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GET /v1/research/publication/?format=api&offset=155440&ordering=year
{ "count": 157100, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=155460&ordering=year", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=155420&ordering=year", "results": [ { "id": 219647, "title": "Resting-State Functional Connectivity Changes in Patients with Functional Movement Disorder.", "abstract": "Functional movement disorder (FMD) is a neurological condition marked by abnormal movements without underlying structural brain pathology. Depression symptoms are frequent in FMD, literature on cognitive functioning is inconsistent. Little is known about the organization of large-scale resting-state networks. This study examined differences in resting-state functional connectivity (FC) patterns, depressive symptoms, and cognitive functioning between FMD patients and healthy controls (HC), and explored associations of FC alterations with depression symptoms, cognition and age. For behavioral comparisons, the Mini-Mental Status Examination (MMSE), Trail-Making Test B (TMT-B) and Geriatric Depression Scale (GDS) of 27 FMD patients and 27 HC were analyzed. To identify resting-state networks and compare intra- and inter-network FC between groups, resting-state fMRI data of 11 FMD patients and 11 HC were analyzed through independent component analysis and dual regression. FMD patients reported significantly higher depressive symptoms on the GDS (U = 226.00, p = .015) and showed better cognitive performance on the MMSE (U = 225.00, p = .014) and TMT-B (U = 227.50, p = .028) compared to HC. Intra-network analyses revealed reduced FC between a cluster of the right anterior prefrontal cortex (aPFC) and the executive right network in FMD, with no significant correlation between this FC strength and depression, cognition or age. There were no significant group differences in inter-network FC. Given the aPFC’s role in metacognitive control, attention shifting, and emotion regulation, this right-lateralized reduced coupling with the executive network may reflect inefficient integration of executive and emotion control mechanisms, potentially contributing to impaired motor inhibition. Future studies with larger samples should further explore these FC patterns using motor inhibition and emotion regulation paradigms to confirm network-specific differences.", "authors": [ "Gruber, L" ], "year": 2025, "source": " [ Diplomarbeit/Master Thesis (UNI) ] Universität Graz; 2025. pp.75. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T09:23:46+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 218542, "title": "Discordant fetal anomalies in monochorionic multiple pregnancies", "abstract": "The phenomenon of monozygotic (MZ) twinning has always captivated scientific interest, especially in the context of monochorionic (MC) twins. Despite their traditional perception as representing two mirror images of another, MC twins occasionally exhibit structural and genetic discordances. These instances challenge the assumption of their identical nature and absolute genetic equivalence and present a unique biological environment for investigating the dynamic relationship of genetics, epigenetics, and environmental influences during early human development.", "authors": [ "Schuligoi, H" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 79", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-11-06T11:31:36+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219658, "title": "Basale Androgene und ihr Zusammenhang mit der Qualität von Embryonen (bei der In-vitro-Fertilisation)", "abstract": "In der vorliegenden Diplomarbeit wird der Einfluss von Androgenen, insbesondere des freien Testosterons (fT) und des Dehydroepiandrosterons (DHEA), auf die Qualität von Embryonen im Rahmen einer In-vitro-Fertilisationen (IVF) untersucht. Androgene nehmen eine zentrale Rolle in der Reproduktionsmedizin ein, da sie die Follikelreifung, Embryonalentwicklung und Endometriumrezeptivität beeinflussen können. Bisherige Studien zeigten widersprüchliche Ergebnisse zum Einfluss von Androgenen auf die IVF-Ergebnisse. Das Ziel dieser Arbeit war es, zu untersuchen, ob und inwiefern der Androgenspiegel mit der Embryoqualität und den Erfolgen der IVF-Methoden in den unterschiedlichen Altersgruppen der Patientinnen zusammenhängen.", "authors": [ "Resch, J" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 75", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219675, "title": "Stellenwert medizinischer Cannabinoide bei der Behandlung von Kreuzschmerzen\r\nEine systematische Literaturrecherche", "abstract": "Kreuzschmerzen zählen zu den häufigsten Ursachen für Arbeitsunfähigkeit und stellen eine erhebliche individuelle sowie gesellschaftliche Belastung dar. In Österreich sind etwa 21% der Erwachsenen von chronischen Schmerzen betroffen. Kreuzschmerzen machen dabei einen erheblichen Teil aus. Die Chronifizierung ist mit hohen sozioökonomischen Kosten verbunden. Im Hinblick auf die begrenzten Therapieoptionen sowie die Risiken langfristiger Opioidtherapien rücken medizinische Cannabinoide zunehmend in den Fokus. In bestehenden Übersichsarbeiten werden chronische Schmerzen generell untersucht, während die Evidenz im Hinblick auf Kreuzschmerzen unzureichend ist.", "authors": [ "Nigl, M" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 95", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 218537, "title": "DIAGNOSTIC POTENTIAL OF IMMUNOLOGIC BIOMARKERS IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES AT RISK FOR INVASIVE MOLD INFECTIONS", "abstract": "Background: Patients with hematological malignancies have an increased risk of invasive mold infections (IMI). Despite progress in the past, IMIs are still associated with high mortality and difficult to diagnose.", "authors": [ "Heldt, S" ], "year": 2025, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp. 282", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-11-06T11:31:36+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219660, "title": "A Review of Animal Models in Colorectal Cancer Research", "abstract": "Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with complex pathophysiology that complicates therapeutic approaches. Despite advancements in surgical and chemotherapeutic options, challenges such as metastasis, drug resistance, and adverse side effects necessitate innovative therapies. Emerging solutions like siRNA-based interventions demonstrate promise but require rigorous preclinical validation to overcome hurdles in stability and delivery. Animal models play a pivotal role in this process, offering a controlled platform to test new treatments. In this systematic review, we analyzed 26 studies from the past 15 years focused on injection-based carcinogenesis in small animal models. Our aim was to identify standardized practices in animal and cell line selection, injection methods, volumes and cell concentrations. The findings highlight the variability in methodologies, underscoring the need for consistency to streamline future research and enhance translational relevance. Our review concludes that adopting precise and minimally invasive approaches, such as endoscopic injection, in anatomically scalable models like rats, could bridge the gap between experimental designs and human CRC pathology. These insights are intended to guide the development of robust and reproducible CRC animal models for advancing therapeutic innovations.", "authors": [ "Eisenberger, K" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 213344, "title": "Antioxidantien und ihre Rolle bei der Bekämpfung von altersbedingtem oxidativem Stress", "abstract": "Als häufigste Todesursache beider Geschlechter weltweit sind kardiovaskuläre Erkrankungen in ihrer Genese oft auf altersassoziierten oxidativen Stress und die daraus resultierenden vaskulären, zellulären, humoralen und immunologischen Veränderungen zurückzuführen. Diese führen zu degenerativen Modifikationen, insbesondere zur Arteriosklerose, die wiederum meist die Hauptursache für die epidemiologisch bedeutsamsten Entitäten wie koronare Herzkrankheit, arterielle Hypertonie, Myokardinfarkt und ischämischen Apoplex ist.\r\nZu Beginn der Arbeit wird der Alterungsprozess und sein Zusammenhang mit oxidativem Stress erläutert sowie die biochemischen Grundlagen der Radikale und Antioxidantien erklärt. Der Hauptteil untersucht, ob eine präventive oder therapeutische Supplementation von Vitamin C, Vitamin E oder Carotinoiden die Entstehung oder die Progredienz solch degenerativer Veränderungen beeinflussen kann. Dafür wurde eine Literaturrecherche mithilfe mehrerer Nachschlagewerke und der Datenbanken PubMed und UpToDate durchgeführt, wobei systematische Reviews, Meta-Analysen sowie pro- und retrospektive Studien analysiert wurden. Als primäres Recherchekriterium wurde die isolierte Wirkung der genannten Antioxidantien auf kardiovaskuläre Parameter gewählt.\r\nInsgesamt fehlen eindeutige Studienergebnisse, die eine evidenzbasierte Empfehlung für oder gegen die isolierte Supplementation der genannten Antioxidantien erlauben. Weitere Studien sind erforderlich, da antioxidative Substanzen weiterhin großes Potenzial für die Gesundheitsprävention aufweisen und insbesondere in der Altersmedizin lebensqualitätssteigernde Effekte haben könnten. In die Untersuchungen sollten sowohl der individuelle Gesundheitszustand als auch Einflussfaktoren wie Ernährungsgewohnheiten und Lebensstil miteinbezogen werden, um Daten zu Dosierung, potenziellen Nebenwirkungen und Wechselwirkungen unterschiedlicher Nährstoffe zu sammeln. Zusätzlich ist eine striktere Differenzierung zwischen den Geschlechtern notwendig, da sich die Stoffwechselsituation und Wirkungskapazitäten unterschiedlicher Stoffe geschlechtsspezifisch unterscheiden können. Die meisten Studien wurden bisher jedoch an männlichen Probanden durchgeführt.", "authors": [ "Thiel, M" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 92", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-01-23T09:25:31+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 218889, "title": "Long-COVID: Clinical Characteristics, Neural Correlates, and Intervention Approaches", "abstract": "Introduction: Long-COVID is a highly heterogeneous condition that encompasses more than 200 symptoms and poses a significant burden on public health systems worldwide. Even five years after the pandemic, knowledge about its personal impact, effective treatment options, and brain alterations in affected individuals remains limited. Methods: Therefore, this thesis comprises three studies that aimed to (1) characterize the symptoms, burdens, and impacts of Long-COVID, (2) investigate structural and functional brain changes associated with cognitive impairment - one of the most frequently reported symptoms - and (3) explore the effectiveness of a tablet-based training program as a potential intervention for cognitive and psychological deficits. Results: The findings of this thesis underscore (1) the substantial impact of Long-COVID on patients’ personal and professional lives, including a broad range of symptoms, high levels of psychological distress, and work-related consequences such as loss of income or inability to work. In addition, (2) significant functional brain alterations were observed between patients with and without cognitive impairment following COVID-19, especially in large-scale brain networks such as the default mode network (DMN), which plays an important role in various mental processes. Finally, (3) the findings of this thesis provide partial support for the use of tablet-based training programs to alleviate subjective cognitive complaints, reduce depressive symptoms, and support memory performance in affected individuals. Conclusion: These findings highlight the diverse clinical presentation of Long-COVID and its significant impact on those affected. Moreover, they underscore the need for a deeper understanding of the neuronal mechanisms underlying its cognitive and psychological symptoms. Future research should aim to identify reliable biomarkers and develop tailored, multimodal interventions to improve the quality of life for those affected.", "authors": [ "Leitner, M" ], "year": 2025, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp. 98", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-12-03T09:49:47+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219655, "title": "Der Vergleich und die Limitationen unterschiedlicher Formeln zur QTc-Zeitberechnung im Kindes- und Jugendalter", "abstract": "Hintergrund: Das QT-Intervall im Elektrokardiogramm (EKG) spiegelt die Gesamtdauer der ventrikulären Depolarisation und Repolarisation wider und stellt somit einen zentralen Parameter zur Beurteilung der kardialen Erregungsrückbildung dar. Aufgrund der Abhängigkeit des QT-Intervalls von der Herzfrequenz wird zur Beurteilung in der Regel die frequenzkorrigierte QT-Zeit (QTc) verwendet. Bisher besteht Uneinigkeit darüber, welche QTc-Formel am besten performt und daher zur QTc-Zeitbestimmung verwendet werden sollte. Besonders in der Pädiatrie treten aufgrund physiologischer Entwicklungsprozesse tendenziell höhere Herzfrequenzen auf, die die Ergebnisse der QTc-Berechnung beeinflussen können. Ziel dieser Arbeit war es daher, die QTc-Zeiten in einem pädiatrischen Kollektiv anhand verschiedener QTc-Formeln (Bazett, Fridericia, Framingham, Goto, Mayeda, Rautaharju-a, Kawataki, Wernicke) zu berechnen und deren Verhalten hinsichtlich einer Abhängigkeit von Herzfrequenz und Geschlecht zu vergleichen.", "authors": [ "Musiol, C" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 101", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219670, "title": "Hereditary Cholestasis Syndromes and Their Clinical Appearance – Review of the literature and cases at the Medical University Graz", "abstract": "Background: Hereditary cholestasis syndromes are a heterogeneous group of rare liver diseases that are caused by genetic defects in genes related with bile acid transport or metabolism. Although they are rare, these diseases are clinically important as affected patients can present with severe clinical symptoms like jaundice, pruritus as well as further complications like chronic liver disease, potentially requiring a liver transplant as ultimate therapy. Cholestatic pruritus can greatly reduce quality of life. With new treatments like ASBT inhibitors now available, it’s important to know how common this condition is in order to understand how many patients could benefit from these new options. Throughout this wide group of syndromes, clinical presentation can vary between types of genetic mutations, age groups, and triggering events such as infections, pregnancy or drug medications, possibly triggering the manifestation of symptoms in patients with a genetic predisposition. Methods: We retrospectively analyzed patients with a suspected hereditary cause of cholestasis who underwent genetic testing at our university hospital throughout the last 20 years. Clinical data, laboratory findings, and genetic variants (e.g. mutations, SNPs) were reviewed to evaluate genotype-phenotype correlations, clinical presentation by age, and potential disease triggers. Results: From medical records, we identified 88 patients, 64 children and 24 adults, with a possible hereditary cause of cholestasis. Only 53 patients presented with a clear cholestatic phenotype (such as PFIC, BRIC, ICP or LPAC). The remaining 35 patients had evidence of cholestasis or mutations but without a final clinical classification at the time of research. Genetic variants were identified in 50 out of 88 patients, most frequently in the ABCB11 and ABCB4 gene. 38 patients had mutations without a clear clinical diagnosis. The clinical presentation varied by age. Pediatric cases (predominantly male (44 out of 64)) were more often associated with ABCB11 variants and presented with jaundice, whereas adult patients (predominantly female (16 out of 24)) more often carried ABCB4 variants and presented with biliary symptoms or gallstone disease. Simply determination of zygosity status of a variant (i.e. homo- or heterozygote variants) cannot predict clinical appearance since remaining function of the protein a critical contributing factor. Pruritus was documented in only approximately 6% of cases at the time of diagnosis but in around 22% during disease course, clustering with ABCB11 variants in children and ABCB4 or ATP8B1 variants in adults. Treatment was mainly symptomatic, with UDCA prescribed in 32 patients and in only two cases a specific antipruritic therapy was documented. An unexpected finding was the occurrence of EBV infections as a potential trigger for cholestatic episodes in eight patients, five of whom had mutations in ABCB11.", "authors": [ "Payam, E" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 59", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219674, "title": "Die minimalinvasive Behandlung der Trikuspidalinsuffizienz mit dem Cardioband System", "abstract": "Hintergrund und Ziele: Die Trikuspidalinsuffizienz, als ein in der alternden Bevölkerung häufig vorkommendes Erkrankungsbild mit hoher Morbidität und Mortalität sowie steigender Prävalenz, stellt das Gesundheitssystem zukünftig vor neue Herausforderungen. Hohes Alter, Komorbiditäten sowie ein vorangeschrittener Krankheitsverlauf bei oftmals spätem Diagnosezeitpunkt limitieren die isolierte chirurgische Therapie, sodass diese häufig nur im Rahmen kombinierter Operationsverfahren (z.B. bei gleichzeitiger Bypass-Operation) Anwendung findet. Lange Zeit stellte daher die alleinige symptomatische medikamentöse Behandlung bei höhergradiger isolierter sekundärer Trikuspidalinsuffizienz, trotz schlechtem Outcome, die einzige Therapieoption dar. Neue Möglichkeiten bietet der interventionelle Therapieansatz, wobei bereits mehrere Device-Systeme Anwendung finden, insbesondere der Transcatheter-Edge-to-Edge-Repair (TEER). Der zentrale Pathomechanismus der funktionellen oder sekundären Trikuspidalinsuffizienz ist die Dilatation des Klappenannulus. Als katheterbasiertes Verfahren zielt deshalb das Cardioband-System, ähnlich der chirurgischen Annuloplastie, auf eine Raffung des Klappenringes, und somit Verringerung des Annulusdurchmessers, ab. Gegenstand dieser Arbeit war, die Sicherheit und Effektivität des Cardioband-Systems innerhalb eines ausgewählten Patientenkollektives zu evaluieren.", "authors": [ "Kulik, J" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 61", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 216801, "title": "The Impact of Portosystemic Shunts on Bile Acid Metabolism in Patients with Liver Cirrhosis - A Pilot Study", "abstract": "Background: While elevated bile acid concentrations in serum are considered a key characteristic of cholestatic liver diseases, changes in bile acid concentrations and profiles in liver cirrhosis without underlying cholestasis have received less attention. Since such changes can be both a consequence and a potential driver of advanced liver diseases and their complications, this study aims at characterizing the deviations in the bile acid profile in patients with liver cirrhosis more precisely. Additionally, we attempt to explore fluctuations in the bile acid profile, following the placement of a transjugular portosystemic shunt (TIPS).", "authors": [ "Hinterhoelzl, F" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 82", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-06-25T10:21:44+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 217062, "title": "Blood transfusion trends and risk factors in primary and revision shoulder arthroplasty: a single centre analysis.", "abstract": null, "authors": [ "Sezgin, EA", "Budin, M", "Aydın, E", "Dasci, MF", "Gehrke, T", "Citak, M" ], "year": 2025, "source": "Int Orthop. 2025; 49(9):2131-2138", "category": 1, "document_type": 1, "sci": "ISI:001528272100001", "pubmed": "40634773", "doi": "10.1007/s00264-025-06605-1", "pmc": null, "organizations": [ "217062-14052" ], "persons": [ "217062-133203-6" ], "imported": "2025-07-14T02:00:00+02:00", "journal": "Int Orthop", "issn": "0341-2695", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 2.6, "impactfactor_year": 2025, "impactfactor_norm": 0.674, "impactfactor_norm_year": 2025, "impactfactor_norm_category": "ORTHOPEDICS-SCIE", "impactfactor_norm_super": 0.674, "impactfactor_norm_super_year": 2025, "impactfactor_norm_super_category": "ORTHOPEDICS-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217828, "title": "Handover from the mountain rescue team to an emergency physician \r\nAttempt at introducing a handover scheme", "abstract": "Effective communication is crucial in emergency medicine, especially in mountain rescue, where unpredictable conditions, high stress and limited resources challenge information exchange. This study introduces PEAKS, a structured patient handover tool specifically designed for mountain rescue scenarios, and evaluates its effectiveness through a simulation-based crossover study.", "authors": [ "Rettensteiner, L" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 66", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-09-16T10:33:24+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 218915, "title": "MICOMWeb: a website for microbial community metabolic modeling of the human gut.", "abstract": null, "authors": [ "Fresno, C", "Oropeza-Valdez, JJ", "Alvarado-Luis, PI", "Peña-González, P", "Tovar, AR", "Torres, N", "Diener, C", "Gibbons, S", "Resendis-Antonio, O" ], "year": 2025, "source": "Gut Microbes. 2025; 17(1): 2587968", "category": 1, "document_type": 1, "sci": "ISI:001628966000001", "pubmed": "41328016", "doi": "10.1080/19490976.2025.2587968", "pmc": "PMC12674444", "organizations": [ "218915-14023" ], "persons": [ "218915-125176-6" ], "imported": "2025-12-03T01:00:00+01:00", "journal": "Gut Microbes", "issn": "1949-0976", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 11.0, "impactfactor_year": 2025, "impactfactor_norm": 0.933, "impactfactor_norm_year": 2025, "impactfactor_norm_category": "MICROBIOLOGY-SCIE", "impactfactor_norm_super": 0.948, "impactfactor_norm_super_year": 2023, "impactfactor_norm_super_category": "MICROBIOLOGY-SCIE", "citations": false, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 218879, "title": "The translation of IP3-triggered Ca2+ release from the ER to the Mitochondria points out the tight connection of the two organelles", "abstract": "Mitochondria play an essential role in cellular Ca2+ signaling. They serve as Ca2+ buffers, initiate apoptotic cell death, and are a central hub for cellular metabolism. The uptake of Ca2+ into the mitochondrial matrix is highly regulated by the mitochondrial calcium uniporter complex (MCUC), a multiprotein complex in the inner mitochondrial membrane. The MCUC consists of the pore-forming protein MCU, the dominant negative subunit MCUb, its essential regulator EMRE, the so-called gatekeepers MICU1 and 2, the assembly factor MCUR1, and, under certain conditions like cancer or aging, the uncoupling proteins UCP2/3. Opening of the MCUC is facilitated by local Ca2+ hotspots, which lead to Ca2+ binding to the EF-hand domains of the MICUs and a subsequent conformational change. In this work, I studied the translation of cytosolic Ca2+ signals from different sources, including the endoplasmatic reticulum (ER) and extracellular space via the store-operated Ca2+ entry (SOCE), to the mitochondrial matrix. I used different concentrations of the IP3-generating agent histamine and the antipsychotic drug risperidone, which exhibits antihistaminic side effects, and correlated the changes in cytosolic Ca2+ signals with those in the mitochondrial matrix. My results confirm the necessity of a cytosolic Ca2+ threshold for achieving activation of mitochondrial Ca2+ uptake and support the hypothesis of source-dependent mitochondrial Ca2+ uptake.", "authors": [ "Bachkoenig, O" ], "year": 2025, "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp. 81", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-12-03T09:49:47+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219657, "title": "Ätiologie, Verlauf und Prognose intrazerebraler Blutungen im jungen Erwachsenenalter", "abstract": "Einleitung: Intrazerebrale Blutungen (ICH) im jungen Erwachsenenalter stellen eine seltene, jedoch klinisch relevante Entität dar, deren Ätiologie und Verlauf sich deutlich von denen älterer PatientInnen unterscheiden. Während ICH im höheren Lebensalter häufig mit kardiovaskulären Risikofaktoren assoziiert sind, sind die Ursachen und prognostischen Faktoren bei jüngeren Betroffenen bislang unzureichend erforscht. Ziel der vorliegenden retrospektiven Arbeit ist es, die Ätiologien, den klinischen Verlauf, sowie den funktionellen Outcome von ICH PatientInnen unter 55 Jahren zu untersuchen.", "authors": [ "Unterberger, J" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 219676, "title": "Ist die Reposition und Immobilisierung ohne Osteosynthese das korrekte Vorgehen bei dislozierten\r\ndistalen Unterarmfrakturen im Kindesalter?", "abstract": "Distale dislozierte Unterarmfrakturen sind häufige Frakturen im Kindesalter. Trotz ihrer hohen Inzidenz gibt es keine standardisierten Leitlinien für eine optimale Behandlung. Während einige Zentren nach Reposition eine chirurgische Stabilisierung mittels Osteosynthese bevorzugen, setzen andere in erster Linie auf eine konservative Behandlung mit geschlossener Reposition und Gipsimmobilisation. Ziel dieser Studie war es, die Wirksamkeit und Stabilität dieses konservativen Ansatzes retrospektiv zu bewerten und die Häufigkeit von sekundären Dislokationen sowie mögliche Einflussfaktoren zu analysieren.", "authors": [ "Wiesinger, O" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 72", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2026-01-07T11:07:20+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 217847, "title": "The predictive value of non-invasive pulse wave analysis in chronic heart failure", "abstract": "Chronic heart failure (CHF) remains a major cause of morbidity and mortality. Pulse waveforms are altered in CHF, but the prognostic value of these changes has not been fully established.", "authors": [ "Belciug, R" ], "year": 2025, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp. 57", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-09-16T10:33:24+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 218032, "title": "The role of Archaea in the human microbiome - A journey towards “breathless” microbes that accompany us", "abstract": "Every person is habitat to a highly individual community of up to 600 different microbial species: the human microbiome. While the impact of the microbiome on human health and disease is indisputable, mainly the impact of bacteria is discussed in the scientific literature. Archaea are often excluded from microbiome discussions due to technical limitations in detection, underrepresentation in public databases, and a lack of characterized pathogenicity. This thesis investigates the role and resilience of anaerobic microorganisms—particularly archaea—in two distinct contexts: their survival in the built environment (BE) and their potential contribution to the microbial etiology of acute appendicitis (AA).", "authors": [ "Blohs, M" ], "year": 2025, "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp. 96", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-10-01T10:18:01+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universität Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false } ] }