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GET /v1/research/publication/?format=api&offset=3280&ordering=-impactfactor_norm
{ "count": 157904, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=3300&ordering=-impactfactor_norm", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=3260&ordering=-impactfactor_norm", "results": [ { "id": 217939, "title": "Anleitung zur anatomischen Präparation", "abstract": null, "authors": [ "Pretterklieber, M" ], "year": 2025, "source": "23. Präparieren für Anatomen; JULY 28-31, 2025; Fribourg, SCHWEIZ. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217939-14018" ], "persons": [ "217939-108616" ], "imported": "2025-09-23T11:57:22+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217884, "title": "Body mass index matters: morbid obese patients have different microorganism profiles in the setting of periprosthetic hip joint infections", "abstract": null, "authors": [ "Budin, M", "Sandiford, NA", "Gehrke, T", "Citak, M" ], "year": 2025, "source": "https://pubmed.ncbi.nlm.nih.gov/40183945/. 2025; -EBJIS Bologna; 11.09.2025-13.09.2025; Bologna. ", "category": 2, "document_type": 18, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217884-14052" ], "persons": [ "217884-133203" ], "imported": "2025-09-18T19:27:59+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217813, "title": "Unterschiede rheumatischer Erkrankungen bei Kindern und Erwachsenen am Beispiel der JIA", "abstract": null, "authors": [ "Skrabl-Baumgartner, A" ], "year": 2025, "source": "Arzt und Praxis. 2025; Sonderheft Pädiatrie(79): 9-13. ", "category": 1, "document_type": 3, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217813-14091" ], "persons": [ "217813-60213" ], "imported": "2025-09-15T14:18:15+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217396, "title": "Genomic profiling of circulating tumor DNA using targeted capture sequencing in advanced HR+/HER- breast cancer patients", "abstract": "Background: HR-positive, HER2-negative breast cancer (HR+/HER2-) is the most common subtype of breast cancer, accounting for around 60-70%. PIK3CA mutations occur in up to 40% of patients and permanently activate the PI3K/AKT/mTOR signaling pathway. This can lead to resistance to therapy and worsen the prognosis. While these mutations are usually determined from tumor tissue, the analysis of cell-free tumor DNA (ctDNA) in plasma offers a minimally invasive alternative, especially for metastases that are difficult to biopsy. The aim of this study was to compare the detection of PIK3CA mutations using SiMSen-Seq, and the AVENIO ctDNA Expanded Kit and to test whether AVENIO can detect additional clinically relevant alterations.
\r\nMethods: 47 patients with HR+/HER2- metastatic breast cancer (mBC) were examined. Blood samples were taken before starting palliative therapy (32 before first-line and 15 before second-line therapy). Tumor fraction was estimated using mFAST-SeqS (z-score). Two methods were used for mutation analysis. On the one hand, SiMSen-Seq, a PCR-based NGS method for the highly sensitive detection of eleven PIK3CA hotspot mutations. On the other hand, AVENIO ctDNA Expanded Kit, an NGS panel for 77 cancer-relevant genes. Sequencing was performed on Illumina platforms and resulting data were analyzed bioinformatically.
\r\nResults: PIK3CA mutations were detected in 21 of 47 patients (44.7%). The most frequent variants were H1047R, E542K and C420R. 35 of 40 mutations (87.5%) were detected by both methods. Only few mutations (n = 4, corresponding to 8.5%) were detected exclusively by one method and these were mostly at low VAF (variant allele frequency) (<1%). AVENIO additionally identified mutations in TP53, ESR1, SMAD4, GATA3 and AKT1. Higher tumor proportions (z-scores) correlated with visceral metastasis.
\r\nConclusion: The AVENIO ctDNA Expanded Kit showed comparable sensitivity to SiMSen-Seq in PIK3CA detection but additionally enabled a broader molecular analysis. The combination of AVENIO, SiMSen-Seq and mFAST-SeqS provides a powerful tool for non-invasive characterization and monitoring of HR+/HER2- mBC. This would allow therapies to be adapted more specifically and resistance developments to be detected at an early stage. Especially in situations where tissue samples are difficult to obtain.", "authors": [ "Potocnik, N" ], "year": 2025, "source": " [ Diplomarbeit/Master Thesis (UNI) ] TU Graz; 2025. pp.66. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-08-22T14:29:23+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "TU Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": false }, { "id": 217642, "title": "From rodents to humans—Translational aspects of burn wound models.", "abstract": null, "authors": [ "Pignet, AL", "Hofmann, E", "Fink, J", "Prevedel, M", "Kamolz, LP", "Kotzbeck, P" ], "year": 2025, "source": "21st European Burns Association Congress. 2025; -EBA 2025; Sep 3-6, 2025; Berlin, GERMANY. ", "category": 2, "document_type": 19, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217642-14076" ], "persons": [ "217642-111830", "217642-117826", "217642-80111", "217642-95211", "217642-100699", "217642-89900" ], "imported": "2025-09-08T10:06:16+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": true, "zmf_use": true, "local_affiliation": true }, { "id": 213230, "title": "Fortgeschrittene Verfahren in der Thoraxchirurgie", "abstract": null, "authors": [ "Swatek, P" ], "year": 2025, "source": "Lung cancer insight; JAN 15, 2025; Graz, Austria. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213230-14077" ], "persons": [ "213230-50145", "213230-50948", "213230-51935", "213230-124334" ], "imported": "2025-01-20T11:28:02+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217073, "title": "Praxisseminar Bewegungsstörungen", "abstract": null, "authors": [ "Schwingenschuh, P" ], "year": 2025, "source": "ÖGN Jahrestagung; MAR 11-14, 2025; Innsbruck, Austria. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217073-14051" ], "persons": [ "217073-50172" ], "imported": "2025-07-14T13:15:05+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 214831, "title": "i.v. Kontrastmittelgabe", "abstract": null, "authors": [ "Schmid, J" ], "year": 2025, "source": "Interne Fortbildung Universitätsklinik für Strahlentherapie-Radioonkologie; FEB 26, 2025; Graz, Austria. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "214831-14104" ], "persons": [ "214831-91529" ], "imported": "2025-03-06T08:58:52+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 218816, "title": "Endokrine Hypertonie", "abstract": null, "authors": [ "Kraus, DA" ], "year": 2025, "source": "53. ÖDG-Jahrestagung 2025; 20.-22.11.2025; Salzburg. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "218816-14080" ], "persons": [ "218816-132242" ], "imported": "2025-11-27T16:58:21+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 218173, "title": "Kongress Newsletter EASL und ESPGHAN 2025 - Cholestatische Lebererkrankungen", "abstract": null, "authors": [ "Kohlmaier, B" ], "year": 2025, "source": "IPSEN Kongress Newsletter. 2025. ", "category": 11, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "218173-14091" ], "persons": [ "218173-75521" ], "imported": "2025-10-10T17:15:32+02:00", "journal": "IPSEN Kongress Newsletter", "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 218162, "title": "Häufigkeit der Kuhmilch-Protein-Allergie bei Säuglingen mit Vorliegen des Symptoms Hämatochezie", "abstract": null, "authors": [ "Pichler, M", "Kohlmaier, B" ], "year": 2025, "source": "Mondseegespräche; JUN 26-28, 2025; Irrsee, AUSTRIA. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "218162-14018", "218162-14091" ], "persons": [ "218162-75521", "218162-118853" ], "imported": "2025-10-10T15:45:04+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217883, "title": "Body mass index matters: morbid obese patients have different microorganism profiles in the setting of periprosthetic hip joint infections", "abstract": null, "authors": [ "Budin, M", "Sandiford, NA", "Gehrke, T", "Citak, M" ], "year": 2025, "source": "https://pubmed.ncbi.nlm.nih.gov/40183945/. 2025; -SICOT Madrid; 03.09.2025-05.09.2025; Madrid. ", "category": 2, "document_type": 18, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217883-14052" ], "persons": [ "217883-133203" ], "imported": "2025-09-18T19:26:05+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217074, "title": "Erste Ergebnisse aus der ÖGN-Mitgliederbefragung zu FNS", "abstract": null, "authors": [ "Schwingenschuh, P" ], "year": 2025, "source": "ÖGN Jahrestagung; MAR 11-14, 2025; Innsbruck, Austria. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217074-14051" ], "persons": [ "217074-50172" ], "imported": "2025-07-14T13:17:07+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 215408, "title": "Digitale Leitlinienentwicklung: Erfahrungen am Beispiel der DEGAM-S3-Leitline Nackenschmerzen", "abstract": null, "authors": [ "Kötter, T", "El-Allawy, A", "Muche-Borowski, C", "Wilfling, D" ], "year": 2025, "source": "26. Jahrestagung des Deutschen Netzwerks für Evidenzbasierte Medizin; MARCH 26-28, 2025; Freiburg, GERMANY. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "215408-14080", "215408-27964" ], "persons": [ "215408-125094" ], "imported": "2025-04-01T13:16:34+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 215302, "title": "What CPAP to use in the Delivery Room? Bench Comparison of Two Methods to provide Continuous Positive Airways Pressure in Neonates ", "abstract": null, "authors": [ "Gruber, V", "Morakeas, S", "Hinder, MK", "Drevhammar, T", "Dronavalli, M", "Tracy, MB" ], "year": 2025, "source": "Gruber V, Tracy MB, Hinder MK, Morakeas S, Dronavalli M, Drevhammar T. What CPAP to use in the delivery room? Bench comparison of two methods to provide continuous positive airways pressure in neonates. BMJ Paediatr Open. 2024 Nov 5;8(1):e002948. doi: 10.1136/bmjpo-2024-002948. PMID: 39500615; PMCID: PMC11552556.. 2025; -PSANZ - Perinatal Society of Australia and New Zealand ; March 16-19,2025; Brisbane, Australia . 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