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GET /v1/research/publication/?format=api&offset=157700&ordering=impactfactor
{ "count": 159558, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=157720&ordering=impactfactor", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=157680&ordering=impactfactor", "results": [ { "id": 209873, "title": "Differential expression of miRNAs in A549 cells and plasma samplesfrom lung adenocarcinoma patients and healthy donors", "abstract": "MicroRNAs (miRNAs) are small non-coding RNA molecules, which take part in gene regulation on the post-transcriptional level. They are involved in different biological processes,\r\nbut also in tumorigenesis. In this thesis, we wanted to extend our knowledge about miRNA expression and its role in lung cancer, to find out a potential circulating miRNA that could be promising as a diagnostic biomarker for early lung cancer detection. In the first part of the thesis, we aimed to analyze the global expression of 752 miRNAs in vitro in A549 lung adenocarcinoma (LUAD) cells and primary, non-malignant bronchial epithelial (BE) cells from healthy donors, and to identify the most prominently deregulated miRNAs. Expression of 752 miRNAs in LUAD and BE cells was assessed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) with the mean-centering restricted (MCR) normalization. Out of 752 miRNAs, 37 miRNAs were significantly deregulated in A549 cells compared to BE cells. After setting ΔΔCt ≥ 2.5, eighteen significantly deregulated miRNAs were chosen, 8 were up- and 10 down-regulated in A549 cells compared to BEC cells. Based on those in vitro data, the second part of this thesis aimed to analyze miRNAs expression in plasma samples from patients\r\nwith histologically diagnosed lung adenocarcinoma and healthy donors (n = 18 for each group, total n = 36). We also aimed to identify stably expressed miRNAs in plasma. We found four significant deregulation miRNAs in plasma samples (miR-15b-3p, miR-148a-3p, miR-193b-3p, and miR-195-5p) in LUAD patients compared to donors’ samples. One miRNA (miR-195- 5p) was up-regulated and three miRNAs (miR-15b-3p, miR148a-3p, and miR-193b-3p) were down-regulated in plasma sample of LUAD patients compared to healthy donors. Two miRNAs were used for normalization (miR-16-5p and miR-191-5p), because of their known and proven stability. Finally, by different in silico tools, we identified the target genes influenced by deregulated circulating miRNAs and determine their assignments to specific pathways relevant to the biology of lung adenocarcinoma. Based on the literature, 107 validated genes are regulated by these four miRNAs. Out of 107 validated target genes, five (PTEN, CXCR4, IGF1R, FGF2, and PD-L1) were described to be regulated with more than one of four deregulated miRNAs. Concerning their molecular function, 107 direct target genes were annotated to five main functional groups: binding, catalytic activity, molecular function regulator, molecular transducer activity, and transporter activity. In conclusion, we could demonstrate the relevant differences between cancer and control miRNA expression in vitro and plasma samples of LUAD patients compared to healthy donors. These four dysregulated miRNAs are promising as diagnostic biomarkers for lung adenocarcinoma.", "authors": [ "Robinson, I" ], "year": 2024, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. 89", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-06-05T09:18:40+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 213630, "title": "Characterization of amniotic fluid derived stem cells: The origin of maternal microchimerism?", "abstract": null, "authors": [ "Bramreiter, B", "Sallinger, K", "Gruber, MC", "Slaats, E", "Schönberger, J", "Schuch, K", "Amtmann, B", "Kurtovic, U", "Klaritsch, P", "Schildberg, F", "Fluhr, H", "Kroneis, T" ], "year": 2024, "source": "ESRI conference 2024; OCT 8-11, 2024; Leiden, NETHERLANDS. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213630-14017", "213630-14038", "213630-14043", "213630-14064", "213630-28083" ], "persons": [ "213630-50155", "213630-104057", "213630-104139", "213630-109522", "213630-109964", "213630-110025", "213630-115382", "213630-116463", "213630-54171", "213630-68413", "213630-114270" ], "imported": "2025-02-03T11:10:52+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 213629, "title": "Torque Teno Virus als potenzielle Biomarker für die Bestimmung von Immunokompetenz bei PatientInnen mit ANCA-assoziierter Vaskulitis.", "abstract": null, "authors": [ "Odler, B", "Riedl, R", "Lee, J", "Cooney, LA", "Merkel, PA", "St Clair, EW", "Fervenza, FC", "Duvuru, G", "Monach, PA", "Jayne, DRW", "Smith, RM", "Lyons, PA", "Little, MA", "Harrison, E", "Almaani, S", "Bond, G", "Rosenkranz, AR", "Specks, U", "Stone, JH", "Kronbichler, A." ], "year": 2024, "source": "Gemeinsame Jahrestagung der ÖGN und ÖGH ; OKT 3-5, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213629-14026", "213629-14084" ], "persons": [ "213629-59026", "213629-72630" ], "imported": "2025-02-03T11:10:37+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 213634, "title": "The effect of plasma exchange on early renal improvement in patients with ANCA-associated vasculitis: a psot-hoc analysis of the PEXIVAS trial.", "abstract": null, "authors": [ "Odler, B", "Riedl, R", "Duvuru, G", "Szpirt, WM", "Hawley, C", "Uchida, L", "Wallace, ZS", "Walters, G", "Muso, Eri", "Tesar, V", "Pusey, CD", "Little, MA", "Merkel, PA", "Walsh, M", "Jayne, DRW", "Kronbichler, A." ], "year": 2024, "source": "21st International Vasculitis Workshop; APRIL 7-10, 2024; Barcelona, SPAIN. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213634-14026" ], "persons": [ "213634-59026" ], "imported": "2025-02-03T11:27:53+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 213628, "title": "Die Wirkung des Plasmaaustauschs auf die frühe Nierenfunktion bei Patienten mit ANCA-assoziierter Vaskulitis und Glomerulonephritis: eine Post-hoc-Analyse der PEXIVAS-Studie", "abstract": null, "authors": [ "Odler, B", "Riedl, R", "Duvuru, G", "Szpirt, WM", "Hawley, C", "Uchida, L", "Wallace, ZS", "Walters, G", "Muso, Eri", "Tesar, V", "Pusey, CD", "Little, MA", "Merkel, PA", "Walsh, M", "Jayne, DRW", "Kronbichler, A. für die PEXIVAS InvestigatorInnen" ], "year": 2024, "source": "Gemeinsame Jahrestagung der ÖGN und ÖGH ; OKT 3-5, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213628-14084" ], "persons": [ "213628-94970" ], "imported": "2025-02-03T11:06:21+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 213635, "title": "Torque teno virus as a potential biomarker for assessment of immunocompetence in patients with ANCA-associated vasculitis.", "abstract": null, "authors": [ "\r\nOdler, B", "Riedl, R", "Lee, J", "Cooney, LA", "Merkel, PA", "St Clair, EW", "Fervenza, FC", "Duvuru, G", "Monach, PA", "Jayne, DRW", "Smith, RM", "Lyons, PA", "Little, MA", "Harrison, E", "Almaani, S", "Bond, G", "Rosenkranz, AR", "Specks, U", "Stone, JH", "Kronbichler, A.\r\n" ], "year": 2024, "source": "21st International Vasculitis Workshop ; APRIL 7-10, 2024; Barcelona, SPAIN. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213635-14026", "213635-14084" ], "persons": [ "213635-59026", "213635-72630" ], "imported": "2025-02-03T11:29:36+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 210402, "title": "The diagnostical approach of globus sensation: Results from a single institution survey", "abstract": "Introduction: Globus pharyngeus, a persistent sensation of a painless foreign body in the throat, drives numerous visits to otorhinolaryngology clinics. The condition's unclear etiology and connections to other ailments hinder the establishment of standardized investigation and treatment approaches. This study, conducted between 2014 and 2019 at the phoniatrics outpatient ward of the University Hospital of Graz, aimed to evaluate diagnostic pathways, findings, and follow-up for patients presenting with globus pharyngeus.\r\nMethods: A retrospective cross-sectional study collected epidemiological data, diagnostic and treatment pathways, and follow-up details for 211 patients identified through the local medical institute for statistics and the \"openMEDOCS\" database. Data analysis involved Microsoft Excel, using descriptive statistics while ensuring patient anonymity.\r\nResults: Among the 211 participants (40.8% male, 59.2% female; mean age 53.5), 79.6% reported chronic complaints. Active smokers accounted for 12.3%, and 26.1% had allergies. The primary complaint was a sensation of a foreign body (64.5%), while the main secondary complaint was burning associated with reflux (20.4%). Flexible laryngoscopy revealed findings in 31.3% of cases, with hyperplasia at the base of the tongue (12.8%) being the most prevalent. The primary recommended post-presentation examination was X-ray or CT/MRI of the neck (46.4%).\r\nConclusion: The collected data were used in conjunction with the current body of research to develop a diagnostic algorithm. By considering potential risk factors (such as a positive smoking history) and warning symptoms, unnecessary examinations are intended to be reduced, thereby alleviating the suffering of patients and relieving the healthcare system as a whole.", "authors": [ "Ortner, L" ], "year": 2024, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2024. pp. 77", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2024-07-08T10:35:23+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 213631, "title": "Das Grazer Vaskulitisregister (GRAVAS): Rationalität und klinisches Forschungprotokoll", "abstract": null, "authors": [ "Odler, B", "Jud, P", "Hammerl, C", "Hofer, B", "Bosch, P", "Berghammer, S", "Little, MA", "Keppler, JS", "Matteo, V", "Thiel, J", "Rosenkranz, AR", "Eller, K." ], "year": 2024, "source": "Gemeinsame Jahrestagung der ÖGN und ÖGH ; OKT 3-5, 2024; Graz, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213631-14084", "213631-14086" ], "persons": [ "213631-115661", "213631-120271", "213631-72630", "213631-100419", "213631-111873", "213631-118469", "213631-119770", "213631-74174", "213631-94413" ], "imported": "2025-02-03T11:14:35+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 213633, "title": "Microchimeric cells: Trans-oral route to and presence in the host", "abstract": null, "authors": [ "Bramreiter, B", "Sallinger, K", "Gruber, MC", "Slaats, E", "Schönberger, J", "Schuch, K", "Amtmann, B", "Kurtovic, U", "Klaritsch, P", "Schildberg, F", "Fluhr, H", "Kroneis, T" ], "year": 2024, "source": "; AUG 30, 2024; Seattle, USA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213633-14017", "213633-14038", "213633-14043", "213633-14064", "213633-28083" ], "persons": [ "213633-104139", "213633-110025", "213633-115382", "213633-50155", "213633-68413", "213633-104057", "213633-109522", "213633-109964", "213633-116463", "213633-54171", "213633-114270" ], "imported": "2025-02-03T11:24:00+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 213622, "title": "Es juckt – chronischer Pruritus in der allgemeinmedizinischen Praxis\r\n", "abstract": null, "authors": [ "Glehr, RC", "Schöberl, T" ], "year": 2024, "source": "Allgemeinmedizin up2date. 2024; 05(01): 61-80. ", "category": 1, "document_type": 3, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213622-27964" ], "persons": [ "213622-100138" ], "imported": "2025-02-03T10:34:02+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 213632, "title": "Characterization of amniotic fluid derived stem cells: The origin of maternal microchimerism?", "abstract": null, "authors": [ "Bramreiter, B", "Sallinger, K", "Gruber, MC", "Slaats, E", "Schönberger, J", "Schuch, K", "Amtmann, B", "Kurtovic, U", "Klaritsch, P", "Schildberg, F", "Fluhr, H", "Kroneis, T" ], "year": 2024, "source": "34th Annual Conference of the German Society for Cytometry; SEPT 10-13, 2024; Berlin, GERMANY. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213632-14017", "213632-14038", "213632-14043", "213632-14064", "213632-28083" ], "persons": [ "213632-104139", "213632-109964", "213632-115382", "213632-54171", "213632-68413", "213632-104057", "213632-109522", "213632-110025", "213632-116463", "213632-50155", "213632-114270" ], "imported": "2025-02-03T11:18:59+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 213650, "title": "CRISPR/Cas9 genome engineering to model TET2 mutant human clonal hematopoiesis and its pro-atherogenic potential.", "abstract": null, "authors": [ "Alihodžić, D", "Özkaya, E", "Foßelteder J", "Sconocchia, T", "Auinger, L", "Schlenke, P", "Sill, H", "Zebisch, A", "Wölfler A", "Vujić, N", "Kratky, D", "Reinisch A" ], "year": 2024, "source": "Austrian Atherosclerosis Society (AAS) Annual Meeting; MAI 2-4, 2024; St. Gilgen, AUSTRIA. 2024. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213650-14013", "213650-14058", "213650-14082" ], "persons": [ "213650-119131", "213650-51857", "213650-51904", "213650-57402", "213650-88593", "213650-98091", "213650-108881", "213650-50747", "213650-51911", "213650-75396", "213650-97755" ], "imported": "2025-02-03T12:41:10+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": true, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 213646, "title": "PATIENT - Donor signature in predicting clinical response of Faecal Microbiota Transplantation (FMT)", "abstract": null, "authors": [ "Durdevic, M", "Podlesny, D", "Kump, P", "Högenauer, C", "Zitnik, M", "Gorkiewicz, G" ], "year": 2024, "source": "Austrian Bioinformatics Workshop 2024; JULY 3, 2024; Graz, AUSTRIA. 2024. 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