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"text": "\n185099\nInositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation.\n\nQi, XY\n\nVahdahi Hassani, F\n\nHoffmann, D\n\nXiao, J\n\nXiong, F\n\nVilleneuve, LR\n\nLjubojevic-Holzer, S\n\nKamler, M\n\nAbu-Taha, I\n\nHeijman, J\n\nBers, DM\n\nDobrev, D\n\nNattel, S\n\nBeiträge in Fachzeitschriften\nNone\n33375812.0\n10.1161/CIRCRESAHA.120.317768\nNone\nRationale: The mechanisms underlying atrial fibrillation (AF), the most common clinical arrhythmia, are poorly understood. Nucleoplasmic Ca2+ regulates gene-expression, but the nature and significance of nuclear Ca2+-changes in AF are largely unknown. Objective: To elucidate mechanisms by which AF alters atrial cardiomyocyte (CM) nuclear Ca2+ ([Ca2+]Nuc) and Ca2+/calmodulin-dependent protein kinase-II (CaMKII)-related signaling.Methods and Results: Atrial CMs were isolated from control and AF-dogs (kept in AF by atrial tachypacing [600 bpm x 1 week]). [Ca2+]Nuc and cytosolic [Ca2+] (Ca2+]Cyto) were recorded via confocal microscopy. Diastolic [Ca2+]Nuc was greater than [Ca2+]Cyto under control conditions, while resting [Ca2+]Nuc was similar to [Ca2+]Cyto; both diastolic and resting [Ca2+]Nuc increased with AF. Inositol-trisphosphate-receptor (IP3R) stimulation produced larger [Ca2+]Nuc increases in AF versus control CMs, and IP3R-blockade suppressed the AF-related [Ca2+]Nuc-differences. AF upregulated nuclear protein-expression of IP3R-type 1 (IP3R1) and of phosphorylated CaMKII (immunohistochemistry and immunoblot), while decreasing the nuclear/cytosolic expression-ratio for histone deacetylase type-4 (HDAC4). Isolated atrial CMs tachypaced at 3 Hz for 24 hours mimicked AF-type [Ca2+]Nuc changes and L-type calcium current (ICaL) decreases versus 1-Hz-paced CMs; these changes were prevented by IP3R knockdown with short-interfering RNA directed against IP3R1. Nuclear/cytosolic HDAC4 expression-ratio was decreased by 3-Hz pacing, while nuclear CaMKII and HDAC4 phosphorylation were increased. Either CaMKII-inhibition (by autocamtide-2-related peptide) or IP3R-knockdown prevented the CaMKII-hyperphosphorylation and nuclear-to-cytosolic HDAC4 shift caused by 3-Hz pacing. In human atrial CMs from AF patients, nuclear IP3R1-expression was significantly increased, with decreased nuclear/non-nuclear HDAC4 ratio. MicroRNA-26a was predicted to target ITPR1 (confirmed by Luciferase assay) and was downregulated in AF atrial CMs; microRNA-26a silencing reproduced AF-induced IP3R1 upregulation and nuclear diastolic Ca2+-loading. Conclusions: AF increases atrial CM nucleoplasmic Ca2+-handling by IP3R1-upregulation involving miR-26a, leading to enhanced IP3R1-CaMKII-HDAC4 signaling and ICaL-downregulation.\n\nHolzer, Senka\n\n\n"
},
{
"text": "\n185209\nReal-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee.\n\nAlgwaiz, G\n\nAljurf, M\n\nKoh, M\n\nHorowitz, MM\n\nLjungman, P\n\nWeisdorf, D\n\nSaber, W\n\nKodera, Y\n\nSzer, J\n\nJawdat, D\n\nWood, WA\n\nBrazauskas, R\n\nLehmann, L\n\nPasquini, MC\n\nSeber, A\n\nLu, PH\n\nAtsuta, Y\n\nRiches, M\n\nPerales, MA\n\nWorel, N\n\nOkamoto, S\n\nSrivastava, A\n\nChemaly, RF\n\nCordonnier, C\n\nDandoy, CE\n\nWingard, JR\n\nKharfan-Dabaja, MA\n\nHamadani, M\n\nMajhail, NS\n\nWaghmare, AA\n\nChao, N\n\nKröger, N\n\nShaw, B\n\nMohty, M\n\nNiederwieser, D\n\nGreinix, H\n\nHashmi, SK\n\nWBMT and the CIBMTR Health Services and International Studies Committee\n\nBeiträge in Fachzeitschriften\nISI:000594542200012\n32717432.0\n10.1016/j.bbmt.2020.07.021\nPMC7380217\nThe current COVID-19 pandemic, caused by SARS-CoV-2, has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers and the recognition of the variability in practice worldwide, the Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT, including diagnostics for SARS-CoV-2 in HCT recipient, pre- and post-HCT management, donor issues, medical tourism, and facilities management. During these crucial times, which may last for months or years, the HCT community must reorganize to proceed with transplantation activity in those patients who urgently require it, albeit with extreme caution. This shared knowledge may be of value to the HCT community in the absence of high-quality evidence-based medicine. © 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.\n Copyright © 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.\n\nGreinix, Hildegard\n\n\n"
},
{
"text": "\n4896\nImpingement syndrome of the ankle following supination external rotation trauma: MR imaging findings with arthroscopic correlation.\n\nSchaffler, GJ\n\nTirman, PF\n\nStoller, DW\n\nGenant, HK\n\nCeballos, C\n\nDillingham, MF\n\nBeiträge in Fachzeitschriften\nISI:000183458600021\n12764653.0\n10.1007/s00330-002-1661-2\nNone\nOur objective was to identify MR imaging findings in patients with syndesmotic soft tissue impingement of the ankle and to investigate the reliability of these imaging characteristics to predict syndesmotic soft tissue impingement syndromes of the ankle. Twenty-one ankles with chronic pain ultimately proven to have anterior soft tissue impingement syndrome were examined by MR imaging during January 1996 to June 2001. The MR imaging protocol included sagittal and coronal short tau inversion recovery (STIR), sagittal T1-weighted spin echo, axial and coronal proton-density, and T2-weighted spin-echo sequences. Nineteen ankles that underwent MR imaging during the same period of time and that had arthroscopically proven diagnosis different than impingement syndrome served as a control group. Fibrovascular scar formations distinct from the syndesmotic ligaments possibly related to syndesmotic soft tissue impingement were recorded. Arthroscopy was performed subsequently in all patients and was considered the gold standard. The statistical analysis revealed an overall frequency of scarred syndesmotic ligaments of 70% in the group with ankle impingement. Fibrovascular scar formations distinct from the syndesmotic ligaments presented with low signal intensity on T1-weighted images and remained low to intermediate in signal intensity on T2-weighted MR imaging. Compared with arthroscopy, MR imaging revealed a sensitivity of 89%, a specificity of 100%, and a diagnostic accuracy of 93% for scarred syndesmotic ligaments. The frequency of scar formation distinct from the syndesmotic ligaments in patients with impingement syndrome of the ankle was not statistically significantly higher than in the control group. In contrast to that, anterior tibial osteophytes and talar osteophytes were statistically significantly higher in the group with anterior impingement than in the control group. Conventional MR imaging was found to be insensitive for the diagnosis of syndesmotic soft tissue impingement of the ankle. Fibrovascular scar tissue distinct from syndesmotic ligaments is suggestive for the diagnosis of soft tissue impingement, but the reliability of these findings is still questionable.\n\nSchaffler, Gottfried\n\n\n"
},
{
"text": "\n9262\nThe cardiac sodium channel shows a regular substate pattern indicating synchronized activity of several ion pathways instead of one.\n\nSchreibmayer, W\n\nTritthart, HA\n\nSchindler, H\n\nBeiträge in Fachzeitschriften\nISI:A1989CB37800025\n2573393.0\n10.1016/0005-2736(89)90288-5\nNone\nCardiac sodium channel substates were induced by using different gating modifiers, namely S-DPI 201-106 (s), toxin II from Anemonia sulcata (a), veratridine (v) and mixtures of these agents (s + v, a + v). Current ratios (normalized substate currents), slope conductances, reversal potentials and saturation characteristics were evaluated for the individual channel substates. The results can be summarized as follows: (i) Current ratios fell into a pattern of six equidistant values (I to VI) irrespective of the modification applied (0.20, 0.34, 0.51, 0.69, 0.85, 1.00). Slope conductances, determinable for substates II, V and VI (4.8, 11.7 and 14.0, respectively), are also consistent with six conductance substates which are integer multiples of a smallest conductance (state I). (ii) The permeability ratio PNa+/PK+ (i.e., reversal potential of substate currents) of the sodium channel was conserved both for different modifications, i.e., by s, a, s + v and a + v, and for the different substates (at least for II, IV and VI) observed for each modification. (iii) Sodium binding to the channel is substate independent. Analysis of slope conductances of states II and VI for three sodium chloride concentrations (71.5, 140 and 303 mM) revealed different maximal conductances (geVImax = 2.9.geIImax) but similar apparent affinities for sodium (KNa + VI = 286 mM; KNa + II = 303 mM). These findings are shown to seriously challenge the commonly unquestioned conception that 'single-current events' reflect ion passage through only one single pathway. The alternative view, that not one pore, but either six or three pores with synchronized gating ('oligochannel') underlie 'single-channel events', is shown to readily account for the observed substate properties and appears not to contradict known properties of 'the sodium channel'. This fundamentally new view of the sodium channel aims to invoke further efforts to distinguish between conceptually distinct models of structure-function relationships for a variety of channels which show multiple substates and conserved ion selectivity.\n\nSchreibmayer, Wolfgang\n\nTritthart, Helmut\n\n\n"
},
{
"text": "\n81347\nPhenotypical characteristics of idiopathic infantile nystagmus with and without mutations in FRMD7.\n\nThomas, S\n\nProudlock, FA\n\nSarvananthan, N\n\nRoberts, EO\n\nAwan, M\n\nMcLean, R\n\nSurendran, M\n\nKumar, ASA\n\nFarooq, SJ\n\nDegg, C\n\nGale, RP\n\nReinecke, RD\n\nWoodruff, G\n\nLangmann, A\n\nLindner, S\n\nJain, S\n\nTarpey, P\n\nRaymond, FL\n\nGottlob, I\n\nBeiträge in Fachzeitschriften\nISI:000255523800013\n18372314.0\n10.1093/brain/awn046\nNone\nIdiopathic infantile nystagmus (IIN) consists of involuntary oscillations of the eyes. The familial form is most commonly X-linked. We recently found mutations in a novel gene FRMD7 (Xq26.2), which provided an opportunity to investigate a genetically defined and homogeneous group of patients with nystagmus. We compared clinical features and eye movement recordings of 90 subjects with mutation in the gene (FRMD7 group) to 48 subjects without mutations but with clinical IIN (non-FRMD7 group). Fifty-eight female obligate carriers of the mutation were also investigated. The median visual acuity (VA) was 0.2 logMAR (Snellen equivalent 6/9) in both groups and most patients had good stereopsis. The prevalence of strabismus was also similar (FRMD7: 7.8%, non-FRMD7: 10%). The presence of anomalous head posture (AHP) was significantly higher in the non-FRMD7 group (P < 0.0001). The amplitude of nystagmus was more strongly dependent on the direction of gaze in the FRMD7 group being lower at primary position (P < 0.0001), compared to non-FRMD7 group (P = 0.83). Pendular nystagmus waveforms were also more frequent in the FRMD7 group (P = 0.003). Fifty-three percent of the obligate female carriers of an FRMD7 mutation were clinically affected. The VA's in affected females were slightly better compared to affected males (P = 0.014). Subnormal optokinetic responses were found in a subgroup of obligate unaffected carriers, which may be interpreted as a sub-clinical manifestation. FRMD7 is a major cause of X-linked IIN. Most clinical and eye movement characteristics were similar in the FRMD7 group and non-FRMD7 group with most patients having good VA and stereopsis and low incidence of strabismus. Fewer patients in the FRMD7 group had AHPs, their amplitude of nystagmus being lower in primary position. Our findings are helpful in the clinical identification of IIN and genetic counselling of nystagmus patients.\n\nLangmann, Andrea\n\n\n"
},
{
"text": "\n108790\nSurvival analysis of 254 patients after manifestation of spinal metastases: evaluation of seven preoperative scoring systems.\n\nWibmer, C\n\nLeithner, A\n\nHofmann, G\n\nClar, H\n\nKapitan, M\n\nBerghold, A\n\nWindhager, R\n\nBeiträge in Fachzeitschriften\nISI:000296553000018\n21304424.0\n10.1097/BRS.0b013e3182011f84\nNone\nSTUDY DESIGN: Retrospective study. OBJECTIVE: This study analyzed the predictive value of the scoring systems of Bauer, Bauer modified, Tokuhashi, Tokuhashi revised, Tomita, van der Linden, and Sioutos as well as the parameters included in these systems. SUMMARY OF BACKGROUND DATA: Metastases of the spinal column are a common manifestation of advanced cancer. Severe pain, pathologic fracture, and neurologic deficit due to spinal metastases need adequate treatment. Besides oncologic aspects and quality of life, treatment decisions should also include the survival prognosis. METHODS: Two hundred fifty-four patients with confirmed spinal metastases were investigated retrospectively (treatment 1998-2006; 62 underwent surgery and 192 had conservative treatment only). Factors related to survival, such as primary tumor, general condition (Karnofsky Performance Status Scale), neurologic deficit, number of spinal and extraspinal bone metastases, visceral metastases, and pathologic fracture, were analyzed. The survival period was calculated from date of diagnosis of the spinal metastases to date of death or last follow-up (minimum follow-up: 12 months). For statistical analysis, univariate and stepwise multivariate Cox regression analyses were performed. RESULTS: Median overall survival for all patients was 10.6 months. The following factors showed significant influence on survival in multivariate analysis: primary tumor (P < 0.0001), status of visceral metastases (P < 0.0001), and systemic therapy (P < 0.0001). Using the recommended group assignment for each system, only Bauer and Bauer modified showed significant results for the distinction between good, moderate, and poor prognosis. The other systems failed to distinguish significantly between good and moderate prognosis. The hazard ratio of the absolute score of all analyzed systems was, however, statistically significant, with a better score leading to lower risk of death. CONCLUSION: According to this analysis, the Bauer and the Bauer modified scores are the most reliable systems for predicting survival. Since the Bauer modified score furthermore consists of only four positive prognostic factors, we emphasize its impact and simplicity.\n\nBerghold, Andrea\n\nHofmann, Guenter\n\nLeithner, Andreas\n\n\n"
},
{
"text": "\n142574\nDiagnosis and treatment of ocular chronic graft-versus-host disease: report from the German-Austrian-Swiss Consensus Conference on Clinical Practice in chronic GVHD.\n\nDietrich-Ntoukas, T\n\nCursiefen, C\n\nWestekemper, H\n\nEberwein, P\n\nReinhard, T\n\nBertz, H\n\nNepp, J\n\nLawitschka, A\n\nHeiligenhaus, A\n\nSeitz, B\n\nMessmer, EM\n\nMeyer-ter-Vehn, T\n\nBasara, N\n\nGreinix, H\n\nDatiles, MB\n\nLee, SJ\n\nPavletic, SZ\n\nWolff, D\n\nBeiträge in Fachzeitschriften\nISI:000300455800016\n22157574.0\n10.1097/ICO.0b013e318226bf97\nNone\nOcular chronic graft-versus-host disease (cGVHD) is one of the most frequent long-term complications after hematopoietic stem cell transplantation and is often associated with significant morbidity and reduced quality of life.\n The German/Austrian/Swiss Consensus Conference on Clinical Practice in cGVHD aimed to summarize the currently available evidence for diagnosis and (topical) treatment and to summarize different treatment modalities of ocular cGVHD. The presented consensus was based on a review of published evidence and a survey on the current clinical practice including transplant centers from Germany, Austria, and Switzerland.\n Ocular cGVHD often affects the lacrimal glands, the conjunctiva, the lids (including meibomian glands), and the cornea but can also involve other parts of the eye such as the sclera. Up to now, there have been no pathognomonic diagnostic features identified. The main therapeutic aim in the management of ocular cGVHD is the treatment of inflammation and dryness to relieve patients' symptoms and to maintain ocular integrity and function. Therapy should be chosen in the context of the patient's overall condition, systemic immunosuppressive therapy, symptoms, ocular surface integrity, and inflammatory activity. The consensus conference proposed new grading criteria and diagnostic recommendations for general monitoring of patients with graft-versus-host-disease for use in clinical practice.\n The evidence levels for diagnosis and treatment of ocular cGVHD are low, and most of the treatment options are based on empirical knowledge. Topical immunosuppression, for example, with cyclosporine, represents a promising strategy to reduce inflammation and dryness in ocular cGVHD. Further clinical trials are necessary to elucidate risk factors for eye manifestation, complications, and visual loss and to evaluate staging criteria and diagnostic and therapeutic measures for ocular cGVHD.\n\nGreinix, Hildegard\n\n\n"
},
{
"text": "\n143576\nMicrovascular Complications in Childhood-Onset Type 1 Diabetes and Celiac Disease: A Multicenter Longitudinal Analysis of 56,514 Patients From the German-Austrian DPV Database.\n\nRohrer, TR\n\nWolf, J\n\nLiptay, S\n\nZimmer, KP\n\nFröhlich-Reiterer, E\n\nScheuing, N\n\nMarg, W\n\nStern, M\n\nKapellen, TM\n\nHauffa, BP\n\nWölfle, J\n\nHoll, RW\n\nDPV Initiative and the German BMBF Competence Network Diabetes Mellitus\n\nBeiträge in Fachzeitschriften\nISI:000353505600019\n25690004.0\n10.2337/dc14-0683\nNone\nTo investigate whether celiac disease (CD) associated with type 1 diabetes increases the risk of microvascular complications.\n Patients (n = 56, 14) aged >10 years with diabetes duration <20 years from 392 centers in Germany and Austria were assigned to one of three categories (n): no CD (50, 33), biopsy-confirmed CD (812), or suspected CD (4, 69; clinical diagnosis or positive antibodies). The confirmed and suspected groups were combined and analyzed for retinopathy or nephropathy. Cox proportional hazards regression was used to adjust for potential confounders (glycated hemoglobin [HbA1c], age at diabetes onset, sex, smoking, dyslipidemia, and hypertension).\n Kaplan-Meier analysis revealed that retinopathy and nephropathy occurred earlier in the presence versus absence of CD: retinopathy at age 26.7 years (95% CI 23.7-30.2) in 25% of patients with CD vs. age 33.7 years (33.2-34.4) in 25% without CD and microalbuminuria at age 32.8 years (29.7-42.5) vs. 42.4 years (41.4-43.3). The adjusted risk for both retinopathy (hazard ratio 1.263 [95% CI 1.078-1.481]) and nephropathy (1.359 [1.228-1.504]) was higher in patients with diabetes and CD versus those without CD. Cox regression revealed CD as an independent risk factor for microvascular complications after adjustment for confounders.\n CD is an independent risk factor for retinopathy and nephropathy in patients with type 1 diabetes. Our study therefore supports the recommendation for regular serologic testing for CD, even in the absence of clinical CD. Further prospective studies are required to investigate whether a gluten-free diet might reduce the risk of microvascular disorders in patients with diabetes and CD.\n © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.\n\nFröhlich-Reiterer, Elke\n\n\n"
},
{
"text": "\n152372\nCirculating leptin and NF-κB activation in peripheral blood mononuclear cells across the menstrual cycle.\n\nFaustmann, G\n\nTiran, B\n\nMaimari, T\n\nKieslinger, P\n\nObermayer-Pietsch, B\n\nGruber, HJ\n\nRoob, JM\n\nWinklhofer-Roob, BM\n\nBeiträge in Fachzeitschriften\nISI:000383457400005\n27093900.0\n10.1002/biof.1281\nNone\nUsing the menstrual cycle as a model, this study focused on longitudinal changes and associations within a physiological network known to play a role in female fertility, including, as biologically active nodes, NF-κB, leptin and adiponectin, β-carotene, adipose tissue, and progesterone. In 28 women, leptin, adiponectin, β-carotene, and progesterone concentrations, NF-κB p65 and p50 activation in peripheral blood mononuclear cells (known to possess estrogen, progesterone and leptin receptors), total body fat (TBF) and subcutaneous adipose tissue (SAT) mass were determined at early (T1) and late follicular (T2) and mid (T3) and late (T4) luteal phase. Leptin and adiponectin concentrations were higher, while NF-κB p65 activation was lower at T3 compared with T1. NF-κB p65 activation was inversely related to leptin concentrations at T1, T3, and T4. β-Carotene was inversely related to leptin (T1, 2, 4) and SAT (T1, 3, 4). NF-κB p50 activation was inversely related to TBF (T4) and SAT (T3, 4), and leptin was positively related to TBF and SAT (T1-T4). Progesterone was inversely related to leptin (T2, 3), adiponectin (T3), TBF (T3, 4), and SAT (T2, 3, 4). By providing evidence of luteal phase-specific reduced NF-κB p65 activation in women under physiological conditions, this study bridges the gap between existing evidence of a Th1-Th2 immune response shift induced by reduced NF-κB p65 activation and a Th1-Th2 shift previously observed at luteal phase. For the first time, inverse regressions suggest inhibitory effects of leptin on NF-κB p65 activation at luteal phase, along with inhibitory effects of leptin as well as adiponectin on progesterone production in corpus luteum. © 2016 The Authors BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology. 24(4):376-387, 2016. \n © 2016 The Authors BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology.\n\nGruber, Hans-Jürgen\n\nKieslinger, Petra\n\nObermayer-Pietsch, Barbara\n\nTiran, Beate\n\n\n"
},
{
"text": "\n165844\nLow skeletal muscle mass outperforms the Charlson Comorbidity Index in risk prediction in patients undergoing pancreatic resections.\n\nWagner, D\n\nMarsoner, K\n\nTomberger, A\n\nHaybaeck, J\n\nHaas, J\n\nWerkgartner, G\n\nCerwenka, H\n\nBacher, H\n\nMischinger, HJ\n\nKornprat, P\n\nBeiträge in Fachzeitschriften\nISI:000433399800017\n29428474.0\n10.1016/j.ejso.2018.01.095\nNone\nLow skeletal muscle mass is a known predictor of morbidity and mortality in patients undergoing major pancreatic surgeries. We sought to combine low skeletal muscle mass with established risk predictors to improve their prognostic capacity for postoperative outcome and morbidity.\n As established parameters to predict preoperative mortality risk for patients, the ASA classification and the Charlson Comorbidity Index (CCI) were used. The Hounsfield Units Average Calculation (HUAC) was measured to define low skeletal muscle mass in 424 patients undergoing pancreatic resections for malignancies. Patients in the lowest sex-adjusted quartile for HUAC were defined as having low skeletal muscle mass (muscle wasting). Multivariable Cox regression analysis was utilized to identify preoperative risk factors associated with postoperative morbidity.\n Median patient age was 63 years (19-87), 47.9% patients were male, and half the cohort had multiple comorbidities (Charlson Comorbidity Index [CCI]>6, 63.2%), 30-day mortality was 5.8% (n = 25). Median HUAC was 19.78 HU (IQR: 15.94-23.54) with 145 patients (34.2%) having low skeletal muscle mass. Preoperative frailty defined by low skeletal muscle mass was associated with an increased risk for postoperative complications (OR 1.55, CI 95% 0.98-2.45, p = 0.014), and a higher 30-day mortality (HR 5.17, CI 95% 1.57-16.69, p = 0.004). With an AUC of 0.85 HUAC showed the highest predictability for 30-day mortality (CI 95% 0.78-0.91, p = 0.0001). Patients with CCI ≥6 and low skeletal muscle mass defined by the HUAC had a 9.78 higher risk of dying in the immediate postoperative phase (HR 9.78, CI 95% 2.98-12.2, p = 0.0001).\n Low skeletal muscle mass predicts postoperative mortality and complications best and it should be incorporated to conventional risk scores to identify high risk patients.\n Copyright © 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.\n\nBacher, Heinz\n\nCerwenka, Herwig\n\nHaas, Josef\n\nHaybäck, Johannes\n\nKornprat, Peter\n\nMarsoner, Katharina\n\nMischinger, Hans-Joerg\n\nWagner, Doris\n\nWerkgartner, Georg\n\n\n"
},
{
"text": "\n173829\nEPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis.\n\nFokkens, W\n\nDesrosiers, M\n\nHarvey, R\n\nHopkins, C\n\nMullol, J\n\nPhilpott, C\n\nAlobid, I\n\nAnselmo-Lima, WT\n\nBachert, C\n\nBaroody, F\n\nBernal-Sprekelsen, M\n\nvon Buchwald, C\n\nCervin, A\n\nCohen, N\n\nConstantinidis, J\n\nDe Gabory, L\n\nDouglas, R\n\nGevaert, P\n\nHafner, A\n\nHellings, P\n\nJoos, G\n\nKalogjera, L\n\nKern, R\n\nKnill, A\n\nKocks, J\n\nLandis, BN\n\nLimpens, J\n\nLebeer, S\n\nLourenco, O\n\nMatricardi, PM\n\nMeco, C\n\nO Mahony, L\n\nReitsma, S\n\nRyan, D\n\nSchlosser, R\n\nSenior, B\n\nSmith, T\n\nTeeling, T\n\nTomazic, PV\n\nToppila-Salmi, S\n\nWang, DY\n\nWang, D\n\nZhang, L\n\nLund, V\n\nBeiträge in Fachzeitschriften\nISI:000469865400002\n30810118.0\n10.4193/Rhin17.253\nNone\nThe European Position Papers on Rhinosinusitis from 2005, 2007 and 2012 have had a measurable impact on the way this common condition with high impact on quality of life is managed around the world. EPOS2020 will be the latest iteration of the guideline, addressing new stakeholders and target users, presenting a summary of the latest literature and evolving treatment modalities, and formulating clear recommendations based on all available evidence.\n Based on the AGREE II framework, this article demonstrates how the EPOS2020 steering group will address six key areas to ensure consistency in quality and presentation of information in the latest rhinosinusitis clinical practice guideline: scope and purpose; stakeholder involvement; rigour of development; clarity of presentation; recommendations and applicability; editorial independence.\n By analysing the guidance from AGREE II, we formulated a detailed development strategy for EPOS2020. We identify new stakeholders and target users and ratify the importance of patient involvement in the latest EPOS guideline. New and expanded areas of research to be addressed are highlighted. We confirm our intention to use mixed methodologies, combining evidence-based medicine with real life studies; when no evidence can be found, use Delphi rounds to achieve clear, inclusive recommendations. We also introduce new concepts for dissemination of the guideline, using Internet and social media to improve accessibility.\n This article is an introduction to the EPOS2020 project, and presents the key goals, core stakeholders, planned methodology and dissemination strategies for the latest version of this influential guideline.\n\nTomazic, Peter Valentin\n\n\n"
},
{
"text": "\n181991\nA core outcome set for studies of gestational diabetes mellitus prevention and treatment.\n\nEgan, AM\n\nBogdanet, D\n\nGriffin, TP\n\nKgosidialwa, O\n\nCervar-Zivkovic, M\n\nDempsey, E\n\nAllotey, J\n\nAlvarado, F\n\nClarson, C\n\nCooray, SD\n\nde Valk, HW\n\nGaljaard, S\n\nLoeken, MR\n\nMaresh, MJA\n\nNapoli, A\n\nO'Shea, PM\n\nWender-Ozegowska, E\n\nvan Poppel, MNM\n\nThangaratinam, S\n\nCrowther, C\n\nBiesty, LM\n\nDevane, D\n\nDunne, FP\n\nINSPIRED research group\n\nBeiträge in Fachzeitschriften\nISI:000521038100001\n32193573.0\n10.1007/s00125-020-05123-6\nPMC7228989\nThe aim of this systematic review was to develop core outcome sets (COSs) for trials evaluating interventions for the prevention or treatment of gestational diabetes mellitus (GDM).\n We identified previously reported outcomes through a systematic review of the literature. These outcomes were presented to key stakeholders (including patient representatives, researchers and clinicians) for prioritisation using a three-round, e-Delphi study. A priori consensus criteria informed which outcomes were brought forward for discussion at a face-to-face consensus meeting where the COS was finalised.\n Our review identified 74 GDM prevention and 116 GDM treatment outcomes, which were presented to stakeholders in round 1 of the e-Delphi study. Round 1 was completed by 173 stakeholders, 70% (121/173) of whom went on to complete round 2; 84% (102/121) of round 2 responders completed round 3. Twenty-two GDM prevention outcomes and 30 GDM treatment outcomes were discussed at the consensus meeting. Owing to significant overlap between included prevention and treatment outcomes, consensus meeting stakeholders agreed to develop a single prevention/treatment COS. Fourteen outcomes were included in the final COS. These consisted of six maternal outcomes (GDM diagnosis, adherence to the intervention, hypertensive disorders of pregnancy, requirement and type of pharmacological therapy for hyperglycaemia, gestational weight gain and mode of birth) and eight neonatal outcomes (birthweight, large for gestational age, small for gestational age, gestational age at birth, preterm birth, neonatal hypoglycaemia, neonatal death and stillbirth).\n This COS will enable future GDM prevention and treatment trials to measure similar outcomes that matter to stakeholders and facilitate comparison and combination of these studies.\n This study was registered prospectively with the Core Outcome Measures in Effectiveness Trials (COMET) database: http://www.comet-initiative.org/studies/details/686/.\n\nCervar-Zivkovic, Mila\n\n\n"
},
{
"text": "\n184381\nMulti-shell Diffusion MRI Models for White Matter Characterization in Cerebral Small Vessel Disease.\n\nKonieczny, MJ\n\nDewenter, A\n\nTer Telgte, A\n\nGesierich, B\n\nWiegertjes, K\n\nFinsterwalder, S\n\nKopczak, A\n\nHübner, M\n\nMalik, R\n\nTuladhar, AM\n\nMarques, JP\n\nNorris, DG\n\nKoch, A\n\nDietrich, O\n\nEwers, M\n\nSchmidt, R\n\nde Leeuw, FE\n\nDuering, M\n\nBeiträge in Fachzeitschriften\nNone\n33199431.0\n10.1212/WNL.0000000000011213\nNone\nTo test the hypothesis that multi-shell diffusion models improve the characterization of microstructural alterations in cerebral small vessel disease (SVD), we assessed associations with processing speed performance, longitudinal change, and reproducibility of diffusion metrics.\n We included 50 patients with sporadic and 59 patients with genetically defined SVD (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL]) with cognitive testing and standardized 3T MRI, including multi-shell diffusion imaging. We applied the simple diffusion tensor imaging (DTI) model and 2 advanced models: diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI). Linear regression and multivariable random forest regression (including conventional SVD markers) were used to determine associations between diffusion metrics and processing speed performance. The detection of short-term disease progression was assessed by linear mixed models in 49 patients with sporadic SVD with longitudinal high-frequency imaging (in total 459 MRIs). Intersite reproducibility was determined in 10 patients with CADASIL scanned back-to-back on 2 different 3T MRI scanners.\n Metrics from DKI showed the strongest associations with processing speed performance (R2 up to 21%) and the largest added benefit on top of conventional SVD imaging markers in patients with sporadic SVD and patients with CADASIL with lower SVD burden. Several metrics from DTI and DKI performed similarly in detecting disease progression. Reproducibility was excellent (intraclass correlation coefficient >0.93) for DTI and DKI metrics. NODDI metrics were less reproducible.\n Multi-shell diffusion imaging and DKI improve the detection and characterization of cognitively relevant microstructural white matter alterations in SVD. Excellent reproducibility of diffusion metrics endorses their use as SVD markers in research and clinical care. Our publicly available intersite dataset facilitates future studies.\n This study provides Class I evidence that in patients with SVD, diffusion MRI metrics are associated with processing speed performance.\n © 2020 American Academy of Neurology.\n\nSchmidt, Reinhold\n\n\n"
},
{
"text": "\n184520\nDevelopment and validation of a prediction model for invasive bacterial infections in febrile children at European Emergency Departments: MOFICHE, a prospective observational study.\n\nHagedoorn, NN\n\nBorensztajn, D\n\nNijman, RG\n\nNieboer, D\n\nHerberg, JA\n\nBalode, A\n\nvon Both, U\n\nCarrol, E\n\nEleftheriou, I\n\nEmonts, M\n\nvan der Flier, M\n\nde Groot, R\n\nKohlmaier, B\n\nLim, E\n\nMaconochie, I\n\nMartinón-Torres, F\n\nPokorn, M\n\nStrle, F\n\nTsolia, M\n\nZavadska, D\n\nZenz, W\n\nLevin, M\n\nVermont, C\n\nMoll, HA\n\nBeiträge in Fachzeitschriften\nNone\n33208397.0\n10.1136/archdischild-2020-319794\nNone\nTo develop and cross-validate a multivariable clinical prediction model to identify invasive bacterial infections (IBI) and to identify patient groups who might benefit from new biomarkers.\n Prospective observational study.\n 12 emergency departments (EDs) in 8 European countries.\n Febrile children aged 0-18 years.\n IBI, defined as bacteraemia, meningitis and bone/joint infection. We derived and cross-validated a model for IBI using variables from the Feverkidstool (clinical symptoms, C reactive protein), neurological signs, non-blanching rash and comorbidity. We assessed discrimination (area under the receiver operating curve) and diagnostic performance at different risk thresholds for IBI: sensitivity, specificity, negative and positive likelihood ratios (LRs).\n Of 16 268 patients, 135 (0.8%) had an IBI. The discriminative ability of the model was 0.84 (95% CI 0.81 to 0.88) and 0.78 (95% CI 0.74 to 0.82) in pooled cross-validations. The model performed well for the rule-out threshold of 0.1% (sensitivity 0.97 (95% CI 0.93 to 0.99), negative LR 0.1 (95% CI 0.0 to 0.2) and for the rule-in threshold of 2.0% (specificity 0.94 (95% CI 0.94 to 0.95), positive LR 8.4 (95% CI 6.9 to 10.0)). The intermediate thresholds of 0.1%-2.0% performed poorly (ranges: sensitivity 0.59-0.93, negative LR 0.14-0.57, specificity 0.52-0.88, positive LR 1.9-4.8) and comprised 9784 patients (60%).\n The rule-out threshold of this model has potential to reduce antibiotic treatment while the rule-in threshold could be used to target treatment in febrile children at the ED. In more than half of patients at intermediate risk, sensitive biomarkers could improve identification of IBI and potentially reduce unnecessary antibiotic prescriptions.\n © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.\n\nKohlmaier, Benno\n\nZenz, Werner\n\n\n"
},
{
"text": "\n186791\nCoronary computed tomography and triple rule out CT in patients with acute chest pain and an intermediate cardiac risk profile. Part 1: impact on patient management.\n\nGruettner, J\n\nFink, C\n\nWalter, T\n\nMeyer, M\n\nApfaltrer, P\n\nSchoepf, UJ\n\nSaur, J\n\nSueselbeck, T\n\nTraunwieser, D\n\nTakx, R\n\nKralev, S\n\nBorggrefe, M\n\nSchoenberg, SO\n\nHenzler, T\n\nBeiträge in Fachzeitschriften\nNone\n22749769.0\n10.1016/j.ejrad.2012.06.001\nNone\nTo evaluate the impact of coronary CT angiography (coronary CTA) or "triple-rule-out" CT angiography (TRO-CTA) on patient management in the work-up of patients with acute chest pain and an intermediate cardiac risk profile.\n 100 patients with acute chest pain and an intermediate cardiac risk for acute coronary syndrome (ACS) underwent coronary CTA or TRO-CTA for the evaluation of chest pain. Patients with a high and low cardiac risk profile were not included in this study. All patients with significant coronary stenosis >50% on coronary CTA underwent invasive coronary catheterization (ICC). Important other pathological findings were recorded. All patients had a 90-day follow-up period for major adverse cardiac events (MACE).\n Based on a negative coronary CTA 60 of 100 patients were discharged on the same day. None of the discharged patients showed MACE during the 90-day follow-up. Coronary CTA revealed a coronary stenosis >50% in 19 of 100 patients. ICC confirmed significant coronary stenosis in 17/19 patients. Among the 17 true positive patients, 9 underwent percutaneous coronary intervention with stent implantation, 7 were received intensified medical therapy, and 1 patient underwent coronary artery bypass surgery. A TRO-CTA protocol was performed in 36/100 patients due to elevated d-dimer levels. Pulmonary embolism was present in 5 patients, pleural effusion of unknown etiology in 3 patients, severe right ventricular dysfunction with pericardial effusion in 1 patient, and an incidental bronchial carcinoma was diagnosed in 1 patient.\n Coronary CTA and TRO-CTA allow a rapid and safe discharge in the majority of patients presenting with acute chest pain and an intermediate risk for ACS while at the same time identifies those with significant coronary artery stenosis.\n Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.\n\nApfaltrer, Paul\n\n\n"
},
{
"text": "\n746\nDilatation by angiotensin II of the rat femoral arterial bed in vivo via pressure/flow-induced release of nitric oxide and prostaglandins.\n\nHeinemann, A\n\nWachter, CH\n\nPeskar, BA\n\nHolzer, P\n\nBeiträge in Fachzeitschriften\nISI:A1997YG22000002\n9401758.0\n10.1038/sj.bjp.0701460\nPMC1565027\n1. The haemodynamic effects of angiotensin II (AII) and, for comparison, arginine vasopressin (AVP) in the femoral and superior mesenteric artery of urethane-anaesthetized rats were analysed with the ultrasonic transit time shift technique. 2. I.v. bolus injection of AII (0.1-3 nmol kg-1) and AVP (0.03-1 nmol kg-1) increased blood pressure which was accompanied by a decrease in blood flow through the superior mesenteric artery and an increase in femoral blood flow. The femoral hyperaemia was in part due to vasodilatation as indicated by a rise of femoral vascular conductance up to 200% relative to baseline. The femoral vasodilatation caused by AVP, but not AII, was followed by vasoconstriction. 3. Blockade of angiotensin AT1 receptors by telmisartan (0.2-20 mumol kg-1) prevented all haemodynamic responses to AII. 4. The femoral dilator responses to AII and AVP depended on the increase in vascular perfusion pressure since vasodilatation was reversed to vasoconstriction when blood pressure was maintained constant by means of a gravity reservoir. However, the AII-evoked femoral vasodilatation was not due to an autonomic or neuroendocrine reflex because it was not depressed by hexamethonium (75 mumol kg-1), prazosin (0.25 mumol kg-1) or propranolol (3 mumol kg-1). 5. The AII-induced femoral vasodilatation was suppressed by blockade of nitric oxide (NO) synthesis with NG-nitro-L-arginine methyl ester (L-NAME, 40 mumol kg-1) and reversed to vasoconstriction when L-NAME was combined with indomethacin (30 mumol kg-1), but was left unaltered by antagonism of endothelin ETA/B receptors with bosentan (37 mumol kg-1). 6. These results demonstrate that the effect of AII to increase systemic blood pressure and the resulting rise of perfusion pressure in the femoral artery stimulates the formation of NO and prostaglandins and thereby dilates the femoral arterial bed. This local vasodilator mechanism is sufficient to mask the direct vasoconstrictor response to AII.\n\nHeinemann, Akos\n\nHolzer, Peter\n\nPeskar, Bernhard\n\n\n"
},
{
"text": "\n3203\nImmunologic changes after transfusion of autologous or allogeneic buffy coat-poor versus WBC-reduced blood transfusions in patients undergoing arthroplasty. II. Activation of T cells, macrophages, and cell-mediated lympholysis.\n\nInnerhofer, P\n\nTilz, G\n\nFuchs, D\n\nLuz, G\n\nHobisch-Hagen, P\n\nSchobersberger, W\n\nNussbaumer, W\n\nLochs, A\n\nIrschick, E\n\nBeiträge in Fachzeitschriften\nISI:000088574900011\n10924610.0\n10.1046%2Fj.1537-2995.2000.40070821.x\nNone\nBACKGROUND: To estimate the impact of RBC preparations on the status of postoperative immune activation, the soluble cytokine receptors of TNFalpha (sTNF-R) and IL-2 (sIL-2R), as well as neopterin and cell-mediated lympholysis (CML), were measured. STUDY DESIGN AND METHODS: Patients undergoing strictly standardized anesthesiologic management for elective orthopedic surgery were enrolled in a prospective study. The perioperative course (Days 0, 3, 7, and 10) of sTNF-R, sIL-2R, neopterin, and CML was compared after random assignment to allogeneic buffy coat-reduced (Group 2, n = 8) or WBC-reduced (Group 3, n = 11) RBC transfusion regimen. Recipients of autologous buffy coat-reduced RBC transfusions (Group 1, n = 15) served as controls. Patients receiving intraoperatively and postoperatively salvaged blood only (n = 10) were separately analyzed as Group 4. RESULTS: In Group 1, a short-lasting increase in soluble cytokine receptors, a diminished cytolytic response (Day 0 vs. Day 7: sTNF-R, p = 0.0001; sIL-2R, p = 0.0004; CML, p = 0. 0238), and an elevation of neopterin (Day 0 vs. Day 3: p = 0.0064) were observed. In contrast, in allogeneically transfused patients, sTNF-R (Group 2, p = 0.0469: Group 3, p = 0.0039), sIL-2R (Group 3, p = 0.002) and neopterin (Group 3, p = 0.0164) increased further from baseline to Day 10 (Day 0 vs. Day 10), and this increase was accompanied by a diminished cytolytic response (Day 0 vs. Day 10: Group 2, p = 0.05; Group 3, p = 0.0076). Patients in Group 4 showed a short-lasting increase in sIL-2R (Day 0 vs. Day 3: p = 0.0078), neopterin (Day 0 vs. Day 3: p = 0.0156) and sTNF-R (Day 0 vs. Day 7: p = 0.0781). CONCLUSION: Allogeneic transfusions seem to prolong the postoperative status of immune activation, even when WBC-filtered RBCs are used for the transfusion regimen.\n\nTilz, Gernot\n\n\n"
},
{
"text": "\n87588\nPharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project.\n\nBousquet, PJ\n\nDemoly, P\n\nRomano, A\n\nAberer, W\n\nBircher, A\n\nBlanca, M\n\nBrockow, K\n\nPichler, W\n\nTorres, MJ\n\nTerreehorst, I\n\nArnoux, B\n\nAtanaskovic-Markovic, M\n\nBarbaud, A\n\nBijl, A\n\nBonadonna, P\n\nBurney, PG\n\nCaimmi, S\n\nCanonica, GW\n\nCernadas, J\n\nDahlen, B\n\nDaures, JP\n\nFernandez, J\n\nGomes, E\n\nGueant, JL\n\nKowalski, ML\n\nKvedariene, V\n\nMertes, PM\n\nMartins, P\n\nNizankowska-Mogilnicka, E\n\nPapadopoulos, N\n\nPonvert, C\n\nPirmohamed, M\n\nRing, J\n\nSalapatas, M\n\nSanz, ML\n\nSzczeklik, A\n\nVan Ganse, E\n\nDe Weck, AL\n\nZuberbier, T\n\nMerk, HF\n\nSachs, B\n\nSidoroff, A\n\nGlobal Allergy, Asthma European Network (GALEN) and Drug Allergy and Hypersensitivity Database (DAHD) and the European Network for Drug Allergy (ENDA)\n\nBeiträge in Fachzeitschriften\nISI:000262634000003\n19178398.0\n10.1111/j.1398-9995.2008.01944.x\nNone\nNonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs. Spontaneous reporting makes up the core data-generating system of pharmacovigilance, but there is a large under-estimation of allergy/hypersensitivity drug reactions. A specific database is therefore required for drug allergy and hypersensitivity using standard operating procedures (SOPs), as the diagnosis of drug allergy/hypersensitivity is difficult and current pharmacovigilance algorithms are insufficient. Although difficult, the diagnosis of drug allergy/hypersensitivity has been standardized by the European Network for Drug Allergy (ENDA) under the aegis of the European Academy of Allergology and Clinical Immunology and SOPs have been published. Based on ENDA and Global Allergy and Asthma European Network (GA(2)LEN, EU Framework Programme 6) SOPs, a Drug Allergy and Hypersensitivity Database (DAHD((R))) has been established under FileMaker((R)) Pro 9. It is already available online in many different languages and can be accessed using a personal login. GA(2)LEN is a European network of 27 partners (16 countries) and 59 collaborating centres (26 countries), which can coordinate and implement the DAHD across Europe. The GA(2)LEN-ENDA-DAHD platform interacting with a pharmacovigilance network appears to be of great interest for the reporting of allergy/hypersensitivity ADRs in conjunction with other pharmacovigilance instruments.\n\nAberer, Werner\n\n\n"
},
{
"text": "\n98634\nAssessment of lung area in normal fetuses at 12-32 weeks.\n\nPeralta, CF\n\nCavoretto, P\n\nCsapo, B\n\nVandecruys, H\n\nNicolaides, KH\n\nBeiträge in Fachzeitschriften\nISI:000234027800006\n16308896.0\n10.1002/uog.2651\nNone\nOBJECTIVE: To establish reference intervals with gestation for the right and left lung areas and lung area to head circumference ratio (LHR). METHODS: This was a cross-sectional study of 650 normal singleton pregnancies at 12-32 weeks of gestation. We measured the left and right lung areas on the cross-sectional plane of the thorax, used for examination of the four-chamber view of the heart, by three different techniques: firstly, manual tracing of the limits of the lungs; secondly, multiplication of the longest diameter of the lung by its longest perpendicular diameter; thirdly, multiplication of the anteroposterior diameter of the lung at the mid-clavicular line by the perpendicular diameter at the midpoint of the anteroposterior diameter. RESULTS: The respective mean left and right lung areas (manual tracing) increased with gestational age, from 36 and 58 mm(2) at 12 weeks to 220 and 325 mm(2) at 20 weeks and 594 and 885 mm(2) at 32 weeks. This 16-fold increase in lung area was accompanied by a four-fold increase in head circumference. Consequently, the left and right LHR increased with gestational age. The most reproducible way of measuring the lung area was by manual tracing of the limits of the lungs and the least reproducible was by multiplying the longest diameter of the lungs by their longest perpendicular diameter. Furthermore, the method employing the longest diameter, compared with the tracing method, overestimated both the left and the right lung areas by about 45% and the method employing the anteroposterior diameter overestimated the area of the right lung by about 35%, but not that of the left lung. CONCLUSIONS: In the antenatal prediction of pulmonary hypoplasia by the assessment of lung area it is important to take gestational age into account. Dividing the lung area by the head circumference does not correct for the gestation-related increase in lung area. Reproducible measurement of the lung area is provided by manual tracing of the limits of the lungs, rather than by multiplication of lung diameters.\n\nCsapo, Bence Daniel\n\n\n"
},
{
"text": "\n99291\nThe Effects of Coronary Artery Bypass Graft Surgery on Health-Related Quality of Life, Cognitive Performance, and Emotional Status Outcomes: A Prospective 6-Month Follow-Up Consultation-Liaison Psychiatry Study.\n\nRothenhäusler, HB\n\nStepan, A\n\nHetterle, R\n\nTrantina-Yates, A\n\nBeiträge in Fachzeitschriften\nISI:000279009500004\n20336599.0\n10.1055/s-0029-1245298\nNone\nThe success of routine coronary artery bypass graft surgery (CABG) is now no longer judged solely by its effects on traditional end points such as mortality rates but by its influence on biopsychosocial dimensions. The aim of this study was to assess the course of health-related quality of life, cognitive and emotional change during the six months after elective CABG, and to investigate how cognitive impairments, depression and posttraumatic stress symptoms were related to quality of life. In a prospective study, we followed up for 6 months 138 of the original 147 patients who had undergone elective CABG surgery. Preoperatively, and at 6 months after surgery, a series of psychometric observer-rating and self-rating scales were administered to evaluate cognitive functioning (SKT), depressive symptoms (BDI), posttraumatic stress symptoms (PTSS-10), and health-related quality of life (SF-36 Health Status Questionnaire). The measurements of health-related quality of life (HRQOL) indicated significantly higher SF-36 values on all of the eight health-related domains from preoperative to 6-month follow-up assessments. However, at 6-month follow-up, patients with clinical depression had significantly lower SF-36 values on all of the eight health-related domains when compared with patients without depression. Also, at 6-month follow-up, patients with posttraumatic stress disorder (PTSD) had significantly lower SF-36 values on six of the eight SF-36 health categories when compared with patients without PTSD. Finally, at 6-month follow-up, patients with cognitive deficits had significantly lower SF-36 values on physical functioning when compared with patients without cognitive impairments. We underscore the need for early and comprehensive bio-psycho-social diagnosis and therapy of post-CABG patients in order to treat emotional distress and CABG-related cognitive impairments and enhance patients' quality of life at an early stage after cardiac surgery.\n\nRothenhäusler, Hans-Bernd\n\nYates, Ameli\n\n\n"
}
]
}