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GET /v1/research/publication/?format=api&offset=3120&ordering=-impactfactor_norm
{ "count": 157757, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=3140&ordering=-impactfactor_norm", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=3100&ordering=-impactfactor_norm", "results": [ { "id": 210535, "title": "Troponin I Kinetics in Patients Treated with Ambulatory Hemodialysis", "abstract": "INTRODUCTION: Whereas cardiac troponins play a fundamental role in the latest guidelines for the diagnosis of myocardial infarction (MI), their evaluation in patients requiring hemodialysis (HD) is afflicted with several challenges. Beside the commonly elevated baseline levels of both clinically relevant subtypes, troponin I and troponin T, in this population, a further uncertainty exists in relation to troponin dynamics during HD and whether effects vary between different membranes and HD modalities. The new generation of medium cut-off membranes, that show higher permeability for middle sized molecules, add an additional layer of complexity to this topic. Due to this lack of clarity, physicians are confronted with ambiguity regarding the evaluation of troponin levels in HD patients presenting with signs of acute coronary syndrome (ACS). \r\nMETHODS: In this controlled, randomized single-center trial, the baseline values of high-sensitive troponin I (hs-cTnI) and the effect of four different dialysis modalities (high-flux HD, low-flux HD, medium cut-off HD and hemodiafiltration) on hs-cTnI levels were investigated in a cross-over study design. Therefore, blood samples for hs-cTnI measurement were taken at baseline, one hour after dialysis start and at the end of every session. Baseline levels of hs-cTnI as well as dynamics in hs-cTnI over time were analyzed. \r\nRESULTS: Nineteen patients were included in the statistical analysis (10 [52.6 %] male; age 31–81, median 66). The baseline hs-cTnI was elevated above the cut-off value for MI in 58.3 % (median 34.25 ng/l; IQR 15.25–121.96) of all cases. Patients with cardiovascular disease presented higher hs-cTnI levels compared to those without (p<.001). There was no effect of dialysis with high-flux, medium cut-off membranes or HDF on hs-cTnI levels (p>.05). In contrast, low-flux HD led to an increase of hs-cTnI levels during one session (Z=2.12; r =.499; p=.034), but not during the first hour (p=.227). This observation could not be shown after correction for hemoconcentration. \r\nCONCLUSION:Dialysis sessions conducted with low-flux membranes may lead to an increase in hs-cTnI levels and therefore complicate interpretation of hs-cTnI levels in HD patients presenting with ACS. Other HD modalities also lead to inconclusive effects in relation of hs-cTnI dynamics since we observed interpersonal variations in hs-cTnI dynamics in both directions. Thus, the interpretation of hs-cTnI in patients undergoing HD is afflicted with a high risk of misinterpretation. Since the majority of HD patients present with baseline hs-cTnI levels above the cut-off value for MI, the interpretation of single hs-cTnI values in this population should be done with particular caution.", "authors": [ "Krietemeyer, B" ], "year": 2024, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2024. pp. 70", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-07-23T09:25:44+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universitaet Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210665, "title": "Smartphone apps: a technical approach for dealing with bipolar disorder?", "abstract": "Background: Early detection and treatment of illness episodes of bipolar disorder is desirable as having a positive impact on both individual episodes and the overall course of illness. Frequently, individuals with bipolar disorder experience behavioural changes, particularly in sleep patterns, at the onset of depressive or (hypo)manic episodes. These early warning signs are individualised but often recurrently similar within a person and are frequently recognised too late by those affected. Continuous monitoring of these early warning signs is, therefore, essential. Technological support through smartphone apps, especially in times of personal or societal crisis, such as the COVID-19 pandemic, could be helpful. \r\nObjectives: In three clinical trials, this thesis examined whether smartphone apps could provide suitable and valid support in early warning management of sleep behaviour. Hence, 1. the desire for such apps among affected individuals was assessed, 2. changes in sleep behaviour during the COVID-19 pandemic were investigated, and 3. the validity of sleep data and acceptance of the product UP! were evaluated.\r\nMethods and Results: 1. A questionnaire survey of individuals with bipolar disorder and their relatives revealed a deficit in complete early warning sign detection and that those affected consider apps as meaningful support and would utilise them. 2. An online survey during the first year of the COVID-19 pandemic found that individuals with bipolar disorder exhibited poorer sleep quality, prolonged sleep onset latency, and increased daytime sleepiness during this crisis period. 3. The UP! software, aimed at automatic behavioural measurements, particularly of sleep, was developed with medical consultation from the outpatient clinic for bipolar disorder by meemo-tec OG. A pilot study demonstrated that the app validly measures sleep onset and wake times compared to an accelerometer and the validated questionnaire \"Pittsburgh Sleep Inventory.\" Furthermore, users were satisfied with the app design and had no concerns regarding data security.\r\nDiscussion: By continuously monitoring behavioural changes for early detection, affected individuals can intervene early, thereby strengthening their self-efficacy. Smartphone apps are widely available, accessible anytime and anywhere, and cost-effective, making them a valuable additional treatment option. Due to the ongoing development of new products, it is essential to collectively assess individual products and evaluate them in terms of validity, effectiveness, efficiency, and side effects in order to create evidence-based guidelines for patients and healthcare providers.", "authors": [ "Fellendorf, F" ], "year": 2024, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. 108", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-08-08T09:39:30+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 178502, "title": "Vitamin D, clinical outcomes and regulation of metabolism", "abstract": "Vitamin D is a pleiotropic steroid hormone and regulates the expression of a wide variety of genes. Vitamin D metabolism is tightly regulated and serum levels show seasonal patterns. Vitamin D deficiency has been linked to skeletal as well as non-skeletal health conditions such as cardiovascular disease. Many aspects of governing the non-skeletal actions of vitamin D and even its metabolism are still poorly understood. We investigated three of these aspects regarding vitamin D catabolism and the usefulness of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) and the vitamin D metabolite ratio (VMR), regarding the seasonality of a cardiovascular biomarker soluble ST2 (sST2) as well as regarding the effects of vitamin D on non-oxidized PTH.\nWe used the data and samples gathered in the Styrian Vitamin D in Hypertension Trial and the Ludwigshafen Risk and Cardiovascular Health Study to assess our hypotheses. In the first sub-study we found that VMR and 24,25(OH)2D3 increased after vitamin D treatment, although, these parameters can’t be used to predict the changes in 25(OH)D levels after vitamin D treatment. In the second sub-study we found that systemic sST2 levels weren’t affected by vitamin D supplementation and in a separate cohort we also demonstrated that sST2 concentrations didn’t change alongside 25(OH)D concentrations and remained mostly constant without significant fluctuations throughout the whole year. In the third sub-study we observed a reduction in both total PHT (tPTH) and n-oxPTH after vitamin D supplementation and our data indicate that measuring n-oxPTH might be a better alternative to tPTH, at least in the case of patients prone to oxidative stress.\nIn conclusion, although vitamin D RCTs have shown mostly negative results in recent years, we found they can still be useful tools for uncovering promising and potentially clinically important findings as indicated by our findings regarding 24,25(OH)2D3, the VMR, sST2 and n-oxPTH.\n", "authors": [ "Francic,V" ], "year": 2019, "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [Dissertation] Medical University of Graz;2019. pp. 102", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2019-12-05T14:11:43+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University of Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210537, "title": "EVALUATION OF CAUSES OF REGISTERED BLINDNESS FOCUSING ON CHILDREN AND WORKING-AGED ADULTS IN AUSTRIA", "abstract": "Purpose: To analyse epidemiological characteristics and causes of blindness and visual impairment in Austria to facilitate planning of further research and governmental planning of health care resources.\r\nMethods: In a retrospective investigation, the central database of care allowance of the Main Confederation of Austrian Social Insurances (MCASI) was searched for patients with visual impairment, blindness, or deaf-blindness. This database accumulates data from all Austrian insurance providers. All entries in 2017 and 2018 were analysed for epidemiological and other characteristics. Additionally, to determine the prevalence and incidence of blindness, visual impairment and deaf-blindness in Austria, the number of all database entries that were present on a cut-off date (February 2nd, 2019) was counted.\r\nSince care money is a considerable source of income in Austria, we assume a practically complete acquisition of nearly all patients who were blind and visually impaired in this country at that time.\r\nResults: On the cut-off date in 2019, 17,730 persons were registered in the central database. This number suggests a prevalence of blindness, visual impairment, or deaf-blindness of 0.2% in Austria.\r\nDuring 2017 and 2018, 5040 entries were included in the MCASI database. Of these, 4404 persons met the inclusion criteria. A total of 2877 persons (65.3%) were female, and 1527 persons (34.7%) were male.\r\nThe overall incidence was calculated to be 25.0 (95% confidence limit (CL) 24.3–25.8) per 100,000 person-years.\r\nA total of 3675 persons (83.4%) were retirees, and 729 (16.6%) were younger than retirement age. The mean age was 75.7 years (± 18.0, median 82). Overall, the incidence was significantly higher for females (32.2, 95% CL 31.0–33.3) than for males (17.7, 95% CL 16.8–18.5). In contrast, in lower age groups (0-29 years), the incidences were higher for males. The leading diagnoses were macular degeneration (1075 patients, 24.4%), other retinal disorders (493 patients, 11.2%) and inherited retinal and choroidal diseases (186 patients, 4.2%).\r\nFor working-aged adults, the leading diagnoses were inherited retinal diseases (85, 13.3%), disorders of the optic nerve and visual pathways (62, 9.7%) and other retinal disorders (51, 8.0%).\r\nConclusion: Inherited retinal diseases are the most frequent causes of severe vision loss in working-aged adults in Austria. Thus, from this perspective, ongoing research for new therapies for those diseases should be expanded, and the costs for the new therapies should be accepted by insurance companies with a low threshold.", "authors": [ "Glatz, M" ], "year": 2024, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universitaet Graz; 2024. pp. 116", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-07-23T09:25:44+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universitaet Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210540, "title": "Structural Brain Networks as Predictors of Cognitive Decline in Alzheimer’s Disease – A Longitudinal Study", "abstract": "Studying grey matter structural covariance networks (SCNs) may enhance our knowledge about Alzheimer’s disease (AD) beyond the information based on the assessment of isolated grey matter areas. We, therefore, aim to (1) identify networks with diagnostic power for the differentiation between AD patients and healthy controls (HC), (2) compare their diagnostic power to established markers (brain volume, hippocampus volume, medial temporal lobe atrophy-score) and (3) determine the networks association to cognitive ability and cognitive decline. \r\nTo identify networks with diagnostic power, we trained a random forest model on a sample of 104 AD patients and 104 age- and sex-matched HC and calculated the variable importances for a set of 20 SCNs. To prevent overfitting, we validated the model on an independent sample of 28 AD patients from another centre and 28 HC. Resulting networks were compared against above mentioned established markers by combining them in an additional random forest model, again, by training and validating in independent cohorts. To determine the networks association to cognitive ability and cognitive decline, multiple linear regression models were used. \r\nTwo of the 20 SCNs showed significant contribution to the discrimination between AD and HC. These two networks comprise a temporal SCN and a secondary somatosensory SCN showing diagnostic accuracy of 81% in the training set and 86% in the validation set. When compared with the already established markers, the SCN performed worse and did not add any further information in a combined model.\r\nWe found the temporal SCN to be associated with verbal memory at baseline, but this effect vanished after controlling for age, sex and education. \r\nWe conclude that SCNs have diagnostic potential, but they do not provide information beyond established clinical tools.", "authors": [ "Wagner, F" ], "year": 2024, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universitaet Graz; 2024. pp. 86", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-07-23T09:25:44+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universitaet Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210964, "title": "Sustained vowels for pre- vs post-treatment COPD classification.", "abstract": null, "authors": [ "Triantafyllopoulos, A", "Batliner, A", "Mayr, W", "Fendler, M", "Pokorny, F", "Gerczuk, M", "Amiriparian, S", "Berghaus, T", "Schuller, B" ], "year": 2024, "source": "Proceedings of the 25th Annual Conference of the International Speech Communication Association, Interspeech 2024. 2024; 1410-1414.-25th Annual Conference of the International Speech Communication Association, Interspeech 2024; SEP 1-5, 2024; Kos Island, GREECE. ", "category": 2, "document_type": 18, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210964-14068" ], "persons": [ "210964-79651" ], "imported": "2024-09-04T14:03:33+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 210962, "title": "Reliable Change Index for the self-administered, IPad-based processing speed test – the PST", "abstract": null, "authors": [ "Hechenberger, S", "Helmlinger, B", "Jordan, S", "Wurth, S", "Heschl, B", "Damulina, A", "Eppinger, S", "Khalil, M", "Enzinger, C", "Pinter, D" ], "year": 2024, "source": "The 10th Annual Meeting of the International MS Cognition Society (IMSCOGS), publication in MSJ. 2024; -The 10th Annual Meeting of the International MS Cognition Society; SEPT 2-3,2024; Bern, SWITZERLAND. ", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "210962-14051" ], "persons": [ "210962-104619", "210962-98464", "210962-57435", "210962-107891", "210962-50173", "210962-66708", "210962-94124" ], "imported": "2024-09-04T11:29:59+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217499, "title": "Definition, classification and diagnosis of pulmonary hypertension according to the 7th World Symposium on Pulmonary Hypertension", "abstract": null, "authors": [ "Kovacs, G", "Douschan, P", "Foris, V", "Zeder, K", "John, T", "Bohr, B", "Müller, J", "Lange, TJ", "Ulrich, S" ], "year": 2025, "source": "Z PNEUMOLOGIE. 2025; ", "category": 1, "document_type": 3, "sci": "ISI:001551383300001", "pubmed": null, "doi": "10.1007/s10405-025-00631-x", "pmc": null, "organizations": [ "217499-14087" ], "persons": [ "217499-100914-6", "217499-87980-6", "217499-79732-6", "217499-59238-2", "217499-104780-6" ], "imported": "2025-08-28T11:15:55+02:00", "journal": "Z PNEUMOLOGIE", "issn": "2731-7404", "collection_publisher": null, "collection_title": "ZEITSCHRIFT FUR PNEUMOLOGIE; ", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 153529, "title": "The History of Liquid Ear Acupuncture and the Current Scientific State of the Art.", "abstract": null, "authors": [ "Litscher, D", "Litscher, G" ], "year": 2016, "source": "J Pharmacopuncture. 2016; 19(2):109-113", "category": 1, "document_type": 3, "sci": "ISI:000383282000002", "pubmed": "27386143", "doi": "10.3831/KPI.2016.19.011", "pmc": "PMC4931295", "organizations": [], "persons": [], "imported": "2016-07-12T02:00:00+02:00", "journal": "J Pharmacopuncture", "issn": "2093-6966", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 153570, "title": "First-in-Man Transcervical Surgical Aortic Valve Replacement Using the CoreVista System.", "abstract": null, "authors": [ "Dapunt, OE", "Luha, O", "Ebner, A", "Sonecki, P", "Spadaccio, C", "Sutherland, FW" ], "year": 2016, "source": "Innovations (Phila). 2016; 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