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GET /v1/research/project/?format=api&offset=1100&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1120&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1080&ordering=-end_effective", "results": [ { "id": 4511, "title": { "de": "Konstruktion und Charakterisierung autologer humaner Larynx-Mucosa Transplantate", "en": "Bioengineering and Characterization of Autologous Human Laryngeal Mucosa Transplants" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-08-01T02:00:00+02:00", "begin_effective": "2016-08-01T02:00:00+02:00", "end_planned": "2019-07-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2016-07-11T16:39:22+02:00", "program": 79, "subprogram": null, "organization": 14068, "category": 10, "type": 10, "partner_function": 4, "manager": 50670, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4511-50670-10", "4511-82902-12", "4511-88652-12", "4511-58794-12", "4511-50826-12" ] }, { "id": 5387, "title": { "de": "Motivation von Trainingsaktivitäten für Menschen mit Demenz mit Sozial Robotik und Dialog-gestütztem Coaching", "en": "Motivation of training activities for people with dementia with social robotics and dialogue-supported coaching" }, "short": "AMIGO", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-09-01T02:00:00+02:00", "begin_effective": "2017-11-01T01:00:00+01:00", "end_planned": "2019-08-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2018-06-11T12:37:11+02:00", "program": null, "subprogram": "FFG benefit", "organization": 14509, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "865646", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 3264, "title": { "de": "Molekulare Mechanismen in der frühen Entwicklung von dendritischen Zellen", "en": "Regulatory mechanisms in early dendritic cell development" }, "short": null, "url": null, "abstract": { "de": null, "en": "Dendritic cells (DCs) are essential immune cells for antigen presentation and are responsible for the initiation of T-cell responses. With the exception of Langerhans cells, all subtypes of DCs are derived from bone marrow-resident hematopoietic stem cells (HSCs). DCs develop from HSCs via several specification steps and intermediate progenitor stages including common myeloid progenitor (CMP) and the monocyte/DC progenitor (MDPs) stages. \r\nThe transcription factor C/EBPa (CCAAT/enhancer binding protein alpha) is known to play an important role in early hematopoiesis. Mice with a homozygous deletion of the Cebpa gene have normal to elevated numbers of CMPs but completely lack granulocytic/monocytic progenitors (GMPs) and all subsequent granulocytic stages indicating that C/EBPa is essential for transition of early myeloid to late myeloid progenitors. Despite its critical role in early myeloid and hence DC progenitors little is known about C/EBPa in early DC development. \r\nPreliminary results from our lab using an inducible bone marrow-specific Cebpa knock-out mouse model (Mx1-Cre CebpaF/F) suggest that C/EBPa indeed has an important role in early DC development. Mice lacking Cebpa in the bone marrow display reduced numbers of both subtypes of conventional DCs (cDCs) in spleen, and even more prominent in lymph nodes and thymus, while plasmacytoid DCs are not affected. The fact that cDCs are formed albeit at reduced numbers indicates that C/EBPa is dispensable for cDC formation but is crucially involved in proliferation and/or inhibition of apoptosis in cDC precursors. In addition, it is currently not known whether cDCs formed in the absence of C/EBPa display full functional activity. Using gene expression profiling we have identified a number of C/EBPa target genes in early DC progenitors including other transcription factors, inflammatory cytokines, genes of the NF-kB-pathway, genes associated with DC maturation and distinct anti-apoptotic factors. Based on these results the aim of this project is to identify critical factors involved in differentiation, proliferation and/or inhibition of apoptosis in early DC progenitors affected by C/EBPa. To experimentally approach this goal we will use Mx1-Cre CebpaF/F experimental and Mx1-Cre Cebpawt/wt control mice and analyze DCs in spleen, lymph nodes and thymus for expression of various DC-specific surface antigens and - after isolation characterize their function. In addition, isolated FLT3+ myeloid progenitors of these mice will be stimulated with FLT3L and monitored in vitro for changes in gene expression and functionality at critical steps during DC formation. \r\n" }, "begin_planned": "2013-08-01T02:00:00+02:00", "begin_effective": "2013-08-01T02:00:00+02:00", "end_planned": "2015-07-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2013-05-08T09:53:08+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51911, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "3264-51911-10", "3264-103865-12" ] }, { "id": 4772, "title": { "de": "Doktoratskolleg \"Metabolische und kardiovaskuäre Erkrankungen\" (2. Förderperiode)", "en": "Doktoratskolleg \"Metabolic and cardiovascular disease\" (2. funding periode)" }, "short": "DK-MCD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2014-07-01T02:00:00+02:00", "begin_effective": "2014-07-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2017-01-01T12:25:51+01:00", "program": 66, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 3, "manager": 51691, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4772-50903-12", "4772-57409-12", "4772-81132-12", "4772-51691-10", "4772-105381-12", "4772-104723-12", "4772-101162-12" ] }, { "id": 4709, "title": { "de": "DNA-seq Biomarker-Identifikation in Subgruppen von Stadium II Kolon-Adenokarzinomen", "en": "DNA-seq biomarker identification in subgroups of stage II colon adenocarcinoma" }, "short": "BmarkerCOAD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-03-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2016-11-29T12:41:23+01:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 51684, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1019 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4709-51684-10" ] }, { "id": 6038, "title": { "de": "Biomarker Veränderungen zeigen PAH Progression und Therapieantwort", "en": "Changes in blood derived biomarkers reflect PAH progression and response to targeted therapy" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-01-01T01:00:00+01:00", "begin_effective": "2020-01-01T01:00:00+01:00", "end_planned": "2020-06-30T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2020-02-03T14:57:40+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 87980, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2396 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6038-87980-10" ] }, { "id": 5810, "title": { "de": "Pilotstudie: Immunologische und mikrobielle Besonderheiten bei chronisch Schmerzkranken mit Fibromyalgie-Syndrom", "en": "Pilot study: Immunological and microbial features of patients suffering from chronic pain due to Fibromyalgia-Syndrome" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-11-01T01:00:00+01:00", "begin_effective": "2019-06-01T02:00:00+02:00", "end_planned": "2019-12-01T01:00:00+01:00", "end_effective": "2020-05-31T02:00:00+02:00", "assignment": "2019-05-27T17:16:28+02:00", "program": null, "subprogram": null, "organization": 14070, "category": 10, "type": 10, "partner_function": 4, "manager": 86560, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5810-57386-12", "5810-86560-10" ] }, { "id": 4348, "title": { "de": "Longitudinale Suszeptibilitätskartierung (QSM) bei Alzheimer", "en": "Longitudinal Susceptibility Mapping (QSM) in Alzheimer ’s Disease" }, "short": "QSM in AD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-01-01T01:00:00+01:00", "begin_effective": "2016-01-01T01:00:00+01:00", "end_planned": "2019-01-01T01:00:00+01:00", "end_effective": "2020-05-31T02:00:00+02:00", "assignment": "2016-03-07T14:19:04+01:00", "program": 108, "subprogram": null, "organization": 14051, "category": 10, "type": 10, "partner_function": 4, "manager": 60116, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI 523", "ethics_committee": null, "edudract_number": null, "persons": [ "4348-60116-10" ] }, { "id": 4187, "title": { "de": "Coordinated Research Infrastructures Building Enduring Life-science Services", "en": "Coordinated Research Infrastructures Building Enduring Life-science Services" }, "short": "CORBEL_Horizon2020", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-09-01T02:00:00+02:00", "begin_effective": "2015-09-01T02:00:00+02:00", "end_planned": "2019-08-31T02:00:00+02:00", "end_effective": "2020-05-31T02:00:00+02:00", "assignment": "2015-12-10T11:21:07+01:00", "program": 109, "subprogram": "INFRADEV-4-2014-2015", "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "654248", "ethics_committee": null, "edudract_number": null, "persons": [ "4187-51663-10" ] }, { "id": 4523, "title": { "de": "p53 in der hepatischen, differenziellen Stressantwort", "en": "p53 in hepatic differential stress response" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2016-09-01T02:00:00+02:00", "end_planned": "2017-06-30T02:00:00+02:00", "end_effective": "2020-05-31T02:00:00+02:00", "assignment": "2016-07-15T15:03:23+02:00", "program": 72, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 89979, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P29328", "ethics_committee": null, "edudract_number": null, "persons": [ "4523-89979-10" ] }, { "id": 5963, "title": { "de": "Programmierung der Funktion von endothelialen Vorläuferzellen durch mütterlichen Metabolismus und Einfluss des fetalen Geschlechts ", "en": "Programming the function of fetal endothelial progenitor cells by maternal metabolism and influences of fetal sex" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-02-10T01:00:00+01:00", "begin_effective": "2020-02-10T01:00:00+01:00", "end_planned": "2020-05-24T02:00:00+02:00", "end_effective": "2020-05-24T02:00:00+02:00", "assignment": "2019-11-20T09:12:39+01:00", "program": null, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 100010, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 431 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5963-100010-10" ] }, { "id": 4940, "title": { "de": "Double hit und double expressor Lymphome - Eine Entität oder nicht?", "en": "Double hit and double expressor lymphoma – Same but different?" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-05-01T02:00:00+02:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2017-12-31T01:00:00+01:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2017-05-02T16:31:20+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 51930, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4940-51930-10" ] }, { "id": 4594, "title": { "de": "DK \"Molecular Fundamentals of Inflamation\" (2. Förderperiode)", "en": "DK \"Molecular Fundamentals of Inflamation\" (2. funding period)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2016-05-01T02:00:00+02:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2016-09-06T10:45:26+02:00", "program": 66, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 51529, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "4594-71386-12", "4594-77692-12", "4594-96374-12", "4594-51529-10" ] }, { "id": 5364, "title": { "de": "Genetische Aberration und NR4A1-Expressionsverlust in aggressiven Lymphomen", "en": "Identifying the genetic event for NR4A1 downregulation\r\nin aggressive lymphomas" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-05-01T02:00:00+02:00", "begin_effective": "2018-05-01T02:00:00+02:00", "end_planned": "2020-04-30T02:00:00+02:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2018-05-16T10:36:08+02:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 59183, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5364-100134-12", "5364-59183-10", "5364-65239-12", "5364-51930-12", "5364-107832-12" ] }, { "id": 5469, "title": { "de": "Offene Innovation zur Potentialbewertung für Virtuelles Achtsamkeitstraining und Imagination für Menschen mit Demenz", "en": "Open innovation for evaluating the potential of virtual mindfulness training and imagination for people with dementia" }, "short": "OpenSense", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-04-01T02:00:00+02:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2018-09-05T12:12:03+02:00", "program": null, "subprogram": "benefit-FFG", "organization": 14509, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "868218", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 7240, "title": { "de": "Endovaskuläre Trophoblasteninvasion von Plazentazotten im 3D Organmodell", "en": "Endovascular trophoblast invasion of placental villi in a 3D organ model" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-05-01T02:00:00+02:00", "end_planned": "2019-07-01T02:00:00+02:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2022-10-31T16:31:57+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 97931, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 530 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "7240-97931-10" ] }, { "id": 5873, "title": { "de": "Beobachtung der Beatmungsvolumina unter Thoraxkompression an der Thiel’schen Leiche", "en": "Observation of Tidalvolumes in a Thiel's Cadaver Model for Cardiopulmonary Resusctiation" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-04-01T02:00:00+02:00", "begin_effective": "2019-08-01T02:00:00+02:00", "end_planned": "2019-08-30T02:00:00+02:00", "end_effective": "2020-04-30T02:00:00+02:00", "assignment": "2019-07-31T11:27:37+02:00", "program": null, "subprogram": null, "organization": 14069, "category": 10, "type": 10, "partner_function": 4, "manager": 74176, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1330 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5873-74176-10" ] }, { "id": 5439, "title": { "de": "Extrazelluläre Vesikel & Kommunikation in Chordom-Zelllinien", "en": "Extracellular Vesicles & Communication in Chordoma Cell Lines" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-04-01T02:00:00+02:00", "end_effective": "2020-04-01T02:00:00+02:00", "assignment": "2018-08-09T12:13:32+02:00", "program": null, "subprogram": null, "organization": 27477, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 30, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4764, "title": { "de": "Bedeutung von microRNAs in Chemotherapie-resistenten hypoxischen Lungenadenokarzinomen", "en": "RELEVANCE OF MicroRNAs IN CHEMOTHERAPY-RESISTANT\r\nHYPOXIC LUNG ADENOCARCINOMA" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2020-03-31T02:00:00+02:00", "assignment": "2017-01-11T12:26:16+01:00", "program": 79, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 50610, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4764-50593-12", "4764-50610-10", "4764-81608-12", "4764-101018-12" ] }, { "id": 5761, "title": { "de": "Funktion von elFs und PI3K/AKT/mTOR Siganlkaskade in der Entstehung von Psoriasis", "en": "Function of eIFs and PI3K/ AKT/ mTOR pathway in the development of psoriasis" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-04-01T02:00:00+02:00", "begin_effective": "2019-04-01T02:00:00+02:00", "end_planned": "2020-04-02T02:00:00+02:00", "end_effective": "2020-03-31T02:00:00+02:00", "assignment": "2019-04-10T13:13:30+02:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": 84167, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5761-84167-10" ] } ] }