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GET /v1/research/project/?format=api&offset=100&ordering=-end_effective
{ "count": 2329, "next": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=120&ordering=-end_effective", "previous": "https://api-test.medunigraz.at/v1/research/project/?format=api&limit=20&offset=80&ordering=-end_effective", "results": [ { "id": 9082, "title": { "de": "Der Einfluss von humanen p53 Varianten auf Gewichtsschwankungs-assoziierte Metaflammation", "en": "Impact of human p53 variants on metaflammation during weight cycling" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-09T15:54:23+02:00", "program": 116, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 124455, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9082-124455-10" ] }, { "id": 8731, "title": { "de": "Metabolische und epigenetische Regulierung von Th9-Zellen", "en": "Metabolic and epigenetic regulation of Th9 cells" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-11-01T01:00:00+01:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2027-10-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-03-17T16:30:44+01:00", "program": 72, "subprogram": null, "organization": 14014, "category": 10, "type": 10, "partner_function": 4, "manager": 78952, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PAT9714324", "ethics_committee": null, "edudract_number": null, "persons": [ "8731-78952-10" ] }, { "id": 9072, "title": { "de": "Bioresorbierbare Mg-Fe Implantate in der Knochenheilung", "en": "Adapting bioresorbable Mg-Fe implants in bone healing" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2026-12-31T01:00:00+01:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-07T13:18:31+02:00", "program": 111, "subprogram": null, "organization": 14052, "category": 10, "type": 10, "partner_function": 2, "manager": 98087, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "PIN5073823", "ethics_committee": null, "edudract_number": null, "persons": [ "9072-98087-10" ] }, { "id": 9083, "title": { "de": "Metabolische Signaturen und Reaktionsvorhersage unter Nährstoffentzug bei Brustkrebs", "en": "Metabolic Signatures and Response Prediction under Nutrient Deprivation in Breast Cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-09-01T02:00:00+02:00", "begin_effective": "2025-09-01T02:00:00+02:00", "end_planned": "2028-08-31T02:00:00+02:00", "end_effective": "2028-08-31T02:00:00+02:00", "assignment": "2025-07-09T16:52:51+02:00", "program": 116, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 107135, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 15 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9083-107135-10" ] }, { "id": 9498, "title": { "de": "Dauer der Surfactant-Applikation und Einfluss auf die Stabilisierung der Vitalparameter bei sehr unreifen Frühgeborenen: 1 Minute versus 5 Minuten – eine prospektive, randomisiert-kontrollierte Phase-IV-Studie.", "en": "Duration of Surfactant administration and impact on Stabilisation of vital parameters in very preterm neonates: 1 minute versus 5 minutes – a prospective randomised-controlled phase IV trial." }, "short": "SurfStab I Trial", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-01-08T01:00:00+01:00", "begin_effective": "2026-01-08T01:00:00+01:00", "end_planned": "2028-08-08T02:00:00+02:00", "end_effective": "2028-08-07T02:00:00+02:00", "assignment": "2025-12-17T12:10:35+01:00", "program": null, "subprogram": null, "organization": 14094, "category": 10, "type": 10, "partner_function": 1, "manager": 82050, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 3942 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9498-82050-10" ] }, { "id": 8325, "title": { "de": "XR2ESILIENCE - BAHNBRECHENDE XR-TECHNOLOGIE ZUR FÖRDERUNG DER RESILIENZ \r\nUND DER PSYCHISCHEN GESUNDHEIT DES GESUNDHEITSPERSONALS", "en": "XR2ESILIENCE - PIONEERING XR TECHNOLOGY FOR THE PROMOTION OF RESILIENCE \r\nAND MENTAL HEALTH OF THE HEALTHCARE WORKFORCE" }, "short": "XR2ESILIENCE", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-12-01T01:00:00+01:00", "begin_effective": "2024-08-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-07-31T02:00:00+02:00", "assignment": "2024-08-05T12:40:49+02:00", "program": 211, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 3, "manager": 79733, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8325-79733-10" ] }, { "id": 8142, "title": { "de": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms", "en": "TARgetinG disease pErsisTence and progression of\r\nMyeloProliferative Neoplasms" }, "short": "TARGET MPN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-01-01T01:00:00+01:00", "begin_effective": "2024-06-01T02:00:00+02:00", "end_planned": "2028-01-01T01:00:00+01:00", "end_effective": "2028-07-10T02:00:00+02:00", "assignment": "2024-04-18T12:35:12+02:00", "program": null, "subprogram": null, "organization": 14085, "category": 10, "type": 10, "partner_function": 4, "manager": 107132, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I06944", "ethics_committee": null, "edudract_number": null, "persons": [ "8142-107132-10", "8142-134381-12", "8142-101484-12", "8142-126596-12" ] }, { "id": 9779, "title": { "de": "Aktivierung des PXR-TFEB-Autophagie-Netzwerks zur Behandlung des Alpha-1-Antitrypsin-Mangels", "en": "Activation of the PXR-TFEB-Autophagy Network to treat Alpha-1-Antitrypsin Deficiency" }, "short": "The PXR-TFEB axis in A1AT", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-07-01T02:00:00+02:00", "begin_effective": "2026-07-01T02:00:00+02:00", "end_planned": "2028-06-30T02:00:00+02:00", "end_effective": "2028-06-30T02:00:00+02:00", "assignment": "2026-05-07T11:59:06+02:00", "program": null, "subprogram": null, "organization": 14081, "category": 10, "type": 10, "partner_function": 4, "manager": 57377, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 3938 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9779-57377-10" ] }, { "id": 4874, "title": { "de": "Analyse des RAS/MAPK-ERK Signalweges bei der akuten myeloischen Leukämie", "en": "Analysis of the RAS/MAPK-ERK signal transduction cascade in acute myeloid leukemia" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2017-04-15T02:00:00+02:00", "begin_effective": "2017-04-01T02:00:00+02:00", "end_planned": "2018-04-14T02:00:00+02:00", "end_effective": "2028-06-30T02:00:00+02:00", "assignment": "2017-03-09T11:45:45+01:00", "program": null, "subprogram": null, "organization": 14082, "category": 10, "type": 10, "partner_function": 4, "manager": 57402, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 423 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "4874-80093-12", "4874-57402-10", "4874-97430-12", "4874-104139-12", "4874-126117-12" ] }, { "id": 8390, "title": { "de": "Intermittierendes Fasten und Bewegung bei Typ 2 Diabetes", "en": "Intermittent Fasting and Exercise in Type 2 Diabetes" }, "short": "INTERFAST-3", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2024-06-15T02:00:00+02:00", "begin_effective": "2024-06-15T02:00:00+02:00", "end_planned": "2027-06-14T02:00:00+02:00", "end_effective": "2028-06-14T02:00:00+02:00", "assignment": "2024-09-17T12:19:28+02:00", "program": 108, "subprogram": null, "organization": 14080, "category": 10, "type": 10, "partner_function": 4, "manager": 50838, "contact": null, "status": 2, "research": 4, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "KLP3413324", "ethics_committee": null, "edudract_number": null, "persons": [ "8390-50838-10" ] }, { "id": 9742, "title": { "de": "Entschlüsselung der Entstehung von TP53-mutierten therapieassoziierten myeloischen Neoplasien.", "en": "Decoding the development of TP53 mutant therapy-related myeloid neoplasms." }, "short": "TP53 mutant t-MN", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-04-01T02:00:00+02:00", "begin_effective": "2026-06-01T02:00:00+02:00", "end_planned": "2028-03-31T02:00:00+02:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2026-04-22T17:21:51+02:00", "program": null, "subprogram": null, "organization": 14058, "category": 10, "type": 10, "partner_function": 3, "manager": 97755, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9742-97755-10" ] }, { "id": 9741, "title": { "de": "Zirkulierende Tumor-DNA (ctDNA) zur Charakterisierung und Detektion minimaler Resterkrankung beim muskel-invasiven Harnblasenkarzinom\r\n\r\n\r\n", "en": "Circulating Tumor DNA (ctDNA) for characterization and detection of minimal residual disease in muscle-invasive bladder cancer" }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-06-01T02:00:00+02:00", "begin_effective": "2026-06-01T02:00:00+02:00", "end_planned": "2028-05-31T02:00:00+02:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2026-04-22T16:56:59+02:00", "program": null, "subprogram": null, "organization": 14056, "category": 10, "type": 10, "partner_function": 1, "manager": 130518, "contact": null, "status": 2, "research": 3, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 1743 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9741-130518-10" ] }, { "id": 8609, "title": { "de": "Exogene eletrische und mechanische Stimulation durch eletronische Haut stimuliert die Zellprofileration der oralen Mundschleimhaut", "en": "Exogenous electrical and mechanical motion stimulation by using an electronic skin for support oral cell proliferation." }, "short": null, "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-02-01T01:00:00+01:00", "begin_effective": "2025-06-01T02:00:00+02:00", "end_planned": "2028-01-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2025-01-21T17:58:12+01:00", "program": null, "subprogram": null, "organization": 14017, "category": 10, "type": 10, "partner_function": 4, "manager": 133140, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "ESP6372324", "ethics_committee": null, "edudract_number": null, "persons": [ "8609-133140-10" ] }, { "id": 7529, "title": { "de": "Impfbare Krankheiten bei schwangeren und stillenden Frauen", "en": "Vaccine preventable diseases in pregnant and lactating women" }, "short": null, "url": null, "abstract": { "de": "Given its effectiveness in protecting pregnant women, foetuses and infants from infectious diseases, maternal immunization has gained interest in recent years. Nevertheless, information on the optimal timing for this vaccination strategy is limited by the relatively poor understanding of the immunobiology of vaccine responses in pregnancy and during lactation. Dynamic changes in immune function occur during gestation that may affect vaccine response in pregnant women if vaccination is given at a different timepoint in pregnancy. Additionally, since several recommendations for vaccination in pregnancy or during lactation are currently in place or being made, the question arises whether the administration of different vaccines has an impact on the induction of the antibody-mediated immune responses and whether this possibly also influence the kinetics of these vaccine-induced antibodies. This implies that repeated sampling after vaccination is needed to describe and analyse antibody kinetics. However, the design of maternal immunization studies is typically informed by generic statistical approaches not dealing with questions as to when and how often samples should be taken in order to gather the right amount of information to investigate antibody kinetics.\r\n\r\nThe objectives are 1) to describe and compare kinetics of antibodies to two different vaccines (Tdap, COVID-19) and to investigate potential interactions; 2) to develop a framework to plan maternal immunization studies.\r\n\r\nIn two ongoing trials, serum and breastmilk samples are collected at several timepoints during and after pregnancy. In the Tdap trial, three cohorts of women are included differing in gestational age at which women are vaccinated with Tdap vaccine. In the COVID-19 trial, the effects of vaccinating pregnant and lactating women with a COVID-19 vaccine are investigated. In this project, we will measure antibody titres in blood and breastmilk samples for the vaccine not being the focus of the respective trial, i.e. getting in all samples information on Tdap and COVID-19. We will use mathematical models combined with statistical tools to analyse dynamic immune response and to improve the design of maternal immunization studies.\r\n\r\nThe main innovations are:1) comparing kinetic behaviour of antibodies induced by two different vaccines on several time points in serum and breastmilk; 2) investigating potential interactions of antibodies induced by two vaccines impacting the kinetics over time; 3) development of novel methodology to analyse and plan maternal immunization studies. Within this project, we focus on pertussis and COVID-19 as examples, but outcomes of this project can be applied to other infectious diseases for which vaccines can be administered in pregnancy or during lactation.", "en": "Aufgrund der hohen Anfälligkeit von Schwangeren, Föten und Säuglingen für Infektionskrankheiten hat die Immunisierung von Müttern in den letzten Jahren an Interesse gewonnen. Dennoch ist der optimale Zeitpunkt für eine Impfung in der Schwangerschaft noch immer unbekannt. Außerdem kommt es während der Schwangerschaft zu dynamischen Veränderungen der Immunfunktion, wenn ein Impfstoff zu einem anderen Schwangerschaftsalter verabreicht wird. Dies kann die Reaktion auf den Impfstoff und die Kinetik der durch den Impfstoff induzierten mütterlichen Antikörper im Blut und in der Muttermilch der Schwangeren beeinflussen.\r\n\r\nDa derzeit mehrere Empfehlungen für Impfungen in der Schwangerschaft gelten bzw. ausgesprochen werden, stellt sich außerdem die Frage, ob die Verabreichung verschiedener Impfstoffe in der Schwangerschaft Auswirkungen auf die Immunreaktionen auf diese Impfstoffe hat und möglicherweise eine Wechselwirkung in der Kinetik der durch verschiedene Impfstoffe induzierten Antikörper verursacht.\r\n\r\nIm Rahmen dieses Projekts wollen wir den optimalen Zeitpunkt für die Impfung in der Schwangerschaft bestimmen, die Antikörperkinetik vergleichen und mögliche Wechselwirkungen bei der Immunantwort untersuchen, wenn verschiedene Impfstoffe (z. B. Pertussis, COVID-19) in der Schwangerschaft verabreicht werden. Wir entwickeln konzeptionelle Rahmen, in denen wir statistische Ansätze mit mathematischen Modellen von Infektionskrankheiten kombinieren, um die Analyse und das Design von Studien zur mütterlichen Immunisierung zu verbessern.\r\n\r\nDer Schwerpunkt des Projekts liegt auf Pertussis und COVID-19, aber die Ergebnisse können auch auf andere Infektionskrankheiten angewendet werden, gegen die Impfstoffe in der Schwangerschaft verabreicht werden können." }, "begin_planned": "2023-01-01T01:00:00+01:00", "begin_effective": "2023-06-01T02:00:00+02:00", "end_planned": "2027-12-31T01:00:00+01:00", "end_effective": "2028-05-31T02:00:00+02:00", "assignment": "2023-04-27T14:12:52+02:00", "program": 111, "subprogram": null, "organization": 14026, "category": 10, "type": 10, "partner_function": 1, "manager": 83644, "contact": null, "status": 2, "research": 1, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 9 ], "funder_projectcode": "I6376", "ethics_committee": null, "edudract_number": null, "persons": [ "7529-83644-10" ] }, { "id": 8809, "title": { "de": "Hybride KI-Modelle für die Erkennung und Überprüfung von Behauptungen", "en": "Hybrid AI Models for Claim Detection and Verification" }, "short": "CLAIM - AI Ökosysteme 2024", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-05-01T02:00:00+02:00", "begin_effective": "2025-05-01T02:00:00+02:00", "end_planned": "2028-05-31T02:00:00+02:00", "end_effective": "2028-04-30T02:00:00+02:00", "assignment": "2025-04-28T12:20:20+02:00", "program": 126, "subprogram": null, "organization": 29444, "category": 10, "type": 10, "partner_function": 2, "manager": 50654, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": "FO999923561", "ethics_committee": null, "edudract_number": null, "persons": [ "8809-50654-10" ] }, { "id": 8764, "title": { "de": "CRP-Sensormessung im Urin mittels smarter Textilien", "en": "Smart textile sensor for analyzing C-reactive protein in urine" }, "short": "UriSens", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", "begin_effective": "2025-05-01T02:00:00+02:00", "end_planned": "2028-12-31T01:00:00+01:00", "end_effective": "2028-04-30T02:00:00+02:00", "assignment": "2025-04-10T12:52:29+02:00", "program": null, "subprogram": "Schlüsseltechnologien im produktionsnahen Umfeld, 2024", "organization": 14080, "category": 10, "type": 10, "partner_function": 2, "manager": 51809, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 416 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "8764-51809-10" ] }, { "id": 7578, "title": { "de": "STEUERUNG MULTIMODALER THERAPIEN GEGEN MINIMALE RESTERKRANKUNGEN DURCH FLÜSSIGBIOPSIEN", "en": "GUIDING MULTI-MODAL THERAPIES AGAINST MINIMAL RESIDUAL DISEASE BY LIQUID BIOPSIES\r\n" }, "short": "GUIDE.MRD ", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2023-05-01T02:00:00+02:00", "begin_effective": "2023-05-01T02:00:00+02:00", "end_planned": "2027-04-30T02:00:00+02:00", "end_effective": "2028-04-30T02:00:00+02:00", "assignment": "2023-05-19T10:58:07+02:00", "program": null, "subprogram": null, "organization": 14021, "category": 10, "type": 10, "partner_function": 2, "manager": 50899, "contact": null, "status": 2, "research": 2, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": "101112066", "ethics_committee": null, "edudract_number": null, "persons": [ "7578-50899-10", "7578-76215-12", "7578-104199-12", "7578-116101-12", "7578-120331-12", "7578-121409-12" ] }, { "id": 9652, "title": { "de": "Br-TRAP: Towards virtual Risk Assessment for Patient-specific stratification in Brugada syndrome", "en": "Br-TRAP: Towards virtual Risk Assessment for Patient-specific stratification in Brugada syndrome" }, "short": "Br-TRAP", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2026-04-22T02:00:00+02:00", "begin_effective": "2026-04-22T02:00:00+02:00", "end_planned": "2028-04-22T02:00:00+02:00", "end_effective": "2028-04-21T02:00:00+02:00", "assignment": "2026-03-05T12:35:53+01:00", "program": 209, "subprogram": null, "organization": 14011, "category": 10, "type": 10, "partner_function": 1, "manager": 128994, "contact": null, "status": 2, "research": 10, "grant": 10, "event": null, "study": null, "language": null, "funders": [ 10 ], "funder_projectcode": null, "ethics_committee": null, "edudract_number": null, "persons": [ "9652-128994-10" ] }, { "id": 8713, "title": { "de": "Galectin-3 gezielte antifungale Prophylaxe bei influenza", "en": "Galectin-3 targeted antifungal prophylaxis in ICU influenza" }, "short": "GALACtiC", "url": null, "abstract": { "de": null, "en": null }, "begin_planned": "2025-01-01T01:00:00+01:00", 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