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GET /v1/research/publication/?format=api&offset=157000&ordering=year
{ "count": 157083, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=157020&ordering=year", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=156980&ordering=year", "results": [ { "id": 220490, "title": "Functional characeterization of patient-derived liver organoids.", "abstract": "Liver diseases represent a major global health challenge, causing around two million deaths annually and approximately 4% of all deaths worldwide. Among these conditions, hepatocellular carcinoma (HCC) stands out as the most common form of liver cancer, accounting for approximately 70% of liver cancer cases. Reliable in vitro models needed to study liver biology and disease are currently limited. Primary human hepatocytes rapidly lose function and have limited proliferative capacity in vitro, which restricts their use for long-term metabolic, toxicological, and signaling studies. Liver organoids have emerged as a powerful alternative to primary cells and immortalized cell lines, as they provide a stable model that better preserves hepatic functionality and architecture, enabling disease modeling, drug testing, and gene editing. In this study, we aimed to isolate and characterize patient derived liver- and HCC organoid lines. After the organoid isolation, the organoids were then pursued to differentiate them to a more hepatic state using a special medium. We further characterized the organoid lines using different stainings and immunohistochemistry, using antibodies against cholangiocyte markers such as Ck7, CkAE1-3, and hepatocyte markers like HepPar1, HSP70, glypican 3, to establish cellular identities and differentiation status. Protein and gene expression analysis by western blot and qPCR were performed to confirm the expression of liver function-related and HCC-associated markers. Liver organoids showed increased expression of hepatic markers under differentiation conditions, including albumin, AFP, Ck19, and HNF4α, as well as metabolic genes such as cytochrome P450 isoforms. In contrast ductal marker Sox9 was downregulated, while EpCAM and Ck19 were unexpectedly upregulated in the differentiated state. HCC-derived organoids displayed similar morphological and molecular liver-like phenotype. Upon development, these liver and tumor organoids consistently showed a shift toward a more mature hepatic phenotype, demonstrating their suitability as physiologically relevant in vitro liver models. These findings highlight organoids’ potential for future applications in metabolic studies, drug screening, and patient-specific disease research.", "authors": [ "Lamprecht, L" ], "year": 2026, "source": " [ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2026. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-02-03T12:00:00+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 220510, "title": "Chronic Hypoparathyroidism: Pathophysiology and Diagnostic Precision in 2025", "abstract": null, "authors": [ "Pilz, S" ], "year": 2026, "source": "Portuguese Congress of Endocrinology 2026; JAN 29 - FEB 1, 2026; Coimbra, PORTUGAL. 2026. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "220510-14080" ], "persons": [ "220510-53344" ], "imported": "2026-02-03T19:48:07+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 220526, "title": "Degenerative Wirbelsäulendeformitäten: vom Bandscheibenvorfall zur degenerativen Skoliose\r\n", "abstract": null, "authors": [ "Ferlic, PW" ], "year": 2026, "source": "7. Symposium der Österreichischen Gesellschaft für Wirbelsäulenchirurgie; JAN 30-31, 2026; Vienna, AUSTRIA. 2026. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "220526-14052" ], "persons": [ "220526-60165" ], "imported": "2026-02-03T23:33:03+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 220281, "title": "Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice.", "abstract": null, "authors": [ "Wilson-Morkeh, H", "Seluk, L", "Bosch, P", "Aguiar, C", "Thiel, J", "Hellmich, B", "Wechsler, ME", "Siddiqui, S" ], "year": 2026, "source": "Allergy. 2026; ", "category": 1, "document_type": 3, "sci": "ISI:001667743500001", "pubmed": "41574554", "doi": "10.1111/all.70215", "pmc": null, "organizations": [ "220281-14086" ], "persons": [ "220281-100419-6", "220281-111873-6" ], "imported": "2026-01-27T01:00:00+01:00", "journal": "Allergy", "issn": "1398-9995", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 12.0, "impactfactor_year": 2026, "impactfactor_norm": 1.0, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "ALLERGY-SCIE", "impactfactor_norm_super": 1.0, "impactfactor_norm_super_year": 2026, "impactfactor_norm_super_category": "ALLERGY-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": true, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 220424, "title": "Artificial Intelligence Competencies and Educational Needs Among ERNICA Members: Results of a Multinational Survey.", "abstract": null, "authors": [ "Till, H", "Elsayed, H", "Obermüller, B", "Gnatzy, R", "Lacher, M", "Tschauner, S", "Verhoeven, R", "Wijnen, R", "Singer, G" ], "year": 2026, "source": "Eur J Pediatr Surg. 2026; ", "category": 1, "document_type": 1, "sci": null, "pubmed": "41558661", "doi": "10.1055/a-2787-2213", "pmc": null, "organizations": [ "220424-14049", "220424-14106" ], "persons": [ "220424-50778-6", "220424-85440-6", "220424-97866-1", "220424-90375-6", "220424-83445-2" ], "imported": "2026-02-01T01:00:00+01:00", "journal": "Eur J Pediatr Surg", "issn": "1439-359X", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 1.4, "impactfactor_year": 2026, "impactfactor_norm": 0.318, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "PEDIATRICS-SCIE", "impactfactor_norm_super": 0.423, "impactfactor_norm_super_year": 2023, "impactfactor_norm_super_category": "PEDIATRICS-SCIE", "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 220276, "title": "Assessment of Knowledge Levels in a Blended-Learning CPD Programme in Periodontology: A Cross-Sectional Comparative Study.", "abstract": null, "authors": [ "Peikert, SA", "Wiegel, SV", "Blank, J", "Woelber, JP", "Ratka-Krüger, P" ], "year": 2026, "source": "Eur J Dent Educ. 2026; ", "category": 1, "document_type": 1, "sci": "ISI:001669480000001", "pubmed": "41578679", "doi": "10.1111/eje.70099", "pmc": null, "organizations": [ "220276-14111" ], "persons": [ "220276-125883-2" ], "imported": "2026-01-27T01:00:00+01:00", "journal": "Eur J Dent Educ", "issn": "1600-0579", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 1.9, "impactfactor_year": 2026, "impactfactor_norm": 0.405, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "EDUCATION, SCIENTIFIC DISCIPLINES-SCIE", "impactfactor_norm_super": 0.405, "impactfactor_norm_super_year": 2026, "impactfactor_norm_super_category": "EDUCATION, SCIENTIFIC DISCIPLINES-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 220083, "title": "PAC regulates endo-, and exocytosis, and lysosomal-mitochondrial stress signaling in human mast cells.", "abstract": null, "authors": [ "Melek, K", "Steiner, P", "Kappel, S", "Gottschalk, B", "Andosch, A", "Duggan, M", "Graier, WF", "Zierler, S", "Peinelt, C" ], "year": 2026, "source": "Cell Commun Signal. 2026; ", "category": 1, "document_type": 1, "sci": null, "pubmed": "41559803", "doi": "10.1186/s12964-026-02661-1", "pmc": null, "organizations": [ "220083-14013" ], "persons": [ "220083-90394-6", "220083-51860-6" ], "imported": "2026-01-21T01:00:00+01:00", "journal": "Cell Commun Signal", "issn": "1478-811X", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 8.9, "impactfactor_year": 2026, "impactfactor_norm": 0.852, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "CELL BIOLOGY-SCIE", "impactfactor_norm_super": 0.852, "impactfactor_norm_super_year": 2026, "impactfactor_norm_super_category": "CELL BIOLOGY-SCIE", "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 220104, "title": "MRI prostate tumor volume predicts the need for systematic biopsies in patients undergoing MRI-targeted biopsy.", "abstract": null, "authors": [ "Zurl, H", "Embacher, S", "Schöllnast, H", "Talakic, E", "Schöpfer-Schwab, S", "Pohl, K", "Scheipner, L", "Jasarevic, S", "Altziebler, J", "Mangge, A", "Mannweiler, S", "Riedl, J", "Bele, U", "Leitsmann, C", "Leitsmann, M", "Hutterer, G", "Ahyai, S", "Mischinger, J" ], "year": 2026, "source": "Minerva Urol Nephrol. 2026; ", "category": 1, "document_type": 1, "sci": null, "pubmed": "41553789", "doi": "10.23736/S2724-6051.25.06375-X", "pmc": null, "organizations": [ "220104-14104", "220104-14085", "220104-14056", "220104-14026", "220104-14020" ], "persons": [ "220104-100216-6", "220104-109461-6", "220104-112949-6", "220104-119774-6", "220104-50839-6", "220104-51931-6", "220104-52008-6", "220104-99792-6", "220104-113095-6", "220104-111791-6", "220104-109990-6", "220104-99872-4", "220104-96506-1", "220104-91876-6", "220104-69677-6", "220104-123330-6", "220104-121670-6" ], "imported": "2026-01-21T01:00:00+01:00", "journal": "Minerva Urol Nephrol", "issn": "2724-6442", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 4.2, "impactfactor_year": 2026, "impactfactor_norm": 0.798, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "UROLOGY & NEPHROLOGY-SCIE", "impactfactor_norm_super": 0.865, "impactfactor_norm_super_year": 2023, "impactfactor_norm_super_category": "UROLOGY + NEPHROLOGY-SCIE", "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 220139, "title": "Nitrogen recycling by the gut microbiome in sarcopenia", "abstract": null, "authors": [ "Haller, R", "Hazia, O", "Feldbacher, N", "Traub, J", "Madl, T", "Habisch, H", "Horvath, A", "Stadlbauer, V" ], "year": 2026, "source": "FRONT MICROBIOL. 2026; 16: 1698437", "category": 1, "document_type": 1, "sci": "ISI:001662961100001", "pubmed": null, "doi": "10.3389/fmicb.2025.1698437", "pmc": null, "organizations": [ "220139-14012", "220139-14081" ], "persons": [ "220139-107131-1", "220139-114553-6", "220139-50989-4", "220139-108411-6", "220139-108983-6", "220139-81091-6", "220139-91207-6" ], "imported": "2026-01-23T08:13:08+01:00", "journal": "FRONT MICROBIOL", "issn": "1664-302X", "collection_publisher": null, "collection_title": "FRONTIERS IN MICROBIOLOGY; ", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 4.5, "impactfactor_year": 2026, "impactfactor_norm": 0.756, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "MICROBIOLOGY-SCIE", "impactfactor_norm_super": 0.756, "impactfactor_norm_super_year": 2026, "impactfactor_norm_super_category": "MICROBIOLOGY-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 220274, "title": "International clinical opinion on transparency, standardisation, and calibration alignment in the performance evaluation of systems for continuous glucose monitoring.", "abstract": null, "authors": [ "Pemberton, JS", "Andrews, RC", "Barnard-Kelly, K", "Battelino, T", "Danne, T", "Heinemann, L", "Kar, P", "Lumb, A", "Maahs, DM", "Mader, JK", "Mathieu, C", "Mohan, V", "Murphy, HR", "Scott, EM", "Sherr, JL", "Smart, CE", "Tauschmann, M", "Williams, A", "Wilmot, EG", "Zaharieva, DP", "Moser, O" ], "year": 2026, "source": "Diabetes Obes Metab. 2026; ", "category": 1, "document_type": 3, "sci": "ISI:001668805100001", "pubmed": "41582769", "doi": "10.1111/dom.70460", "pmc": null, "organizations": [ "220274-14080" ], "persons": [ "220274-87294-4", "220274-50877-6" ], "imported": "2026-01-27T01:00:00+01:00", "journal": "Diabetes Obes Metab", "issn": "1463-1326", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 5.7, "impactfactor_year": 2026, "impactfactor_norm": 0.803, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "ENDOCRINOLOGY & METABOLISM-SCIE", "impactfactor_norm_super": 0.825, "impactfactor_norm_super_year": 2023, "impactfactor_norm_super_category": "ENDOCRINOLOGY + METABOLISM-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 220004, "title": "Low Serum Lysophospholipids Predict Increased In-Hospital Mortality in Patients With Acute Heart Failure.", "abstract": null, "authors": [ "Klobučar, I", "Pregartner, G", "Rechberger, G", "Eichmann, TO", "Potočnjak, I", "Trbušić, M", "Habisch, H", "Pfeifer, B", "Madl, T", "Berghold, A", "Frank, S", "Degoricija, V" ], "year": 2026, "source": "J Am Heart Assoc. 2026; e043828", "category": 1, "document_type": 1, "sci": "ISI:001666194900001", "pubmed": "41553073", "doi": "10.1161/JAHA.125.043828", "pmc": null, "organizations": [ "220004-14013", "220004-14012", "220004-17225", "220004-14026" ], "persons": [ "220004-91207-6", "220004-99786-6", "220004-108411-6", "220004-111459-6", "220004-51344-6", "220004-51988-4", "220004-84730-6" ], "imported": "2026-01-20T01:00:00+01:00", "journal": "J Am Heart Assoc", "issn": "2047-9980", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 5.3, "impactfactor_year": 2026, "impactfactor_norm": 0.75, "impactfactor_norm_year": 2026, "impactfactor_norm_category": "CARDIAC & CARDIOVASCULAR SYSTEMS-SCIE", "impactfactor_norm_super": 0.75, "impactfactor_norm_super_year": 2026, "impactfactor_norm_super_category": "CARDIAC + CARDIOVASCULAR SYSTEMS-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 216886, "title": "Stimulation of the human ventral tegmental area increases strategic betting.", "abstract": null, "authors": [ "Hirschbichler, ST", "Lagrata, S", "Shedd, N", "Akram, H", "Schwingenschuh, P", "Waiß, C", "Oberndorfer, S", "Matharu, MS", "Manohar, SG" ], "year": 2026, "source": "Brain. 2025; ", "category": 1, "document_type": 1, "sci": "ISI:001667522700001", "pubmed": "40576361", "doi": "10.1093/brain/awaf210", "pmc": null, "organizations": [ "216886-14051" ], "persons": [ "216886-50172-6", "216886-117505-2" ], "imported": "2025-06-30T02:00:00+02:00", "journal": "Brain", "issn": "1460-2156", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 11.7, "impactfactor_year": 2025, "impactfactor_norm": 0.981, "impactfactor_norm_year": 2025, "impactfactor_norm_category": "CLINICAL NEUROLOGY-SCIE", "impactfactor_norm_super": 0.981, "impactfactor_norm_super_year": 2025, "impactfactor_norm_super_category": "CLINICAL NEUROLOGY-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 219093, "title": "Editorial: Phylogeny, Ontogeny, and Neural Mechanisms of Social Interaction.", "abstract": null, "authors": [ "Liebal, K", "Nordahl-Hansen, A", "Kanngiesser, P", "Marschik, PB" ], "year": 2026, "source": "Neurosci Biobehav Rev. 2025; 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