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GET /v1/research/publication/?format=api&offset=158180
{ "count": 159558, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=158200", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=158160", "results": [ { "id": 211964, "title": "In-host evolution of Burkholderia pseudomallei.", "abstract": "Burkholderia pseudomallei is a gram-negative rod-shaped bacterium responsible for the severe disease melioidosis. B. pseudomallei has the capability to infect both non-phagocytic and phagocytic cells and has evolved several mechanisms to evade the host immune system. A previous study identified a B. pseudomallei isolate, which showed altered survival within macrophages compared to its isogenic wildtype after passage through human macrophages. The aim of this study was to further characterize the virulence of this isolate (E8_evolved) and to elucidate the underlying mechanisms. B. pseudomallei E8_evolved exhibited increased intracellular invasion and cytotoxicity compared to the isogenic wildtype. This suggests a potentially increased invasion or improved phagosomal escape, potentially leading to a higher bacterial load early in the infection. To determine whether pyroptosis is responsible for the observed increase in cytotoxicity, western blot analyses were performed. The cleavage product of gasdermin D, an indicator of pyroptosis, was detected at a similar intensity in E8_evolved and the wildtype strain. Next caspase-1 and caspase-4, which activate gasdermin D during canonical or non-canonical inflammasome activation, were investigated. While caspase-1 cleavage was similar in both strains, the caspase-4 cleavage product showed increased intensity in E8_evolved indicating increased activation. As no phosphorylated MLKL was detected, necroptosis can be excluded as a potential cause of cell lysis. Additionally, it was observed that the increased cytotoxicity is not associated with elevated production and secretion of the cytokines TNF-α, IL-1α, and IL-1β. Specifically, the concentration of the cytokine TNF-α is reduced in the mutant strain three hours post-infection. To explore changes at the DNA level, a whole genome sequencing analysis of the mutant strain was conducted. This analysis revealed two mutations in the potential T3SS regulatory protein HpaA, specifically in the amino acids VAL25 and ARG28. However, since this protein remains uncharacterized, further research is required to fully understand its role and validate the potential impact of these mutations. Taken together, the mutant exhibits enhanced invasion and bacterial loads, potentially attributable to mutations in the putative T3SS regulatory protein HpaA.", "authors": [ "Harlander, J" ], "year": 2024, "source": " [ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2024. pp.57. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-11-07T09:18:56+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 211951, "title": "Vascular, cardiometabolic and immunovirological changes in people living with HIV: Longitudinal data analysis from the EndoAfrica Study, South Africa", "abstract": null, "authors": [ "Strijdom, H", "de Boever, P", "Kessler, HH", "Stelzl, E", "Webster, I", "Everson, F", "Goswami, N" ], "year": 2024, "source": "Clin Chem Lab Med; Congress Abstracts. 2024; 62(6):eA188-eA211.-ISMD2024 Thirteenth International Symposium on\r\nMolecular Diagnostics; JUN 13-14, 2024; Graz, AUSTRIA. ", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "211951-14010", "211951-14023" ], "persons": [ "211951-57932", "211951-50514", "211951-51812" ], "imported": "2024-11-06T11:43:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211948, "title": "Panel Diskussion – Future challenges for radiographers.\r\n", "abstract": null, "authors": [ "England, A", "Kolar, A", "Fuchsjäger, M" ], "year": 2024, "source": "International Day of Radiology 2024; NOV 8, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "211948-14104" ], "persons": [ "211948-82111" ], "imported": "2024-11-06T11:40:29+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211941, "title": "International Day of Radiology 2024 - Einführung und Vorstellung des Programms", "abstract": null, "authors": [ "Fuchsjäger, M" ], "year": 2024, "source": "International Day of Radiology 2024; NOV 8, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "211941-14104" ], "persons": [ "211941-82111" ], "imported": "2024-11-06T10:02:59+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211924, "title": "Ex-Vivo Genetic Modulation of Organs for Transplantation.", "abstract": null, "authors": [ "Stimmeder, S", "Leber, B" ], "year": 2023, "source": "Chirurgische Herbsttage 2023; OCT 23-24, 2023; Graz, AUSTRIA. 2023. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "211924-14073" ], "persons": [ "211924-62756", "211924-111188" ], "imported": "2024-11-04T19:44:59+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211913, "title": "Impact of proton and carbon ion irradiation on endochondral ossification processes: Findings from an ex-vivo femur organotypic culture model.", "abstract": null, "authors": [ "Etschmaier, V", "Glänzer, D", "Eck, N", "Schäfer, U", "Leithner, A", "Georg, D", "Lohberger, B" ], "year": 2024, "source": "Abstract bei German Medical Science. 2024; -Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2024); OCT 22-25, 2024; Berlin, GERMANY. ", "category": 2, "document_type": 22, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "211913-14050", "211913-14052" ], "persons": [ "211913-61927", "211913-100991", "211913-50696", "211913-53237", "211913-61131", "211913-87214" ], "imported": "2024-11-04T15:44:22+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211879, "title": "The sinus tract as a limb salvage strategy in treatment-resistant bone and joint infections: Insights from a multicenter study.", "abstract": null, "authors": [ "Klim, SM", "McNally, MA", "Trebse, R", "Sigmund, IK", "Leithner, A", "Wanko, S", "Hauer, G", "Glehr, M" ], "year": 2024, "source": "Abstracts of the 22nd International Society of Limb Salvage General Meeting. 2024; -22nd International Society of Limb Salvage General Meeting; OCT 8-11, 2024; Brisbane, AUSTRALIA. ", "category": 2, "document_type": 22, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "211879-14052" ], "persons": [ "211879-101863", "211879-53237" ], "imported": "2024-11-02T13:48:30+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 211851, "title": "Update alte und neue Impfungen", "abstract": null, "authors": [ "Grisold, A", "" ], "year": 2024, "source": "Hygiene trifft Mikrobiologie; 24.-25.10.2024; Wien, Österreich. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "211851-14023" ], "persons": [ "211851-51863" ], "imported": "2024-10-29T08:06:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 131775, "title": "Galectin-3 in heart failure with preserved ejection fraction.", "abstract": null, "authors": [ "de Boer, RA", "Edelmann, F", "Cohen-Solal, A", "Mamas, MA", "Maisel, A", "Pieske, B" ], "year": 2013, "source": "Eur J Heart Fail. 2013; 15(10):1095-1101", "category": 1, "document_type": 3, "sci": "ISI:000325175700004", "pubmed": "23650131", "doi": "10.1093/eurjhf/hft077", "pmc": null, "organizations": [ "131775-14083" ], "persons": [], "imported": "2013-11-14T16:24:27+01:00", "journal": "EUR J HEART FAIL", "issn": "1388-9842", "collection_publisher": null, "collection_title": "EUROPEAN JOURNAL OF HEART FAILURE", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 6.577, "impactfactor_year": 2013, "impactfactor_norm": 0.928, "impactfactor_norm_year": 2013, "impactfactor_norm_category": "CARDIAC & CARDIOVASCULAR SYSTEMS", "impactfactor_norm_super": 0.928, "impactfactor_norm_super_year": 2013, "impactfactor_norm_super_category": "CARDIAC + CARDIOVASCULAR SYSTEMS", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 131861, "title": "The impact of aging on regulatory T-cells.", "abstract": null, "authors": [ "Fessler, J", "Ficjan, A", "Duftner, C", "Dejaco, C" ], "year": 2013, "source": "Front Immunol. 2013; 4(1):231-231", "category": 1, "document_type": 1, "sci": "ISI:000209374100227", "pubmed": "23964277", "doi": "10.3389/fimmu.2013.00231", "pmc": "PMC3734364", "organizations": [ "131861-14086" ], "persons": [ "131861-66227-4", "131861-78952-1" ], "imported": "2013-11-20T01:00:00+01:00", "journal": "Front Immunol", "issn": "1664-3224", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 132154, "title": "Dermoscopy of acral melanoma: a multicenter study on behalf of the international dermoscopy society.", "abstract": null, "authors": [ "Braun, RP", "Thomas, L", "Dusza, SW", "Gaide, O", "Menzies, S", "Dalle, S", "Blum, A", "Argenziano, G", "Zalaudek, I", "Kopf, A", "Rabinovitz, H", "Oliviero, M", "Perrinaud, A", "Cabo, H", "Pizzichetta, M", "Pozo, L", "Langford, D", "Tanaka, M", "Saida, T", "Perusquia Ortiz, AM", "Kreusch, J", "De Giorgi, V", "Piccolo, D", "Grichnik, JM", "Kittler, H", "Puig, S", "Malvehy, J", "Seidenari, S", "Stanganelli, I", "French, L", "Marghoob, AA" ], "year": 2013, "source": "Dermatology. 2013; 227(4):373-380", "category": 1, "document_type": 1, "sci": "ISI:000329443100014", "pubmed": "24296632", "doi": "10.1159/000356178", "pmc": null, "organizations": [ "132154-14047" ], "persons": [ "132154-50151-6" ], "imported": "2013-12-04T01:00:00+01:00", "journal": "Dermatology", "issn": "1421-9832", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 1.685, "impactfactor_year": 2013, "impactfactor_norm": 0.557, "impactfactor_norm_year": 2013, "impactfactor_norm_category": "DERMATOLOGY", "impactfactor_norm_super": 0.8, "impactfactor_norm_super_year": 2010, "impactfactor_norm_super_category": "DERMATOLOGY", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 132209, "title": "Reply to the Letter to the Editor: Adverse reactions of artificial bone graft substitutes: lessons learned from using tricalcium phosphate geneX ®.", "abstract": null, "authors": [ "Friesenbichler, J", "Maurer-Ertl, W", "Sadoghi, P", "Pirker-Fruehauf, U", "Bodo, K", "Leithner, A" ], "year": 2014, "source": "Clin Orthop Relat Res. 2014; 472(2):767-768", "category": 1, "document_type": 20, "sci": "ISI:000330585000056", "pubmed": "24323690", "doi": "10.1007/s11999-013-3421-9", "pmc": "PMC3890181", "organizations": [ "132209-14020", "132209-14052" ], "persons": [ "132209-53237-6", "132209-59379-4" ], "imported": "2013-12-11T01:00:00+01:00", "journal": "Clin Orthop Relat Res", "issn": "0009-921X", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 2.765, "impactfactor_year": 2014, "impactfactor_norm": 0.861, "impactfactor_norm_year": 2014, "impactfactor_norm_category": "ORTHOPEDICS-SCI", "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 132501, "title": "Patatin-like phospholipase domain-containing protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis.", "abstract": null, "authors": [ "Finkenstedt, A", "Auer, C", "Glodny, B", "Posch, U", "Steitzer, H", "Lanzer, G", "Pratschke, J", "Biebl, M", "Steurer, M", "Graziadei, I", "Vogel, W", "Zoller, H" ], "year": 2013, "source": "Clin Gastroenterol Hepatol. 2013; 11(12):1667-1672", "category": 1, "document_type": 1, "sci": "ISI:000327484800030", "pubmed": "23872669", "doi": "10.1016/j.cgh.2013.06.025", "pmc": null, "organizations": [ "132501-14058" ], "persons": [], "imported": "2014-01-02T14:39:38+01:00", "journal": "CLIN GASTROENTEROL HEPATOL", "issn": "1542-3565", "collection_publisher": null, "collection_title": "CLINICAL GASTROENTEROLOGY AND HEPATOLOGY", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 6.534, "impactfactor_year": 2013, "impactfactor_norm": 0.92, "impactfactor_norm_year": 2013, "impactfactor_norm_category": "GASTROENTEROLOGY & HEPATOLOGY", "impactfactor_norm_super": 0.92, "impactfactor_norm_super_year": 2013, "impactfactor_norm_super_category": "GASTROENTEROLOGY + HEPATOLOGY", "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 132576, "title": "Flight style optimization in ski jumping on normal, large, and ski flying hills.", "abstract": null, "authors": [ "Jung, A", "Staat, M", "Müller, W" ], "year": 2014, "source": "J Biomech. 2014; 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