List projects.

Fields

id (integer)

Primary key.

Expansions

To activate relation expansion add the desired fields as a comma separated list to the expand query parameter like this:

?expand=<field>,<field>,<field>,...

The following relational fields can be expanded:

  • organization
  • category
  • type
  • partner_function
  • manager
  • contact
  • status
  • grant
  • research
  • event
  • study
  • language
  • program
  • funders

Filters

To filter for exact value matches:

?<fieldname>=<value>

Possible exact filters:

  • organization
  • category
  • manager
  • contact
  • status
  • grant
  • research
  • study
  • language
  • funders
  • program

For advanced filtering use lookups:

?<fieldname>__<lookup>=<value>

All fields with advanced lookups can also be used for exact value matches as described above.

Possible advanced lookups:

  • begin_planned: gt, gte, lt, lte
  • begin_effective: gt, gte, lt, lte
  • end_planned: gt, gte, lt, lte
  • end_effective: gt, gte, lt, lte
GET /v1/research/project/?format=api&offset=1020&ordering=end_effective
HTTP 200 OK
  Allow: GET, HEAD, OPTIONS
  Content-Type: application/json
  Vary: Accept
  
  {
    "count": 2265,
    "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1040&ordering=end_effective",
    "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1000&ordering=end_effective",
    "results": [
        {
            "id": 3377,
            "title": {
                "de": "Pathophysiologie und Behandlung von Cholemischer Nephropathie",
                "en": "Pathophysiology and Treatment of Cholemic Nephropathy"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-06-01T02:00:00+02:00",
            "begin_effective": "2013-06-01T02:00:00+02:00",
            "end_planned": "2016-05-31T02:00:00+02:00",
            "end_effective": "2018-09-30T02:00:00+02:00",
            "assignment": "2013-09-19T11:45:29+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14081,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 52938,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P25911",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3377-50626-12",
                "3377-54247-12",
                "3377-57377-12",
                "3377-57596-12",
                "3377-66436-12",
                "3377-66467-12",
                "3377-70622-12",
                "3377-87214-12",
                "3377-53167-12",
                "3377-52938-10"
            ]
        },
        {
            "id": 3830,
            "title": {
                "de": "Kurzfristige Auswirkung des statischen Dehnens auf neuromechnische Eigenschaften",
                "en": "Temporal effects of acute static stretching on neuromechanics of the muscle-tendon-unit"
            },
            "short": "STRETCH",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-07-01T02:00:00+02:00",
            "begin_effective": "2014-07-01T02:00:00+02:00",
            "end_planned": "2017-06-30T02:00:00+02:00",
            "end_effective": "2018-09-30T02:00:00+02:00",
            "assignment": "2014-12-04T11:28:45+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51814,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P27665 ",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3830-51814-10"
            ]
        },
        {
            "id": 3127,
            "title": {
                "de": "Überleben nach Vitamin D-Gabe bei Patienten mit Bronchus –oder Oesophaguskarzinom.",
                "en": "Survival after substitution of Vitamin-D in patients with lung cancer or oesophageal carcinoma. "
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-01-01T01:00:00+01:00",
            "begin_effective": "2013-01-01T01:00:00+01:00",
            "end_planned": "2016-12-31T01:00:00+01:00",
            "end_effective": "2018-09-30T02:00:00+02:00",
            "assignment": "2012-12-21T09:28:00+01:00",
            "program": 79,
            "subprogram": null,
            "organization": 14077,
            "category": 10,
            "type": 10,
            "partner_function": 1,
            "manager": 50145,
            "contact": 50145,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3127-50143-12",
                "3127-50145-10"
            ]
        },
        {
            "id": 4809,
            "title": {
                "de": "MCF-7 knock out von GIRK1",
                "en": "MCF-7 knock out of GIRK1"
            },
            "short": "Brustkrebsforschung",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-09-30T02:00:00+02:00",
            "assignment": "2017-02-07T15:31:52+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 80816,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1743
            ],
            "funder_projectcode": "MEFO-19",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4809-80816-10"
            ]
        },
        {
            "id": 5640,
            "title": {
                "de": "Liquid Biopsy mittels Apherese",
                "en": "Liquid biopsy by apheresis"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-10-02T02:00:00+02:00",
            "begin_effective": "2017-10-02T02:00:00+02:00",
            "end_planned": "2018-09-30T02:00:00+02:00",
            "end_effective": "2018-09-30T02:00:00+02:00",
            "assignment": "2019-01-24T14:25:18+01:00",
            "program": null,
            "subprogram": "ESMO Fellowship (European Society for Medical Oncology)",
            "organization": 14085,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 86226,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5640-86226-10"
            ]
        },
        {
            "id": 5174,
            "title": {
                "de": "Wird die Osteogenese in osteoporotischen Tiermodell durch Einsatz von Magnesiumimplantaten unterstützt?",
                "en": "Do magnesium implants support osteogenesis in an ovariectomy\r\ninduced osteoporotic animal model? "
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2018-01-01T01:00:00+01:00",
            "begin_effective": "2018-01-01T01:00:00+01:00",
            "end_planned": "2018-10-01T02:00:00+02:00",
            "end_effective": "2018-10-01T02:00:00+02:00",
            "assignment": "2017-12-20T11:03:06+01:00",
            "program": 103,
            "subprogram": "ÖGKM Projektpreis",
            "organization": 14052,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 98087,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1565
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5174-98087-10"
            ]
        },
        {
            "id": 4331,
            "title": {
                "de": "Mikrobiom interstitieller Pneumonien",
                "en": "Microbiome of interstitial Pneumonias"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-06-01T02:00:00+02:00",
            "begin_effective": "2016-06-01T02:00:00+02:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-10-08T02:00:00+02:00",
            "assignment": "2016-02-29T14:55:11+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": []
        },
        {
            "id": 3108,
            "title": {
                "de": "RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research",
                "en": "RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research"
            },
            "short": "RD-CONNECT",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-01-01T01:00:00+01:00",
            "begin_effective": "2012-11-01T01:00:00+01:00",
            "end_planned": "2018-12-31T01:00:00+01:00",
            "end_effective": "2018-10-31T01:00:00+01:00",
            "assignment": "2012-12-13T14:50:49+01:00",
            "program": 24,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51663,
            "contact": null,
            "status": 2,
            "research": 2,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "305444",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3108-51449-12",
                "3108-51663-10"
            ]
        },
        {
            "id": 4849,
            "title": {
                "de": "Assessing the Role of Circadian Alterations, Cardio-postrual Interactions and Vascular Changes in Cognitive Functional Decline",
                "en": "Assessing the Role of Circadian Alterations, Cardio-postrual Interactions and Vascular Changes in Cognitive Functional Decline"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-01-01T01:00:00+01:00",
            "begin_effective": "2017-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-10-31T01:00:00+01:00",
            "assignment": "2017-02-21T14:53:59+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14010,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 57932,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                15
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4849-57932-10"
            ]
        },
        {
            "id": 3713,
            "title": {
                "de": "Some like it hot: Female preferences based on male body temperature in acoustic insects.",
                "en": "Some like it hot: Female preferences based on male body temperature in acoustic insects."
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-06-01T02:00:00+02:00",
            "begin_effective": "2014-06-01T02:00:00+02:00",
            "end_planned": "2017-05-31T02:00:00+02:00",
            "end_effective": "2018-10-31T01:00:00+01:00",
            "assignment": "2014-07-17T13:10:14+02:00",
            "program": 72,
            "subprogram": "Nationaler Forschungspartner",
            "organization": 14017,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 50960,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P27145",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3713-50960-10"
            ]
        },
        {
            "id": 3794,
            "title": {
                "de": "Entwicklungsgrundlagen der Mediaverkalkung",
                "en": "Developmental Basis of Media Calcification"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2015-01-01T01:00:00+01:00",
            "begin_effective": "2015-01-01T01:00:00+01:00",
            "end_planned": "2017-12-31T01:00:00+01:00",
            "end_effective": "2018-10-31T01:00:00+01:00",
            "assignment": "2014-10-24T12:16:43+02:00",
            "program": 72,
            "subprogram": null,
            "organization": 14079,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 74175,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P 27537",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3794-74174-12",
                "3794-74175-10",
                "3794-75657-12",
                "3794-86124-12",
                "3794-86588-12"
            ]
        },
        {
            "id": 3414,
            "title": {
                "de": "Prospektive Validierung der genomischen Signaturen zur Erfassung der Chemosensitivität der axillären Lymphknoten nach neoadjuvanter Chemotherapie beim HER2 negativem Mammakarzinom",
                "en": "Prospective Validation of Genomic Signatures to Predict Treatment Response in the Axillary Nodes after Neoadjuvant Chemotherapy in Patients with HER2 Normal Breast Cancer"
            },
            "short": "GENOMISCHE SIGNATUREN",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-11-01T01:00:00+01:00",
            "begin_effective": "2013-11-01T01:00:00+01:00",
            "end_planned": "2016-11-01T01:00:00+01:00",
            "end_effective": "2018-11-30T01:00:00+01:00",
            "assignment": "2013-10-28T09:00:44+01:00",
            "program": 108,
            "subprogram": null,
            "organization": 14020,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 60413,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "KLI406",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3414-60413-10"
            ]
        },
        {
            "id": 3552,
            "title": {
                "de": "Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior",
                "en": "Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior"
            },
            "short": "MYNEWGUT",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-12-01T01:00:00+01:00",
            "begin_effective": "2013-12-01T01:00:00+01:00",
            "end_planned": "2018-11-30T01:00:00+01:00",
            "end_effective": "2018-11-30T01:00:00+01:00",
            "assignment": "2014-02-03T13:02:28+01:00",
            "program": 24,
            "subprogram": "KBBE.2013.2.2-02: Factors influencing the human gut\r\nmicrobiome and its effect on the development of diet-related diseases and brain development",
            "organization": 14022,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 51529,
            "contact": null,
            "status": 2,
            "research": 5,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                10
            ],
            "funder_projectcode": "613979",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3552-71386-12",
                "3552-71487-12",
                "3552-77692-12",
                "3552-51529-10"
            ]
        },
        {
            "id": 3803,
            "title": {
                "de": "CB1/CB2R-unabhängigen Signale durch Cannabinoids in Endothel ",
                "en": "CB1/CB2R-independent cannabinoid signaling in endothelium"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2013-10-01T02:00:00+02:00",
            "begin_effective": "2013-10-01T02:00:00+02:00",
            "end_planned": "2016-09-30T02:00:00+02:00",
            "end_effective": "2018-11-30T01:00:00+01:00",
            "assignment": "2014-11-06T16:11:55+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14013,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 60219,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P 27238",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3803-60219-10"
            ]
        },
        {
            "id": 3687,
            "title": {
                "de": "Saisonale Unterschiede im Nasenschleimproteom und Einfluss der Immuntherapie",
                "en": "Seasonal differences in nasal mucus proteome and impact of immunotherapy"
            },
            "short": "SeasDiffImmunotherapyNasalMucusProteome",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2014-05-01T02:00:00+02:00",
            "begin_effective": "2014-08-01T02:00:00+02:00",
            "end_planned": "2017-05-01T02:00:00+02:00",
            "end_effective": "2018-11-30T01:00:00+01:00",
            "assignment": "2014-06-23T10:40:56+02:00",
            "program": 108,
            "subprogram": null,
            "organization": 14066,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": null,
            "contact": null,
            "status": 2,
            "research": 4,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "KLI425",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "3687-58794-11",
                "3687-58794-12"
            ]
        },
        {
            "id": 5126,
            "title": {
                "de": "Der Einfluss des Neuroblastoms und dessen Chemotherapie auf die volatilen organischen Substanzen im Stuhl",
                "en": "Influence of Neuroblastoma and its Chemotherapy on volatile organic compounds."
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-09-01T02:00:00+02:00",
            "begin_effective": "2017-12-01T01:00:00+01:00",
            "end_planned": "2018-12-31T01:00:00+01:00",
            "end_effective": "2018-11-30T01:00:00+01:00",
            "assignment": "2017-11-16T09:30:48+01:00",
            "program": null,
            "subprogram": null,
            "organization": 14049,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50778,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5126-50778-10",
                "5126-54087-12",
                "5126-82670-12"
            ]
        },
        {
            "id": 4513,
            "title": {
                "de": "Einfluss pränataler Humanmilch Oligosaccharide auf feto-plazentare Angiogenese in Gestationsdiabetes",
                "en": "Prenatal Human Milk Oligosaccharides Alter Feto-placental Angiogenesis in Gestational Diabetes"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2016-08-01T02:00:00+02:00",
            "begin_effective": "2016-08-01T02:00:00+02:00",
            "end_planned": "2018-01-31T01:00:00+01:00",
            "end_effective": "2018-11-30T01:00:00+01:00",
            "assignment": "2016-07-11T16:42:14+02:00",
            "program": 79,
            "subprogram": null,
            "organization": 14038,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 88993,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                12
            ],
            "funder_projectcode": "16927",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4513-88993-10"
            ]
        },
        {
            "id": 5328,
            "title": {
                "de": "Das Mikrobiom der Harnblase bei Frühgeburtlichkeit – Eine Pilotstudie",
                "en": "The urine microbiome and preterm complications - a pilot study"
            },
            "short": "UMIC",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2018-05-01T02:00:00+02:00",
            "begin_effective": "2018-05-01T02:00:00+02:00",
            "end_planned": "2018-12-01T01:00:00+01:00",
            "end_effective": "2018-12-01T01:00:00+01:00",
            "assignment": "2018-04-05T17:30:45+02:00",
            "program": null,
            "subprogram": null,
            "organization": 14023,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 90021,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                457
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "5328-90021-10"
            ]
        },
        {
            "id": 4830,
            "title": {
                "de": "Neue therapeutische Agentien für die Kombinationstherapie von Chordomen",
                "en": "Novel therapeutic agents for chordoma combination treatment"
            },
            "short": "Chordom Kombinationstherapie",
            "url": null,
            "abstract": {
                "de": null,
                "en": null
            },
            "begin_planned": "2017-05-01T02:00:00+02:00",
            "begin_effective": "2017-05-01T02:00:00+02:00",
            "end_planned": "2018-12-31T01:00:00+01:00",
            "end_effective": "2018-12-31T01:00:00+01:00",
            "assignment": "2017-02-14T11:23:52+01:00",
            "program": null,
            "subprogram": "ISNK: Ingrid Shaker Nessmann Krebsforschungsvereinigung",
            "organization": 14052,
            "category": 10,
            "type": 10,
            "partner_function": 4,
            "manager": 50448,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                1765
            ],
            "funder_projectcode": null,
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4830-50448-10"
            ]
        },
        {
            "id": 4243,
            "title": {
                "de": "Synthese licht-aktiver Modulatoren/Marker von TRPC3/6-Kanälen",
                "en": "Synthesis of light-responsive modulators/labels of TRPC3/6-channels"
            },
            "short": null,
            "url": null,
            "abstract": {
                "de": null,
                "en": "Novel light-responsive modulators/labels of TRPC3/6-channels\r\nMammalian Transient Receptor Potential (TRP) channels include six related protein\r\nfamilies. Members of the human TRP Canonical (TRPC) subfamily\r\n(TRPC1/3/4/5/6/7), form channels that mediate Ca2+- and Na+-ion entry and are\r\nexpressed in many mammalian cell types to serve a broad-range of important\r\nphysiological processes. Recently, TRPC3/6 channels have been implicated in the\r\npathogenesis of cardiovascular disorders including heart failure, arrhythmias, and\r\nsudden death. Consequently, TRPC channels have emerged as highly promising\r\ntargets for drug development, while, at the same time, their exact cellular function and\r\nprinciples of pharmacologic modulation are still incompletely understood and require\r\nbetter understanding. For this, novel strategies to experimentally control channel\r\nfunction are urgently needed. These channels are endogenously controlled by plasma\r\nmembrane lipid metabolites, which are difficult to administer in most experimental\r\nsettings. Novel modulating or blocking ligands with potentially suitable selectivity for\r\nexact experimental control of TRPC3/6 channel have just recently been reported. One\r\nobjective of this proposal is therefore the synthesis of small modulators\r\n(inhibitors/activators) of TRPC3/6-channels that response to light, allowing the\r\ncontrol of biological events with unparalleled spatial and temporal precision – so\r\ncalled “photoswitches” (e.g. azobenzens). Taking advantage of our experience in the\r\nsynthesis of pyrazole-based inhibitors of TRPC3/6-channels and benzimidazolonebased\r\nactivators as well as our expertise in microwave and continuous-flow\r\nchemistry, we aim to generate and explore various photoswitchable ligands in\r\nconnection to the emerging pharmacology of TRPC3/6-channels. Another objective\r\nof ours, involving small photoresponsive molecules, is the synthesis of photoaffinity\r\nlabels to help in the elucidation of potential ligand-binding sites in the TRPC3/6-\r\nchannels as well as on the structure elucidation of TRPC3/6-channels.\r\nThe research proposed herein is meant to become a significant contribution to\r\na thrilling and rapidly growing field for optoregulation of biological functions in\r\nmammalian cells and for better understanding on the TRPC3/6-channel machinery. If\r\npositive results are obtained, the arising pharmacology will importantly aid\r\ninvestigations of the physiological and pathophysiological roles of TRPC channels,\r\nfacilitate the validation of TRPCs as potential therapeutic targets in different\r\nchannelopathies, and possibly provide foundations for drug discovery and\r\ndevelopment."
            },
            "begin_planned": "2015-05-01T02:00:00+02:00",
            "begin_effective": "2015-05-01T02:00:00+02:00",
            "end_planned": "2018-04-30T02:00:00+02:00",
            "end_effective": "2018-12-31T01:00:00+01:00",
            "assignment": "2016-01-22T13:09:43+01:00",
            "program": 72,
            "subprogram": null,
            "organization": 14011,
            "category": 10,
            "type": 10,
            "partner_function": 2,
            "manager": 78591,
            "contact": null,
            "status": 2,
            "research": 1,
            "grant": 10,
            "event": null,
            "study": null,
            "language": null,
            "funders": [
                9
            ],
            "funder_projectcode": "P 28243-B27   ",
            "ethics_committee": null,
            "edudract_number": null,
            "persons": [
                "4243-78591-10"
            ]
        }
    ]
}