzepts zur Charakterisierung und dem Deployment einer einer integrativen\r\nHealthy Ageing Region unter Berücksichtigung von Active und Assisted-Living Technologien\r\nund Smart City –Komponenten.\r\n", "en": "Integrative Strategies for Healthy Ageing Regions" }, "short": "i-Share", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-24T13:55:59+01:00", "program": 75, "subprogram": "HumanTechnologyInterface:\r\nHealthy Ageing–Assisted Living\r\nProjekttitel:", "organization": 14046, "category": 10, "type": 10, "partner_function": 2, "manager": 51745, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 55 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4783-51745-10" ] }, { "id": 4928, "title": { "de": "Mikrobiom trifft Plasmidom – pathogenes Infektionsrisiko, gesunde Mikroorganismen und biologische Vielfalt in einem funktionellen Krankenhaus", "en": "Microbiome meets plasmidome – connecting pathogenic infection risk, healthy microbes, and environmental biodiversity in a functional hospital setting" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2019-01-31T01:00:00+01:00", "end_effective": "2019-01-31T01:00:00+01:00", "assignment": "2017-04-19T11:20:07+02:00", "program": null, "subprogram": "START - Med Uni Graz", "organization": 14046, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4928-95317-12", "4928-98573-12" ] }, { "id": 4663, "title": { "de": "Entwicklung, Umsetzung und Evaluierung eines Schulungsprogrammes für Pflegende zum Thema Mangelernährungs-Screening im Krankenhaus", "en": "Development, Implementation and Evaluation of a malnutrition screening education program for nurses in hospital setting" }, "short": "MEScH", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2018-02-01T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2016-10-19T14:10:01+02:00", "program": null, "subprogram": "AKE Förderpreis 2016 (Arbeitsgemeinschaft für Klinische Ernährung)", "organization": 14509, "category": 10, "type": 10, "partner_function": 4, "manager": 82963, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4663-82963-10" ] } ] }