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GET /v1/research/project/?format=api&offset=100&ordering=begin_effective
{ "count": 2140, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=120&ordering=begin_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=80&ordering=begin_effective", "results": [ { "id": 276, "title": { "de": "SAFE: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network ", "en": "SAFE: Special Non-Invasive Advances in Foetal and Neonatal Evaluation Network " }, "short": "SAFE", "url": null, "abstract": { "de": "The establishment of non-invasive markers for prenatal diagnosis and neo-natal screening is a very important research goal. Current invasive procedures have (1)a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psycological distress. Currently around 5 % of pregnant women in the developed world undergo invasive prenatal diagnosis procedures, mainly due to an increased risk for foetal chromosome abnormalities(such as trisomy 21 Down syndrome). In populations with a high penetrance of an inherited genetic disorder, such as the hemoglobinopathies, cystic fibrosis or Tay Sachs syndrome, it may be advantageous to determine the genotype early in life (neonates), as this will alert individuals, who are found o be carriers of the risk of having an affected child.\r\nThe transplacental passage of foetal cells into the maternal circulation is now well established, and a number of studies have been undertaken in order to isolate these rare foetal cells for prenatal diagnostic purposes. In spite of the technical problems imposed by the scarcity of these foetal cells, substantial progress has been made by individual research groups in Europe. There is now an urgent need to integrate these fragmented and diverse activities into a coherent strategy for non-invasive prenatal diagnosis.\r\nThe recent discovery of relatively abundant quantities of cell free DNA in maternal plasma and serum has opened a new avenue for the prenatal diagnosis of the latter group of genetic disorders as well as the determination of the foetal RhD genotype in pregnancies at risk for HDN (haemolytic disease of the foetus and newborn). In addition elevations in the concentration of the new found molecular analyte may be indicative of pregnancies bearing an aneuploid foetus or those at risk for pregnancy related disorders such as preterm labour or preeclampsia. This opens the possibility for new screening tools.\r\nThe advent of high throughput gene-CHIP technology will facilitate effective screening programs for common inherited genetic disorders. Thir will alert individuals to the possibility of having an affected foetus if the partner has a certain genetic constellation; a frequent dispensation in certain populations. The program will create a leading European Network of Excellence in the area of non-invasive prenatal diagnosis and neonatal screening.", "en": "The establishment of non-invasive markers for prenatal diagnosis and neo-natal screening is a very important research goal. Current invasive procedures have (1)a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psycological distress. Currently around 5 % of pregnant women in the developed world undergo invasive prenatal diagnosis procedures, mainly due to an increased risk for foetal chromosome abnormalities(such as trisomy 21 Down syndrome). In populations with a high penetrance of an inherited genetic disorder, such as the hemoglobinopathies, cystic fibrosis or Tay Sachs syndrome, it may be advantageous to determine the genotype early in life (neonates), as this will alert individuals, who are found o be carriers of the risk of having an affected child.\r\nThe transplacental passage of foetal cells into the maternal circulation is now well established, and a number of studies have been undertaken in order to isolate these rare foetal cells for prenatal diagnostic purposes. In spite of the technical problems imposed by the scarcity of these foetal cells, substantial progress has been made by individual research groups in Europe. There is now an urgent need to integrate these fragmented and diverse activities into a coherent strategy for non-invasive prenatal diagnosis.\r\nThe recent discovery of relatively abundant quantities of cell free DNA in maternal plasma and serum has opened a new avenue for the prenatal diagnosis of the latter group of genetic disorders as well as the determination of the foetal RhD genotype in pregnancies at risk for HDN (haemolytic disease of the foetus and newborn). In addition elevations in the concentration of the new found molecular analyte may be indicative of pregnancies bearing an aneuploid foetus or those at risk for pregnancy related disorders such as preterm labour or preeclampsia. This opens the possibility for new screening tools.\r\nThe advent of high throughput gene-CHIP technology will facilitate effective screening programs for common inherited genetic disorders. Thir will alert individuals to the possibility of having an affected foetus if the partner has a certain genetic constellation; a frequent dispensation in certain populations. The program will create a leading European Network of Excellence in the area of non-invasive prenatal diagnosis and neonatal screening." }, "begin_planned": null, "begin_effective": "2004-03-01T01:00:00+01:00", "end_planned": null, "end_effective": "2009-02-28T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 51540, "contact": 51540, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "276-51540-10" ] }, { "id": 690, "title": { "de": "Gesundheitsförderung am Arbeitsplatz: Resourcenstärkung bei Pflegepersonal schwerkranker PatientInnen durch individiuell optimiertes Stressmanagement.", "en": "Gesundheitsförderung am Arbeitsplatz: Resourcenstärkung bei Pflegepersonal schwerkranker PatientInnen durch individiuell optimiertes Stressmanagement." }, "short": "Gesundheitsförderung am Arbeitsplatz", "url": null, "abstract": { "de": "Das vorliegende Projekt hat sich zum Ziel gesetzt, den Effekt verschiedener Interventionen zur Stressbewältigung am Arbeitsplatz Krankenhaus, und zwar bei Pflegepersonal schwerkranker PatientInnen, auf das Ausmaß erlebter Belastungen, auf die Befindlichkeit, die Belastungs-Erholungs-Bilanz, das Stress-Coping und die erlebte Selbstwirksamkeit zu überprüfen.\r\nSoziale Berufe wie z.B.: Pflegeberufe gehören bezüglich physiologischer und psychologischer Stressfolgen zu den gefährdensten Berufsgruppen. Ob und inwieweit es zu schädlichen Auswirkungen infolge beruflicher Belastung kommt, hängt u.a. vom erlebten Ausmaß und der Bewertung längerfristiger beruflicher Belastungssituationen, zusätzlichen Belastungen aus anderen Lebensbereichen (z.B.: Familiensituation), dem Ernährungs- und Erholungsverhalten sowie dem iindividuellen Stress-Coping und der Ausprägung der Selbstwirksamkeitserwartung ab.\r\nIn die Studie eingeschlossen werden 100 (20 pro Gruppe) vollzeitberufstätige im LKH Graz im Pflegebereich schwerkranker Personen tätige weibliche und männliche Personen im Alter zwischen 25 und 60 Jahren. Untersucht werden soll der Effekt von drei alternativ angebotenen Interventionen: 1.) Defizitorientierte individuelle Substitution von Aminosäuren, 2.) Personenbezogenes Stressmanagement, 3.) Team Ressource Management, sowie eine Kombination dieser.", "en": "Das vorliegende Projekt hat sich zum Ziel gesetzt, den Effekt verschiedener Interventionen zur Stressbewältigung am Arbeitsplatz Krankenhaus, und zwar bei Pflegepersonal schwerkranker PatientInnen, auf das Ausmaß erlebter Belastungen, auf die Befindlichkeit, die Belastungs-Erholungs-Bilanz, das Stress-Coping und die erlebte Selbstwirksamkeit zu überprüfen.\r\nSoziale Berufe wie z.B.: Pflegeberufe gehören bezüglich physiologischer und psychologischer Stressfolgen zu den gefährdensten Berufsgruppen. Ob und inwieweit es zu schädlichen Auswirkungen infolge beruflicher Belastung kommt, hängt u.a. vom erlebten Ausmaß und der Bewertung längerfristiger beruflicher Belastungssituationen, zusätzlichen Belastungen aus anderen Lebensbereichen (z.B.: Familiensituation), dem Ernährungs- und Erholungsverhalten sowie dem iindividuellen Stress-Coping und der Ausprägung der Selbstwirksamkeitserwartung ab.\r\nIn die Studie eingeschlossen werden 100 (20 pro Gruppe) vollzeitberufstätige im LKH Graz im Pflegebereich schwerkranker Personen tätige weibliche und männliche Personen im Alter zwischen 25 und 60 Jahren. Untersucht werden soll der Effekt von drei alternativ angebotenen Interventionen: 1.) Defizitorientierte individuelle Substitution von Aminosäuren, 2.) Personenbezogenes Stressmanagement, 3.) Team Ressource Management, sowie eine Kombination dieser." }, "begin_planned": "2004-05-01T02:00:00+02:00", "begin_effective": "2004-05-01T02:00:00+02:00", "end_planned": "2006-03-31T02:00:00+02:00", "end_effective": "2006-03-31T02:00:00+02:00", "assignment": "2006-02-03T14:44:14+01:00", "program": 77, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 19 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "690-50020-12" ] }, { "id": 302, "title": { "de": "HEALTHY AIMS: Implantable micro-sensors and micro-systems for ambulatory measurement and control in medical products. ", "en": "HEALTHY AIMS: Implantable micro-sensors and micro-systems for ambulatory measurement and control in medical products. " }, "short": "Healthy Aims", "url": null, "abstract": { "de": "In this project key microsystem technologies and communication methods will be developed that bring intelligence directly to the human, in the form of medical implants and ambulatory measurement systems, and also enable information from these devices to be transmitted out into the wider environment. The microsystem technologies to be developed can be applied to any generic Ambient intelligent' system comprising sensors, actuators, an intelligent processor and a wiring loom. The medical applications have been chosen for 2 reasons. Firstly, they will progress the existing State of the Art in Microsystems in terms of size, reliability, and power constraints far more than many other application sectors. In addition there will be a direct positive impact into the health of EU citizens. The overall objective is to develop the technologies that go to make up a microsystem, and then produce specific medical devices to exploit these technologies. The 4 year project, with 26 partners, is structured with the focus on the microsystem technology development, most of which doesn't include silicon. Thin is seen as crucial if complete microsystems are to be realised in the coming few years. The project includes participants from all of the disciplines necessary to produce a complete generic microsystem. The result will be a range of core technologies and medical devices utilising these core technologies. Intelligence will be given back to people where part of their own internal system has failed. Quality of life will be improved for millions of EU citizens and the long term cost of treating people will reduce sinificantly. The resulting final medical products include cochlear and retina implants, nerve stimulation, bladder control and blood monitoríng systems. It is estimated from the available statistics that around 50% of the western poulation i.e. around 500 million citizens, will suffer from at least one of the health problems targeted in this project.", "en": "In this project key microsystem technologies and communication methods will be developed that bring intelligence directly to the human, in the form of medical implants and ambulatory measurement systems, and also enable information from these devices to be transmitted out into the wider environment. The microsystem technologies to be developed can be applied to any generic Ambient intelligent' system comprising sensors, actuators, an intelligent processor and a wiring loom. The medical applications have been chosen for 2 reasons. Firstly, they will progress the existing State of the Art in Microsystems in terms of size, reliability, and power constraints far more than many other application sectors. In addition there will be a direct positive impact into the health of EU citizens. The overall objective is to develop the technologies that go to make up a microsystem, and then produce specific medical devices to exploit these technologies. The 4 year project, with 26 partners, is structured with the focus on the microsystem technology development, most of which doesn't include silicon. Thin is seen as crucial if complete microsystems are to be realised in the coming few years. The project includes participants from all of the disciplines necessary to produce a complete generic microsystem. The result will be a range of core technologies and medical devices utilising these core technologies. Intelligence will be given back to people where part of their own internal system has failed. Quality of life will be improved for millions of EU citizens and the long term cost of treating people will reduce sinificantly. The resulting final medical products include cochlear and retina implants, nerve stimulation, bladder control and blood monitoríng systems. It is estimated from the available statistics that around 50% of the western poulation i.e. around 500 million citizens, will suffer from at least one of the health problems targeted in this project." }, "begin_planned": null, "begin_effective": "2004-06-01T02:00:00+02:00", "end_planned": null, "end_effective": "2008-05-31T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": "TP2: Information Society Technologies", "organization": 14043, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 269, "title": { "de": "Intrazelluläre Lokalisierung und Funktion eines neuen Proteins mit der Sterol-Sensing-Domäne in den Makrophagen", "en": "Intrazelluläre Lokalisierung und Funktion eines neuen Proteins mit der Sterol-Sensing-Domäne in den Makrophagen" }, "short": "Neues Protein mit Sterol-Sensing-Domäne", "url": null, "abstract": { "de": "Die Anhäufung von Cholesterin in Makrophagen aufgrund erhöhter Cholesterinsynthese bzw. der Aufnahme zirkulierender Lipoproteinen aus dem Blut führt zu ihrer Verwandlung in Schaumzellen und Ablagerung in den Gefäßwänden. Diese Ereignisse führen zu peripherer Atherosklerose, koronarer Herzerkrankung, Herzinfarkt und Gehirnschlag. Intrazelluläre Proteine, die in ihrer Struktur eine sogenannte sterol-sensing Domäne (SSD) aufweisen spielen eine entscheidende Rolle bei der Konstanthaltung des intrazellulären Cholesterinhaushaltes. Obwohl die Strukur einiger SSD-Proteine ermittelt werden konnte, blieb die Rolle vieler weiterer SSD-Proteine bisher unbekannt. Daher haben wir es uns zum Zeiel gesetzt die Regulation der Synthese, sowie die intrazelluläre Lokalisierung eines bis heute unerforschten SSD-Proteins mittels molekularbiologischer, biochemischer und immunhistochemischer Methoden zu ermitteln. Weiters sollen die Auswrikungen dieses Proteins auf die Cholesterin-Biosynthese und Cholesteringehalt in den Makrophagen untersucht werden. Die Ergebnisse diese Projektes sollen fundamentale neue Erkenntnisse über die Funktion von SSD Proteinen liefern und zum allgemeinen Verständnis des Mechanismus der Cholesterin Homeostase in Makrophagen und ihrer Rolle bei der Entstehung vaskulärer Erkrankungen beitragen.", "en": "Die Anhäufung von Cholesterin in Makrophagen aufgrund erhöhter Cholesterinsynthese bzw. der Aufnahme zirkulierender Lipoproteinen aus dem Blut führt zu ihrer Verwandlung in Schaumzellen und Ablagerung in den Gefäßwänden. Diese Ereignisse führen zu peripherer Atherosklerose, koronarer Herzerkrankung, Herzinfarkt und Gehirnschlag. Intrazelluläre Proteine, die in ihrer Struktur eine sogenannte sterol-sensing Domäne (SSD) aufweisen spielen eine entscheidende Rolle bei der Konstanthaltung des intrazellulären Cholesterinhaushaltes. Obwohl die Strukur einiger SSD-Proteine ermittelt werden konnte, blieb die Rolle vieler weiterer SSD-Proteine bisher unbekannt. Daher haben wir es uns zum Zeiel gesetzt die Regulation der Synthese, sowie die intrazelluläre Lokalisierung eines bis heute unerforschten SSD-Proteins mittels molekularbiologischer, biochemischer und immunhistochemischer Methoden zu ermitteln. Weiters sollen die Auswrikungen dieses Proteins auf die Cholesterin-Biosynthese und Cholesteringehalt in den Makrophagen untersucht werden. Die Ergebnisse diese Projektes sollen fundamentale neue Erkenntnisse über die Funktion von SSD Proteinen liefern und zum allgemeinen Verständnis des Mechanismus der Cholesterin Homeostase in Makrophagen und ihrer Rolle bei der Entstehung vaskulärer Erkrankungen beitragen." }, "begin_planned": null, "begin_effective": "2004-07-01T02:00:00+02:00", "end_planned": null, "end_effective": "2006-06-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 299, "title": { "de": "Chemotherapie von Phäochromocytomen: In vitro and in vivo Modelle als neue Testsysteme", "en": "Chemotherapie von Phäochromocytomen: In vitro and in vivo Modelle als neue Testsysteme" }, "short": "Chemotherapie von Phäochromocytomen", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2004-08-01T02:00:00+02:00", "end_planned": null, "end_effective": "2007-08-31T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 81, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 354, "title": { "de": "Die Rolle von MT1-MMP bei Veränderungen im Gefäßsystem in Plazenten von Diabetikerinnen", "en": "Die Rolle von MT1-MMP bei Veränderungen im Gefäßsystem in Plazenten von Diabetikerinnen" }, "short": "MT1-MMP bei Plazenten v. Diabetikerinnen", "url": null, "abstract": { "de": "Diabetes in der Schwangerschaft kann schwere negative Konsequenzen für Mutter und Kind haben. Auch die Plazenta (Mutterkuchen) weist oft strukturelle und funktionelle Unterschiede auf, die starken Einfluss auf die Entwicklung des Kindes haben können. Unter anderem kommt es in der Plazenta zu einer stärkeren Ausbildung der Gefäße, was auf verstärkter Bildung von Blutgefäßen (Angiogenese) hindeutet.\r\nIn vorangegangenen Experimenten konnten wir zeigen, dass in Blutgefäße auskleidenden Endothelzellen der Plazenta unter diabetes-ähnlichen Bedingungen (hohe Glukose- bzw. Insulinkonzentration) die Menge von MT1-MMP zunimmt. MT1-MMP spielt eine wichtige Rolle in der Angiogenese, da es das Protein MMP2 durch Spaltung aktiviert, welches dann Gewebe vor dem wachsenden Gefäß abbaut und somit Endothelzellen einwandern können.\r\nIn diesem Projekt soll die Rolle von MT1-MMP bei der verstärkten Vaskularisierung in Plazenten diabetischer Mütter untersucht werden. Einerseits werden Untersuchungen in vivo an Plazentagewebe von gesunden und diabetischen Frauen durchgeführt, andererseits werden isolierte Endothelzellen in vitro unter diabetes-ähnlichen Bedingungen bezüglich Angiogenese relevanter Faktoren untersucht.", "en": "Diabetes in der Schwangerschaft kann schwere negative Konsequenzen für Mutter und Kind haben. Auch die Plazenta (Mutterkuchen) weist oft strukturelle und funktionelle Unterschiede auf, die starken Einfluss auf die Entwicklung des Kindes haben können. Unter anderem kommt es in der Plazenta zu einer stärkeren Ausbildung der Gefäße, was auf verstärkter Bildung von Blutgefäßen (Angiogenese) hindeutet.\r\nIn vorangegangenen Experimenten konnten wir zeigen, dass in Blutgefäße auskleidenden Endothelzellen der Plazenta unter diabetes-ähnlichen Bedingungen (hohe Glukose- bzw. Insulinkonzentration) die Menge von MT1-MMP zunimmt. MT1-MMP spielt eine wichtige Rolle in der Angiogenese, da es das Protein MMP2 durch Spaltung aktiviert, welches dann Gewebe vor dem wachsenden Gefäß abbaut und somit Endothelzellen einwandern können.\r\nIn diesem Projekt soll die Rolle von MT1-MMP bei der verstärkten Vaskularisierung in Plazenten diabetischer Mütter untersucht werden. Einerseits werden Untersuchungen in vivo an Plazentagewebe von gesunden und diabetischen Frauen durchgeführt, andererseits werden isolierte Endothelzellen in vitro unter diabetes-ähnlichen Bedingungen bezüglich Angiogenese relevanter Faktoren untersucht." }, "begin_planned": null, "begin_effective": "2004-09-01T02:00:00+02:00", "end_planned": null, "end_effective": "2006-08-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14038, "category": 10, "type": 10, "partner_function": 4, "manager": 50674, "contact": 50674, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "354-50674-10" ] }, { "id": 289, "title": { "de": "Gene-Silencing mittels siRNA in kleinzelligen Lungenkarzinomen", "en": "Gene-Silencing mittels siRNA in kleinzelligen Lungenkarzinomen" }, "short": "Gene-Silencing mittels siRNA ", "url": null, "abstract": { "de": "Das Silencing von Genen mithilfe kleiner doppelsträngiger RNAs (dsRNA) ist eine neue Methode für das Studium funktioneller Zusammenhänge von Genaktivierung und gegenseitiger Regulation. Die dsRNA wird intrazellulär mithilfe multifaktorieller Ebzymkomplexe (Dicer, RISC) in einzelsträngige siRNA umgebaut. Durch Silencing kann ein Zielgen ausgeschaltet und der daraus resultierende Effekt auf die Expression anderer Gene studiert werden. Diese Expression wird mittels einer Hybridisierung auf cDNA chips erreicht.\r\nZiel dieser Untersuchung ist es, die Auswirkung des Silencing der mRNA für c-Met, Ash1, NCAM, und PCNA auf die Signaling Kaskade beim SCLC zu untersuchen. Aus den daraus gewonnenen Erkenntnissen kann dann mittels bereits erhältlicher Inhibitoren in einer Folgeuntersuchung ein therapeutischer Einsatz getestet werden.", "en": "Das Silencing von Genen mithilfe kleiner doppelsträngiger RNAs (dsRNA) ist eine neue Methode für das Studium funktioneller Zusammenhänge von Genaktivierung und gegenseitiger Regulation. Die dsRNA wird intrazellulär mithilfe multifaktorieller Ebzymkomplexe (Dicer, RISC) in einzelsträngige siRNA umgebaut. Durch Silencing kann ein Zielgen ausgeschaltet und der daraus resultierende Effekt auf die Expression anderer Gene studiert werden. Diese Expression wird mittels einer Hybridisierung auf cDNA chips erreicht.\r\nZiel dieser Untersuchung ist es, die Auswirkung des Silencing der mRNA für c-Met, Ash1, NCAM, und PCNA auf die Signaling Kaskade beim SCLC zu untersuchen. Aus den daraus gewonnenen Erkenntnissen kann dann mittels bereits erhältlicher Inhibitoren in einer Folgeuntersuchung ein therapeutischer Einsatz getestet werden." }, "begin_planned": null, "begin_effective": "2004-09-01T02:00:00+02:00", "end_planned": null, "end_effective": "2006-08-31T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 4, "manager": 51523, "contact": 51523, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "289-51523-10" ] }, { "id": 281, "title": { "de": "Activation of a nuclear receptor impairs cycloocygenase-2expression but induces apoptosis in human choriocarcinoma cell lines: A possible therapeutic approach for treatment", "en": "Activation of a nuclear receptor impairs cycloocygenase-2expression but induces apoptosis in human choriocarcinoma cell lines: A possible therapeutic approach for treatment" }, "short": "Cycloocygenase-2expression ", "url": null, "abstract": { "de": "Cyclooxygenase-2 (COX-2), the inducible isoform of COX is the enzyme that catalyzes the rate-limiting step in prostaglandin synthesis from arachidonic acid. Various prostaglandins are produced in a cell type-specific manner, and they elicit cellular functions via signaling through G-protein-coupled membrane receptors, and in some cases, through the nuclear receptor peroxisome proliferator-activated receptor (PPAR) e.g. PPARgamma. In a number of cell and animal models, induction of COX-2 has been shown to promote cell growth, inhibit apoptosis and enhance cell motility and adhesion. Compelling eidence from genetic and clinical studies indicate that COX-2 upregulation is a key step in carcinogenesis. Overexpression of COX-2 is sufficient to cause tumorigenesis in animal models and inhibition of the COX-2 pathway results in reduction in tumor incidence and progression, but increased apoptosis (programmed cell death), in parallel. Recent findings revealed that PPARgamma-agonists induce apoptosis in cancer cells via down-regulation of COX-2. PPARgamma binds to specific response elements as heterodimers with the retinoid X receptor and activates transcription in response to a variety of endogenous and exogenous ligands. PPARgamma is needed for plasental development and modulates differentiation of human trophoblast. As the trophoblast may also give rise to choriocarcinomas -malignant tumors of epithelial origin- the present application is aimed to focus on PPARgamma-dependent activities mediating expression and regulation of COX-2 and subsequent induction of apoptotic pathways in choriocarcinoma celll lines in vitro. In this scenario, COX-2 inhibition could afford its effects against choriocarcinoma by modulating COX-2 expression and activity. An exciting corollary to this ongoing pathway is that the parallel increase in apoptotic events via PPARgamma-dependent modulation of COX-2 may exhibit chemoprotective and even chemotherapeutive effects against choriocarcinoma in humans.", "en": "Cyclooxygenase-2 (COX-2), the inducible isoform of COX is the enzyme that catalyzes the rate-limiting step in prostaglandin synthesis from arachidonic acid. Various prostaglandins are produced in a cell type-specific manner, and they elicit cellular functions via signaling through G-protein-coupled membrane receptors, and in some cases, through the nuclear receptor peroxisome proliferator-activated receptor (PPAR) e.g. PPARgamma. In a number of cell and animal models, induction of COX-2 has been shown to promote cell growth, inhibit apoptosis and enhance cell motility and adhesion. Compelling eidence from genetic and clinical studies indicate that COX-2 upregulation is a key step in carcinogenesis. Overexpression of COX-2 is sufficient to cause tumorigenesis in animal models and inhibition of the COX-2 pathway results in reduction in tumor incidence and progression, but increased apoptosis (programmed cell death), in parallel. Recent findings revealed that PPARgamma-agonists induce apoptosis in cancer cells via down-regulation of COX-2. PPARgamma binds to specific response elements as heterodimers with the retinoid X receptor and activates transcription in response to a variety of endogenous and exogenous ligands. PPARgamma is needed for plasental development and modulates differentiation of human trophoblast. As the trophoblast may also give rise to choriocarcinomas -malignant tumors of epithelial origin- the present application is aimed to focus on PPARgamma-dependent activities mediating expression and regulation of COX-2 and subsequent induction of apoptotic pathways in choriocarcinoma celll lines in vitro. In this scenario, COX-2 inhibition could afford its effects against choriocarcinoma by modulating COX-2 expression and activity. An exciting corollary to this ongoing pathway is that the parallel increase in apoptotic events via PPARgamma-dependent modulation of COX-2 may exhibit chemoprotective and even chemotherapeutive effects against choriocarcinoma in humans." }, "begin_planned": null, "begin_effective": "2004-10-01T02:00:00+02:00", "end_planned": null, "end_effective": "2006-10-01T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 51714, "contact": 51714, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 142 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "281-51714-10" ] }, { "id": 301, "title": { "de": "EMBIC: The Control of Embryo Implantation", "en": "EMBIC:The Control of Embryo Implantation" }, "short": "EMBIC", "url": null, "abstract": { "de": "We aim to build an European virtual laboratory on major mechanism of implantation by thoroughly exploring what knock out mice have recently established as cellular - cytokine networks/ key pathways promoting the development of 2 de novo organs: the decidua basalis and the mature placenta. At present, fragmentation of experimental capacity and disparate approaches result in lack of a comprehensive skills base, and lack of access to very specialised approaches and technological platforms such as animal experimentation in very strict conditions, genomics and proteomics facilities or multicentric clinical evaluation. These require to be used in a coordinated fashion to maximise their effect in this area.\r\nWe will thus: 1.) Assemble critical talents and approaches, to develop an integrative, evaluative, capacity to set up EMBIC; 2.) Integrate EMBIC laboratories using crucial models and coordination of the joint programme of activities; 3.) Constitute a European cohort of infertile women with creation of RT generated DNA, sera and micro-biopsy tissue samples banks; 4.) Establish guidelines for management of infertile women combined with diagnosis procedures and ultimately recombinant technologies therapies for selected pathologies; 5.) Open the network of validated platforms for education and cooperative experimentation.\r\nEMBIC will contribute and benefit from the creation of integrated platforms based on animal models, genomic and proteomic facilities, protein intra-net database set-up, integrated clinical set-up. EMBIC will spread excellence by facilitaing the exchange of scientists within the laboratories, promote recruitment/training of out network post-docs, organise workshops and satellite meetings in pan European or regional Immunology/Fertility meetings and an annual summer school.", "en": "We aim to build an European virtual laboratory on major mechanism of implantation by thoroughly exploring what knock out mice have recently established as cellular - cytokine networks/ key pathways promoting the development of 2 de novo organs: the decidua basalis and the mature placenta. At present, fragmentation of experimental capacity and disparate approaches result in lack of a comprehensive skills base, and lack of access to very specialised approaches and technological platforms such as animal experimentation in very strict conditions, genomics and proteomics facilities or multicentric clinical evaluation. These require to be used in a coordinated fashion to maximise their effect in this area.\r\nWe will thus: 1.) Assemble critical talents and approaches, to develop an integrative, evaluative, capacity to set up EMBIC; 2.) Integrate EMBIC laboratories using crucial models and coordination of the joint programme of activities; 3.) Constitute a European cohort of infertile women with creation of RT generated DNA, sera and micro-biopsy tissue samples banks; 4.) Establish guidelines for management of infertile women combined with diagnosis procedures and ultimately recombinant technologies therapies for selected pathologies; 5.) Open the network of validated platforms for education and cooperative experimentation.\r\nEMBIC will contribute and benefit from the creation of integrated platforms based on animal models, genomic and proteomic facilities, protein intra-net database set-up, integrated clinical set-up. EMBIC will spread excellence by facilitaing the exchange of scientists within the laboratories, promote recruitment/training of out network post-docs, organise workshops and satellite meetings in pan European or regional Immunology/Fertility meetings and an annual summer school." }, "begin_planned": null, "begin_effective": "2004-10-01T02:00:00+02:00", "end_planned": null, "end_effective": "2008-09-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 21, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 2, "manager": 51540, "contact": 51540, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "301-51714-12", "301-51871-12", "301-51878-12", "301-51364-12", "301-51540-10", "301-51718-12", "301-50394-12", "301-51666-12", "301-51634-12" ] }, { "id": 270, "title": { "de": "Nukleäre Rezeptoren als Lipidsensoren an der Blut-Hirn Schranke", "en": "Nuclear receptors as lipid sensors at the blood-brain barrier" }, "short": "Nukleäre Rezeptoren als Lipidsensoren", "url": null, "abstract": { "de": "Nukleäre Rezeptoren gehören zur Familie der liganden-aktivierten Transkriptionsfaktoren, die die Expression von spezifischen Targetgenen regulieren, um verschiedenste metabolische Prozesse zu beeinflussen. Zwei Mitglieder, Peroxisomen-proliferator-aktivierte Rezeptoren (PPARs) und Leber-X-rezeptoren (LXRs) steuern die Expression von Schlüssel-Genen im Lipidmetabolismus. Das Ziel dieses Projektes ist die Erforschung der Liganden-Aktivierung von PPARs und LXRs und die Definition ihrer Rolle als Lipid-Sensoren und Regulatoren des Cholesterin- und Fettsäuremetabolismus an der Blut-Hirn Schranke. Die putative Rolle von PPARs und LXRs an der Blut-Hirn Schranke basiert auf folgenden Fakten: (i) Diverse neurodegenerative Störungen stehen in direktem Zusammenhang mit funktionellem Lipid- und Lipoproteinmetabolismus (ii) Das Gehirn bedarf einer Versorgung mit essentiellen, mehrfach ungesättigten Fettsäuren aus der Zirkulation. (iii), Überschüssiges Gehirn-Cholesterin wird in Form von 24(S)hydroxycholesterin über die Blut-Hirn Schranke in die Zirkulation transportiert. (iv) Endothelzellen der Blut-Hirn Schranke expremieren Targetgene für nukleäre Rezeptoren, die zenral am reversen Cholesterintransport und/oder an der zellulären Aufnahme von Fettsäuren beteiligt sind. \r\nWir postulieren, daß Ligandenaktivierung von PPARs und LXRs den reversen Cholesterintransport und die Aufnahme von PUFAs an der Blut-Hirn Schranke beeinflußt. Dadurch werden nukleäre Rezeptoren zu neuen Targets für die Therapie neurodegenerativer Erkrankungen. Um diese Hypothese zu validieren werden folgende Ziele addressiert:\r\n1.\tIdentifikation der wirksamsten endogenen und pharmazeutischen Liganden für PPARa, b, g und LXRa, b in microcapillären Schweinehirnendothelzellen.\r\n2.\tEvaluierung der durch nukleäre Rezeptoren vermittelten Regulation der Expression spezifischer Targetgene, die zentrale Rollen im Lipid-Turnover and der Blut-Hirn Schranke einnehmen.\r\n3.\tWirkungsweise von (synthetischen) Agonisten für PPARs und LXRs auf die Eliminierung von Cholesterin und 24(S)-hydroxycholesterin (i.e., auf den reversen Cholesterintransport) über ein in vitro Modell der Blut-Hirn Schranke.\r\n4.\tWirkungsweise von Liganden nukleärer Rezeptoren auf die Zufuhr mehrfach-ungesättigter Fettsäuren über ein in vitro Modell der Blut-Hirn Schranke.\r\n5.\tLarge-scale Genexpressionsanalyse zerebraler und gehirn-microvaskulärer PPAR und LXR Targetgene mittels cDNA-Microarrays im Mausmodell.\r\n", "en": "Nuclear receptors represent a large super family of ligand-dependent transcription factors that regulate the expression of target genes to affect diverse metabolic processes. Two members, peroxisome-proliferator activated receptors(PPARs) and liver X receptors(LXRs), control the transcription of key-genes involved in lipid metabolism, transport and elimination. PPARs and LXRs are lipid sensors that control central pathways in (chole)sterol and fatty acid metabolism at the blood-brain barrier (BBB). The proposed role of PPARs and LXRs at the BBB is based on the following background:(i) Several neurodegenerative disorders are tightly coupled to functional lipid and lipoprotein metabolism; (ii) Brain function and development rely on a supply with essential polyunsaturated fatty acids from the circulation; (iii) Excess brain cholesterol is eliminated after oxidative conversion to 24(S)OH-cholesterol;(iv) Brain endothelial cells express target genes for nuclear recertors that display gate-keeping functions in peripheral reverse cholesterol transport and/or in fatty acid uptake.The central hypothesis underlying the present application suggests that LXR and PPAR activation regulates reverse cholesterol transport and fatty acid supply at the BBB. Therefore, these nuclear receptors may provide promising drug target for the treatment of lipid-related neurodegenerative disorders in the near future. In order to validate this hypothesis the following aims are: \r\n1.) Identification of the most potent endogenous ligands and therapeutic drugs for activation of the nuclear receptors PPARalpha, beta, gamma and LXRalpha, beta in porcine brain capillary endothelial cells.\r\n2.) Evaluation of nuclear receptor-mediated regulation of the expression of specific target genes taking central roles during lipid turnover at the BBB.\r\n3.) Effects of (synthetic) agonists for PPARs and LXRs on elimination of cholesterol and 24(S)OH-cholesterol(i.e.,on reverse cholesterol transport) across an in vitro model of the BBB. \r\n4.) Effects of nuclear receptor ligands on the supply of essential polyunsaturated fatty acids across an in vitro model of the BBB.\r\n5.) Identification of cerebral and brain-microvascular PPAR and LXR target genes via large-scale gene expression profiling in the mouse model." }, "begin_planned": null, "begin_effective": "2004-10-01T02:00:00+02:00", "end_planned": null, "end_effective": "2007-11-30T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 72, "subprogram": null, "organization": 14013, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "P17474", "ethics_committee": null, "edudract_number": null, "persons": [] }, { "id": 310, "title": { "de": "Endotoxinwirkung auf Schrittmacherströme", "en": "Endotoxin effects on pacemaker currrents" }, "short": "Endotoxinwirkung auf Schrittmacherströme", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2004-10-01T02:00:00+02:00", "end_planned": null, "end_effective": "2006-06-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 4, "manager": 51681, "contact": 51681, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "310-51681-10", "310-50615-12", "310-50417-12", "310-51592-12", "310-50969-12" ] }, { "id": 314, "title": { "de": "Analyse von vier funktionellen genetischen Polymorphismen von Integrinen und ihr Einfluss auf Brustkrebsrisiko und Metastasierungsverhalten bei Brustkrebspatientinnen", "en": "Analysis of four genetic polymorphisms of integrins and their association with breast cancer risk and progression" }, "short": "genetische Polymorphismen bei Brustkrebs", "url": null, "abstract": { "de": "Die wichtigsten Adhäsionsrezeptoren für Thrombozyten sind auch auf Brustkrebszellen vorhanden. Sie spielen eine Schlüsselrolle in der tumorinduzierten Thrombozytenaggregation und in Adhäsionsinteraktionen, die notwendig sind für Tumorinvasion und Metastasierung. Dadurch spielen diese Moleküle eine bedeutsame Rolle, was den Verlauf und die Prognose einer bösartigen Tumorerkrankung betrifft. Mittlerweile wurden Polymorphismen nachgewiesen, welche die Plasmaspiegel, die Struktur und somit auch die Funktion dieser Rezeptoren beeinflussen. Für das Risiko und den Verlauf von kardiovaskulären Erkrankungen konnte in rezenten Studien eine eindeutige Assoziation gezeigt werden.\r\nWir wollen eine populationsbasierte Studie mit ca. 800 Brustkrebspatientinnen und 800 Kontrollen durchführen, bei der die Häufigkeit dieser Polymorphismen untersucht wird, um eine etwaige Assoziation mit Brustkrebsrisikoerhöhung, wie in der oben genannten Studie angenommen, nachzuweisen sowie eine Beeinflussung des Krankheitsverlaufs bzw. der Metastasierungswahrscheinlichkeit zu untersuchen.\r\nDas Wissen über solche genetisch beeinflussten Brustkrebsanfälligkeiten verbessert die Möglichkeit einer individuell angepassten Therapie und Verlaufskontrolle. Bei dem Nachweis einer Assoziation dieser obengenannten funktionellen Polymorphismen mit erhöhtem Brustkrebsrisiko wäre der Einsatz molekular zielgerichteter Therapeutiker (Adhäsionsrezeptorblocker) eine zusätzliche Behandlungsoption.", "en": "Die wichtigsten Adhäsionsrezeptoren für Thrombozyten sind auch auf Brustkrebszellen vorhanden. Sie spielen eine Schlüsselrolle in der tumorinduzierten Thrombozytenaggregation und in Adhäsionsinteraktionen, die notwendig sind für Tumorinvasion und Metastasierung. Dadurch spielen diese Moleküle eine bedeutsame Rolle, was den Verlauf und die Prognose einer bösartigen Tumorerkrankung betrifft. Mittlerweile wurden Polymorphismen nachgewiesen, welche die Plasmaspiegel, die Struktur und somit auch die Funktion dieser Rezeptoren beeinflussen. Für das Risiko und den Verlauf von kardiovaskulären Erkrankungen konnte in rezenten Studien eine eindeutige Assoziation gezeigt werden.\r\nWir wollen eine populationsbasierte Studie mit ca. 800 Brustkrebspatientinnen und 800 Kontrollen durchführen, bei der die Häufigkeit dieser Polymorphismen untersucht wird, um eine etwaige Assoziation mit Brustkrebsrisikoerhöhung, wie in der oben genannten Studie angenommen, nachzuweisen sowie eine Beeinflussung des Krankheitsverlaufs bzw. der Metastasierungswahrscheinlichkeit zu untersuchen.\r\nDas Wissen über solche genetisch beeinflussten Brustkrebsanfälligkeiten verbessert die Möglichkeit einer individuell angepassten Therapie und Verlaufskontrolle. Bei dem Nachweis einer Assoziation dieser obengenannten funktionellen Polymorphismen mit erhöhtem Brustkrebsrisiko wäre der Einsatz molekular zielgerichteter Therapeutiker (Adhäsionsrezeptorblocker) eine zusätzliche Behandlungsoption." }, "begin_planned": null, "begin_effective": "2004-10-15T02:00:00+02:00", "end_planned": null, "end_effective": "2005-10-14T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 52 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "314-52003-12", "314-51045-12", "314-50910-12", "314-50495-12" ] }, { "id": 288, "title": { "de": "A gene expression data set for breast cancer", "en": "A gene expression data set for breast cancer" }, "short": "Gene express data set for breast cancer", "url": null, "abstract": { "de": "The goal of the proposed project is to generate a fully disease-representative gene expression database for breast cancer containing genome-wide gene expression profiles and extensive pathologic and clinical data for each sample with ehich to decode the biological significance of the expression data. This resource will introduce new levels of quality and scope of gene expression data for cancer research.\r\nTo achieve this objective there is a need for an extensively documented collection of frozen and formalin-fixed primary breast cancer samples and state-of-the-art DNA microarray/bioinformatic and tissue microarray analysis platforms. This unique combination of resources can only be achieved in the context of a collaboration between GEN-AU and NGFN-funded programmes. The Disease Bank programme, lead by the Institute of Pathology in Graz, has access to one of the world's largest and highest quality collections of diseased tissues which includes 2600 frozen and 17000 formalin-fixed breast cancer samples with associated clinical, pathological and outcome data. The programme also has access to a proprietary tissue microarray robot for the rapid construction of highly standardised tissue microarrays. The NGFN-funded Division of Molecular Genome Analysis at the DKFZ in Heidelberg has developed highly standardised, high density DNA arrays containing 36000 genes and sophisticated bioinformatic tools for data analysis.\r\nAn important feature of the proposed study is that, throughout, great attention will be paid to sample preparation and documentation so as to generate a resource that is sufficiently standardised to be placed in the public domain and accessed by all scientists working in the breast cancer field. The availability of this resource will introduce a new era of breast cancer research in which the emphasis is shifted to hypothesis-driven data mining and the rapid transfer of research findings into clinical practice.", "en": "The goal of the proposed project is to generate a fully disease-representative gene expression database for breast cancer containing genome-wide gene expression profiles and extensive pathologic and clinical data for each sample with ehich to decode the biological significance of the expression data. This resource will introduce new levels of quality and scope of gene expression data for cancer research.\r\nTo achieve this objective there is a need for an extensively documented collection of frozen and formalin-fixed primary breast cancer samples and state-of-the-art DNA microarray/bioinformatic and tissue microarray analysis platforms. This unique combination of resources can only be achieved in the context of a collaboration between GEN-AU and NGFN-funded programmes. The Disease Bank programme, lead by the Institute of Pathology in Graz, has access to one of the world's largest and highest quality collections of diseased tissues which includes 2600 frozen and 17000 formalin-fixed breast cancer samples with associated clinical, pathological and outcome data. The programme also has access to a proprietary tissue microarray robot for the rapid construction of highly standardised tissue microarrays. The NGFN-funded Division of Molecular Genome Analysis at the DKFZ in Heidelberg has developed highly standardised, high density DNA arrays containing 36000 genes and sophisticated bioinformatic tools for data analysis.\r\nAn important feature of the proposed study is that, throughout, great attention will be paid to sample preparation and documentation so as to generate a resource that is sufficiently standardised to be placed in the public domain and accessed by all scientists working in the breast cancer field. The availability of this resource will introduce a new era of breast cancer research in which the emphasis is shifted to hypothesis-driven data mining and the rapid transfer of research findings into clinical practice." }, "begin_planned": null, "begin_effective": "2004-11-01T01:00:00+01:00", "end_planned": null, "end_effective": "2006-05-31T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 73, "subprogram": null, "organization": 14020, "category": 10, "type": 10, "partner_function": 2, "manager": 51663, "contact": 51663, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 152 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "288-51663-10" ] }, { "id": 252, "title": { "de": "Effects of hepoxilin A3 and its analogues on the function of human eosiophil and basophil granulocytes", "en": "Effects of hepoxilin A3 and its analogues on the function of human eosiophil and basophil granulocytes" }, "short": "Effects of hepoxilin A3 on granulocytes", "url": null, "abstract": { "de": "Hepoxilins are formed from arachidonic acid via 12-lipoxygenase pathway. Three isoforms of 12-lipoxygenase have been described and are widely expressed in immune cells an tissue, such as skin and lung. With respect to its diverse biological actions hepoxilin A3 is considered as the most relevant of this class of eicosanoids. In vivo and in vitro studies suggest that hepoxilin A3 has both pro-inflammatory and anti-inflammatory actions, and might play a role in the resolution phase of inflammatory conditions. Although hepoxilins are likely to be abundant at sites of allergic reactions, such as lung and skin, no data is available to-date on the effect of hepoxilins on eosinophil and basophil function, which are important effector cells involved in early- and late-phase allergic responses. In preliminary experiments we observed that hepoxilin A3 is a potent and highly effective inhibitor of eosinophil chemotaxis in vitro. Therefore, the proposed studies aim at further clarifying the actions of hepoxilin A3 on eosinophil and basophil function, including chemotaxis to a wide range of chemoattratants, degranulation, respiratory burst, cell survival and mobilisation of eosinophils from the bone marrow. In addition to their cytotoxic products eosinophils are also an important source of inflammatory mediators, such as leukotrienes and cytokienes.\r\nWe expect this study to provide better insights into the role of 12-lipogenases in general, and hepoxilins in particular, in regulating eosinophil and basophil function in order to predict the biological and pharmacological relevance hepoxilins in allergic disease. The study might hence yield novel regimes for the treatment of allergic diseases.", "en": "Hepoxilins are formed from arachidonic acid via 12-lipoxygenase pathway. Three isoforms of 12-lipoxygenase have been described and are widely expressed in immune cells an tissue, such as skin and lung. With respect to its diverse biological actions hepoxilin A3 is considered as the most relevant of this class of eicosanoids. In vivo and in vitro studies suggest that hepoxilin A3 has both pro-inflammatory and anti-inflammatory actions, and might play a role in the resolution phase of inflammatory conditions. Although hepoxilins are likely to be abundant at sites of allergic reactions, such as lung and skin, no data is available to-date on the effect of hepoxilins on eosinophil and basophil function, which are important effector cells involved in early- and late-phase allergic responses. In preliminary experiments we observed that hepoxilin A3 is a potent and highly effective inhibitor of eosinophil chemotaxis in vitro. Therefore, the proposed studies aim at further clarifying the actions of hepoxilin A3 on eosinophil and basophil function, including chemotaxis to a wide range of chemoattratants, degranulation, respiratory burst, cell survival and mobilisation of eosinophils from the bone marrow. In addition to their cytotoxic products eosinophils are also an important source of inflammatory mediators, such as leukotrienes and cytokienes.\r\nWe expect this study to provide better insights into the role of 12-lipogenases in general, and hepoxilins in particular, in regulating eosinophil and basophil function in order to predict the biological and pharmacological relevance hepoxilins in allergic disease. The study might hence yield novel regimes for the treatment of allergic diseases." }, "begin_planned": null, "begin_effective": "2004-11-01T01:00:00+01:00", "end_planned": null, "end_effective": "2006-04-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14022, "category": 10, "type": 10, "partner_function": 4, "manager": null, "contact": 51756, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "252-51756-10" ] }, { "id": 239, "title": { "de": "Quantifizierung der Expression des GLUT4 Gens (Insulinabhängiges transmembranäres Glukose-Transportmolekül) im atrialen humanen Myocard bei hypertonen und normotonen Patienten unter ischämischen und Kontrollbedingungen.", "en": "Quantifizierung der Expression des GLUT4 Gens (Insulinabhängiges transmembranäres Glukose-Transportmolekül) im atrialen humanen Myocard bei hypertonen und normotonen Patienten unter ischämischen und Kontrollbedingungen." }, "short": "Quantifizierung", "url": null, "abstract": { "de": "Das transmembranäre insulinabhängige Glukose-Transportmolekül GLUT4 spielt eine wesentliche Rolle für den Zucker- und Energiestoffwechsel des Herzens sowie für die Flüssigkeitsverteilung zwischen den Körperkompartments. Frühere Untersuchungen unserer und anderer Arbeitsgruppen konnten im Tier und Humanexperiment Hinweise finden, dass diesem Molekül in der Entwicklung des Bluthochdrucks eine besondere Bedeutung zukommt. Hypothese: Die Expression des GLUT4 Gens im Herzmuskel (und evtl. anderen Teilen des Herzkreislaufsystems) ist bei Patienten mit Bluthochdruck gegenüber Menschen mit normalem Blutdruck verringert und wird bei Durchblutungsstörungen modifiziert. Methodik: Mittels kombinierter RT-real-time-GLUT-PCR (Light Cycler) soll an menschlichen Herzmuskelzellen eine quantitative Erfassung der GLUT4 Genexpression erfolgen. Langfristiges Ziel: ein tieferes Verständnis der Entstehung des Bluthochdrucks soll neue Therapiemöglichkeiten erschließen.", "en": "Das transmembranäre insulinabhängige Glukose-Transportmolekül GLUT4 spielt eine wesentliche Rolle für den Zucker- und Energiestoffwechsel des Herzens sowie für die Flüssigkeitsverteilung zwischen den Körperkompartments. Frühere Untersuchungen unserer und anderer Arbeitsgruppen konnten im Tier und Humanexperiment Hinweise finden, dass diesem Molekül in der Entwicklung des Bluthochdrucks eine besondere Bedeutung zukommt. Hypothese: Die Expression des GLUT4 Gens im Herzmuskel (und evtl. anderen Teilen des Herzkreislaufsystems) ist bei Patienten mit Bluthochdruck gegenüber Menschen mit normalem Blutdruck verringert und wird bei Durchblutungsstörungen modifiziert. Methodik: Mittels kombinierter RT-real-time-GLUT-PCR (Light Cycler) soll an menschlichen Herzmuskelzellen eine quantitative Erfassung der GLUT4 Genexpression erfolgen. Langfristiges Ziel: ein tieferes Verständnis der Entstehung des Bluthochdrucks soll neue Therapiemöglichkeiten erschließen." }, "begin_planned": null, "begin_effective": "2004-12-01T01:00:00+01:00", "end_planned": null, "end_effective": "2008-04-30T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14083, "category": 10, "type": 10, "partner_function": 4, "manager": 51533, "contact": 51533, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "239-51533-10" ] }, { "id": 433, "title": { "de": "Intensivbehandlungen, Dauerschäden und Todesfälle bei Infektionskrankheiten, die durch Schutzimpfungen zu vermeiden gewesen wären", "en": "Intensivbehandlungen, Dauerschäden und Todesfälle bei Infektionskrankheiten, die durch Schutzimpfungen zu vermeiden gewesen wären" }, "short": "Schutzimpfungen", "url": null, "abstract": { "de": "Um die steirische Bevölkerung besser über die enormen Vorteile des Impfens informieren zu können, plant die Univ.-Klinik f. Kinder- und Jugendheilkunde Graz ein Dokumentationszentrum über die Auswirkungen derjenigen Erkrankungen zu errichten, die duch Schutzimpfungen verhindert werden hätten können. In diesem Projekt werden alle Kinder erfasst, die eine Erkrankung durchgemacht haben, die entweder zum Tod, zu einem bleibenden Schaden oder zu einer Intensivbehandlung geführt hat und die durch eine Schutzimpung zu vermeiden gewesen wäre. ", "en": "Um die steirische Bevölkerung besser über die enormen Vorteile des Impfens informieren zu können, plant die Univ.-Klinik f. Kinder- und Jugendheilkunde Graz ein Dokumentationszentrum über die Auswirkungen derjenigen Erkrankungen zu errichten, die duch Schutzimpfungen verhindert werden hätten können. In diesem Projekt werden alle Kinder erfasst, die eine Erkrankung durchgemacht haben, die entweder zum Tod, zu einem bleibenden Schaden oder zu einer Intensivbehandlung geführt hat und die durch eine Schutzimpung zu vermeiden gewesen wäre." }, "begin_planned": null, "begin_effective": "2004-12-14T01:00:00+01:00", "end_planned": null, "end_effective": "2006-01-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14091, "category": 10, "type": 10, "partner_function": 4, "manager": 51647, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "433-51647-10" ] }, { "id": 439, "title": { "de": "Möglichkeiten der pharmakologischen und nicht-pharmakologischen Beeinflussung lokaler Knochenumbauprozesse vor, während und nach kieferorthopädischen Behandlungen zur Optimierung von Therapiedauer und Nachhaltigkeit des Regulierungsergebnisses", "en": "Möglichkeiten der pharmakologischen und nicht-pharmakologischen Beeinflussung lokaler Knochenumbauprozesse vor, während und nach kieferorthopädischen Behandlungen zur Optimierung von Therapiedauer und Nachhaltigkeit des Regulierungsergebnisses" }, "short": "Lokale Knochenumbauprozesse", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": null, "begin_effective": "2005-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2007-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51874, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "439-51874-10" ] }, { "id": 348, "title": { "de": "Augenscreening im Vorschulalter", "en": "Augenscreening im Vorschulalter" }, "short": "Augenscreening im Vorschulalter", "url": null, "abstract": { "de": "Die jährliche Evaluierung der Inanspruchnahme der Mutter-Kind-Pass-Untersuchungen hat ergeben, dass die im 2. Lebensjahr vorgesehene Augenarztuntersuchung nur in 23% durchgeführt wurde. Die Kinder mit Mikrostrabismus (Kleinwinkelschielen) und Refraktionsanomalien (Brechungsanomalien der Augen wie Weitsichtigkeit, Kurzsichtigkeit, Stabsichtigkeit), besonders Anisometropien (unterschiedliche Brechkraft an beiden Augen), die unerkannt zu schwerer Amblyopie (Schwachsichtigkeit) führen, werden dadurch erst im Schulalter diagnostiziert - zu spät für jegliche Behandlung. Ziel des Projektes ist es, möglichst alle Kinder der Steiermark im Vorschulalter (2.-4-Lj) zu erreichen, über ein Screening Programm Pathologien zu erfassen und einer in diesem Alter noch möglichen Therapie zuzuführen um Amblyopien zu verhindern. Am Jahresende wird ein detailliertes Ergebnis präsentiert.", "en": "Die jährliche Evaluierung der Inanspruchnahme der Mutter-Kind-Pass-Untersuchungen hat ergeben, dass die im 2. Lebensjahr vorgesehene Augenarztuntersuchung nur in 23% durchgeführt wurde. Die Kinder mit Mikrostrabismus (Kleinwinkelschielen) und Refraktionsanomalien (Brechungsanomalien der Augen wie Weitsichtigkeit, Kurzsichtigkeit, Stabsichtigkeit), besonders Anisometropien (unterschiedliche Brechkraft an beiden Augen), die unerkannt zu schwerer Amblyopie (Schwachsichtigkeit) führen, werden dadurch erst im Schulalter diagnostiziert - zu spät für jegliche Behandlung. Ziel des Projektes ist es, möglichst alle Kinder der Steiermark im Vorschulalter (2.-4-Lj) zu erreichen, über ein Screening Programm Pathologien zu erfassen und einer in diesem Alter noch möglichen Therapie zuzuführen um Amblyopien zu verhindern. Am Jahresende wird ein detailliertes Ergebnis präsentiert." }, "begin_planned": null, "begin_effective": "2005-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2006-07-31T02:00:00+02:00", "assignment": "2005-10-26T02:00:00+02:00", "program": null, "subprogram": null, "organization": 14043, "category": 10, "type": 10, "partner_function": 4, "manager": 51583, "contact": 51583, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 135 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "348-51583-10" ] }, { "id": 333, "title": { "de": "Psycho-Neuro-Immunologie. Einfluss einer psychosozialen Intervention auf T und NK Zellfunktion von Patientinnen mit Mammakarzinom", "en": "Psycho-Neuro-Immunologie. Einfluss einer psychosozialen Intervention auf T und NK Zellfunktion von Patientinnen mit Mammakarzinom" }, "short": "Psycho-Neuro-Immunologie Mammakarzinom", "url": null, "abstract": { "de": "The autonomic, neuroendocrine, and the immune systems are orchestrated in part to preserve conditions compatible with life. The critical question in immunosurveillance against cancer is whether differences between individuals with regard to immunologic host-defense mechanisms can predict the incidende or progression of cancer. Acute as well as chronic stressors have been associated with reduction of various in vitro measures of immune function. Even acute commonplace stressful events like a final examination scenario for medical students or \"the public speaking situation\" are associated with transient changes in immunologic parameters (e.g. natural killer(NK) cell number and cytotoxity, T helper/inducer cell number, production of interferon (IFN) gamma by lymphocytes stimulated with Concavalin-A, etc.) along with elevated stress hormone levels and cardiovascular activation compared to controls. The aims of the study are: * Further evaluation of differences in immune parameters of patients with breast cancer compared to their significant others and non related healthy volunteers focusing on differences in the relative number of T and NK cell subpopulations, onset of apoptosis and functional parameters like the kinetics of perforin release of stimulated T and NK cells. *Assessment of hormonal parameters in the three study populations and their correlation to immune parameters as well as psychosocial parameters. * Investigation of the influence of psychosocial intervention on the immune system with special regard to T cell- and NK cell subpopulations, rate of apoptosis and perforin release of these immune cells in patients with operated breast cancer compared to significant others and healthy volunteers.", "en": "The autonomic, neuroendocrine, and the immune systems are orchestrated in part to preserve conditions compatible with life. The critical question in immunosurveillance against cancer is whether differences between individuals with regard to immunologic host-defense mechanisms can predict the incidende or progression of cancer. Acute as well as chronic stressors have been associated with reduction of various in vitro measures of immune function. Even acute commonplace stressful events like a final examination scenario for medical students or \"the public speaking situation\" are associated with transient changes in immunologic parameters (e.g. natural killer(NK) cell number and cytotoxity, T helper/inducer cell number, production of interferon (IFN) gamma by lymphocytes stimulated with Concavalin-A, etc.) along with elevated stress hormone levels and cardiovascular activation compared to controls. The aims of the study are: * Further evaluation of differences in immune parameters of patients with breast cancer compared to their significant others and non related healthy volunteers focusing on differences in the relative number of T and NK cell subpopulations, onset of apoptosis and functional parameters like the kinetics of perforin release of stimulated T and NK cells. * Assessment of hormonal parameters in the three study populations and their correlation to immune parameters as well as psychosocial parameters. * Investigation of the influence of psychosocial intervention on the immune system with special regard to T cell- and NK cell subpopulations, rate of apoptosis and perforin release of these immune cells in patients with operated breast cancer compared to significant others and healthy volunteers" }, "begin_planned": null, "begin_effective": "2005-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2006-10-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 79, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 51692, "contact": 51692, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 12 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "333-52003-12", "333-51692-10", "333-50563-12" ] }, { "id": 298, "title": { "de": "In vivo aging as regenerative defect. Effects of adrenergic and oxidative stress on stem cell functions", "en": "In vivo aging as regenerative defect. Effects of adrenergic and oxidative stress on stem cell functions" }, "short": "In vivo aging as regenerative defect", "url": null, "abstract": { "de": "We plan to study stem cell biology in the context of the aging process. Besides a gross characterization of stem cells with regard to tissue regeneration, we will also investigate, if and how oxidative stress and catecholamines influence the growth and regenartive capcity of adult stem cells in the bone marrow, and, by the same token, affect aging, age-associated disease and life span. Experimentally, this will be tested in the Senescence-Accelerated-Mouse-Prone/Resistant Model. Several substrains with differing in age-associated pathology are available.\r\nIn particular, we will determine *the regenerative capacity of b one marrow stem cells in the context of aging and age-associated pathology, *if stem cell survival and functions can be affected by catecholamines and/or oxidative stress, *if aging and age associated pathology can be reduced by transplantation of bone marrow cells from young but not old donors.", "en": "We plan to study stem cell biology in the context of the aging process. Besides a gross characterization of stem cells with regard to tissue regeneration, we will also investigate, if and how oxidative stress and catecholamines influence the growth and regenartive capcity of adult stem cells in the bone marrow, and, by the same token, affect aging, age-associated disease and life span. Experimentally, this will be tested in the Senescence-Accelerated-Mouse-Prone/Resistant Model. Several substrains with differing in age-associated pathology are available.\r\nIn particular, we will determine *the regenerative capacity of b one marrow stem cells in the context of aging and age-associated pathology, *if stem cell survival and functions can be affected by catecholamines and/or oxidative stress, *if aging and age associated pathology can be reduced by transplantation of bone marrow cells from young but not old donors." }, "begin_planned": null, "begin_effective": "2005-01-01T01:00:00+01:00", "end_planned": null, "end_effective": "2007-12-31T01:00:00+01:00", "assignment": "2005-10-26T02:00:00+02:00", "program": 72, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 2, "manager": null, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "298-50379-12" ] } ] }