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GET /v1/research/project/?format=api&offset=1020&ordering=begin_planned
{ "count": 2265, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1040&ordering=begin_planned", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=1000&ordering=begin_planned", "results": [ { "id": 4765, "title": { "de": "Nicht-Protein Kodierende RNA und deren klinische Relevanz in Bauchspeicheldrüsenkrebs ", "en": "Non-coding RNA networks and their role in pancreatic cancer patients" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-01T01:00:00+01:00", "begin_effective": "2017-02-01T01:00:00+01:00", "end_planned": "2020-01-31T01:00:00+01:00", "end_effective": "2020-01-31T01:00:00+01:00", "assignment": "2017-01-11T12:26:52+01:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 66005, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4765-66005-10" ] }, { "id": 6064, "title": { "de": "Das Aktin-Zytoskelett und der Transkriptionsfaktor NFkB und IkappaB als prädiktive Faktoren für Leberregeneration und die Entstehung von Leberzellcarcinomen nach Major-Resektionen. ", "en": "The actin cytoskeleton and transkriptionfactor NFkB as predictive factors for liver regeneration and hepatocellular carcinogenesis after hemihepatectomy." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-02-20T01:00:00+01:00", "begin_effective": "2017-02-20T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2020-02-21T11:45:20+01:00", "program": null, "subprogram": null, "organization": 14108, "category": 10, "type": 10, "partner_function": 2, "manager": 98605, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1170 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "6064-98605-10" ] }, { "id": 4858, "title": { "de": "Das Mikrobiom der Lunge im Kindesalter", "en": "The SPAM –Project \r\n(Studying the Paediatric Airway Microbiome)\r\nA Prospective Multicentric Clinical Study\r\n" }, "short": "SPAM", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2019-03-01T01:00:00+01:00", "end_effective": "2019-03-01T01:00:00+01:00", "assignment": "2017-02-28T09:34:51+01:00", "program": null, "subprogram": null, "organization": 14049, "category": 10, "type": 10, "partner_function": 4, "manager": 83445, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 550 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4858-83445-10" ] }, { "id": 4969, "title": { "de": "Einfluss von Haut- und Darmmikrobiom auf Wirkung und Nebenwirkungen der Immuntherapie beim fortgeschrittenem Melanom", "en": "Investigating microbiome-derived biomarkers of tumor response to checkpoint inhibitors in\r\nadvanced melanoma" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2019-12-31T01:00:00+01:00", "end_effective": "2024-04-30T02:00:00+02:00", "assignment": "2017-05-30T12:31:35+02:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1765 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4865, "title": { "de": "Kalziumdomäne in Orai1 reguliert NFAT abhängige Gene", "en": "Calcium domain in Orai1 regulates NFAT dependent genes" }, "short": null, "url": null, "abstract": { "de": "Kalziumdomäne in Orai1 reguliert Gene im Immunsystem\r\nKalzium steuert das Immunsystem vielseitig, etwa indem es spezielle Gene aktiviert. Diese Gen-regulation führt zur raschen Teilung von Immunzellen oder zur Abwehr eindringender Bakterien. Für diese zellulären Prozesse strömt Kalzium über eine Pore, den sogenannte Ionenkanal Orai1, in die Immunzelle ein. Orai1 wirkt somit wie ein Schalter, den die Immunzelle entweder oszillatorisch oder langanhaltend öffnen kann. Mutationen in Orai1 können zu schweren Immunkrankheiten führen. In diesem Projekt möchten Dr. Rainer Schindl und seine Mitarbeiter herausfinden, wie die Genregulation der Immunzellen durch molekulare Strukturen des Kalziumtransports gesteuert wird. In Vorexperimenten konnten wir bereits mit Supercomputern eine Bindung von Kalzium an den Ionenkanal Orai1 simulieren. Unsere Hypothese ist, dass diese Kalzium Bindedomäne den Kalzium Einstrom reguliert, und für die Genregulation von entscheidender Bedeutung ist. Zur experimentellen Untersuchung wird die Kalzium Bindestruktur genetisch verändert und mit dem ursprünglichen Orai1 Ionenkanal verglichen. Sowohl der Einstrom von Kalzium in die Zelle, die Aktivierung von Genen als auch die anschließende Produktion von Proteinen werden gemessen. Diese Methoden erlauben es eine mechanistische Verbindung von molekularen Orai1 Strukturen über Kalzium Transportwege bis hin zur Produktion von Proteinen herzustellen. Die Charakterisierung der Kalzium Bindestruktur im Orai1 Kanal verspricht fundamental neue Erkenntnisse über den Kalziumtransport in die Immunzelle. Die Regulation des Kalzium Einstroms wird klären wie Gene effizient aktiviert werden können.\r\n", "en": "Calcium domain in Orai1 regulates genes in the immune system\r\nCalcium is a main trigger for the immune system due to its regulation of gene expression. This signaling process controls both the proliferation of immune cells and the defense against bacteria. To mediate these cellular processes, calcium influx occurs via special pores, termed the Orai1 ion channel. Orai1 acts like a trigger that can be oscillatory or sustained opened by an immune cell. Mutations within Orai1 can result in severe immune diseases. Within this project, Dr. Rainer Schindl and his team aim to resolve which molecular structures are required for the calcium transport into immune cells and subsequent gene regulation. In preliminary experiments, we used super computers to simulate the binding of calcium with the ion channel Orai1. We hypothesize that this calcium binding domain is crucial for gene regulation. Hence the calcium binding structure will be genetically modified and compared experimentally with the function of the original Orai1 ion channel. We will record the influx of calcium into the cell, the activation of genes and the production of proteins. These methods allow to mechanistically link the molecular Orai1 structures, with calcium transport pathways and the production of proteins. The characterization of Orai1 calcium binding structure aims to provide fundamental insight into calcium transport in immune cells. Regulation of calcium influx will determine how genes are activated efficiently. \r\n" }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2020-02-29T01:00:00+01:00", "end_effective": "2021-03-31T02:00:00+02:00", "assignment": "2017-03-02T14:37:06+01:00", "program": 72, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 98848, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P 28701", "ethics_committee": null, "edudract_number": null, "persons": [ "4865-98848-10" ] }, { "id": 4806, "title": { "de": "Mechanismen der Entstehung von Vorhofflimmern bei Hyperglykämie", "en": "Mechanisms underlying the development of atrial fibrillation in hyperglycemia" }, "short": "GlucoAF", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2020-12-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2017-02-06T11:34:23+01:00", "program": null, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 63032, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 468 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4806-63032-10" ] }, { "id": 4654, "title": { "de": "Einfluss adhärenter Blutplättchen auf den Zottentrophoblast", "en": "The role of adhering maternal platelets on villous trophoblast" }, "short": "Platelets and trophoblasts", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-10-01T02:00:00+02:00", "end_planned": "2020-02-28T01:00:00+01:00", "end_effective": "2021-03-31T02:00:00+02:00", "assignment": "2016-10-14T13:12:11+02:00", "program": 72, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 53232, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P29639", "ethics_committee": null, "edudract_number": null, "persons": [ "4654-53232-10" ] }, { "id": 4793, "title": { "de": "Lipasen und Lipidsignaling ", "en": "Lipases and Lipid Signaling" }, "short": "BioTechMed", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-01T01:00:00+01:00", "begin_effective": "2017-03-01T01:00:00+01:00", "end_planned": "2019-02-28T01:00:00+01:00", "end_effective": "2019-02-28T01:00:00+01:00", "assignment": "2017-01-02T11:28:55+01:00", "program": null, "subprogram": "BioTechMed Flagship Project", "organization": 14038, "category": 10, "type": 10, "partner_function": 2, "manager": 50442, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 2325 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4793-50442-10" ] }, { "id": 4869, "title": { "de": "Methodenetablierun am Rasterkraftmikroskop", "en": "Method establishment at the atomic force microscope" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-03-02T01:00:00+01:00", "begin_effective": "2017-03-02T01:00:00+01:00", "end_planned": "2021-12-31T01:00:00+01:00", "end_effective": "2027-12-31T01:00:00+01:00", "assignment": "2017-03-06T10:31:36+01:00", "program": null, "subprogram": null, "organization": 17230, "category": 10, "type": 10, "partner_function": 4, "manager": 53900, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": "MEFO-22", "ethics_committee": null, "edudract_number": null, "persons": [ "4869-53900-10" ] }, { "id": 4896, "title": { "de": "Zerebrale Sauerstoffsättigung zur Steuerung der Versorgung", "en": "Cerebral tissue Oxygen Saturation to Guide Oxygen Delivery \r\nin preterm neonates during immediate transition after birth\r\n" }, "short": "COSGOD III", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2022-02-28T01:00:00+01:00", "assignment": "2017-03-23T15:27:42+01:00", "program": 108, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 3, "manager": 50907, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLI615", "ethics_committee": null, "edudract_number": null, "persons": [ "4896-50907-10" ] }, { "id": 5044, "title": { "de": "Diabetes mellitus und assoziierte Risikofaktoren bei bipolarer Störung", "en": "Diabetes mellitus und associated risk factors in bipolar disorder" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-09-01T02:00:00+02:00", "end_planned": "2018-04-01T02:00:00+02:00", "end_effective": "2021-02-28T01:00:00+01:00", "assignment": "2017-08-23T12:39:33+02:00", "program": null, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 1, "manager": 79733, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 457 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5044-79733-10" ] }, { "id": 5081, "title": { "de": "Angehörigenmanagement auf der Intensivstation: \r\neine randomisierte kontrollierte Studie", "en": "Family information management in the intensive care unit:\r\nA randomized controlled trial\r\n" }, "short": "ICU Families", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2019-03-31T01:00:00+01:00", "end_effective": "2020-12-31T01:00:00+01:00", "assignment": "2017-10-03T12:23:14+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 58615, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1748 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "5081-58615-10" ] }, { "id": 4769, "title": { "de": "Strukturelle und funktionelle Konnektivität bei zerebraler Kleingefäßerkrankung:\r\nMechanistische Erkenntnisse von vererbten und sporadischen Fällen", "en": "Structural and functional connectivity in cerebral small vessel\r\ndisease: Mechanistic insights from inherited and sporadic cases" }, "short": "Connectivity in cerebral microangiopathy", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2020-03-31T02:00:00+02:00", "end_effective": "2021-09-30T02:00:00+02:00", "assignment": "2017-01-12T11:05:22+01:00", "program": 64, "subprogram": "DACH", "organization": 14051, "category": 10, "type": 10, "partner_function": 1, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I2889", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 5017, "title": { "de": "Akupunktur und 'moderne' Augenerkrankungen - Eine transkontinentale Pilotstudie", "en": "Acupuncture and 'modern' eye diseases - A transcontinental pilot study" }, "short": "EPU-2017", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-09-01T02:00:00+02:00", "end_planned": "2018-03-31T02:00:00+02:00", "end_effective": "2018-08-31T02:00:00+02:00", "assignment": "2017-07-21T12:59:55+02:00", "program": null, "subprogram": null, "organization": 14044, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 762 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 4762, "title": { "de": "Hochauflösende In Silico Modelle der Gesamten Herzfunktion", "en": "High-resolution In Silico Models of Total Heart Function" }, "short": "INSILICARDIO", "url": null, "abstract": { "de": "Fortschritte bei der Entwicklung von tomographischen Verfahren ermöglichen in beispielloser Weise die Anatomie des Herzens abzubilden. Allerdings hatten diese Technologien bisher einen relativ geringen Einfluss auf die Entwicklung von medizinischen Implantaten oder die Verbesserung von klinischen Behandlungsmethoden.\r\nDer Einsatz von bildgebenden Verfahren zur Extraktion von wichtigen funktionellen Informationen und der Kopplung von Bildinformationen mit physiologischen Aspekten, die nicht durch Bildgebung allein verstanden werden können, stellt eine große Herausforderung dar. In silico Modelle, also computerunterstützte Simulationen, bergen enormes Potenzial zur Bewältigung dieser Herausforderungen und können zu einem besseren Verständnis der Herzfunktion, sei es im gesunden oder auch im erkrankten Zustand, führen. Ein entscheidender Vorteil ist hierbei die Möglichkeit diagnostische und therapeutische Methoden zu optimieren ohne dabei Patienten zusätzlichen Risiken oder Schmerzen auszusetzen. In silico Experimente können somit bei der Untersuchung von klinisch relevanten Problemen, wie zum Beispiel Herzklappenchirurgie, Ballon-Angioplastie oder Stenting, äußerst hilfreich sein.\r\nDie Herzfunktion ergibt sich aus der Interaktion verschiedener Physiken, unter anderem der Elektrophysiologie, der Strukturmechanik und der Strömungsmechanik. Während die beteiligten Physiken klar bidirektional wechselwirken, werden sie in praktisch allen Studien isoliert betrachtet. Dies ist zu einem guten Teil auf die Komplexität von Multiphysik-Modellen und den Schwierigkeiten, die bei der Entwicklung von modernen numerischen Methoden und deren effizienten Implementierung auf modernen Rechnerarchitekturen auftauchen, zurückzuführen. Die Bewältigung dieser Herausforderungen ist das zentrale Themas dieses Projektes und die Durchführung setzt auf die Kombination der Expertisen der Antragsteller: Christoph Augustin und Gernot Plank in der Modellierung der Elektrophysiologie und der Strukturmechanik und Shawn Shadden in der Computermodellierung des Blutflusses.\r\nDieses ambitionierte Unterfangen geht weit über den aktuellen Stand der Technik hinaus. Kombinierte Modelle von Herz und Blutgefäßen ermöglichen die Berechnung von natürlichen Randbedingungen für die Simulation des Blutflusses und das Studium von Rückkopplungsmechanismen die die Pumpleistung des Herzens beeinflussen können. Im Endeffekt wird dieses Modell eines der modernsten Werkzeuge der Grundlagenforschung sein, das einen mechanistischen Einblick in die Herzpumpfunktion gewährt. Von wesentlicher Bedeutung ist in diesem Kontext auch die Überprüfung, Parametrisierung und Validierung dieses Modells mit klinischen Datensätzen, die von klinischen Partnern zur Verfügung gestellt werden.\r\nDas Ziel dieser Forschung ist ein innovatives Multiphysik-Computermodell der gesamten Herzfunktion um eine biophysikalisch detaillierte und bidirektional gekoppelte Erforschung der elektromechanischen Funktion des Herzens im gesunden wie im kranken Zustand zu ermöglichen.", "en": "Advances in tomographic imaging have enabled unprecedented ability to image cardiac anatomy. However, these technologies have had relatively modest clinical impact. Key challenge have been the use of imaging to extract important functional information and to understand how image-derived information couples with other physiological aspects that cannot be understood through imaging alone. In-silico models hold vast potential to address these challenges by enabling the integration of imaging data into quantitative frameworks that can aid in better understanding cardiac function in health and disease, and developing optimal treatment strategies.\r\nCardiac function arises from interactions between different physics, including electrophysiology, structural mechanics and fluid dynamics. While these physics are bidirectionally linked, virtually all reported modeling studies have considered them in isolation. In no small part this is due to the complexity of multiphysics models and the difficulties in devising advanced numerical methods and their efficient implementation on modern computing architectures. Addressing these challenges as we propose is key to keep model execution and analysis cycles tractable and, thus, to leverage modeling in a translational context. The proposed work goes beyond the state-of-the-art in many regards. Combined models of both heart and attached outflow vessels will be used to provide natural inflow boundary conditions for simulating blood flow and to facilitate studying feedback mechanisms between flow and pressure in the outflow vessels and pumping performance. This set of novel features and the parallel efficiency of the implemented methods will provide a unique platform for translational research. At the fundamental level, this model will be among the most advanced basic research tools for gaining mechanistic insight into cardiac pumping function. This challenging endeavor is feasible only as it builds upon combining the expertise of the applicant Christoph Augustin (Medical University of Graz) in modeling electrophysiology and soft tissue mechanics, and the host Shawn Shadden (UC Berkeley) in computational modeling of blood flow. Clinical datasets for model parametrization and validation are provided by Titus Kühne at the German Heart Centre Berlin, as well as by clinical collaborators of Prof. Shadden at the University of California San Francisco.Technical challenges to be addressed relate to multiphysics coupling methods which converge robustly and scale efficiently. While such methods have been developed recently for single physics cardiac simulations, this has not been the case for coupled multiphysics models of total heart function. This will be addressed by massively parallel implementations which are based on domain decomposition and strongly scalable iterative methods using appropriate preconditioning and stabilization techniques. In summary, the overall objective is to develop the most advanced in-silico model of total heart function, to facilitate biophysically detailed studies of electro-mechano-fluidic function of the heart. This model will be parametrized, verified and employed to study bidirectional cause-effect relationships between flow and pressure in the outflow vessels and pumping performance." }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-03-31T02:00:00+02:00", "end_effective": "2017-04-01T02:00:00+02:00", "assignment": "2017-01-11T11:38:59+01:00", "program": 101, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 79791, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4762-79791-10" ] }, { "id": 4981, "title": { "de": "Hautnah - TeleHaut", "en": "Skin close and tele" }, "short": "Hautnah - TeleHaut", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-06-01T02:00:00+02:00", "end_planned": "2019-10-01T02:00:00+02:00", "end_effective": "2019-11-30T01:00:00+01:00", "assignment": "2017-06-13T14:35:07+02:00", "program": null, "subprogram": "FFG Talente Praktika für Schülerinnen und Schüler", "organization": 14047, "category": 10, "type": 10, "partner_function": 3, "manager": 51711, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "860148", "ethics_committee": null, "edudract_number": null, "persons": [ "4981-51711-10" ] }, { "id": 4709, "title": { "de": "DNA-seq Biomarker-Identifikation in Subgruppen von Stadium II Kolon-Adenokarzinomen", "en": "DNA-seq biomarker identification in subgroups of stage II colon adenocarcinoma" }, "short": "BmarkerCOAD", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-01T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-03-31T02:00:00+02:00", "end_effective": "2020-06-30T02:00:00+02:00", "assignment": "2016-11-29T12:41:23+01:00", "program": null, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 4, "manager": 51684, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1019 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4709-51684-10" ] }, { "id": 4874, "title": { "de": "Analyse des RAS/MAPK-ERK Signalweges bei der akuten myeloischen Leukämie", "en": "Analysis of the RAS/MAPK-ERK signal transduction cascade in acute myeloid leukemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-15T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-04-14T02:00:00+02:00", "end_effective": "2028-06-30T02:00:00+02:00", "assignment": "2017-03-09T11:45:45+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4874-80093-12", "4874-57402-10", "4874-97430-12", "4874-104139-12", "4874-126117-12" ] }, { "id": 4830, "title": { "de": "Neue therapeutische Agentien für die Kombinationstherapie von Chordomen", "en": "Novel therapeutic agents for chordoma combination treatment" }, "short": "Chordom Kombinationstherapie", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-05-01T02:00:00+02:00", "begin_effective": "2017-05-01T02:00:00+02:00", "end_planned": "2018-12-31T01:00:00+01:00", "end_effective": "2018-12-31T01:00:00+01:00", "assignment": "2017-02-14T11:23:52+01:00", "program": null, "subprogram": "ISNK: Ingrid Shaker Nessmann Krebsforschungsvereinigung", "organization": 14052, "category": 10, "type": 10, "partner_function": 4, "manager": 50448, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1765 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4830-50448-10" ] }, { "id": 5092, "title": { "de": "Einfluss von mikrobiom-assoziierten Serum-Metaboliten auf die Wirksamkeit von Immuntherapie bei Patienten mit fortgeschrittenem Melanom - Pilotstudie", "en": "Microbial Metabolic Influences On Immunotherapeutic Efficacy Of Immune-\r\nCheckpoint Blockers In Patients With Advanced Melanoma: Pilot Study" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-05-01T02:00:00+02:00", "begin_effective": "2017-08-01T02:00:00+02:00", "end_planned": "2019-04-30T02:00:00+02:00", "end_effective": "2020-07-31T02:00:00+02:00", "assignment": "2017-10-13T14:53:34+02:00", "program": null, "subprogram": null, "organization": 14047, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 5, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1983 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] } ] }