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GET /v1/research/publication/?format=api&offset=154660&ordering=year
{ "count": 157186, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=154680&ordering=year", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=154640&ordering=year", "results": [ { "id": 218816, "title": "Endokrine Hypertonie", "abstract": null, "authors": [ "Kraus, DA" ], "year": 2025, "source": "53. ÖDG-Jahrestagung 2025; 20.-22.11.2025; Salzburg. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "218816-14080" ], "persons": [ "218816-132242" ], "imported": "2025-11-27T16:58:21+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 214831, "title": "i.v. Kontrastmittelgabe", "abstract": null, "authors": [ "Schmid, J" ], "year": 2025, "source": "Interne Fortbildung Universitätsklinik für Strahlentherapie-Radioonkologie; FEB 26, 2025; Graz, Austria. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "214831-14104" ], "persons": [ "214831-91529" ], "imported": "2025-03-06T08:58:52+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217073, "title": "Praxisseminar Bewegungsstörungen", "abstract": null, "authors": [ "Schwingenschuh, P" ], "year": 2025, "source": "ÖGN Jahrestagung; MAR 11-14, 2025; Innsbruck, Austria. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217073-14051" ], "persons": [ "217073-50172" ], "imported": "2025-07-14T13:15:05+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 213230, "title": "Fortgeschrittene Verfahren in der Thoraxchirurgie", "abstract": null, "authors": [ "Swatek, P" ], "year": 2025, "source": "Lung cancer insight; JAN 15, 2025; Graz, Austria. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "213230-14077" ], "persons": [ "213230-50145", "213230-50948", "213230-51935", "213230-124334" ], "imported": "2025-01-20T11:28:02+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217642, "title": "From rodents to humans—Translational aspects of burn wound models.", "abstract": null, "authors": [ "Pignet, AL", "Hofmann, E", "Fink, J", "Prevedel, M", "Kamolz, LP", "Kotzbeck, P" ], "year": 2025, "source": "21st European Burns Association Congress. 2025; -EBA 2025; Sep 3-6, 2025; Berlin, GERMANY. ", "category": 2, "document_type": 19, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217642-14076" ], "persons": [ "217642-111830", "217642-117826", "217642-80111", "217642-95211", "217642-100699", "217642-89900" ], "imported": "2025-09-08T10:06:16+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": true, "zmf_use": true, "local_affiliation": true }, { "id": 217396, "title": "Genomic profiling of circulating tumor DNA using targeted capture sequencing in advanced HR+/HER- breast cancer patients", "abstract": "Background: HR-positive, HER2-negative breast cancer (HR+/HER2-) is the most common subtype of breast cancer, accounting for around 60-70%. PIK3CA mutations occur in up to 40% of patients and permanently activate the PI3K/AKT/mTOR signaling pathway. This can lead to resistance to therapy and worsen the prognosis. While these mutations are usually determined from tumor tissue, the analysis of cell-free tumor DNA (ctDNA) in plasma offers a minimally invasive alternative, especially for metastases that are difficult to biopsy. The aim of this study was to compare the detection of PIK3CA mutations using SiMSen-Seq, and the AVENIO ctDNA Expanded Kit and to test whether AVENIO can detect additional clinically relevant alterations.
\r\nMethods: 47 patients with HR+/HER2- metastatic breast cancer (mBC) were examined. Blood samples were taken before starting palliative therapy (32 before first-line and 15 before second-line therapy). Tumor fraction was estimated using mFAST-SeqS (z-score). Two methods were used for mutation analysis. On the one hand, SiMSen-Seq, a PCR-based NGS method for the highly sensitive detection of eleven PIK3CA hotspot mutations. On the other hand, AVENIO ctDNA Expanded Kit, an NGS panel for 77 cancer-relevant genes. Sequencing was performed on Illumina platforms and resulting data were analyzed bioinformatically.
\r\nResults: PIK3CA mutations were detected in 21 of 47 patients (44.7%). The most frequent variants were H1047R, E542K and C420R. 35 of 40 mutations (87.5%) were detected by both methods. Only few mutations (n = 4, corresponding to 8.5%) were detected exclusively by one method and these were mostly at low VAF (variant allele frequency) (<1%). AVENIO additionally identified mutations in TP53, ESR1, SMAD4, GATA3 and AKT1. Higher tumor proportions (z-scores) correlated with visceral metastasis.
\r\nConclusion: The AVENIO ctDNA Expanded Kit showed comparable sensitivity to SiMSen-Seq in PIK3CA detection but additionally enabled a broader molecular analysis. The combination of AVENIO, SiMSen-Seq and mFAST-SeqS provides a powerful tool for non-invasive characterization and monitoring of HR+/HER2- mBC. This would allow therapies to be adapted more specifically and resistance developments to be detected at an early stage. Especially in situations where tissue samples are difficult to obtain.", "authors": [ "Potocnik, N" ], "year": 2025, "source": " [ Diplomarbeit/Master Thesis (UNI) ] TU Graz; 2025. pp.66. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2025-08-22T14:29:23+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "TU Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": false }, { "id": 217813, "title": "Unterschiede rheumatischer Erkrankungen bei Kindern und Erwachsenen am Beispiel der JIA", "abstract": null, "authors": [ "Skrabl-Baumgartner, A" ], "year": 2025, "source": "Arzt und Praxis. 2025; Sonderheft Pädiatrie(79): 9-13. ", "category": 1, "document_type": 3, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217813-14091" ], "persons": [ "217813-60213" ], "imported": "2025-09-15T14:18:15+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217884, "title": "Body mass index matters: morbid obese patients have different microorganism profiles in the setting of periprosthetic hip joint infections", "abstract": null, "authors": [ "Budin, M", "Sandiford, NA", "Gehrke, T", "Citak, M" ], "year": 2025, "source": "https://pubmed.ncbi.nlm.nih.gov/40183945/. 2025; -EBJIS Bologna; 11.09.2025-13.09.2025; Bologna. ", "category": 2, "document_type": 18, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217884-14052" ], "persons": [ "217884-133203" ], "imported": "2025-09-18T19:27:59+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 217939, "title": "Anleitung zur anatomischen Präparation", "abstract": null, "authors": [ "Pretterklieber, M" ], "year": 2025, "source": "23. Präparieren für Anatomen; JULY 28-31, 2025; Fribourg, SCHWEIZ. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217939-14018" ], "persons": [ "217939-108616" ], "imported": "2025-09-23T11:57:22+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 215284, "title": "Zugangswege Hüfte und Oberschenkel", "abstract": null, "authors": [ "Puchwein, P" ], "year": 2025, "source": "AO Trauma Kurs - Prinzipien der operativen Zugangswege in Unfallchirurgie und Orthopädie; FEB 10-12, 2025; Graz, AUSTRIA. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "215284-14052" ], "persons": [ "215284-62925" ], "imported": "2025-03-18T12:33:04+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 216818, "title": "Österreichischer Demenzbericht 2025\r\nWissenschaftlicher Bericht", "abstract": null, "authors": [ "Herausgeber: Juraszovich, B", "Mayer, LK", "Marent, J", "Mitautor: Jagsch, C" ], "year": 2025, "source": ". 2025", "category": 12, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "216818-29484" ], "persons": [ "216818-71002" ], "imported": "2025-06-26T13:10:25+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 217872, "title": "Die Position der Arteria alveolaris inferior im Unterkiefer Gefäßnervenbündel", "abstract": null, "authors": [ "Bruneder, S" ], "year": 2025, "source": "OEGMKG Jahreskongress ; 28.01.-31.01.2025; Bad Hofgstein. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "217872-14112" ], "persons": [ "217872-83444" ], "imported": "2025-09-17T16:48:19+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 218164, "title": "Gallengangsobstruktion bei einem 6 Wochen alten \r\nSäugling", "abstract": null, "authors": [ "Genetti, M", "Bauchinger, S", "Gallistl, S", "Entenmann, A", "Kohlmaier, B" ], "year": 2025, "source": "Monatsschr Kinderheilkd 2025 · 173 (Suppl 2):\r\nS103–S152. 2025; -ÖGKJ Jahrestagung; SEPT 10-12, 2025; Graz, AUSTRIA. ", "category": 2, "document_type": 19, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "218164-14091" ], "persons": [ "218164-51963", "218164-75521", "218164-83601" ], "imported": "2025-10-10T15:54:33+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 216183, "title": "Autophagy is essential for NAD+ replenishment therapy of HFpEF\r\n", "abstract": null, "authors": [ "Sedej, S" ], "year": 2025, "source": "Create Global Symposium; MAY 10, 2025; Osaka, JAPAN. 2025. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "216183-14083" ], "persons": [ "216183-60041" ], "imported": "2025-05-16T14:41:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 216768, "title": "Selen in der Schilddrüse - Evidenzbasierte Aspekte eines unterschätzen Spurenelements", "abstract": null, "authors": [ "Nazerani-Zemann, T" ], "year": 2025, "source": "Fortbildung im Rahmen der Morgenbesprechung der Klin. Abtlg. für Nuklearmedizin; JUN 24, 2025; 2025. 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