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Ob zur Beschreibung von Symptomen, zur Erklärung der Pathophysiologie einer Krankheit oder zur Darstellung verschiedener Therapieoptionen für die Entscheidungsfindung mit Patient*innen – bildhafte Sprache wird gerne zur Hilfe gezogen. Dennoch ist unklar, welche Wirkungen undmöglichen Nebenwirkungen mit Metaphern verbunden sind. Dieses Scoping Review hat zum Ziel, einen Überblick über den aktuellen Forschungsstand zu geben.","authors":["Englisch, C"],"year":2026,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2026. pp. ","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-02-09T08:35:25+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":220797,"title":"Die Rolle von Statinen und PCSK9-Inhibitoren im Hypercholesterinämie-Management: Ein Vergleich der klinischen Wirksamkeit und Sicherheit","abstract":"Die Wirkstoffklasse der Statine und jene der PCSK9-Inhibitoren werden beide in der Therapie der Dyslipidämie eingesetzt. Die Statine sind schon lange auf dem Markt und haben sich als Standardtherapie in den Leitlinien verankert. Die PCSK9-Inhibitoren sind erst seit 10 Jahren auf dem Markt und damit wesentlich jünger als die Statine, sind jedoch Objekt ständiger Forschung und scheinen den Statinen zumindest in einigen Punkten überlegen zu sein.","authors":["Kuehebacher, L"],"year":2026,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2026. pp. ","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-02-09T08:35:25+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":220806,"title":"Der Einfluss von Statinen auf den Schweregrad und Verlauf der venösen Thromboembolie – eine retrospektive Datenanalyse zwischen 01.01.2010 und 31.12.2019","abstract":"Es gibt Hinweise darauf, dass die Inzidenz venöser thrombotischer Ereignisse (einschließlich Lungenembolien, LE) unter Statintherapie bei PatientInnen reduziert wird. Es bedarf weiterer Untersuchungen, um zu klären, ob Statine auf den Schweregrad einer Lungenembolie Einfluss nehmen können. Im Rahmen der vorliegenden Arbeit wurde ein möglicher Zusammenhang zwischen der Einnahme von Statinen und dem Schweregrad der LE in einer retrospektiven Patientenkohorte analysiert. Eine retrospektive Auswertung klinischer Daten erfolgte bei PatientInnen mit CT-angiographisch bestätigter Lungenembolie, die im Zeitraum vom 01.01.2010 bis zum 31.12.2019 an der Universitätsklinik Graz behandelt wurden. Die Schweregradklassifikation basierte auf den ESC-Leitlinien von 2019.","authors":["Wachmann, B"],"year":2026,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2026. pp. ","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-02-09T08:35:25+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":220810,"title":"Targeting Disordered Transcription Factors","abstract":"Intrinsically disordered proteins (IDPs) and regions (IDRs) play essential roles in cellular regulation, with their functions strongly influenced by post-translational modifications. Their dysregulation often contributes to disease mechanisms in neurodegeneration and cancer. This  thesis integrates nuclear magnetic resonance spectroscopy (NMR) metabolomics, NMR of proteins and de novo peptide design to address four research aims. First study explores region specific metabolic differences linked to altered arginine methylation in distinct subtypes of frontotemporal dementia with TDP-43 pathology and Alzheimer’s disease. The second part of  the thesis dissects in vitro the interaction between the transcription factor FOXM1 and Wnt signalling component β-catenin, revealing a binding mechanism in which β-catenin engages  multiple sites within FOXM1. Finally, solvent paramagnetic relaxation enhancement  measurements were corrected by applying a theoretical model to minimize solvent-exchange driven errors, improving analysis for highly solvent-exposed disordered proteins.  Together, these studies advance our understanding of metabolic alterations and their correlation with posttranslational modifications in IDP-associated neurodegenerative diseases, elucidate molecular mechanisms of pro-oncogenic IDR-involving interactions, and introduce methodological advances for studying of highly solvent-exposed IDPs with NMR.","authors":["Rakhimbekova, A"],"year":2026,"source":"PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2026. pp. ","category":5,"document_type":16,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-02-09T08:35:25+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":220759,"title":"Evidenz zusammenfassen.","abstract":null,"authors":["Bornemann-Cimenti, H"],"year":2026,"source":"Anaesthesia Reserch Network; FEB 2, 2026; Graz, AUSTRIA. 2026. ","category":3,"document_type":null,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["220759-14069"],"persons":["220759-58422"],"imported":"2026-02-09T07:45:46+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":true,"conference_place":true,"conference_international":false,"scientific_event":true,"invited_lecture":true,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true}]}