Publication List

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            "title": "The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation.",
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                "Jiang, X",
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                "Tan, C",
                "Exley, MA",
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                "Melum, E"
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            "title": "Actionable Explainable AI (AxAI): A Practical Example with Aggregation Functions for Adaptive Classification and Textual Explanations for Interpretable Machine Learning.",
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                "Hudec, M",
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                "Koch, C",
                "Pfeifer, B",
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                "Holzinger, A"
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            "title": "Lymphocytic infiltration alters tissue composition and cell-cell  signalling in salivary glands of patients suffering from Sjögren’s  disease",
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                "Anto Michel, N",
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            "source": "Abstract/Poster was presented during the annual meeting of the ÖGR 2025 in Vienna, Austria. 2025; -Jahrestagung der Österreichischen Gesellschaft für Rheumatologie und Rehabilitation (ÖGR) 2025; Nov 27-29, 2025; Vienna, Austria. ",
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            "title": "Methods of magnetization transfer MRI for assessing brain white matter damage.",
            "abstract": "Magnetic-resonance-imaging (MRI) is one of the most important non-invasive techniques in Neuroimaging and is particularly appreciated for its high soft-tissue contrast. MRI assesses the magnetic property of protons as well as their chemical environment and acquires brain morphometry in high resolution of less than one millimeter. Moreover, MRI enables the assessment of functional activation, diffusion, perfusion, metabolites and exchange-processes. In diseases, such as multiple sclerosis (MS), MRI is used to detect inflammation and blood brain barrier disruption, which might lead to neuronal loss and demyelination. In the early stage of the disease, such white matter (WM) changes cause an increased interstitial water content, which can be seen as hyperintense spots in fluid attenuated sequences. So-called white matter hyperintensities (WMH) are a hallmark of MS and determine the clinical progression. However, histopathological studies revealed, that the WMH depict just the tip of the iceberg while the underlying pathology might be far more widespread. A higher sensitivity can be achieved using magnetization transfer (MT), a physical process based on the exchange of magnetization between water-protons and protons bound to macromolecules of lipids, such as myelin sheets. Further, MT allows to assess microstructural changes also in the normal appearing white matter (NAWM) before WMH become visible.",
            "authors": [
                "Pirpamer, L"
            ],
            "year": 2022,
            "source": " [ Dissertation ] TU Graz; 2022. pp.106. ",
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            "id": 217622,
            "title": "Oscillometric blood pressure measurement with a stepper motor driven piston pump.",
            "abstract": "An indicator of cerebrovascular diseases is the compliance of blood vessels in the brain with a diameter less than 200 µm. It is not possible to observe these vessels by conventional magnetic resonance imaging, but cerebrovascular compliance mapping is a new method to achieve this. Therefore, a continuous measurement of the mean arterial pressure is necessary during the scanning process, alongside a way to alter the blood pressure. A stressor that induces a blood pressure change has already been developed, but no device currently available on the market can fulfil the necessary requirements for measuring the mean arterial pressure fast enough and inside a magnetic resonance scanner. Consequently, a new oscillometric blood pressure measurement apparatus was developed that utilizes a piston pump and a long tube. The piston pump enables the measurement during inflation as well, thus allowing the mean arterial pressure to be tracked. The long tube allows the ferromagnetic material containing device to be positioned outside the critical range of the scanner. An electronic circuit was constructed to control the pneumatic system and a BMC data acquisition board was employed to gather the data. A C# program was developed to guide and process the measurement. A stable, real-time algorithm minimizes the required duration of acquiring the mean arterial pressure while still being able to track the changes. A standard oscillometric apparatus was employed to validate the accuracy of the new instrument. The new device is capable of measuring the mean arterial pressure approximately every 14 seconds with a pressure alteration velocity of 3 mmHg/s. This velocity can be increased, which would result in a further decrease in measurement time at the cost of accuracy. The proposed device can be used directly in the MR scanner for the determination of the cerebrovascular compliance.",
            "authors": [
                "Schüttengruber, PC"
            ],
            "year": 2024,
            "source": " [ Diplomarbeit/Master Thesis (UNI) ] TU Graz; 2024. pp.78. ",
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        {
            "id": 217621,
            "title": "Magnetic Resonance Elastography of the Human Brain.",
            "abstract": "Magnetic resonance imaging (MRI) is one of the most essential imaging modalities in neuroscience. Routine MRI of the brain is often key supportive to successful diagnosis and monitoring of neurological diseases. Nevertheless, various neurological disorder characteristics may be undistinguishable by clinically established MRI contrasts, encouraging research and development of advanced MRI techniques. Many neurological diseases cause changes in the cerebral microstructure and concomitant alterations in the mechanical tissue properties. Motivated by manual palpation, where irregularities in the mechanical stiffness of tissue are assessed by hand, magnetic resonance elastography (MRE) enables visualization and quantification of mechanical tissue properties. Especially in neuroscience, the novel image contrast of MRE offers innovative possibilities for characterizing the brain tissue and for detecting tissue alterations. Even in encapsulated and deeper lying tissues such as the brain, which is usually not accessible to manual palpation in vivo. Technically, MRE probes the propagation of induced mechanical wave motions within the tissue at several points in time. The gathered image series is used to estimate the underlying mechanical properties such as the tissue shear modulus or stiffness. In this thesis, a novel MRE acquisition sequence scheme was developed for the investigation of the human brain. This imaging scheme allows sampling the propagation of the wave at several discrete time points in a single run. The benefits of the presented approach are short acquisition times coupled with reduced imaging artifacts and the use of low frequencies for the mechanical wave motion excitation. This is especially desirable in brain MRE to investigate deeper lying cerebral areas, as low frequency waves propagate deeper into the tissue. In a second approach, the scheme was enhanced to additionally acquire the three-dimensional motion components at once. Phantom experiments were performed to validate the proposed methods. The method was also validated in the brain of healthy subjects and regional shear moduli were assessed in different brain areas at an excitation frequency of 20 Hz. Due to the reduced acquisition time, the proposed MRE sequence can be integrated into a clinical MRI protocol and is currently part of an ongoing brain MRE study in patients with multiple sclerosis.",
            "authors": [
                "Strasser, JK"
            ],
            "year": 2021,
            "source": " [ Dissertation ] TU GRaz; 2021. pp.100. ",
            "category": 5,
            "document_type": 16,
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            "imported": "2025-09-02T14:00:49+02:00",
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            "edition": null,
            "university": "TU GRaz",
            "country": "40",
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        },
        {
            "id": 206164,
            "title": "Outcome eines Myokardinfarkt-assoziierten kardiogenen Schocks an einem Tertiärzentrum",
            "abstract": "Einleitung\r\nDer infarktassoziierte kardiogene Schock (CS) geht auch heute noch mit hoher Morbidität und Mortalität einher. Der akute Myokardinfarkt (AMI) kann durch eine Eingefäß- oder Mehrgefäßerkrankung bedingt sein und resultiert in Hypoperfusion und Myokardhypoxie. Die prognostischen Auswirkungen der Lokalisation der „culprit lesion“ sowie die positiven Ergebnisse einer vollständigen akuten Revaskularisierung werden immer noch diskutiert. In dieser Arbeit werden unter anderem die prognostischen Auswirkungen des initialen Gefäßstatus und dessen Interventionsergebnis analysiert und interpretiert.\r\nMethoden\r\nDiese Studie ist eine prospektive Single-Center-Registerstudie, die Daten von Mai 2019 bis April 2023 inkludiert. 558 Patienten/Patientinnen (28,5% wbl.) wurden in dieser Zeit mit Vasopressor-pflichtigem Kreislaufschock im Herzkatheterlabor des LKH Graz vorstellig. Die Daten wurden in einem Prüfbogen (CRF) gesammelt und hinsichtlich intrahospitaler Mortalität analysiert und statistisch ausgewertet.\r\nErgebnisse\r\nPersonen mit Mehrgefäßerkrankung haben verglichen mit Eingefäßerkrankung ein signifikant höheres Risiko intrahospital zu versterben ([RR]: 0,727 (95%-KI: 0,539 ; 0,981); x2=5,042; p=0,025). Bei initial identifizierter LAD als „culprit lesion“ ist das intrahospitale Mortalitätsrisiko verglichen mit den anderen Gefäßen signifikant erhöht ([RR]: 0,782 (95%-KI: 0,629 ; 0,973); x2=4,799; p=0,028), hingegen kann bei identifizierter RCA als „culprit lesion“ ein signifikant geringeres intrahospitales Mortalitätsrisiko nachgewiesen werden ([RR]: 1,320 (95%-KI:1,019 ; 1,711); x2= 4,863; p= 0,027).\r\nErgänzend konnte eine signifikante entgegengesetzte Assoziation zwischen akuter vollständiger Revaskularisierung und intrahospitaler Mortalität aufgezeichnet werden ([RR]=1,559 (95%-KI: 1,209 ; 2,010); x2=13,441; p<0,001). Eine unvollständige Revaskularisierung geht mit einer erhöhten intrahospitalen Mortalitätsrate einher.\r\nConclusio\r\nDie ohnehin ernüchternde Prognose des CS kann unter anderem von initialem Gefäßstatus und Interventionsergebnis positiv und negativ beeinflusst werden. Eine akute vollständige Revaskularisierung sollte in jedem Fall intendiert werden.",
            "authors": [
                "Bachl, E"
            ],
            "year": 2023,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2023. pp. 104",
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        {
            "id": 217623,
            "title": "A technical concept for using the cold pressor test during MRI.",
            "abstract": "Cerebrovascular compliance (CVC) mapping with magnetic resonance imaging (MRI) is based on measuring vasoconstriction with quantitative susceptibility mapping (QSM) as a consequence of a change in arterial blood pressure. CVC has many clinical applications, but its potential largely depends on the capabilities to non-invasively inducing a stressor for the arterial blood pressure. To achieve a change in arterial blood pressure (BP), the use of cold pressor test (CPT) has been investigated in previous studies. However, the correlation between the parameters and the greatest possible effect has never been collected. In this study, the correlation between temperature, application time and application area was investigated in relation to the BP change. The results showed, that all stimuli led to a significant and clearly visible change of the arterial BP. Further a trend could be detected, that a larger application area and a longer application time leads to a greater increase in BP, but it was not possible to verify the observations with statistically significance. The temperature for the test must be between 0 °C and 4 °C to obtain a significant BP change without posing a risk to the subject or patient. To enable application in a magnetic resonance (MR) scanner, a method for cold application without direct fluid contact was sought and a device was designed. The application part is made of aluminium nitride (ALN) ceramics and was adapted to the sole of the foot. Cold liquid flows through the cooling device. In order to be able to switch from hot to cold within a few seconds, two fluid circuits were implemented. Before starting the test, warm liquid is pumped through the application part to bring the foot to body temperature. By starting the test, the coolant is pumped through the application part. After the set time has elapsed, the warm circuit is reactivated to allow rewarming. The development of this device was carried out in compliance with the medical device regulation (MDR) and applicable standards to allow approval as a medical electrical device.",
            "authors": [
                "Schobel, L"
            ],
            "year": 2023,
            "source": " [ Diplomarbeit/Master Thesis (UNI) ] TU Graz; 2023. pp.84. ",
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        {
            "id": 107590,
            "title": "Kleines Repetitorium der Höhenmedizin IV: Schlaf in ungewohnter Höhe ist nicht immer erholsam",
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            "authors": [
                "Domej, W",
                "Miggitsch, EM",
                "Schwaberger, G",
                "Hofmann, P"
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            "year": 2010,
            "source": "Alpinmedizinischer Rundbrief. 2010; 42(1): 13-15. ",
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            "id": 217628,
            "title": "Exploring the atoms of thought. Frequency band-dependent EEG microstate analysis of musical exposure compared to resting-state using sLORETA",
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            "authors": [
                "Repnik, L.G. & Jäncke, L"
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            "year": 2024,
            "source": "Initiative Brain Research Styria (INGESt.) Day 2024; Dez 2, 2024; Graz. 2024. ",
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        {
            "id": 214031,
            "title": "Precision matters: leveraging quality and machine learning to tackle prostate cancer resistance",
            "abstract": null,
            "authors": [
                "El-Heliebi, A"
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            "year": 2025,
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        {
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                "Domej, W"
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            "year": 2010,
            "source": "Universum Innere Medizin. 2010; 05(2010): 92-93. ",
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            "title": "Antikoagulation und Sport",
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                "Gary, T"
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            "id": 218155,
            "title": "BIG Data und künstliche Intelligenz im Glaukommanagement",
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            "authors": [
                "Falb, T"
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            "year": 2025,
            "source": "Glaucoma Afterwork Session; 08.10.2025; Graz, AUSTRIA;. 2025. ",
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            "title": "Etablierung einer Ionenpumpe für die lokale Behandlung von Gehirntumoren an in vivo Modellen.",
            "abstract": "Heutzutage kommt die Diagnose „Glioblastoma multiforme“ einem Todesurteil gleich. Trotz intensiver Forschungsbemühungen, die sich nun fast über zwei Jahrzehnte erstrecken ist es nicht gelungen die Überlebensrate von Patienten, die oft nur knapp über einem Jahr liegt, zu verlängern - vorausgesetzt ein operativer Eingriff ist zumutbar. Durch die beschränkte Zugänglichkeit durch die Bluthirnschranke, die hohe Teilungsrate der Tumorzellen und die vielseitige Therapeutika Resistenz ist die Behandlung und die vollständige Heilung nach wie vor eine enorme Herausforderung. In dieser Dissertation wird ein neues Konzept präsentiert, welches die lokale Behandlung solcher komplexen Tumore im Hirn ermöglichen soll. Sogenannte organische elektronische Pumpen (OEIP) können eingesetzt werden um Chemotherapeutika gezielt und kontrolliert zu verabreichen und bieten somit die Möglichkeit einer konstanten, lokalen Behandlung über einen längeren Zeitraum hinweg. Wir konnten zeigen, dass neben dem effektiven Vorreiter Gemcitabine (Gem) auch weitere Chemotherapeutika über die OEIP transportiert werden können, um GBM-Zellen effektiv zu therapieren. Darüber hinaus waren wir in der Lage mithilfe des sogenannten Chorioallantoischen Membran Assays (CAM) die Ionenpumpen erfolgreich auf GBM-Tumoren zu betreiben. Der konstant anhaltende und kontrollierte Betrieb der Ionenpumpen führte zur Induktion apoptotischer Signale und beeinflusste den Zellzyklus der wachsenden Tumore. Außerdem konnten wir zeigen, dass die OEIP als einzige Behandlung in der Lage waren das Tumorwachstum über längere Zeit zu inhibieren. Durch diese Experimente konnten wir nicht nur die in vitro Resultate bestätigen und erweitern, sondern auch mit komplexeren in vivo Experimenten dazu beitragen, die Technologie weiterzuentwickeln, um das Fundament für eine neue Behandlungsform für Gehirntumore voranzutreiben.",
            "authors": [
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            "year": 2024,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin;  [ Dissertation ] Medizinische Universität Graz; 2024. ",
            "category": 5,
            "document_type": 16,
            "sci": null,
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            "id": 217637,
            "title": "Psychosoziale Indikation bei der Entscheidung zu einer Blutstammzelltransplantation mit fremden Zellen.\r\n",
            "abstract": null,
            "authors": [
                "Nagele, E"
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            "year": 2025,
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            "id": 218221,
            "title": "Forschungsprojekt SiMed - Sichere Medikation und CoPilot-Gesundheit",
            "abstract": null,
            "authors": [
                "Tarbauer, V"
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            "year": 2025,
            "source": "Digital Health Experience ; OKT 9, 2025; Pörtschach am Wörthersee. 2025. ",
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            "id": 217636,
            "title": "Automatisierte Netzausbauplanung.",
            "abstract": "Der zunehmende Ausbau dezentraler Erzeugungsanlagen, Elektromobilität und elektrifizierter Wärmeerzeugung stellt das bestehende Stromnetz vor erhebliche Herausforderungen hinsichtlich seiner Kapazitätsgrenzen und Ausfallsicherheit. Im Rahmen des Hochschullehrgangs mit Schwerpunkt Energie- und Netzplanung gewinnt die Thematik der effizienten Netzausbauplanung zunehmend an Relevanz. Diese Masterarbeit befasst sich mit der Frage, welchen Mehrwert der Einsatz neuartiger Gleichstrombetriebsmittel (DC) gegenüber klassischen Wechselstromlösungen (AC) in der Netzausbauplanung generieren kann.\r\nZiel der Arbeit ist es, ein Verfahren zu entwickeln, das Engpässe im Stromnetz frühzeitig erkennt und auf dieser Basis automatisierte Ausbaumaßnahmen vorschlägt. Besonderes Augenmerk liegt auf der Integration von DC-Technologien als mögliche Optimierungsstrategie. Die Methodik basiert auf einer Kombination aus fundierter Literaturrecherche, Dokumentenanalyse sowie einer mathematischen Modellierung und Simulation mit der Open-Source-Software „Pandapower“ in Python. Dazu wurde ein realitätsnahes Beispielnetz erstellt und mit drei Ausbauvarianten (Zuleitung gleicher Typ, Leitung mit größerem Querschnitt, Gleichstromleitung) simuliert.\r\nDie Ergebnisse zeigen, dass alle Varianten zu einer Verbesserung der Netzauslastung beitragen. Besonders der Einsatz von DC-Betriebsmitteln führte sowohl im kurzfristigen als auch langfristigen Vergleich zu signifikant verbesserten Auslastungswerten. Damit ergibt sich ein deutlicher Hinweis auf das technische Potenzial von Gleichstromlösungen in zukünftigen Verteilnetzen. Die Arbeit liefert somit einen praxisorientierten Beitrag zur automatisierten und zukunftssicheren Netzausbauplanung unter Berücksichtigung innovativer Technologien.",
            "authors": [
                "Boettner, S"
            ],
            "year": 2025,
            "source": " [ Diplomarbeit/Master Thesis (FH) ] Hochschule Burgenland; 2025. pp.184. ",
            "category": 5,
            "document_type": 28,
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            "country": "40",
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            "id": 217639,
            "title": "Detecting tolerance in non-albicans Candida species from blood culture- a pilot for the ECMM-Candida IV study",
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                "Vahedi-Shahandatshi, R",
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                "A. Cornely, O",
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