{"count":159558,"next":"https://api-test.medunigraz.at/v1/research/publication/?format=json&limit=20&offset=158080&ordering=impactfactor_norm","previous":"https://api-test.medunigraz.at/v1/research/publication/?format=json&limit=20&offset=158040&ordering=impactfactor_norm","results":[{"id":152792,"title":"Burn prevention in the face of global wealth inequality.","abstract":null,"authors":["Hundeshagen, G","Wurzer, P","Forbes, AA","Cambiaso-Daniel, J","Nunez-Lopez, O","Branski, LK","Herndon, DN"],"year":2016,"source":"Safety in Health. 2016; 2(5): 1-5. 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","category":1,"document_type":3,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["217813-14091"],"persons":["217813-60213"],"imported":"2025-09-15T14:18:15+02:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true},{"id":196835,"title":"Is direct negative pressure therapy (NPT) damaging intraabdominal organs? - An animal experimental stress model","abstract":null,"authors":["Delcev, P","Sauseng, S","Wiederstein-Grasser, I","Preisegger, KH","Schemmer, P","Mischinger, H","Auer-Schönbach, T"],"year":2022,"source":"European Surgery. 2022; 54(1):73-73.-63rd Annual Meeting of the Austrian Society of Surgery; June 15-17, 2022; Graz, AUSTRIA. ","category":2,"document_type":9,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["196835-14045","196835-14073","196835-28393"],"persons":["196835-51595","196835-62305"],"imported":"2022-08-05T20:19:54+02:00","journal":null,"issn":"1682-8631","collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":true,"conference_place":true,"conference_international":false,"scientific_event":true,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":true,"biobank_use":true,"bmf_use":true,"zmf_use":true,"local_affiliation":true},{"id":219665,"title":"Die Bedeutung von Ki-67 in der Diagnostik von neuroendokrinen Lungentumoren","abstract":"Hintergrund: Neuroendokrine Tumoren der Lunge (pulmonale NET) bilden eine heterogene Entität mit variabler biologischer Aktivität und Prognose. Die präzise histopathologische Klassifikation ist essenziell für die Wahl geeigneter therapeutischer Strategien und die Abschätzung des klinischen Verlaufs. Während der Proliferationsmarker Ki-67 in der Diagnostik gastroenteropankreatischer NETs etabliert ist, wird seine diagnostische und prognostische Relevanz bei pulmonalen NET bislang zurückhaltender behandelt. In der aktuellen WHO-Klassifikation 2021 wird der Ki-67 Proliferationsindex als wünschenswertes Kriterium genannt. Ziel der vorliegenden Arbeit war es, im Rahmen eines systematischen Literaturreviews den aktuellen Kenntnisstand zur Bedeutung von Ki-67 bei neuroendokrinen\nLungentumoren zusammenzufassen und dessen potenziellen Stellenwert für die zukünftige Integration in die standardisierte Diagnostik zu evaluieren. Analysiert wurden internationale Leitlinien, technische Aspekte der Ki-67-Bestimmung, deren Reproduzierbarkeit sowie der prognostische und differentialdiagnostische Nutzen des Markers.","authors":["Voelcker, A"],"year":2025,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 94","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-01-07T11:07:20+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":147634,"title":"Möglichkeiten zur Verringerung von Bakteriämierisiken bei Verwendung von zentralvenösen Kathetern und Port-Systemen zur parenteralen Ernährung (PE) und als Hämodialysezugang","abstract":null,"authors":["Drissi, M","Masin, M","Schilcher, G","Meyer, TM","Hollenbeck, M"],"year":2015,"source":"Nutrition News. 2015; 3(15): 17-21. ","category":1,"document_type":3,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["147634-14084"],"persons":["147634-50740"],"imported":"2015-10-17T01:44:44+02:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true},{"id":219667,"title":"Die Wertigkeit der MRT-Diagnostik von Muskelverletzungen bei Fußballern und ihre Aussagekraft bezüglich der Rekonvaleszenz","abstract":"Einleitung: Muskelverletzungen zählen im Profifußball zu den häufigsten Ursachen für Ausfallzeiten. Die Magnetresonanztomographie hat sich dabei als zentrales diagnostischen Verfahren etabliert. Obwohl derzeit eine Vielzahl an MRT-Klassifikationssysteme vorliegen, besteht weiterhin kein Konsens über deren prognostische Relevanz. Auf dieser Grundlage wurde das Bildmaterial des Studienkollektivs mit den gebräuchlichsten Klassifikationssystemen abgeglichen und den klinischen Informationen gegenübergestellt. Ziel dieser Arbeit war es, die prognostische Wertigkeit der MRT-Diagnostik bei Muskelverletzungen und ihre Aussagekraft bezüglich der Rekonvaleszenz zu untersuchen.","authors":["Resch, D"],"year":2025,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 74","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-01-07T11:07:20+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":219649,"title":"Genotyp-Phänotyp-Korrelationen bei Patient*innen mit Hypertropher Kardiomyopathie","abstract":"Die hypertrophe Kardiomyopathie (HCM) gehört zu den häufigsten genetisch bedingten Erkrankungen des Herzens und wird in 30-40% der Fälle durch Mutationen in den sarkomerischen Genen versursacht. Darüber hinaus zählt HCM zu den häufigsten Ursachen eines plötzlichen Herztodes (SCD) bei jungen Erwachsenen. Das Hauptziel dieser Studie war es, die Genotyp-positive und die Genotyp-negative Gruppe des Patient*innenkollektivs aus dem Grazer HCM-Register hinsichtlich der Häufigkeit einer positiven Familienanamnese für HCM und SCD sowie der Prävalenz der Begleiterkrankungen genauer zu analysieren.","authors":["Katerenchuk, A"],"year":2025,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 64","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2026-01-07T11:07:20+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":147882,"title":"Learning and reporting system in a tertiary university hospital compared to the Austrian-wide open access system","abstract":null,"authors":["Sendlhofer, G","Kober, B","Leitgeb, K","Schanbacher M"],"year":2015,"source":"Safety in Health, Supplement 1. 2015; Volume 1(1):1-19.-Sicherheit im Krankenhaus: Von der Strategie zur Umsetzung; Sep 29-30,2015; Graz, Austria. ","category":2,"document_type":9,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["147882-14076","147882-14112"],"persons":["147882-51269","147882-78071"],"imported":"2015-10-30T16:02:20+01:00","journal":null,"issn":"2056-5917","collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":true,"conference_place":true,"conference_international":true,"scientific_event":true,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true},{"id":145495,"title":"Die Therapie der Stressinkontinenz der Frau","abstract":null,"authors":["Mirna, A","Tammaa, A"],"year":2002,"source":"Nachrichten der Österreichischen Gesellschaft für Urologie und Andrologie (NÖGU). 2002; 25:  20-23. ","category":1,"document_type":3,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2015-05-25T19:38:05+02:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":217884,"title":"Body mass index matters: morbid obese patients have different microorganism profiles in the setting of periprosthetic hip joint infections","abstract":null,"authors":["Budin, M","Sandiford, NA","Gehrke, T","Citak, M"],"year":2025,"source":"https://pubmed.ncbi.nlm.nih.gov/40183945/. 2025; -EBJIS Bologna; 11.09.2025-13.09.2025; Bologna. ","category":2,"document_type":18,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["217884-14052"],"persons":["217884-133203"],"imported":"2025-09-18T19:27:59+02:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":true,"conference_place":true,"conference_international":true,"scientific_event":true,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":true,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true},{"id":217939,"title":"Anleitung zur anatomischen Präparation","abstract":null,"authors":["Pretterklieber, M"],"year":2025,"source":"23. Präparieren für Anatomen; JULY 28-31, 2025; Fribourg, SCHWEIZ. 2025. ","category":3,"document_type":null,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["217939-14018"],"persons":["217939-108616"],"imported":"2025-09-23T11:57:22+02:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":true,"conference_place":true,"conference_international":true,"scientific_event":true,"invited_lecture":true,"keynote_speaker":true,"selected_presentation":true,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true},{"id":211838,"title":"Die klinische Relevanz der kardiopulmonalen Belastbarkeit bei PatientInnen mit Leberzirrhose– eine retrospektive Studie","abstract":"Grundlagen und Ziele: Die Leberzirrhose geht häufig mit einer Minderung der kardiopulmonalen Belastbarkeit einher, die in Transplantkollektiven prognostische Relevanz hat. Ob die Leistungsfähigkeit auch abseits des Transplant-Settings klinisch relevant ist, wurde bislang unzureichend untersucht und soll in dieser Arbeit für PatientInnen mit Leberzirrhose in allen Child-Pugh Stadien evaluiert werden.","authors":["Laule, A"],"year":2024,"source":"Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 77","category":5,"document_type":15,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2024-10-28T09:03:36+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":217835,"title":"ctDNA as a predictor of treatment response in NSCLC patients treated with immune modulating therapy","abstract":"Non-small cell lung cancer (NSCLC) remains one of the most lethal malignancies worldwide, and while immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for advances stages, reliable biomarkers to predict treatment response and guide clinical decision-making are still lacking. This study investigated the potential of circulating tumor DNA (ctDNA) dynamics as a minimally invasive biomarker to predict and monitor treatment outcomes in NSCLC patients undergoing ICI therapy. The study evaluated both the technical feasibility and clinical relevance of ctDNA profiling, leveraging high- sensitivity next-generation sequencing (NGS) approaches. To identify the most suitable ctDNA detection method, multiple commercial assays were rigorously validated using standardized reference materials with known variant allele frequencies (VAF). The AVENIO ctDNA Expanded Kit demonstrated the highest sensitivity and specificity, detecting 65% of expected variant even at a 0.1% VAF. Based on this performance, the assay was applied to a cohort of 167 patients with IIIB-IV NSCLC treated with ICIs. ctDNA was extracted from plasma samples at two time points: before treatment start (t0) and after two cycles (t1). ctDNA levels were quantified using multiple proxies, including average mutant molecules per milliliter (aMM) and VAF metrics. Dynamic changes in ctDNA levels, particularly a ≥50% reduction in aMM were strongly correlated with improved progression-free survival (median 10.0 vs. 2.0 months) and overall survival median (18.4 vs. 5.9 months). Furthermore, a landmark analysis at two months confirmed the early predictive value of molecular response, supporting its utility for real-time clinical decision-making. To ensure specificity of tumor-derived variants, paired sequencing of peripheral blood mononuclear cells (PBMCs) was performed to exclude clonal hematopoiesis (CH)-related mutations, which were found in about 45% of patients. This correction substantially improved response classification and reduced false-positive ctDNA signals. Additionally, patients with STK11 or KEAP1 mutations exhibited significantly poorer outcomes. These findings demonstrate that ctDNA dynamics, when corrected for CH interference and measured using a validated assay, serve as a robust early biomarker of treatment response and survival in advanced NSCLC, offering valuable guidance for personalized treatment strategies.","authors":["Hammer, S"],"year":2025,"source":"Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp. 127","category":5,"document_type":16,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2025-09-16T10:33:24+02:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Medizinische Universität Graz","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":215284,"title":"Zugangswege Hüfte und Oberschenkel","abstract":null,"authors":["Puchwein, P"],"year":2025,"source":"AO Trauma Kurs - Prinzipien der operativen Zugangswege in Unfallchirurgie und Orthopädie; FEB 10-12, 2025; Graz, AUSTRIA. 2025. ","category":3,"document_type":null,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["215284-14052"],"persons":["215284-62925"],"imported":"2025-03-18T12:33:04+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":true,"conference_place":true,"conference_international":false,"scientific_event":true,"invited_lecture":true,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":true},{"id":216818,"title":"Österreichischer Demenzbericht 2025\r\nWissenschaftlicher Bericht","abstract":null,"authors":["Herausgeber: Juraszovich, B","Mayer, LK","Marent, J","Mitautor: Jagsch, C"],"year":2025,"source":". 2025","category":12,"document_type":null,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":["216818-29484"],"persons":["216818-71002"],"imported":"2025-06-26T13:10:25+02:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":null,"country":null,"case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":185819,"title":"Maternal Obesity in Early Human Pregnancy: Placental DNA Integrity and Stress Response","abstract":"In the first trimester (FT) of human pregnancy, the intrauterine environment directly affects development of the rapidly growing placenta. Maternal obesity - a frequent manifestation of metabolic derangements - is associated with metabolic complications, systemic low-grade inflammation and genotoxicity. Considering that the developing placenta is exposed to obesity-associated changes in the early intrauterine environment, we hypothesize that maternal obesity affects DNA integrity that triggers DNA damage responses (ATM/ATR signaling) and affects placental stress response with consequences for trophoblast turnover in early human pregnancy, respectively. The present study aimed to determine FT placental DNA damage, telomere shortening and subsequent effects on DNA damage repair and cell cycle regulation. Furthermore, we aimed to characterize FT placental stress status and final effects on trophoblast proliferation and apoptosis. \r\nFor this purpose, placental tissue (week 4-12 p.m.) was obtained from non-smoking (self-report and serum cotinine measurement) women terminating pregnancy for psycho-social reasons. DNA damage and oxygen-induced modification in total tissue were determined by COMET assay. We quantified DNA damage (γH2AX) and oxidative DNA modification (8-OHdG), proliferation (Ki67) and apoptosis (TUNEL, caspase cleaved cytokeratin 18) in villous cytotrophoblasts (CTB) using a semi-quantitative in situ analysis based on immunofluorescence triple-staining. Telomere length in total placental tissue and laser-capture microdissected trophoblast was quantified by RT-qPCR and confirmed by quantitative fluorescence in situ hybridization (Q-FISH). Pre-selected placental stress markers, cytokines, DNA damage repair and cell cycle related genes were assessed using a PCR-gene panel and Nanostring assay, while proteins were quantified by a cell cycle-specific protein array or immunoblotting. Data was analyzed using a multivariate linear regression model with adjustments for gestational age and tissue processing time.\r\nThe key findings of this study were: \r\ni. Maternal obesity in early pregnancy was not associated with oxidative DNA modifications (8-OHdG) in total tissue and CTB. Other indicators of oxidative stress such as products of lipid peroxidation and protein nitration as well as the classical stress marker HSP70 were unaltered by maternal obesity in early pregnancy. Furthermore, gene expression of placental antioxidants (MGST3, SOD3, GSTP1, GLRX, TXNRD1) and heme oxygenase 1 (HO-1) was lower in obese pregnant women, while placental Nrf2 expression and HO-1 protein levels were not altered in samples from obese pregnant women.\r\nii. ii.Maternal obesity affected placental inflammatory cytokine expression (IL1A, IL6) and stress signaling genes (ASK2, MAPK11, MAPK12, MAPK13, JNK1) in FT placentas.\r\niii. iii.Maternal obesity induced placental DNA damage specifically in CTBs. CTB telomeres in situ were shorter in maternal obesity. Shortening was associated with high C-peptide levels, low insulin sensitivity or high BMI. Despite higher ATM/ATR protein levels and increased substrate phosphorylation in FT placentas of obese pregnant women, selected downstream proteins remained unaffected, while central DNA damage repair transducers (HDAC1, HDAC8, PARP1, FEN1, ku70, BLM) were downregulated in FT placentas from obese pregnant women. This dysregulated damage repair was also accompanied by an induction of cell cycle arrest. \r\niv. iv.Finally, we found decreased CTB proliferation and an increase in apoptosis in FT placentas from obese pregnant women, while senescence was unaltered. \r\nAltogether, these results argue for absence of oxidative stress in first trimester placentas of obese women. They also suggest that maternal obesity in the first trimester affects CTB turnover and therefore alter placental development, potentially ensuing adverse consequences for maternal and fetal health.","authors":["Hoch, D"],"year":2021,"source":"PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Graz Medical University; 2021. pp. 143","category":5,"document_type":16,"sci":null,"pubmed":null,"doi":null,"pmc":null,"organizations":[],"persons":[],"imported":"2021-02-02T09:50:09+01:00","journal":null,"issn":null,"collection_publisher":null,"collection_title":null,"edition":null,"university":"Graz Medical University","country":"40","case_report":false,"impactfactor":null,"impactfactor_year":null,"impactfactor_norm":null,"impactfactor_norm_year":null,"impactfactor_norm_category":null,"impactfactor_norm_super":null,"impactfactor_norm_super_year":null,"impactfactor_norm_super_category":null,"citations":null,"conference_name":null,"conference_place":null,"conference_international":false,"scientific_event":false,"invited_lecture":false,"keynote_speaker":false,"selected_presentation":false,"biobank_use":false,"bmf_use":false,"zmf_use":false,"local_affiliation":false},{"id":218967,"title":"Gründe für das Nichtdurchführen einer Notfallnarkose bei bewusstlossen Patient*innen im Notarztdienst– eine retrospektive Analyse","abstract":null,"authors":["Heuschneider, L","Eichlseder, M","Eichinger, M","Pichler, A","Graziani, D","Bader, M","Labenbacher, S","Hammer, S","Schreiber, N","Zoidl, P","Freidorfer, D","Niederer, M"],"year":2025,"source":"https://www.divi25.de/abstracts. 2025; -KONGRESS DER DEUTSCHEN INTERDISZIPLINÄREN VEREINIGUNG FÜR INTENSIV- UND NOTFALLMEDIZIN E.V. (DIVI); DEZ 3-5, 2025; Hamburg, Germany. 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