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GET /v1/research/project/?format=api&offset=1140&ordering=-begin_effective
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1160&ordering=-begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1120&ordering=-begin_effective", "results": [ { "id": 4850, "title": { "de": "Assessing Hypertension Risk and Vascular Function (Dys) Function in South African Adolescents", "en": "Assessing Hypertension Risk and Vascular Function (Dys) Function in South African Adolescents" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2019-05-31T02:00:00+02:00", "assignment": "2017-02-21T14:57:46+01:00", "program": 92, "subprogram": null, "organization": 14010, "category": 10, "type": 10, "partner_function": 4, "manager": 57932, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4850-57932-10" ] }, { "id": 4720, "title": { "de": "Die künstliche Bauchspeicheldrüse bei Kindern mit Typ 1 Diabetes im Alter von 1 bis 7 Jahren.", "en": "The artificial pancreas in children aged 1 to 7 years with type 1 diabetes" }, "short": "KidsAP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-09T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-07-10T02:00:00+02:00", "end_effective": "2021-12-31T01:00:00+01:00", "assignment": "2016-12-02T13:52:43+01:00", "program": 109, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 50877, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "731560", "ethics_committee": null, "edudract_number": null, "persons": [ "4720-50877-10", "4720-59231-12", "4720-87054-12", "4720-97866-12", "4720-100522-12", "4720-99940-12" ] }, { "id": 4729, "title": { "de": "ETABLIERUNG EINER NEUEN METHODE ZUR BEURTEILUNG DER DARMWANDBARRIERE", "en": "ESTABLISHING A NEW METHOD FOR FUNCTIONAL ANALYSIS OF THE GUT BARRIER" }, "short": "Darmwand SAXS", "url": null, "abstract": { "de": "Hintergrund: Die Darmwand stellt eine essentielle Barriere des Körpers gegen Invasion von Bakterien und bakteriellen Toxinen dar. Verschiedene Erkrankungen wie Sepsis, Tumorkachexie, Adipositas oder chronisch entzündliche Darmerkrankungen führen zu einer Störung der Darmwandbarriere mit erhöhter Durchlässigkeit für bakterielle Toxine und konsekutiver Entzündungsreaktion. Aus diesem Grund ist die Beurteilung der Darmwanddurchlässigkeit essentieller Bestandteil verschiedener Grundlagenforschungsprojekte. Bisherige Methoden erlauben jedoch keine vollständige und zufriedenstellende Analyse der Darmwandbarriere. \r\nZiel: Ziel dieser Untersuchung ist es die Technik des small angle x-ray-scattering (SAXS) an einem Sepsismodell zu erproben, damit neue Erkenntnisse über die Darmwand zu erlangen und eine neue Technik zu etablieren.\u2028Tiere: 16 wild type Mäuse werden in 2 Gruppen geteilt. Die Kontrollgruppe erhält nur FITC Dextran per Sonde und wird 16h später euthanasiert. Bei den Tieren der zweiten Gruppe wird mittels CLP (cecal ligation and puncture) eine Sepsis erzeugt. Auch diese Tiere erhalten FITC dextran per Sonde. \r\nMethodik: Bei der Euthanasie wird Blut gewonnen und daraus der Serumgehalt von FITC als funktioneller Parameter der Darmdurchlässigkeit spektrophotometrisch bestimmt. Zusätzlich wird die Entzündung der Darmwand in HE Schnitten quantifiziert und der Darm elektronenmikroskopisch untersucht. Zusätzlich werden Ileumabschnitte mittels SAXS untersucht. Die Permeabilitätsparameter zwischen den Gruppen werden verglichen. Zusätzlich werden die Ergebnisse der Standardmethoden mit denen des SAXS korreliert. \r\nDissemination: Bisher gibt es keine Daten zur Darmwandanalyse mittels SAXS in der medizinischen Literatur. Die Ergebnisse sollen hochwertig veröffentlicht und auf internationalen Kongressen präsentiert werden. Zudem legen sie die Basis für weitere Forschungsanträge. Da unzählige Pathologien mit gestörter Darmwandbarriere vergesellschaftet sind und diese Technik auch bei der Versuchstierreduktion hilft, könnte mit dieser Methode durch die Kooperation zwischen Medizinischer Universität Graz und Universität für Bodenkultur Wien wissenschaftliches Neuland ergründet und neue Standards gelegt werden. \r\n\r\n", "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-03-31T02:00:00+02:00", "assignment": "2016-12-12T11:48:08+01:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 54087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-20", "ethics_committee": null, "edudract_number": null, "persons": [ "4729-50778-12", "4729-54087-10", "4729-82670-12" ] }, { "id": 4791, "title": { "de": "BioTechMed Leuchtturmprojekt Lipid Signaling", "en": "BioTechMed Leuchtturmprojekt Lipid Signaling" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-02T11:25:35+01:00", "program": 90, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4791-51756-10" ] }, { "id": 4718, "title": { "de": "SPIDIA für personalisierte Medizin - Standardisierung generischer Präanalytischen Methoden für In-Vitro DIAgnostics für personalisierte Medizin", "en": "SPIDIA for Personalized Medicine - Standardisation of generic Pre-analytical procedures for In-vitro DIAgnostics for Personalized Medicine" }, "short": "SPIDIA4P_Horizon", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2021-06-30T02:00:00+02:00", "assignment": "2016-12-01T14:50:29+01:00", "program": 109, "subprogram": "SC1-HCO-02-2016", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "733112", "ethics_committee": null, "edudract_number": null, "persons": [ "4718-51870-12", "4718-51663-10" ] }, { "id": 4789, "title": { "de": "Lipasen und Lipidsignaling", "en": "Lipases and Lipid Signaling" }, "short": "Lipid Signaling", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2017-01-02T11:17:22+01:00", "program": null, "subprogram": "BioTechMed Flagship Project", "organization": 14013, "category": 10, "type": 10, "partner_function": 3, "manager": 51904, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4789-51904-10" ] }, { "id": 4649, "title": { "de": "EULAR Empfehlungen für die Durchführung von Studien zur Berechnung der Arbeitskraft zur Versorgung der Bevölkerung im Bereich Rheumatologie", "en": "EULAR points to consider for the conduction of workforce requirement studies in rheumatology" }, "short": "EULAR worforce requirements", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-06-30T02:00:00+02:00", "end_effective": "2018-06-30T02:00:00+02:00", "assignment": "2016-10-11T16:23:37+02:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 66227, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4649-66227-10" ] }, { "id": 4794, "title": { "de": "Flagship project: Gesundes Altern und Epigenetik", "en": "Flagship project: Healthy aging and epigenetics" }, "short": "EpiAge", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2017-01-02T12:47:55+01:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4662, "title": { "de": "Entwicklung eines personalisierten Modelles der Rheumatoiden Arthritis", "en": "Development of a Personalized Model of Rheumatoid Arthritis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2016-10-19T11:46:15+02:00", "program": null, "subprogram": "Skoda Preis 2016", "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": 53560, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 204 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4662-53560-10", "4662-78952-12", "4662-89855-12" ] }, { "id": 4795, "title": { "de": "Lipasen und Lipidsignaling", "en": "Lipases and Lipid Signaling" }, "short": "Lipid signaling", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2019-12-31T01:00:00+01:00", "assignment": "2017-01-02T13:20:54+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 2, "manager": 59025, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4795-59025-10" ] }, { "id": 4768, "title": { "de": "Regulatorische Immunzellen als neue Marker in der Nierentransplantation", "en": "Regulatory immune cell subtypes as new biomarkers in renal transplant recipients - a pilot study" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2020-02-29T01:00:00+01:00", "assignment": "2017-01-11T16:29:25+01:00", "program": 79, "subprogram": null, "organization": 14084, "category": 10, "type": 10, "partner_function": 4, "manager": 74174, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "17212", "ethics_committee": null, "edudract_number": null, "persons": [ "4768-74174-10", "4768-86124-12", "4768-107070-12" ] }, { "id": 4661, "title": { "de": "Der Einfluss des Neuroblastoms und dessen Chemotherapie auf die Darmwandbarriere, den Metabolismus und die Entzündungsreaktion. ", "en": "The influence of neuroblastoma and its chemotherapy on gut barrier, inflammation and metabolism." }, "short": "NB Gut barrier", "url": null, "abstract": { "de": "Das Neuroblastom (NB) ist der häufigste extrakranielle solide Tumor im Kindesalter. Obwohl die Kachexie mit Myo- und Lipolyse im Rahmen kindlicher Tumorerkrankungen eine Seltenheit ist, wurden in den letzten Jahren bei vielen verschiedenen Tumorarten Veränderungen des Metabolismus mit signifikantem Einfluss auf Morbidität und Mortalität festgestellt. In diesem Bezug konnten von unserer Arbeitsgruppe erstmalig Störungen des Glukose- und Lipidstoffwechsels beim Neuroblastom Modell in Nacktratten nachgewiesen werden. Die diesen Störungen zugrundeliegenden Pathomechanismen bei NB PatientInnen bleiben jedoch zu einem großen Teil unbekannt. Erste Daten aus anderen Tumormodellen (Leukämie) lassen jedoch einen Zusammenhang zwischen dem intestinalen Mikrobiom – also der Gesamtheit der Darmbakterien – Tumor, Metabolismus und Entzündungssystem erahnen. Dies stellt eine neue Ansatzmöglichkeit in der Tumortherapie dar, da sich das Mikrobiom durch die Gabe von Antibiotika, Bakteriziden, Prä-, Pro- und Synbiotika relativ leicht beeinflussen lässt. Diesbezügliche Daten für solide kindliche Tumore liegen derzeit jedoch nicht vor.\r\nIn diesem Projekt stellen wir die Hypothese, dass das Neuroblastom zu tiefgreifenden Alterationen des intestinalen Mikrobioms mit konsekutiven Veränderungen der Darmbarriere und des Gallensäurenpools mit nachfolgenden pro-inflammatorischem Zustandsbildern und Veränderungen des Lipid- und Kohlenhydratstoffwechsels führt. Damit werden mehrere bisher nicht ausreichend erforschte Themenschwerpunkte aufgegriffen: 1) das Mikrobiom beim NB als solider kindlicher Tumor, 2) das Zusammenspiel Mikrobiom – Gallensäuren – Entzündungskaskade – Metabolismus und 3) der Einfluss der Dysbiose im Rahmen der Tumorerkrankung auf Darmwandbarriere und Entzündungskaskade.\r\nEin etabliertes Modell in Foxn1nu athymischen Nacktmäusen wird zum Anzüchten von Neuroblastommetastasen (Zelllinie MHH-NB11) verwendet. Nach 10 Wochen Tumorwachstum erfolgt eine Analyse des intestinalen Mikrobioms mittels next generation sequencing. Weiters wird der inflammatorische und metabolische Zustand der Tiere (Gallensäuren in Stuhl und Serum, kurzkettige Fettsäuren im Zökum, Zytokin- und Inkretinprofil, Glucosetoleranz, Serumlipide) beurteilt. Zusätzlich wird die Darmwandbarriere mittels Elektronenmikroskopie und Immunhistochemie untersucht und die Lipopolysaccharidspiegel systemisch und im Pfortaderblut bestimmt. Die Daten der Tumortiere werden mit einer Shamgruppe verglichen. Zusätzlich wird der Einfluss der Chemotherapie mit Cyclophosphamid auf die untersuchten Parameter analysiert.\r\nDieser Antrag verwendet neueste mikrobiologische Methoden zur Darstellung der Beziehung zwischen Mikrobiom, Entzündungskaskade und Stoffwechsel beim Neuroblastom. Die Ergebnisse dieser Studie könnten die Krebstherapie der Zukunft erheblich beeinflussen und somit dazu beitragen, die Morbidität und Mortalität von krebskranken Kindern zu verringern.\r\n", "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-03-31T02:00:00+02:00", "assignment": "2016-10-19T11:02:24+02:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 54087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743, 1950 ], "funder_projectcode": "MEFO-12", "ethics_committee": null, "edudract_number": null, "persons": [ "4661-50778-12", "4661-54087-10", "4661-82670-12", "4661-83445-12" ] }, { "id": 4782, "title": { "de": "Bild-basiertes Lernen für prädiktive personalisierte Modelle der Herzfunktion", "en": "Image-based Learning in Predictive Personalized Models of Total Heart Function" }, "short": "ILEARNHEART", "url": null, "abstract": { "de": "The heart is an electrically controlled mechanical pump, which drives blood flow from its cavities into the vascular system through deformation of its walls. Its function emerges from a bidirectional transduction of processes across multiple physical systems as well as spatial and temporal scales. This multiscale-multiphysics nature renders the heart an inherently challenging organ to study through reductionist approaches alone. This fundamental problem can be addressed by using biophysically detailed in silico models. Today in basic sciences such models are considered an indispensable element in any advanced physiology study as they offer the unique ability to mechanistically analyze cause-effect relationships at high spatio-temporal resolutions in the intact organ across scales and physics.\r\n\r\nDriven by recent advances in medical imaging and simulation technologies, a translational trend emerged which is geared towards evolving modeling into a clinical modality. In the clinic image-based analysis of the dynamics of electrophysiological activity, deformation and blood flow is of pivotal importance in the diagnostic assessment of cardiac function. Due to the sparse and noisy nature of medical image data computational analysis tools are essential for providing a more objective quantitative evaluation of a patient's condition. Moreover, relevant biomarkers cannot be measured directly and must be derived from images by computational analysis, a process which is often enriched by PDE models of the underlying physics. To further gain clinical traction such image-informed in silico models must be personalized for a given patient to provide clinically useful biomarkers, which can serve to indicate or stratify disease or allow for virtual testing of treatments and prediction of outcomes acutely and longitudinally. Personalization requires the conception of sophisticated data assimilation procedures to facilitate model adaptation to a patient's cardiac anatomy and function. Such data-model fusion techniques are highly non-trivial to devise for clinical electro-mechano-fluidic (EMF) models due to the large number of and the non-linear relation between model components that must be fit.\r\n\r\nThis project combines expertise in cardiac modeling and simulation, computational image analysis, learning - based data assimilation techniques and high performance computing algorithms to render feasible the development of robust and efficient data-model fusion framework for the image-based personalization of models of total heart function. The long term aim is the development of a clinical assist modality for the optimization and outcome prediction of valve (aortic/mitral) replacement therapies in the left heart. It is anticipated that such personalized EMF models will play an essential role in informing clinical decision making in future precision therapies. ", "en": "The heart is an electrically controlled mechanical pump, which drives blood flow from its cavities into the vascular system through deformation of its walls. Its function emerges from a bidirectional transduction of processes across multiple physical systems as well as spatial and temporal scales. This multiscale-multiphysics nature renders the heart an inherently challenging organ to study through reductionist approaches alone. This fundamental problem can be addressed by using biophysically detailed in silico models. Today in basic sciences such models are considered an indispensable element in any advanced physiology study as they offer the unique ability to mechanistically analyze cause-effect relationships at high spatio-temporal resolutions in the intact organ across scales and physics.\r\n\r\nDriven by recent advances in medical imaging and simulation technologies, a translational trend emerged which is geared towards evolving modeling into a clinical modality. In the clinic image-based analysis of the dynamics of electrophysiological activity, deformation and blood flow is of pivotal importance in the diagnostic assessment of cardiac function. Due to the sparse and noisy nature of medical image data computational analysis tools are essential for providing a more objective quantitative evaluation of a patient's condition. Moreover, relevant biomarkers cannot be measured directly and must be derived from images by computational analysis, a process which is often enriched by PDE models of the underlying physics. To further gain clinical traction such image-informed in silico models must be personalized for a given patient to provide clinically useful biomarkers, which can serve to indicate or stratify disease or allow for virtual testing of treatments and prediction of outcomes acutely and longitudinally. Personalization requires the conception of sophisticated data assimilation procedures to facilitate model adaptation to a patient's cardiac anatomy and function. Such data-model fusion techniques are highly non-trivial to devise for clinical electro-mechano-fluidic (EMF) models due to the large number of and the non-linear relation between model components that must be fit.\r\n\r\nThis project combines expertise in cardiac modeling and simulation, computational image analysis, learning - based data assimilation techniques and high performance computing algorithms to render feasible the development of robust and efficient data-model fusion framework for the image-based personalization of models of total heart function. The long term aim is the development of a clinical assist modality for the optimization and outcome prediction of valve (aortic/mitral) replacement therapies in the left heart. It is anticipated that such personalized EMF models will play an essential role in informing clinical decision making in future precision therapies. " }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2017-01-02T13:42:53+01:00", "program": null, "subprogram": "BioTechMed Flagship Project", "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 50966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4782-50966-10", "4782-96212-12", "4782-98304-12" ] }, { "id": 4809, "title": { "de": "MCF-7 knock out von GIRK1", "en": "MCF-7 knock out of GIRK1" }, "short": "Brustkrebsforschung", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2018-09-30T02:00:00+02:00", "assignment": "2017-02-07T15:31:52+01:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 80816, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-19", "ethics_committee": null, "edudract_number": null, "persons": [ "4809-80816-10" ] }, { "id": 4759, "title": { "de": "Die Rolle langer, nicht-kodierender RNS in Tumorstammzellen des Nierenzellkarzinoms.", "en": "Role of long non-coding RNAs in renal cancer stem cells." }, "short": "longncRNA in RCC-CSC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2017-12-31T01:00:00+01:00", "assignment": "2017-01-11T10:02:18+01:00", "program": 103, "subprogram": null, "organization": 14056, "category": 10, "type": 10, "partner_function": 4, "manager": 59858, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4759-59858-10" ] }, { "id": 6060, "title": { "de": "ADOPT BBMR-ERIC ", "en": "ADOPT BBMR-ERIC " }, "short": "Adopt", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2020-02-19T16:43:59+01:00", "program": 109, "subprogram": null, "organization": 28392, "category": 10, "type": 10, "partner_function": 2, "manager": 58453, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6060-58453-10" ] }, { "id": 4716, "title": { "de": "Aktivierung des Tumorsuppressors p53 durch Fasten zur Verlängerung der Lebensspanne", "en": "Activating the tumor suppressor p53 by fasting for life-span extension" }, "short": "p53 and Aging", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-12-01T01:00:00+01:00", "begin_effective": "2016-12-01T01:00:00+01:00", "end_planned": "2017-11-30T01:00:00+01:00", "end_effective": "2017-11-30T01:00:00+01:00", "assignment": "2016-12-01T11:04:59+01:00", "program": null, "subprogram": "Subventionsansuchen an die Stadt Graz Wissenschaft", "organization": 14017, "category": 10, "type": 10, "partner_function": 1, "manager": 89979, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4716-89979-10" ] }, { "id": 4757, "title": { "de": "Humane Trophoblaststammzellen - Charakterisierung humaner Trophoblastzell-Subpopulationen mit Stammzell-ähnlichen Eigenschaften", "en": "Human trophoblast stem cells - characterizing subpopulations of human trophoblasts presenting with stem-cell properties" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-12-01T01:00:00+01:00", "begin_effective": "2016-12-01T01:00:00+01:00", "end_planned": "2017-05-31T02:00:00+02:00", "end_effective": "2017-05-31T02:00:00+02:00", "assignment": "2017-01-10T16:17:14+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 54171, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4757-54171-10" ] }, { "id": 4695, "title": { "de": "Die Verwendung von CXCR4 Antagonisten zur Therapie von aggressiven B-Zell Lymphomen", "en": "The use of CXCR4 antagonists for therapeutic targeting of aggressive B-cell lymphomas" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2016-12-01T01:00:00+01:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2019-06-30T02:00:00+02:00", "assignment": "2016-11-18T10:52:24+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59496, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4695-59496-10" ] }, { "id": 4697, "title": { "de": "Untersuchungen zur tumorsuppressiven Funktion von Nr4a3 in der cMYC induzierten Lymphomentstehung", "en": "Investigating the role of nuclear orphan receptor NR4A3 in Myc-driven lymphomagenesis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-01-01T01:00:00+01:00", "begin_effective": "2016-12-01T01:00:00+01:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2019-06-30T02:00:00+02:00", "assignment": "2016-11-21T14:35:22+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4697-100134-12", "4697-59183-10", "4697-59496-12", "4697-51930-12", "4697-106234-12" ] } ] }