Publication List
List publications.
Fields
id (integer)
Primary key.
name (string)
Name of doctoral school.
emails (string[])
Contact emails.
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year:gt,gte,lt,ltesci:iexact,contains,icontains,startswith,istartswithpubmed:iexact,contains,icontains,startswith,istartswithdoi:iexact,contains,icontains,startswith,istartswithpmc:iexact,contains,icontains,startswith,istartswithorganization_authorship:inimpact:isnull,gt,gte,lt,lteimported:isnull,gt,gte,lt,lte,date
GET /v1/research/publication/?format=api&offset=156480&ordering=impactfactor
{ "count": 156889, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=156500&ordering=impactfactor", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=156460&ordering=impactfactor", "results": [ { "id": 164631, "title": "Comprehensive expression analysis indicates translation initiation factors as novel biomarkers for aggressive B-cell lymphomas", "abstract": null, "authors": [ "Unterluggauer, J", "Seeboeck, R", "Tomazic, PV", "Huber, HJ", "Fechter, K", "Steinbauer, E", "Rinner, B", "Pichler, M", "Weniger, M", "Kueppers, R", "Sill, H", "Schicho, R", "Neumeister, P", "Beham-Schmid, C", "Deutsch, A", "Haybaeck, J" ], "year": 2017, "source": "Doctoral Day 2017 Medical University of Graz; DEZ 13, 2017; Graz, AUSTRIA. 2017. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164631-14020", "164631-14022", "164631-14066", "164631-14082", "164631-14085", "164631-27477" ], "persons": [ "164631-50826", "164631-51857", "164631-51930", "164631-56687", "164631-59183", "164631-59496" ], "imported": "2018-01-18T11:21:52+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 164632, "title": "The general movement assessment helps us to identify preterm infants at risk for cognitive dysfunction.", "abstract": null, "authors": [ "Einspieler, C", "Bos, AF", "Libertus, ME", "Marschik, PB" ], "year": 2017, "source": "Developmental Period Medicine (Medycyna Wieku Rozwojowego). 2017; 21: 9-9.-XXXIII International Symposium of the Polish Neonatal Society; OCT 12-14, 2017; Cracow, POLAND. ", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164632-14068" ], "persons": [ "164632-58883" ], "imported": "2018-01-18T11:46:19+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164633, "title": "What does the general movement assessment add to the examination of the asphyxiated term infant? ", "abstract": null, "authors": [ "Enspieler, C", "Ferrari, F" ], "year": 2017, "source": "Developmental Period Medicine (Medycyna Wieku Rozwojowego). 2017; 21: 10-10.-XXXIII International Symposium of the Polish Neonatal Society; OCT 12-14, 2017; Cracow, POLAND. ", "category": 2, "document_type": 9, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164633-14068" ], "persons": [], "imported": "2018-01-18T11:51:31+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164634, "title": "Towards the Augmented Pathologist: Challenges of Explainable-AI in Digital Pathology. ", "abstract": null, "authors": [ "Holzinger, A", "Malle, B", "Kieseberg, P", "Roth, PM", "Müller, H", "Reihs, R", "Zatloukal, K\r\n" ], "year": 2017, "source": "arXiv:1712.06657, 2017. 2017", "category": 12, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164634-14020", "164634-14026" ], "persons": [ "164634-51050", "164634-51449", "164634-51663" ], "imported": "2018-01-18T11:53:07+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": true, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 164635, "title": "Overall Progress and Status of BBMRI.at.", "abstract": null, "authors": [ "Zatloukal, K" ], "year": 2017, "source": "BBMRI.at Evaluation Panel Meeting; DEC 11, 2017; Vienna, AUSTRIA. 2017. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164635-14020" ], "persons": [ "164635-51663" ], "imported": "2018-01-18T12:04:07+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": true, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 164636, "title": "Bone morphogenetic protein 7 (BMP7) signature defines psoriatic niche and instructs human inflammatory Langerhans cells", "abstract": null, "authors": [ "Borek, I", "Köffel, R", "Feichtinger, J", "Yasmin, N", "Glitzner, E", "Krump, C", "Thallinger, G", "Wolf, P", "Sibilia, M", "Strobl, H" ], "year": 2018, "source": "Joint DK Retreat; JAN 13-17, 2018 ; Obergurgl, AUSTRIA. 2018. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164636-14006", "164636-14014", "164636-14047" ], "persons": [ "164636-51618", "164636-79192", "164636-86731" ], "imported": "2018-01-18T14:02:09+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164637, "title": "Significance of voxel-based morphometry in studying mild cognitive impairment. ", "abstract": null, "authors": [ "Damulina, A", "Konovalov, R", "Kadukov, A" ], "year": 2016, "source": "European Journal of Neurology 2016. 2016; -2nd CONGRESS OF THE EUROPEAN ACADEMY OF NEUROLOGY; MAY 28-31; Copenhagen, Denmark. ", "category": 2, "document_type": 22, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164637-14051" ], "persons": [ "164637-98464" ], "imported": "2018-01-18T14:27:59+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 164642, "title": "Pulmonary Histiocytic Sarcoma: A Case Report and\r\nLiterature Review", "abstract": null, "authors": [ "Flego, V", "Popper, H", "Volaric, D", "Bulat-Kardum, L" ], "year": 2017, "source": "American Journal of Pulmonary and Respiratory Medicine. 2017; 2(4): 38-41. ", "category": 1, "document_type": 1, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164642-14020" ], "persons": [], "imported": "2018-01-18T15:25:41+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": true, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164643, "title": "Halsweh, Ohrenweh und Co. - Die HNO-Heilkunde einfach erklärt", "abstract": null, "authors": [ "Thurnher, D", "" ], "year": 2017, "source": "KroneFIT: Die Gesundheitsmesse; MAI 5-6, 2017; Graz, AUSTRIA. 2017. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164643-14066" ], "persons": [ "164643-91899" ], "imported": "2018-01-18T15:38:23+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164644, "title": "Systematics and standards in neck dissection - en-block or level dissections.", "abstract": null, "authors": [ "Thurnher, D", "" ], "year": 2017, "source": "Deutscher HNO-Kongress; MAI 24-26, 2017; Erfurt, GERMANY. 2017. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164644-14066" ], "persons": [ "164644-91899" ], "imported": "2018-01-18T15:47:53+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 202418, "title": "[Inpatient care in child and adolescent psychiatry-Who gets treatment?].", "abstract": null, "authors": [ "Sevecke, K", "Wenter, A", "Böge, I" ], "year": 2022, "source": "Neuropsychiatr. 2022; 36(4): 179-187. ", "category": 1, "document_type": 3, "sci": "ISI:000880360100002", "pubmed": "36348224", "doi": "10.1007/s40211-022-00443-y", "pmc": "PMC9643980", "organizations": [], "persons": [ "202418-114977-6" ], "imported": "2023-04-05T02:00:00+02:00", "journal": "Neuropsychiatr", "issn": "2194-1327", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 164648, "title": "Preventing the first fracture", "abstract": null, "authors": [ "Fahrleitner-Pammer,A", "" ], "year": 2018, "source": "Sales training EliLilly ; 16.-18.Jan 2018; Pöllau . 2018. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164648-14080" ], "persons": [ "164648-51063" ], "imported": "2018-01-18T18:14:06+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164649, "title": "Unterschenkelfrakturen", "abstract": null, "authors": [ "Holzer, L" ], "year": 2018, "source": "Fortbildung, AUVA-Unfallkrankenhaus Klagenfurt; JÄN 18, 2018; Klagenfurt am Wörthersee, AUSTRIA. 2018. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164649-14052" ], "persons": [], "imported": "2018-01-19T06:04:02+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 202331, "title": "An Update on Patent Ductus Arteriosus and What is Coming Next.", "abstract": null, "authors": [ "Erdeve, Ö", "Okulu, E", "Singh, Y", "Sindelar, R", "Oncel, MY", "Terrin, G", "Boscarino, G", "Bülbül, A", "Sallmon, H", "Atasay, B", "Ovalı, F", "Clyman, RI" ], "year": 2022, "source": "Turk Arch Pediatr. 2022; 57(2):118-131", "category": 1, "document_type": 1, "sci": "ISI:000770052000002", "pubmed": "35383006", "doi": "10.5152/TurkArchPediatr.2022.21361", "pmc": "PMC9366181", "organizations": [], "persons": [ "202331-119047-6" ], "imported": "2023-03-30T02:00:00+02:00", "journal": "Turk Arch Pediatr", "issn": "2757-6256", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 164652, "title": "Clinical application of NGS \r\n", "abstract": null, "authors": [ "Hoefler, G." ], "year": 2017, "source": "Meeting on standard NGS for clinical tissues; APR 26-77, 2017; Aviano. 2017. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164652-14020" ], "persons": [], "imported": "2018-01-19T11:34:55+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164653, "title": "Tumor lipid metabolism", "abstract": null, "authors": [ "G. Hoefler" ], "year": 2017, "source": "FEBS Advanced Lecture Course on Oncometabolism; JUN 18-24, 2017; Figueira da Foz, PORTUGAL. 2017. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "164653-14020" ], "persons": [], "imported": "2018-01-19T12:10:06+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 164654, "title": "Parodontitis: eine orale Manifestation der Psoriasis?", "abstract": "Hintergrund: \nParodontitis und Psoriasis sind chronisch-entzündliche Erkrankungen mit zahlreichen überlappenden Charakteristika. Überschneidungen zeigen sich bei den Triggerfaktoren (z.B. Rauchen, Stress), im Muster und der Verteilung der entzündlichen Mediatoren (mit erhöhten IL-17- und TNF-a-Spiegeln) und Zellen (wie ¿d-T-Zellen, TH17-Zellen, dendritischen Zellen und neutrophilen Granulozyten) sowie in der erhöhten Rate an Komorbiditäten (wie metabolischen, kardiovaskulären und autoinflammatorischen Erkrankungen). Darüber hinaus weisen jüngste Studien auf eine signifikant höhere Parodontitis-Rate bei PatientInnen mit Psoriasis im Vergleich zur Normalbevölkerung hin. \n\nZiel:\nDas Ziel dieser Arbeit war es, die bestehende Evidenz für den Zusammenhang zwischen Psoriasis und Parodontitis zu erweitern und möglicherweise auch potentielle Risikofaktoren für eine mit Psoriasis assoziierte Parodontitis zu identifizieren.\n\nMaterial und Methoden: \nBei PatientInnen mit exazerbierter Psoriasis und PatientInnen mit chronisch spontaner Urticaria (CSU) wurde zwischen 01/2007 und 02/2016 an der Dermatologischen Abteilung des Klinikum Klagenfurt routinemäßig eine dentale Fokalsuche durchgeführt. Die Odds-Ratio (OR) zwischen Psoriasis und Parodontitis wurde in einem Fall-Kontroll-Studiendesign mit CSU-PatientInnen als Vergleichsgruppe bestimmt. Potentielle Risikofaktoren wie Alter, Geschlecht, Krankheitsdauer, Psoriasis-Subtyp, Ausgangs-PASI (Psoriasis Area and Severity Index), Psoriasis-Familienanamnese, Body Mass Index (BMI) und Anzahl der Komorbiditäten wurden durch logistische Regression auf statistische Signifikanz (p <0,05) untersucht. Das Studienvorhaben wurde durch die Ethikkommission Kärnten mit der Ethikkommissionsnummer MZ 04/16 genehmigt. Die Studie wurde in Übereinstimmung mit den Grundsätzen der Erklärung von Helsinki durchgeführt. \n\nErgebnisse: \nDie statistische Analyse zeigte eine erhöhte Parodontitis-Prävalenz bei Psoriasis-PatientInnen im Vergleich zu CSU-PatientInnen mit einer OR von 3,76 [95% CI 1,60-10,27, p 0,001]. In der Analyse der Psoriasis-Subtypen war der inverse Typ - mit Befall der intertriginösen Areale - signifikant mit dem Bestehen einer Parodontitis assoziiert (OR von 5,11 [95% CI 1,36-20,38, p 0,006]).\n\nDiskussion: \nDie Ergebnisse dieser Studie erweitern die Evidenz für Psoriasis-assoziierte Parodontitis und konnten erstmalig die Verbindung zwischen dem inversen Subtyp der Psoriasis und einer Parodontitis identifizieren. \n\n", "authors": [ "Hirtenfelder, A" ], "year": 2018, "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2018. pp. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2018-01-19T12:15:23+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Graz Medical University", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 164655, "title": "Änderungen des Redoxzustandes von humanem Serumalbumin während normobarer Hypoxie", "abstract": "Dass Hypoxie zum Auftreten von oxidativen Stress in biologischen Systemen führt, wurde bereits mehrfach gezeigt. Die Quellen der dabei auftretenden reaktiven Sauerstoffspezies (ROS) sind vielfältig und noch nicht endgültig geklärt. Am Institut für Physiologische Chemie der Medizinischen Universtiät Graz wurden bereits zahlreiche Untersuchungen zur Auswirkung von oxidativem Stress auf den Redoxstatus von humanem Serumalbumin durchgeführt. Mit der Verfügbarkeit einer Hypoxiekammer am Institut für Sportwissenschaften in Graz, war es naheliegend, die Auswirkungen von akuter, normobarer Hypoxie auf die Verteilung der Redox-Fraktionen von Albumin im Rahmen dieser Diplomarbeit zu untersuchen.\nFür die Piloststudie wurden 33 gesunde junge Probanden und Probandinnen für vier Stunden einer hypoxischen Atmosphäre (Äquivalenzhöhe 5.000 m) ausgesetzt. Vor und nach dem Versuch wurden die einzelnen Albuminfraktionen mittels HPLC bestimmt. Um etwaige Veränderung mit einem etablierten Marker für oxidativen Stress zu vergleichen, wurde der MDA-Spiegel vor und nach dem Versuch bestimmt.\nNach den Analysen konnten 21 Probanden und Probandinnen in die statistischen Auswertungen miteinbezogen werden. Die Hypoxie-Exposition führte zu einer Abnahme des Anteils der reduzierten Albuminform (HMA) um 1,6% und zugleich zu einer Zunahme des Anteils der mild oxidierten Albuminfraktion (HNA-1) um 1,4%. Diese Veränderungen sind statistisch signifikant. Die irreversibel oxidierte Albuminfraktion (HNA-2) blieb beinahe unverändert. Auch der MDA-Wert blieb unverändert. Zudem konnte ein deutlicher Anstieg des Leukozytenwertes selektiv bei den Männern beobachtet werden. Dieser Geschlechterunterschied ist statistisch signifikant.\nDie Ergebnisse sollten im Rahmen von größer angelegten Studien überprüft werden. Dabei sollte auch die Phase der Reoxygenierung in die Auswertung miteinbezogen werden.", "authors": [ "Holzinger, J" ], "year": 2017, "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2017. pp. 99", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2018-01-19T12:15:23+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Graz Medical University", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 164656, "title": "Hormonelle Störungen nach schweren Schädel-Hirn-Traumen", "abstract": "Hintergrund: Ein schweres Schädel-Hirn-Trauma (SHT) führt häufig zu einer posttraumatischen Hypophysendysfunktion. Es gibt derzeit weder eine eindeutige Häufigkeitsangabe, noch ein einheitliches Screening-Verfahren anhand prädiktiver Faktoren. Ziel dieser Arbeit war die Ermittlung der Häufigkeit dieser hormonellen Störungen. Zusätzlich wurden potentielle prädiktive Faktoren eruiert.\n\nMethoden: Retrospektiv wurden 51 PatientInnen rekrutiert, welche im Zeitraum von 2010 bis 2016 an der Universitätsklinik für Neurochirurgie des LKH-Univ. Klinikum Graz aufgrund eines schweren SHT hospitalisiert wurden. Ausgewertet wurden der Schweregrad des Traumas (Glasgow Coma Score (GCS)), der Hormonstatus, die Hormonsubstitution und der Entlassungsstatus (Glasgow Outcome Score (GOS)). Die statistische Analyse erfolgte mittels deskriptiver Statistik, Chi-Quadrat-Tests und der Rangkorrelation nach Spearman.\n\nErgebnisse: In der akuten Phase nach einem schweren SHT zeigten 49/51 PatientInnen (96,1 %) hormonelle Veränderungen. Folgende Defizite wurden gefunden: Bei 39/44 PatientInnen (88,6 %) zeigte sich ein Defizit an Gesamttestosteron, bei 12/18 PatientInnen (66,7 %) an freiem Testosteron, bei 32/49 PatientInnen (65,3 %) an ACTH, bei 19/48 PatientInnen (39,6 %) an Cortisol, bei 23/51 PatientInnen (45,1 %) an fT3, bei 6/51 PatientInnen (11,8 %) an fT4 und bei 5/51 PatientInnen (9,8 %) an TSH. 32/37 PatientInnen (86,5 %) zeigten ein Defizit an Vitamin D3. Ein signifikanter Zusammenhang wurde zwischen einem niedrigen GCS (3 – 5) und einem posttraumatischen Defizit an Gesamttestosteron (p = 0,031) und freiem Testosteron (p = 0,045) eruiert. Zwischen einer längeren Intensivliegedauer (über 31 Tage) und der Entwicklung eines TSH-Defizits wurde ebenfalls ein signifikanter Zusammenhang beobachtet (p = 0,028). 32/51 PatientInnen (62,7 %) benötigten eine Substitutionstherapie.\n\nConclusio: Eine posttraumatische Hypophysendysfunktion tritt mit großer Wahr-scheinlichkeit nach einem schweren SHT auf. Ausmaß und Dauer einer medikamentösen Substitution sind noch nicht klar definierbar. Zur Identifikation eindeutig prädiktiver Faktoren bedarf es weiterer Untersuchungen.\n", "authors": [ "Prötsch, J" ], "year": 2017, "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2017. pp. 79", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2018-01-19T12:15:23+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Graz Medical University", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 164657, "title": "The influence of bile acid conjugation on hepatic and intestinal metabolism", "abstract": "Background\nBile acids (BAs) are formed in the liver, stored in the gallbladder and secreted into the intestine. Under physiologic conditions, almost exclusively conjugated BAs are secreted into the intestine. However, unconjugated BAs are used widely in BA-feeding experiments and solely in clinical practice.\n\nAims and Methods\nThis study aimed to investigate the impact of taurine-conjugation on hepatic and intestinal metabolism. In an animal experiment mice were fed the unconjugated BAs cholic acid (CA) and ursodeoxycholic acid (UDCA) or the corresponding taurine-conjugated BAs taurocholic acid (TCA) and tauroursodeoxycholic acid (TUDCA) for 7 hours, 4 days and 3 weeks. Biometric measurements and liver functions tests were performed. Hepatic BA synthesis, hydroxylation and excretion were assessed by Q-PCR for cytochrome P-450 (Cyp)7a1, Cyp8b1, Cyp3a11, Cyp2b10 and organic solute transporter (Ost)-ß. Expression levels of peroxisome proliferator-activated receptor alpha (Ppar-a) and its target genes (Acox1, G0s2 and Cyp4a14) were quantified in the liver. Further, we determined insulin-like growth factor binding protein 1 (Igfbp1) mRNA levels in the liver and protein levels in serum by Western blot analysis. Ileal expression of fibroblast growth factor 15 (Fgf15), small heterodimer partner (Shp), ileal bile acid-binding protein (I-BABP) and Ost-ß was also measured.\n\nResults\nTaurine-conjugation of both CA and UDCA reduced liver weight after 3 weeks. TUDCA increased body weight gain compared to UDCA after 3 weeks. Conjugated BAs tended to repress Cyp7a1 and Cyp8b1 less without reaching statistical significance in most groups. TUDCA repressed Ost-ß in liver tissue stronger than UDCA. Cyp3a11 and Cyp2b10 expression tended to be lower in conjugated groups. Ppar-a and Acox1 were induced by TUDCA but not by UDCA after 4 days and 3 weeks, suggesting a conjugation-dependent modulation of Ppar-¿ signaling by BAs. Igfbp1 mRNA levels in the liver and protein levels in serum were massively elevated by TCA but hardly affected by CA. Taurine-conjugation had only minor effects on ileal expression of Fgf15, Shp, I-BABP and Ost-ß.\n\nConclusion\nThe observed conjugation-dependent effects on the expression of major regulatory enzymes of BA, lipid and glucose metabolism may question the transferability of experiments using unconjugated BAs to a physiologic condition.\n", "authors": [ "Wenzl, F" ], "year": 2018, "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2018. pp. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2018-01-19T12:15:23+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Graz Medical University", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false } ] }