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Methods: Therefore, this thesis comprises three studies that aimed to (1) characterize the symptoms, burdens, and impacts of Long-COVID, (2) investigate structural and functional brain changes associated with cognitive impairment - one of the most frequently reported symptoms - and (3) explore the effectiveness of a tablet-based training program as a potential intervention for cognitive and psychological deficits. Results: The findings of this thesis underscore (1) the substantial impact of Long-COVID on patients’ personal and professional lives, including a broad range of symptoms, high levels of psychological distress, and work-related consequences such as loss of income or inability to work. In addition, (2) significant functional brain alterations were observed between patients with and without cognitive impairment following COVID-19, especially in large-scale brain networks such as the default mode network (DMN), which plays an important role in various mental processes. Finally, (3) the findings of this thesis provide partial support for the use of tablet-based training programs to alleviate subjective cognitive complaints, reduce depressive symptoms, and support memory performance in affected individuals. Conclusion: These findings highlight the diverse clinical presentation of Long-COVID and its significant impact on those affected. Moreover, they underscore the need for a deeper understanding of the neuronal mechanisms underlying its cognitive and psychological symptoms. Future research should aim to identify reliable biomarkers and develop tailored, multimodal interventions to improve the quality of life for those affected.","authors":["Leitner, M"],"year":2025,"source":"Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp. 98","category":5,"document_type":16,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2025-12-03T09:49:47+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":119579,"title":"Evaluation of a new assay for detection of herpes simplex virus type 1 and type 2 DNA by real-time PCR","abstract":null,"authors":["Haas, I","Muehlbauer, G","Bozic, M","Stelzl, E","Koidl, C","Berger, A","Berg, J","Vince, A","Rabenau, H","Kessler, HH"],"year":2004,"source":"LaboratoriumsMedizin / Journal of Laboratory Medicine. 2004; 28:  361-367. 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Diese führen zu degenerativen Modifikationen, insbesondere zur Arteriosklerose, die wiederum meist die Hauptursache für die epidemiologisch bedeutsamsten Entitäten wie koronare Herzkrankheit, arterielle Hypertonie, Myokardinfarkt und ischämischen Apoplex ist.\r\nZu Beginn der Arbeit wird der Alterungsprozess und sein Zusammenhang mit oxidativem Stress erläutert sowie die biochemischen Grundlagen der Radikale und Antioxidantien erklärt. Der Hauptteil untersucht, ob eine präventive oder therapeutische Supplementation von Vitamin C, Vitamin E oder Carotinoiden die Entstehung oder die Progredienz solch degenerativer Veränderungen beeinflussen kann. Dafür wurde eine Literaturrecherche mithilfe mehrerer Nachschlagewerke und der Datenbanken PubMed und UpToDate durchgeführt, wobei systematische Reviews, Meta-Analysen sowie pro- und retrospektive Studien analysiert wurden. Als primäres Recherchekriterium wurde die isolierte Wirkung der genannten Antioxidantien auf kardiovaskuläre Parameter gewählt.\r\nInsgesamt fehlen eindeutige Studienergebnisse, die eine evidenzbasierte Empfehlung für oder gegen die isolierte Supplementation der genannten Antioxidantien erlauben. Weitere Studien sind erforderlich, da antioxidative Substanzen weiterhin großes Potenzial für die Gesundheitsprävention aufweisen und insbesondere in der Altersmedizin lebensqualitätssteigernde Effekte haben könnten. In die Untersuchungen sollten sowohl der individuelle Gesundheitszustand als auch Einflussfaktoren wie Ernährungsgewohnheiten und Lebensstil miteinbezogen werden, um Daten zu Dosierung, potenziellen Nebenwirkungen und Wechselwirkungen unterschiedlicher Nährstoffe zu sammeln. Zusätzlich ist eine striktere Differenzierung zwischen den Geschlechtern notwendig, da sich die Stoffwechselsituation und Wirkungskapazitäten unterschiedlicher Stoffe geschlechtsspezifisch unterscheiden können. Die meisten Studien wurden bisher jedoch an männlichen Probanden durchgeführt.","authors":["Thiel, M"],"year":2025,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 92","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2025-01-23T09:25:31+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":219998,"title":"Update systemische Therapie des HCC","abstract":null,"authors":["Wagner, M",""],"year":2026,"source":"Gastrointestinale Tumore 2026 - Gegenwart und Ausblick; JAN 15, 2026; Oberwart, AUSTRIA. 2026. 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Despite advancements in surgical and chemotherapeutic options, challenges such as metastasis, drug resistance, and adverse side effects necessitate innovative therapies. Emerging solutions like siRNA-based interventions demonstrate promise but require rigorous preclinical validation to overcome hurdles in stability and delivery. Animal models play a pivotal role in this process, offering a controlled platform to test new treatments. In this systematic review, we analyzed 26 studies from the past 15 years focused on injection-based carcinogenesis in small animal models. Our aim was to identify standardized practices in animal and cell line selection, injection methods, volumes and cell concentrations. The findings highlight the variability in methodologies, underscoring the need for consistency to streamline future research and enhance translational relevance. Our review concludes that adopting precise and minimally invasive approaches, such as endoscopic injection, in anatomically scalable models like rats, could bridge the gap between experimental designs and human CRC pathology. These insights are intended to guide the development of robust and reproducible CRC animal models for advancing therapeutic innovations.","authors":["Eisenberger, K"],"year":2025,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. ","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-01-07T11:07:20+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":209173,"title":"[Latent safety threats in a pediatric emergency department: Using in situ simulation to test a new trauma room concept].","abstract":null,"authors":["Große, Lordemann, A","Sommerfeldt, D","Mileder, L"],"year":2024,"source":"Z Evid Fortbild Qual Gesundhwes. 2024; ","category":1,"document_type":1,"sci":"ISI:001266368500001","pubmed":"38644149","doi":"10.1016/j.zefq.2024.03.005","pmc":null,"organizations":["209173-14094"],"persons":["209173-68534-6"],"imported":"2024-04-22T02:00:00+02:00","journal":"Z Evid Fortbild Qual Gesundhwes","issn":"1865-9217","collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":true,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true},{"id":219982,"title":"Das relative Energiedefizit Syndrom (RED-S) im Sport","abstract":null,"authors":["Windhaber, J"],"year":2025,"source":"Weinviertler Sportärztetage; November 8, 2025; Retz, AUSTRIA. 2025. 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