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GET /v1/research/project/?format=api&offset=1100&ordering=end_planned
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1120&ordering=end_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1080&ordering=end_planned", "results": [ { "id": 5744, "title": { "de": "Die Rolle von Neurofilament Konzentrationen als diagnostischer und prognostischer Marker für die Alzheimer Krankheit: Eine Substudie des prospektiven Demenzregister Österreich (PRODEM-Austria) ", "en": "Neurofilament concentrations as diagnostic and prognostic markers for Alzheimer´s disease: a substudy of the prospective dementia registry Austria (PRODEM-Austria)" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-02-01T01:00:00+01:00", "begin_effective": "2019-02-01T01:00:00+01:00", "end_planned": "2020-02-01T01:00:00+01:00", "end_effective": "2020-02-01T01:00:00+01:00", "assignment": "2019-03-25T14:44:56+01:00", "program": null, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2269 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4654, "title": { "de": "Einfluss adhärenter Blutplättchen auf den Zottentrophoblast", "en": "The role of adhering maternal platelets on villous trophoblast" }, "short": "Platelets and trophoblasts", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-10-01T02:00:00+02:00", "end_planned": "2020-02-28T01:00:00+01:00", "end_effective": "2021-03-31T02:00:00+02:00", "assignment": "2016-10-14T13:12:11+02:00", "program": 72, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P29639", "ethics_committee": null, "edudract_number": null, "persons": [ "4654-53232-10" ] }, { "id": 4073, "title": { "de": "Screening für chronische Niereninsuffizienz bei alter Menschen in Europa", "en": "Screening for Chronic Kidney Disease (CKD) among Older People across Europe (SCOPE)" }, "short": "SCOPE_Horizon", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-03-01T01:00:00+01:00", "begin_effective": "2015-05-01T02:00:00+02:00", "end_planned": "2020-02-28T01:00:00+01:00", "end_effective": "2021-08-05T02:00:00+02:00", "assignment": "2015-08-10T13:23:05+02:00", "program": 109, "subprogram": "Horizon 2020- PHC 6- two step, step 2", "organization": 14084, "category": 10, "type": 10, "partner_function": 2, "manager": 51739, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "634869", "ethics_committee": null, "edudract_number": null, "persons": [ "4073-51739-10", "4073-51745-11", "4073-99741-12", "4073-100384-12" ] }, { "id": 4773, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" - Koordination (2. Förderperiode)", "en": "DK \"Molecular Fundamentals of Inflammation\" - Koordination (2. funding periode)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-03-01T01:00:00+01:00", "begin_effective": "2016-03-01T01:00:00+01:00", "end_planned": "2020-02-29T01:00:00+01:00", "end_effective": "2021-06-30T02:00:00+02:00", "assignment": "2017-01-01T13:19:09+01:00", "program": 66, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 1, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "4773-51756-10" ] }, { "id": 5723, "title": { "de": "Einfluss des Exposoms auf das humane Hautmikrobiom", "en": "Impact of the exposome on the human skin microbiome" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-03-01T01:00:00+01:00", "begin_effective": "2019-03-01T01:00:00+01:00", "end_planned": "2020-02-29T01:00:00+01:00", "end_effective": "2021-02-28T01:00:00+01:00", "assignment": "2019-03-07T13:25:39+01:00", "program": null, "subprogram": null, "organization": 14023, "category": 10, "type": 10, "partner_function": 4, "manager": 90021, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5723-90021-10" ] }, { "id": 4865, "title": { "de": "Kalziumdomäne in Orai1 reguliert NFAT abhängige Gene", "en": "Calcium domain in Orai1 regulates NFAT dependent genes" }, "short": null, "url": null, "abstract": { "de": "Kalziumdomäne in Orai1 reguliert Gene im Immunsystem\r\nKalzium steuert das Immunsystem vielseitig, etwa indem es spezielle Gene aktiviert. Diese Gen-regulation führt zur raschen Teilung von Immunzellen oder zur Abwehr eindringender Bakterien. Für diese zellulären Prozesse strömt Kalzium über eine Pore, den sogenannte Ionenkanal Orai1, in die Immunzelle ein. Orai1 wirkt somit wie ein Schalter, den die Immunzelle entweder oszillatorisch oder langanhaltend öffnen kann. Mutationen in Orai1 können zu schweren Immunkrankheiten führen. In diesem Projekt möchten Dr. Rainer Schindl und seine Mitarbeiter herausfinden, wie die Genregulation der Immunzellen durch molekulare Strukturen des Kalziumtransports gesteuert wird. In Vorexperimenten konnten wir bereits mit Supercomputern eine Bindung von Kalzium an den Ionenkanal Orai1 simulieren. Unsere Hypothese ist, dass diese Kalzium Bindedomäne den Kalzium Einstrom reguliert, und für die Genregulation von entscheidender Bedeutung ist. Zur experimentellen Untersuchung wird die Kalzium Bindestruktur genetisch verändert und mit dem ursprünglichen Orai1 Ionenkanal verglichen. Sowohl der Einstrom von Kalzium in die Zelle, die Aktivierung von Genen als auch die anschließende Produktion von Proteinen werden gemessen. Diese Methoden erlauben es eine mechanistische Verbindung von molekularen Orai1 Strukturen über Kalzium Transportwege bis hin zur Produktion von Proteinen herzustellen. Die Charakterisierung der Kalzium Bindestruktur im Orai1 Kanal verspricht fundamental neue Erkenntnisse über den Kalziumtransport in die Immunzelle. Die Regulation des Kalzium Einstroms wird klären wie Gene effizient aktiviert werden können.\r\n", "en": "Calcium domain in Orai1 regulates genes in the immune system\r\nCalcium is a main trigger for the immune system due to its regulation of gene expression. This signaling process controls both the proliferation of immune cells and the defense against bacteria. To mediate these cellular processes, calcium influx occurs via special pores, termed the Orai1 ion channel. Orai1 acts like a trigger that can be oscillatory or sustained opened by an immune cell. Mutations within Orai1 can result in severe immune diseases. Within this project, Dr. Rainer Schindl and his team aim to resolve which molecular structures are required for the calcium transport into immune cells and subsequent gene regulation. In preliminary experiments, we used super computers to simulate the binding of calcium with the ion channel Orai1. We hypothesize that this calcium binding domain is crucial for gene regulation. Hence the calcium binding structure will be genetically modified and compared experimentally with the function of the original Orai1 ion channel. We will record the influx of calcium into the cell, the activation of genes and the production of proteins. These methods allow to mechanistically link the molecular Orai1 structures, with calcium transport pathways and the production of proteins. The characterization of Orai1 calcium binding structure aims to provide fundamental insight into calcium transport in immune cells. Regulation of calcium influx will determine how genes are activated efficiently. \r\n" }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2020-02-29T01:00:00+01:00", "end_effective": "2021-03-31T02:00:00+02:00", "assignment": "2017-03-02T14:37:06+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 98848, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 28701", "ethics_committee": null, "edudract_number": null, "persons": [ "4865-98848-10" ] }, { "id": 5600, "title": { "de": "Effekte der humanen Stammzellentherapie an einem personalisiertem Mausmodel der rheumatoiden Arthritis", "en": "Effects of human stem cell therapy on a personalized model of rheumatoid arthritis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-03-01T01:00:00+01:00", "begin_effective": "2019-03-01T01:00:00+01:00", "end_planned": "2020-03-01T01:00:00+01:00", "end_effective": "2022-12-31T01:00:00+01:00", "assignment": "2018-12-19T15:14:13+01:00", "program": null, "subprogram": null, "organization": 14086, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 87 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 7148, "title": { "de": "OeAD Marietta Blau", "en": "OeAD Marietta Blau" }, "short": "OeAD Marietta Blau", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-05-01T02:00:00+02:00", "begin_effective": "2019-05-01T02:00:00+02:00", "end_planned": "2020-03-30T02:00:00+02:00", "end_effective": "2020-03-30T02:00:00+02:00", "assignment": "2022-08-26T11:04:36+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 89664, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 20 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7148-89664-10" ] }, { "id": 4385, "title": { "de": "Exzellenzzentrum für superauflösende Mikroskopie und zelluläre\r\nUltrastrukturforschung", "en": "Exzellenzzentrum für superauflösende Mikroskopie und zelluläre\r\nUltrastrukturforschung" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2013-11-01T01:00:00+01:00", "begin_effective": "2013-11-01T01:00:00+01:00", "end_planned": "2020-03-30T02:00:00+02:00", "end_effective": "2020-03-30T02:00:00+02:00", "assignment": "2016-04-07T16:32:08+02:00", "program": null, "subprogram": "HRSM 2013", "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": 51860, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4385-51860-10" ] }, { "id": 4896, "title": { "de": "Zerebrale Sauerstoffsättigung zur Steuerung der Versorgung", "en": "Cerebral tissue Oxygen Saturation to Guide Oxygen Delivery \r\nin preterm neonates during immediate transition after birth\r\n" }, "short": "COSGOD III", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2022-02-28T01:00:00+01:00", "assignment": "2017-03-23T15:27:42+01:00", "program": 108, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 3, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI615", "ethics_committee": null, "edudract_number": null, "persons": [ "4896-50907-10" ] }, { "id": 5560, "title": { "de": "Prototypische Entwicklung und klinische Testung eines innovativen eHealth Systems zur umfassenden Qualitätssicherung und Therapieunterstützung in Einrichtungen der Akutgeriatrie und Remobilisation", "en": "Prototypical development and clinical testing of an innovative eHealth system for comprehensive quality assurance and therapy support in acute geriatrics and remobilization facilities" }, "short": "CDS-BARS", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2018-11-30T09:25:34+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 65558, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5560-54235-12", "5560-65558-10" ] }, { "id": 4897, "title": { "de": "Multiskale biomechanische Untersuchung und Materialmodellierung von gesunden und erkrankten Arterien", "en": "Multiscale biomechanical investigation and material modeling\r\nof healthy and diseased human arteries" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2021-09-21T02:00:00+02:00", "assignment": "2017-03-23T15:31:39+01:00", "program": 64, "subprogram": "Nationaler Forschungspartner", "organization": 25164, "category": 10, "type": 10, "partner_function": 2, "manager": 58881, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P30260", "ethics_committee": null, "edudract_number": null, "persons": [ "4897-58881-10" ] }, { "id": 5743, "title": { "de": "PEPCK als möglicher Angriffspunkt bei Lungenkrebs", "en": "PEPCK as possible therapeutic target in lung cancer" }, "short": "PEPCK in lung cancer", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-04-01T02:00:00+02:00", "begin_effective": "2019-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2019-03-25T12:51:12+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-07", "ethics_committee": null, "edudract_number": null, "persons": [ "5743-57557-10" ] }, { "id": 4769, "title": { "de": "Strukturelle und funktionelle Konnektivität bei zerebraler Kleingefäßerkrankung:\r\nMechanistische Erkenntnisse von vererbten und sporadischen Fällen", "en": "Structural and functional connectivity in cerebral small vessel\r\ndisease: Mechanistic insights from inherited and sporadic cases" }, "short": "Connectivity in cerebral microangiopathy", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2021-09-30T02:00:00+02:00", "assignment": "2017-01-12T11:05:22+01:00", "program": 64, "subprogram": "DACH", "organization": 14051, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I2889", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5720, "title": { "de": "Entwicklung eines leberschützenden Präkonditionierungscocktails", "en": "Development of a liver protective preconditioning cocktail" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-04-01T02:00:00+02:00", "begin_effective": "2019-04-01T02:00:00+02:00", "end_planned": "2020-04-01T02:00:00+02:00", "end_effective": "2024-12-31T01:00:00+01:00", "assignment": "2019-03-04T10:26:22+01:00", "program": null, "subprogram": null, "organization": 14073, "category": 10, "type": 10, "partner_function": 4, "manager": 50144, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-37", "ethics_committee": null, "edudract_number": null, "persons": [ "5720-50144-10" ] }, { "id": 5428, "title": { "de": "Endo/lysosomale Beweglichkeit & Funktion in Leber -Physiologie und -Pathology", "en": "Endo/lysosome motility & function in liver physiology and liver pathology" }, "short": "“Wissenschaftspreis der ÖGGH”", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-04-01T02:00:00+02:00", "end_effective": "2022-03-31T02:00:00+02:00", "assignment": "2018-08-03T17:24:25+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 57596, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 203 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5428-57596-10", "5428-113189-12", "5428-123430-12" ] }, { "id": 5439, "title": { "de": "Extrazelluläre Vesikel & Kommunikation in Chordom-Zelllinien", "en": "Extracellular Vesicles & Communication in Chordoma Cell Lines" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-04-01T02:00:00+02:00", "end_effective": "2020-04-01T02:00:00+02:00", "assignment": "2018-08-09T12:13:32+02:00", "program": null, "subprogram": null, "organization": 27477, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 30, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5761, "title": { "de": "Funktion von elFs und PI3K/AKT/mTOR Siganlkaskade in der Entstehung von Psoriasis", "en": "Function of eIFs and PI3K/ AKT/ mTOR pathway in the development of psoriasis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-04-01T02:00:00+02:00", "begin_effective": "2019-04-01T02:00:00+02:00", "end_planned": "2020-04-02T02:00:00+02:00", "end_effective": "2020-03-31T02:00:00+02:00", "assignment": "2019-04-10T13:13:30+02:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 84167, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5761-84167-10" ] }, { "id": 5738, "title": { "de": "Expressionsmanipulation von osteoporose-assoziierter microRNAs in humanen Osteoblasten", "en": "Expression manipulation of osteoporosis-associated microRNAs in human MSC-derived osteoblasts " }, "short": "Neue Biomarker für die Osteoporose", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-05-01T02:00:00+02:00", "begin_effective": "2019-05-01T02:00:00+02:00", "end_planned": "2020-04-30T02:00:00+02:00", "end_effective": "2026-03-31T02:00:00+02:00", "assignment": "2019-03-15T10:52:00+01:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50909, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-43", "ethics_committee": null, "edudract_number": null, "persons": [ "5738-50909-10" ] }, { "id": 5770, "title": { "de": "Transdisziplinäre und forschungsgeleitete Hochschullehre im Hochtechnologiebereich am Beispiel eines Mikro CTs - ein innovatives Konzept zur Stärkung des steirischen Hochschulraumes.", "en": "Transdisziplinäre und forschungsgeleitete Hochschullehre im Hochtechnologiebereich am Beispiel eines Mikro CTs - ein innovatives Konzept zur Stärkung des steirischen Hochschulraumes." }, "short": "Triple4Science", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-02-01T01:00:00+01:00", "begin_effective": "2019-02-01T01:00:00+01:00", "end_planned": "2020-04-30T02:00:00+02:00", "end_effective": "2020-07-31T02:00:00+02:00", "assignment": "2019-04-24T14:31:05+02:00", "program": null, "subprogram": null, "organization": 14054, "category": 10, "type": 10, "partner_function": 2, "manager": 57389, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 55 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5770-57389-10" ] } ] }