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GET /v1/research/project/?format=api&offset=1060&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1080&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1040&ordering=-end_effective", "results": [ { "id": 4782, "title": { "de": "Bild-basiertes Lernen für prädiktive personalisierte Modelle der Herzfunktion", "en": "Image-based Learning in Predictive Personalized Models of Total Heart Function" }, "short": "ILEARNHEART", "url": null, "abstract": { "de": "The heart is an electrically controlled mechanical pump, which drives blood flow from its cavities into the vascular system through deformation of its walls. Its function emerges from a bidirectional transduction of processes across multiple physical systems as well as spatial and temporal scales. This multiscale-multiphysics nature renders the heart an inherently challenging organ to study through reductionist approaches alone. This fundamental problem can be addressed by using biophysically detailed in silico models. Today in basic sciences such models are considered an indispensable element in any advanced physiology study as they offer the unique ability to mechanistically analyze cause-effect relationships at high spatio-temporal resolutions in the intact organ across scales and physics.\r\n\r\nDriven by recent advances in medical imaging and simulation technologies, a translational trend emerged which is geared towards evolving modeling into a clinical modality. In the clinic image-based analysis of the dynamics of electrophysiological activity, deformation and blood flow is of pivotal importance in the diagnostic assessment of cardiac function. Due to the sparse and noisy nature of medical image data computational analysis tools are essential for providing a more objective quantitative evaluation of a patient's condition. Moreover, relevant biomarkers cannot be measured directly and must be derived from images by computational analysis, a process which is often enriched by PDE models of the underlying physics. To further gain clinical traction such image-informed in silico models must be personalized for a given patient to provide clinically useful biomarkers, which can serve to indicate or stratify disease or allow for virtual testing of treatments and prediction of outcomes acutely and longitudinally. Personalization requires the conception of sophisticated data assimilation procedures to facilitate model adaptation to a patient's cardiac anatomy and function. Such data-model fusion techniques are highly non-trivial to devise for clinical electro-mechano-fluidic (EMF) models due to the large number of and the non-linear relation between model components that must be fit.\r\n\r\nThis project combines expertise in cardiac modeling and simulation, computational image analysis, learning - based data assimilation techniques and high performance computing algorithms to render feasible the development of robust and efficient data-model fusion framework for the image-based personalization of models of total heart function. The long term aim is the development of a clinical assist modality for the optimization and outcome prediction of valve (aortic/mitral) replacement therapies in the left heart. It is anticipated that such personalized EMF models will play an essential role in informing clinical decision making in future precision therapies. ", "en": "The heart is an electrically controlled mechanical pump, which drives blood flow from its cavities into the vascular system through deformation of its walls. Its function emerges from a bidirectional transduction of processes across multiple physical systems as well as spatial and temporal scales. This multiscale-multiphysics nature renders the heart an inherently challenging organ to study through reductionist approaches alone. This fundamental problem can be addressed by using biophysically detailed in silico models. Today in basic sciences such models are considered an indispensable element in any advanced physiology study as they offer the unique ability to mechanistically analyze cause-effect relationships at high spatio-temporal resolutions in the intact organ across scales and physics.\r\n\r\nDriven by recent advances in medical imaging and simulation technologies, a translational trend emerged which is geared towards evolving modeling into a clinical modality. In the clinic image-based analysis of the dynamics of electrophysiological activity, deformation and blood flow is of pivotal importance in the diagnostic assessment of cardiac function. Due to the sparse and noisy nature of medical image data computational analysis tools are essential for providing a more objective quantitative evaluation of a patient's condition. Moreover, relevant biomarkers cannot be measured directly and must be derived from images by computational analysis, a process which is often enriched by PDE models of the underlying physics. To further gain clinical traction such image-informed in silico models must be personalized for a given patient to provide clinically useful biomarkers, which can serve to indicate or stratify disease or allow for virtual testing of treatments and prediction of outcomes acutely and longitudinally. Personalization requires the conception of sophisticated data assimilation procedures to facilitate model adaptation to a patient's cardiac anatomy and function. Such data-model fusion techniques are highly non-trivial to devise for clinical electro-mechano-fluidic (EMF) models due to the large number of and the non-linear relation between model components that must be fit.\r\n\r\nThis project combines expertise in cardiac modeling and simulation, computational image analysis, learning - based data assimilation techniques and high performance computing algorithms to render feasible the development of robust and efficient data-model fusion framework for the image-based personalization of models of total heart function. The long term aim is the development of a clinical assist modality for the optimization and outcome prediction of valve (aortic/mitral) replacement therapies in the left heart. It is anticipated that such personalized EMF models will play an essential role in informing clinical decision making in future precision therapies. " }, "begin_planned": "2017-01-01T01:00:00+01:00", "begin_effective": "2017-01-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2017-01-02T13:42:53+01:00", "program": null, "subprogram": "BioTechMed Flagship Project", "organization": 14011, "category": 10, "type": 10, "partner_function": 3, "manager": 50966, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4782-50966-10", "4782-96212-12", "4782-98304-12" ] }, { "id": 4598, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" (2. Förderperiode)", "en": "DK \"Molecular Fundamentals of Inflammation\" (2. Förderperiode)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2016-10-01T02:00:00+02:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-12-02T01:00:00+01:00", "assignment": "2016-09-06T11:58:59+02:00", "program": 66, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 53252, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "4598-53252-10" ] }, { "id": 4596, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" (2. funding period)", "en": "DK \"Molecular Fundamentals of Inflammation\" (2. Förderperiode)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2016-10-01T02:00:00+02:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-12-02T01:00:00+01:00", "assignment": "2016-09-06T10:53:17+02:00", "program": 66, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 50496, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "4596-50496-10", "4596-91349-12", "4596-91390-12", "4596-99824-12", "4596-99483-12", "4596-107131-12" ] }, { "id": 4603, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" (2. funding period)", "en": "DK \"Molecular Fundamentals of Inflammation\" (2. funding period)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-12-01T01:00:00+01:00", "assignment": "2016-09-06T12:09:49+02:00", "program": 66, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 2, "manager": 51618, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4603-54011-12", "4603-83662-12", "4603-84167-12", "4603-88082-12", "4603-98990-12", "4603-51618-10", "4603-100552-12", "4603-107955-12" ] }, { "id": 4602, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" (2. Förderperiode)", "en": "DK \"Molecular Fundamentals of Inflammation (2. funding period)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2016-10-01T02:00:00+02:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-12-01T01:00:00+01:00", "assignment": "2016-09-06T12:07:45+02:00", "program": 66, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 2, "manager": 79192, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "4602-79192-10" ] }, { "id": 4599, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" (2. Förderperiode)", "en": "DK \"Molecular Fundamentals of Inflammation\" (2nd funding period)" }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2016-09-05T02:00:00+02:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-12-01T01:00:00+01:00", "assignment": "2016-09-06T12:01:47+02:00", "program": 66, "subprogram": null, "organization": 14084, "category": 10, "type": 10, "partner_function": 2, "manager": 74174, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4599-74174-10", "4599-75657-12", "4599-86588-12" ] }, { "id": 5903, "title": { "de": "Augmented Reality Assistenz-Technologien im Kontext der Pflege-Services für Menschen mit Demenz im Häuslichen Umfeld", "en": "Augmented reality assistance technologies in the context of care services for people with dementia in the home care" }, "short": "AR-Demenz", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-09-01T02:00:00+02:00", "begin_effective": "2019-09-01T02:00:00+02:00", "end_planned": "2020-08-31T02:00:00+02:00", "end_effective": "2020-11-30T01:00:00+01:00", "assignment": "2019-09-05T13:01:13+02:00", "program": null, "subprogram": null, "organization": 14509, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5567, "title": { "de": "Entschluesselung des komplizierten Interaktionsnetzwerkes im β-Catenin Destruktion Komplex - Das Axin-1 Paradigma", "en": "Deciphering the Intricate Interaction Network in the β-Catenin Destruktion Complex - The Axin-1 Paradigm" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-12-01T01:00:00+01:00", "begin_effective": "2018-12-01T01:00:00+01:00", "end_planned": "2020-11-30T01:00:00+01:00", "end_effective": "2020-11-30T01:00:00+01:00", "assignment": "2018-12-05T10:51:12+01:00", "program": null, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5871, "title": { "de": "Analyse von genetischen und Umweltfaktoren bei der Entstehung von Aggression mit Hilfe von Zebrafischen", "en": "Analysis of the genetic and environmental basis of aggression using zebrafish" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-09-01T02:00:00+02:00", "begin_effective": "2019-09-16T02:00:00+02:00", "end_planned": "2020-09-01T02:00:00+02:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2019-07-30T14:55:13+02:00", "program": 69, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": 71386, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "J4090", "ethics_committee": null, "edudract_number": null, "persons": [ "5871-71386-10" ] }, { "id": 5550, "title": { "de": "Humanisierte Xenotransplantationsmodelle zur Optimierung der Therapie von akuter myeloischer Leukämie. ", "en": "Humanized xenotransplantation models of acute myeloid leukemia to predict patient outcome and direct therapy." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-11-01T01:00:00+01:00", "begin_effective": "2018-11-01T01:00:00+01:00", "end_planned": "2020-10-31T01:00:00+01:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2018-11-15T14:47:34+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 50747, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1375 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5550-50747-10" ] }, { "id": 6100, "title": { "de": "In-vitro Verifikation von Virus-Inhibitoren", "en": "In-vitro verification of virus inhibitors" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2020-03-16T01:00:00+01:00", "begin_effective": "2020-04-01T02:00:00+02:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2020-03-16T13:55:16+01:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 51663, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-50", "ethics_committee": null, "edudract_number": null, "persons": [ "6100-51663-10" ] }, { "id": 5927, "title": { "de": "Maßnahmen zur \r\nAttraktivierung der Allgemeinmedizin \r\n", "en": "Maßnahmen zur \r\nAttraktivierung der Allgemeinmedizin \r\n" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-11-01T01:00:00+01:00", "begin_effective": "2019-11-01T01:00:00+01:00", "end_planned": "2020-10-31T01:00:00+01:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2019-10-16T10:46:08+02:00", "program": null, "subprogram": null, "organization": 27964, "category": 10, "type": 10, "partner_function": 4, "manager": 51098, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2160 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5927-51098-10" ] }, { "id": 4848, "title": { "de": "Sarkopenie und physische Gebrechlichkeit bei alten Menschen: \r\nEine multidimensionale Behandlungsstrategie", "en": "Sarcopenia and Physical fRailty IN older people:\r\nmulti-componenT Treatment strategies " }, "short": "SPRINTT_IMI_FP7", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-07-15T02:00:00+02:00", "begin_effective": "2016-07-01T02:00:00+02:00", "end_planned": "2018-10-30T01:00:00+01:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2017-02-21T11:10:59+01:00", "program": null, "subprogram": "IMI", "organization": 14046, "category": 10, "type": 10, "partner_function": 2, "manager": 51745, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "115621", "ethics_committee": null, "edudract_number": null, "persons": [ "4848-51745-10", "4848-99239-12" ] }, { "id": 5922, "title": { "de": "Frontier NMR", "en": "Frontier NMR" }, "short": "Frontier NMR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-03-01T01:00:00+01:00", "begin_effective": "2019-05-01T02:00:00+02:00", "end_planned": "2020-08-30T02:00:00+02:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2019-10-02T11:04:16+02:00", "program": null, "subprogram": null, "organization": 14012, "category": 10, "type": 10, "partner_function": 2, "manager": 91207, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 55 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5922-91207-10" ] }, { "id": 4664, "title": { "de": "Stoffwechsel-basierte Therapie gegen diastolische Herzinsuffizienz", "en": "Metabolic Therapy for Managing Diastolic Heart Failure" }, "short": "MINOTAUR", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2020-01-31T01:00:00+01:00", "end_effective": "2020-10-31T01:00:00+01:00", "assignment": "2016-10-19T15:00:07+02:00", "program": 64, "subprogram": "ERA-Net", "organization": 14083, "category": 10, "type": 10, "partner_function": 3, "manager": 60041, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I3301", "ethics_committee": null, "edudract_number": null, "persons": [ "4664-60041-10", "4664-59941-12", "4664-94512-12", "4664-107389-12" ] }, { "id": 4595, "title": { "de": "DK \"Molecular Fundamentals of Inflammation\" (2. Förderperiode) ", "en": "DK \"Molecular Fundamentals of Inflammation\" (2. funding period) " }, "short": "DK-MOLIN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2016-10-01T02:00:00+02:00", "begin_effective": "2016-10-01T02:00:00+02:00", "end_planned": "2020-09-30T02:00:00+02:00", "end_effective": "2020-10-02T02:00:00+02:00", "assignment": "2016-09-06T10:49:37+02:00", "program": 66, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 2, "manager": 51756, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "W1241", "ethics_committee": null, "edudract_number": null, "persons": [ "4595-51756-10" ] }, { "id": 4194, "title": { "de": "PCK2 in Lungentumoren: Rolle für Metabolismus und Wachstum", "en": "The role of PCK2 in lung cancer metabolism and growth" }, "short": "PCK2 in Lungentumoren", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2015-11-01T01:00:00+01:00", "begin_effective": "2016-02-01T01:00:00+01:00", "end_planned": "2018-10-31T01:00:00+01:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2015-12-15T11:22:27+01:00", "program": 72, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P28692", "ethics_committee": null, "edudract_number": null, "persons": [ "4194-58591-12", "4194-71794-12", "4194-81608-12", "4194-105621-12", "4194-57557-10" ] }, { "id": 5527, "title": { "de": "Modellierung des BAP1 Tumor Prädispositions Syndroms unter Verwendung von iPSC generierten Melanozyten zur Untersuchung der frühen genetischen und epigenetischen Stufen der Melanomentstehung ", "en": "Modelling the BAP1 Tumor predisposition syndrome using iPSC-derived melanocytes to investigate the early genetic and epigenetic steps of melanoma development" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2018-10-01T02:00:00+02:00", "begin_effective": "2018-10-01T02:00:00+02:00", "end_planned": "2020-10-01T02:00:00+02:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2018-10-23T16:24:21+02:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 894 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5511, "title": { "de": "Folgen negativer Arbeitsbedingungen für die Gesundheit im späteren Leben: Geschlechterunterschiede\r\n", "en": "Effects of negative working conditions on health in later life: Gender differences " }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-01-01T01:00:00+01:00", "begin_effective": "2019-01-01T01:00:00+01:00", "end_planned": "2020-06-30T02:00:00+02:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2018-10-09T17:42:43+02:00", "program": 79, "subprogram": null, "organization": 14024, "category": 10, "type": 10, "partner_function": 4, "manager": 51845, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": "17888", "ethics_committee": null, "edudract_number": null, "persons": [ "5511-51845-10" ] }, { "id": 5743, "title": { "de": "PEPCK als möglicher Angriffspunkt bei Lungenkrebs", "en": "PEPCK as possible therapeutic target in lung cancer" }, "short": "PEPCK in lung cancer", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2019-04-01T02:00:00+02:00", "begin_effective": "2019-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2020-09-30T02:00:00+02:00", "assignment": "2019-03-25T12:51:12+01:00", "program": null, "subprogram": null, "organization": 14087, "category": 10, "type": 10, "partner_function": 4, "manager": 57557, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-07", "ethics_committee": null, "edudract_number": null, "persons": [ "5743-57557-10" ] } ] }