Publication List

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            "id": 187203,
            "title": "Progress: Fortschreiten der Erkrankung unter medikamentöser Therapie Was ist Progress, wie klärt man ihn systematisch ab, was kann man tun?",
            "abstract": null,
            "authors": [
                "Szkandera, J"
            ],
            "year": 2021,
            "source": "1. TriNationales GIST-Patienten-Forum; MARCH 26-27; Berlin, DEUTSCHLAND. 2021. ",
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        {
            "id": 187208,
            "title": "Genetic links of the Big Five personality traits in bipolar disorder",
            "abstract": "Introduction: Genetic factors play an important role in BD development and onset in dependency of provoking triggers, like early life stress, coping mechanisms and social stability as described by the stress-vulnerability model. Furthermore, specific personality traits that are genetically transmitted to some extent have an impact on the course of BD. Now, in this thesis we observed the genetic influences on personality differences in BD patients. \r\n\r\nMethods: Blood samples were taken from 40 male and 43 female BD patients and sent to the Institute of Human Genetics Graz for DNA-isolation with the salting out technique. Genotyping was performed with the Omniexpress1.1 bead chip from Illumina at the Life & Brain Center Bonn. Guided by hypotheses, the isolation of the following gene variants took place: COMT (rs4680), BDNF (rs6265), 5-HTR2A (rs6311, rs6313) and the CLOCK genes CLOCK (rs534654, rs1801260, rs12649507) and PER3 (rs10462021, rs10864315, rs228682, rs228642).\r\nThe ‘Big Five’ personality traits were assessed by the NEO-FFI, a questionnaire with 60 different statements, in order to receive a quantitative analysis of our participants’ personality. \r\nIBM SPSS version 25 was used for the analysis of this thesis’ data. We examined the differences of personality traits in genotype carriers. Age was inserted as covariate in our model for openness for experience and extraversion. \r\n\r\nResults: Two of the investigated genotypes of PER3 showed a significant difference for the personality trait neuroticism in BD patients. PER3 rs228682 showed higher scores in AG and AA genotype carriers in comparison to the GG genotype (F(2/78) = .03, p = .003, Eta= .140), whilst PER3 rs228642 showed higher scores for the group AG+GG than AA (F(1/79) = .01, p = .008, Eta= .085).\r\nThe analysis identified trends (p <0.1) concerning the association between personality traits and genotypes of COMT (rs4680), 5-HTR2A (rs6311, rs6313) and PER3 (rs228642).\r\n\r\nConclusion: The PER3 polymorphisms rs228682 and rs228642 showed a significant difference for the personality trait neuroticism. Additional trends toward statistical significance concerning personality differences were determined for the genes COMT (rs4680), 5-HTR2A (rs6311, 6313) and PER3 (rs228642).\r\nFurther analyses with larger sample sizes are definitely needed to receive valid answers and to gain more knowledge about BD pathomechanisms and personality development/variety in BD patients.",
            "authors": [
                "Kirchschlager, T"
            ],
            "year": 2021,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2021. pp. 68",
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        {
            "id": 187209,
            "title": "Intratympanic triamcinolone acetonide as a salvage therapy for idiopathic sudden sensorineural hearing loss",
            "abstract": "Introduction\r\nIntratympanic steroid (ITS) injections are increasingly used as salvage treatment for idiopathic sudden sensorineural hearing loss (ISSHNL). No consensus exists on the ideal ITS treatment protocol regarding medication, total injection count and interval length. The widely used corticosteroids are dexamethasone and methylprednisolone. There are limited data for triamcinolone acetonide as medication for this treatment modality. Since the initiation of ITS treatment at the Medical University of Graz in 2014, a protocol consisting up to 3x intratympanic triamcinolone acetonide injections at 1-week intervals has been used. In January 2020, the protocol was revised by shortening the interval length and implementation of an additional 4th injection. The present dissertation project included two parts: The primary objective of the first part was to evaluate the efficacy of triamcinolone acetonide as medication for ITS salvage treatment of ISSNHL. The aim of the second part was to compare the revised and initial ITS protocols on hearing outcome.\r\n\r\nMaterials and Methods\r\nIn the first part (= cohort study), 152 patients diagnosed with ISSNHL between January 2014 and August 2019, who failed to response sufficiently to primary systemic corticosteroid therapy, and who received up to 3x ITS injections at 1-week intervals as a salvage treatment, were retrospectively reviewed. The primary outcome measure was the absolute hearing improvement by ITS salvage treatment. Secondary outcome measures were a clinically significant ITS hearing improvement (>10 dB), grade of hearing recovery, and recovery into a serviceable hearing range (≤50 dB). In the second part (= case-control study), 32 primary-refractory ISSNHL patients who received up to 4x ITS injections every 2-4 days between August 2019 and December 2020, were retrospectively enrolled. These patients (= revised-protocol group), were 1:1 matched to subjects out of the cohort study (= initial-protocol group). Hearing outcomes between the revised and initial ITS salvage treatment protocols were compared by using the same outcome measures as in the cohort study.\r\n\r\nResults\r\nIn the cohort study, patients improved in mean hearing function by 15.9 ± 18.9 dB due to salvage treatment with intratympanic triamcinolone acetonide injections. 52.6% of the patients had a clinically significant ITS hearing improvement. A complete and partial hearing recovery were achieved from 9.9% and 48% of the patients, respectively. 23.9% of the patients with an unserviceable hearing level returned by ITS salvage treatment into a serviceable hearing range. In the case-control study, both ITS salvage treatment protocols resulted in a statistically significant decline in hearing thresholds (p<0.05). The initial protocol improved patient’s hearing function by 12 ± 11.7 dB (p<0.001, d=1, P=99%). Hearing thresholds decreased by 13.4 ± 19.1 dB in the revised-protocol group (p<0.001, d=0.7, P=98%). A clinically significant hearing improvement was seen in 18 patients (58.1%) in the initial-protocol group, and in 14 patients (41.9%) in the revised-protocol group. There were no statistically significant differences in all hearing outcome measures between protocol groups (p>0.05). \r\n\r\nConclusion\r\nTriamcinolone acetonide in ITS salvage treatment of ISSNHL resulted in similar significant hearing outcomes compared to previous studies using commonly applied corticosteroids, namely, dexamethasone and methylprednisolone. Therefore, triamcinolone acetonide constitutes an effective candidate for the ITS treatment of ISSNHL. Both ITS protocols resulted in a similar significant hearing recovery. These results indicate that a shorter injection interval does not lead to better hearing outcomes. Moreover, the usage of fewer ITS injections may reduce costs, physical/mental stress of the patients and lower the risk of persistent tympanic perforations, while maintaining similar treatment efficacy.",
            "authors": [
                "Andrianakis, A"
            ],
            "year": 2021,
            "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2021. pp. 158",
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        {
            "id": 187210,
            "title": "Investigating the Stress-Resistance of the Cancer Cell Secretory Pathway",
            "abstract": "Secretory proteins are a large and important part of the human proteome. They are either membrane-associated or soluble proteins and most of them first target the endoplasmic reticulum (ER) to enter the classical secretory pathway. Cargo proteins start their journey through this pathway from the ER to the Golgi via vesicular structures, representing the initial step in this process. Modern, high-resolution imaging techniques in combination with innovative genetically encoded, fluorescent protein (FP)-based tools allow the synchronization and real-time visualization of such trafficking events. It has been shown that many tumor cells rely heavily on protein secretion to maintain cancer-specific hallmarks like high growth and proliferation rates and also enable metastasis. Despite this knowledge about the role of the secretory pathway in cancer cells, not a lot is known about its general energy supply and specifically its resistance to stress. In this thesis, we applied state-of-the-art techniques to allow a closer look into the complex interrelation between metabolic activity and early secretory trafficking events in cancer cells as well as test the sensitivity of ER-to-Golgi transport to energy and Ca2+ stresses. The experiments revealed a yet unseen stability of secretory transport under significant energy stress by nutrient starvation, mimicking a situation tumor cells might encounter during their life. Surprisingly, the cancer cell model also displayed high efficiency in ER-to-Golgi trafficking upon short-term Ca2+ stress induction. However, treatment with the antimetabolite 2-deoxy-D-glucose (2-DG) effectively and almost completely abolished secretory transport of luminal and transmembrane cargo constructs, underlining the importance of the glycolysis-based energy supply to maintain effective protein trafficking in cells exhibiting the Warburg effect. We further demonstrated the impact of 2-DG on the cellular Ca2+ homeostasis and the motility of vesicular structures within cells. Furthermore, the structural integrity of ER and the microtubule network, as a crucial mediator of directed, long-distance intracellular transport, were investigated under severe energy stress. In an attempt to complement high-resolution fluorescence imaging methods, a novel genetically-encoded sensor based on new FP-technologies was introduced opening up new possibilities. By applying innovative methodical approaches we demonstrated a high stress-resistance of the secretory pathway in the cancer cell model. These new insights into ER-to-Golgi transport efficiency under energy and Ca2+ stress also emphasize the importance of the secretory pathway as a potential target in future cancer therapy.",
            "authors": [
                "Rauter, T"
            ],
            "year": 2021,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Graz Medical University; 2021. pp. 123",
            "category": 5,
            "document_type": 16,
            "sci": null,
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        {
            "id": 187212,
            "title": "Changes of intestinal microbiota composition and diversity in very low birthweigt infants related to strategies of NEC prophylaxis",
            "abstract": "Background\r\nAt the Division of Neonatology, Department of Pediatrics, Medical University Graz, a unique regimen for prophylaxis of necrotizing enterocolitis (NEC) in preterm infants <1500g birth weight is used. This regimen includes the combined use of antibiotics, mycostatics and probiotics, as well as a structured feeding regimen. The incidence of NEC in preterm infants treated by this regimen has been shown to be as low as 0.7% when treatment was initiated at the first day of life, compared to international incidence rates reported to be about 5.1%. We hypothesized that differences in hospital regimens influence diversity and composition of intestinal microbiota development. Thus, intestinal microbial diversity and abundance as well as development of the intestinal microbiome within the first two weeks of life were analyzed from stool samples.\r\n\r\nMethods\r\nThe doctoral thesis was carried out as a prospective controlled triplecenter cohort study in preterm infants with a birth weight <1500g (i.e. very low birth weight, VLBW). Partizipating centers were located in south eastern Austria (NICU, Department of Pediatrics, Medical University Graz; NICU, Department of Pediatrics, General Hospital of Klagenfurt; NICU, Department of Pediatrics, General Hospital of Leoben). At the Division of Neonatology, Department of Pediatrics, General Hospital of Klagenfurt a different probiotic supplement containing different strains and a different feeding strategy are used. Furthermore, oral antibiotics are not routinely used. At the Department of Pediatrics, General Hospital of Leoben no probiotic supplements are used but antibiotics, mycostatics and feeding regimens adhere to the Graz protocol. Seven stool samples from each of the 54 included infants, 18 from each center, collected every other day throughout the first two weeks of life, were analyzed by 16srRNA analysis. All 378 samples were analyzed at the Core Facility for Molecular\r\nBiology at the Medical University of Graz. Data was processed and interpreted with the help of biostatisticians and statisticians, as well as specialists of the Interactive Microbiome Research Unit Graz.\r\n\r\nResults\r\nRegarding gestational age, birth weight, APGAR scores and oxygen demand, nostatistical differences were found between the three groups. Overall, 2029 different\r\ntaxa were detected, showing a predominance of the probiotic genera Lactobacillus and Bifidobacterium, and further comprising Enterococcus and Staphylococcus. With the use of probiotic supplementation, an earlier increase in bacterial load was found. Although predominating in samples from infants who were supplemented with probiotics, Lactobacillus and Bifidobacterium contributed only marginally to the intestinal microbiome if no probiotics supplementation was administered. However, some infants did not respond to probiotics supplementation. By the end of the second week of life microbial diversity in samples of all partizipating centers showed a similar pattern. Microbial samples from all centers clustered significantly, yet varied from each other.\r\n\r\nConclusion\r\nThe administration of probiotics supplementation in very low birth weight preterm infants seems to be safe. Furthermore, it seems to initiate an earlier increase in bacterial load with a predominance of probiotic strains, which might be essential for the prevention of neonatal morbidities and NEC. Meconium samples were found not to be sterile but already containing bacterial DNA. Oral antibiotics did not influence the development of the stool microbiome in a negative way, and did not interfere with probiotics colonization despite combined use. Hospital regimens lead to centerspecific and distinct clustering as a microbial hallmark.",
            "authors": [
                "Kurath-Koller, S"
            ],
            "year": 2021,
            "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2021. pp. 107",
            "category": 5,
            "document_type": 16,
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                "187212-14093"
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                "187212-59876"
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        {
            "id": 187213,
            "title": "Hypertrophic Cardiomyopathy -\r\nThe Examination of Contemporary Insights with Regard to Genetic Aspects, Various Implications, Morphologic Variants, and Therapeutic Intervention",
            "abstract": "Introduction: The relevance of the ailment Hypertrophic Cardiomyopathy, with its clinical identification in existence in collectively 122 countries of the world, is of global scale. The disease’s etiologic basis in the extent of up to 60% of persons within their adolescence or adulthood represents mutations encountered in genes encoding for cardiac sarcomeric proteins.\r\nMethods: The present Diploma Thesis constitutes the result of Literature Research. Literature contained in Textbooks, Studies, and Reviews were utilized. Furthermore, the resource PubMed® and medical research platform Ovid® were applied.\r\nResults: A condition’s Genotype-Phenotype Correlation, even though not unequivocally evident, is discussed while an incomplete and age associated Penetrance has been demonstrated as well as determinants such as Complex Genotypes and Modifier Genes exert influence on the condition. Furthermore, Epigenetics as well as environmental factors have been taken into consideration of influencing Hypertrophic Cardiomyopathy. Hypertrophic Cardiomyopathy is encountered with a variability in morphologic expression, holding different hypertrophic patterns. Its manifestation of hypertrophy presents a substantial interindividual variation with regard to its extent as well as distribution. Possibility of a disease’s subdivision into an asymmetric, concentric, apical, and midventricular form as well as a mass-like manifestation, right ventricular involvement and genotype positive phenotype negative conjuncture, is existent. Therapeutic intervention includes inter alia the implementation of general measures and a pharmacological approach in reference to either, collectives subject to Left Ventricular Outflow Tract Obstruction and individuals in absence of the entity. In case of persons presenting Left Ventricular Outflow Tract Obstruction, invasive therapeutic contingencies constitute the procedures of Ventricular Septal Myectomy and Alcohol Septal Ablation. While Cardiac Pacing as a therapeutic measure is not unequivocally established, the option of Cardiac Transplantation in a subdivision of individuals presenting affirmative eligibility, is available.\r\nConclusion: The condition of Hypertrophic Cardiomyopathy has been subject of a considerable extent of persons directing their attention to. As much information as has been gathered up until present time, entire elucidation of this in part question raising ailment has not been attained.",
            "authors": [
                "Demian, C"
            ],
            "year": 2021,
            "source": "Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2021. pp. 176",
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        {
            "id": 187214,
            "title": "ELECTROCHEMICAL BIOMARKER DETECTION IN COMMON METABOLIC DISORDERS",
            "abstract": "This thesis represents the scientific work done between August 2016 and November 2020 within the PhD programme AMBRA. Its main focus was the detection of biomarkers in common metabolic disorders including diabetes mellitus (DM), polycystic ovary syndrome (PCOS) and cardiovascular disease (CVD), as well as the complex interaction of biomarkers between these research areas. A better interdisciplinary understanding and development of new diagnostic approaches was also a purpose of this thesis. Therefore, chapter I, Biomarker detection with new electrochemical sensor systems, is meant as a developmental technical basis with the aim to serve as framework for the detection and monitoring of biomarkers involved in glucose metabolism. \r\nAdditionally, chapter II, biomarker research in common metabolic disorders using longitudinal study data, and chapter III, detection of PCOS biomarkers after isoflavone intervention, are also linked by using several biomarker approaches and the special need for a point-of-care (POC) testing solution. This will be possible done? by the newly developed analytical method in this thesis - electrochemical biomarker detection. \r\nIn this thesis, data from 1050 patients, including over 2800 datasets were collected, sorted, monitored and categorized over the years. The whole dataset includes more than 300 clinically relevant parameters and in addition 650.000 genotype analyses, NMR metabolomic results, and questionnaire data. Parts of this thesis was already published as one first author paper with an additional one currently in submission. It will also serve as a basis for many further publications to identify or validate new biomarkers.",
            "authors": [
                "Haudum, C"
            ],
            "year": 2021,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Graz Medical University; 2021. pp. ",
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            "document_type": 16,
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        },
        {
            "id": 187215,
            "title": "Investigating novel treatment options to suppress eosinophil effector responses",
            "abstract": "Allergic diseases are a major healthcare problem worldwide affecting up to one third of the global population. Due to their increasing prevalence, they have become one of the most common chronic conditions in childhood. One of the immune cells strongly linked to an aberrant allergic response are eosinophils, which induce tissue damage and remodelling upon their over-activation. Hence, eosinophils have long been considered as important drug targets for development of essential anti-allergic therapeutics. However, additional homeostatic functions of eosinophils have recently been discovered, which warrant the development of alternative treatment options aimed at their over-activation and not elimination. Accordingly, this PhD thesis investigates novel treatment options for targeting eosinophil effector responses as well as provides tools for studying their biology.\r\nIn the first part of my thesis I discovered that endogenous bioactive mediators and cleavage products of inflammatory secretory phospholipases lysophosphatidylcholines (LPCs) inhibit human eosinophil over-activation. We could show that saturated LPCs disrupted lipid-raft mediated signalling on the surface of eosinophils and thereby dampened their effector responses upon activation. Similarly, LPCs suppressed the migration of mouse eosinophils in lungs of animals upon eotaxin stimulation. Thus, our data have uncovered LPCs as compounds with strong modulatory activity on eosinophils and as potential lead compounds used for drug development.  \r\nA disadvantage of using LPCs is that LPCs are rapidly metabolised upon application. Therefore, we next tested a metabolically stable structural analogue (miltefosine) and its mode of action on eosinophils. Miltefosine is an orally bioavailable drug, registered for treatment of the parasitic disease leishmaniasis with proven immunomodulatory functions. Comparable to our findings with LPC, we could observe inhibition of human eosinophil activation upon miltefosine treatment. What is more, we have successfully used miltefosine in preclinical studies, where it significantly reduced the infiltration of eosinophils and other immune cells in models of allergy. Importantly, miltefosine application improved lung function parameters following methacholine challenge in mice proving its suitability as a drug candidate for treatment of eosinophil-associated diseases. \r\nRecent progress in the field of drug targeting of eosinophils has been made with the development of a specific monoclonal antibody that activates the human eosinophil receptor Siglec-8. Targeting Siglec-8 eliminates eosinophils through antibody-dependent cellular cytotoxicity. During my research stay in the USA at the Feinberg School of Medicine in Chicago (Lab of Prof. Bruce Bochner), I investigated a novel transgenic mouse strain in which eosinophils express human Siglec-8 and murine Siglec-F is absent. We were able to show that this mouse strain has great advantages for transient eosinophil depletion. By characterising a novel transgenic mouse model with human-like Siglec expression on eosinophils, we have given research laboratories an entirely new tool to completely deplete eosinophils. \r\nAs part of my thesis I reviewed and evaluated the existing and often conflicting literature on the function of LPCs in the vasculature and summarised it in a review article. In the review article, we highlight LPCs as major endogenous mediators involved in all stages of vascular inflammation and associated diseases. \r\nIn summary, during my thesis I was able to show that lipid raft modulators such as endogenous LPC or its synthetic analogue miltefosine could serve as alternative approaches to target eosinophil overactivation. Furthermore, by characterising a novel transgenic mouse model with human-like Siglec expression on eosinophils, we have provided researchers with a novel tool for superior eosinophil elimination and for further exploration of the Siglec-8 biology.",
            "authors": [
                "Knuplez, E"
            ],
            "year": 2021,
            "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Graz Medical University; 2021. pp. 151",
            "category": 5,
            "document_type": 16,
            "sci": null,
            "pubmed": null,
            "doi": null,
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            "edition": null,
            "university": "Graz Medical University",
            "country": "40",
            "case_report": false,
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        },
        {
            "id": 187216,
            "title": "Repetitive transkranielle Magnetstimulation bei PatientInnen mit chronischen Lumbalgien",
            "abstract": "Zusammenfassung\r\n\r\nGegenstand:\r\nIm Fokus der zugrundeliegenden Studie liegt die repetitive, transkranielle Magnetstimulation zur Behandlung chronischer Schmerzen. Es wurden zwei unterschiedliche rTMS Paradigmen bei PatientInnen mit chronischen Lumbalgien in zwei unterschiedlichen Hirnregionen, dem motorischen Areal (M1) und dem dorsolateralen präfrontalen Cortex (DLPFC), angewandt und mit einer Kontrollgruppe verglichen.\r\n\r\nMethode:\r\n34 PatientInnen mit chronischen Lumbalgien wurden mittels neuronavigierter repetitiver transkranieller Magnetstimulation siebenmal behandelt. Die PatientInnen wurden randomisiert einer von drei Gruppen zugeteilt (M1, DLPFC, Sham). Die TMS wurde 5x in der ersten Woche und je 1x in der dritten und vierten Woche appliziert. Vor- und nach jeder Behandlung wurde die Schmerzintensität mittels NRS-Score ermittelt. Zu Beginn der Behandlungsserie und nach 4 Wochen wurden die Schmerz-, Angst-, Stress- und Depressionsausprägung mittels ausgewählter Module des deutschen Schmerzfragebogens evaluiert. \r\n\r\nErgebnisse:\r\nEs zeigte sich eine signifikante Reduktion der Schmerzintensität zwischen der ersten (vor Beginn der Stimulation mit rTMS) und der zweiten Evaluierung (nach 4 Wochen Stimulation mit rTMS), p=0.015 - die angegebene Schmerzintensität wurde geringer.\r\nKein statistisch signifikanter Unterschied konnte bezüglich der Stress-, Depressions- und Angstausprägung vor- und nach 4 Wochen Behandlung mit rTMS nachgewiesen werden. Es wurden kaum Nebenwirkungen und keine klinische Verschlechterungen beobachtet.\r\n\r\nSchlussfolgerung:\r\nRepetitive transkranielle Magnetstimulation kann die Schmerzintensität bei PatientInnen mit chronischen Lumbalgien signifikant reduzieren und ist deshalb eine vielversprechende Methode, zusätzlich zu konventionellen Therapieansätzen. Weitere Studien sind notwendig um den beobachteten Effekt innerhalb repräsentativer Kohorten zu validieren.",
            "authors": [
                "Hlavka, E"
            ],
            "year": 2021,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2021. pp. 89",
            "category": 5,
            "document_type": 15,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [],
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            "imported": "2021-04-06T10:51:20+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": null,
            "collection_title": null,
            "edition": null,
            "university": "Medizinische Universitaet Graz",
            "country": "40",
            "case_report": false,
            "impactfactor": null,
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            "local_affiliation": false
        },
        {
            "id": 187217,
            "title": "Korrelation der sonographischen kindlichen Gewichtsschätzung in den letzten 2 Wochen vor Geburt und dem tatsächlichen Geburtsgewicht bei Neugeborenen mit Schulterdystokie",
            "abstract": "Fragestellung: Wie korreliert das sonographisch gemessene Geburtsgewicht kurz vor Geburt mit dem tatsächlichen Geburtsgewicht bei Kindern mit Schulterdystokie? Wie verhält sich ein möglicher sonographischer Messfehler des kindlichen Gewichts in diesem besonderen Kollektiv? Haben schwerere Kinder mit einem höheren Messfehler ein schlechteres perinatologisches Outcome?\r\nMaterial und Methoden: Im Rahmen einer retrospektiven Studie wurden alle Fälle mit Schulterdystokie der letzten 10 Jahre (2009-2018) an der UFK Graz analysiert. Die sonographische Schätzung des Geburtsgewichts der Kinder in den letzten zwei Wochen vor Geburt wurde mit dem tatsächlichen Geburtsgewicht in Relation gesetzt. Die Kinder wurden anhand ihres Geburtsgewichts in fünf Gruppen unterteilt. Als signifikanter Messfehler wurden plus/minus ≥ 10 % des tatsächlichen Geburtsgewichts angesehen. Zusätzlich wurde das Outcome der Kinder (Verletzungen, peripartale Asphyxie-Kriterien und Notwendigkeit der Aufnahme auf der Neugeborenen Intensivstation) in Abhängigkeit vom Geburtsgewicht untersucht (Diskriminierungsgrenze 4000g). Ein p-Wert von < 0,05 wurde als signifikant angesehen.\r\nErgebnisse: Von 21.768 vaginalen Geburten während des Beobachtungszeitraums erfüllten 214 (0,98%) die Kriterien einer Schulterdystokie. Ein Geburtsgewicht ≥ 4000g hatten 82 (38 %) und ≥ 4500g hatten 20 (9 %) Kinder. Die sonographische Gewichtsschätzung vor Geburt korrelierte gut bei den Kindern < 3500g Geburtsgewicht. Bei Geburtsgewicht > 4000g divergierte das geschätzte vom tatsächlichen Gewicht stark, mit einem Messfehler im Mittel von 1300g. In 87 (41%) Fällen war der sonographische Messfehler ≥ 10% bei der präpartalen Gewichtsschätzung, wobei Kinder < 3000g eher überschätzt und Kinder > 3000g eher unterschätzt wurden. Der Messfehler war umso größer je höher das Geburtsgewicht war und besonders hoch ab einem Geburtsgewicht von 4500g (Messfehler im Mittel um 1000g). Die Unterschiede zwischen den einzelnen Gruppen waren signifikant mit einem p = 0,000. Bezüglich des Outcomes der Kinder, gab es einen signifikanten Unterschied zwischen dem Geburtsgewicht. Dabei zeigte sich, dass schwerere Kinder ein schlechteres Outcome hatten (p = 0,01).\r\nSchlussfolgerung: Da das Risiko der Schulterdystokie bei Makrosomie erhöht ist, ist die präpartale Gewichtsschätzung des Feten zur Risikoabschätzung von besonderer Bedeutung. Unsere Untersuchung zeigte entsprechend auch der bisherigen Literatur, dass besonders ab einem Geburtsgewicht von 4000g der Messfehler des sonographisch geschätzten Geburtsgewichts besonders groß ist. Weitere Forschung und Daten auf dem Gebiet der zuverlässigen Gewichtsschätzung, sowie sonstiger möglicher Risikofaktoren für die Schulterdystokie sind essenziel.",
            "authors": [
                "Grentner, L"
            ],
            "year": 2021,
            "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2021. pp. 68",
            "category": 5,
            "document_type": 15,
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            "university": "Medizinische Universitaet Graz",
            "country": "40",
            "case_report": false,
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        },
        {
            "id": 187219,
            "title": "Potassium channels in pulmonary circulation.",
            "abstract": null,
            "authors": [
                "Olschewski, A"
            ],
            "year": 2021,
            "source": "Joint Meeting of the Biophysical Society and the Hungarian Academy; April 6, 2021; Debrecen. 2021. ",
            "category": 3,
            "document_type": null,
            "sci": null,
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            "doi": null,
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                "187219-14044"
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                "187219-54345"
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            "bmf_use": false,
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            "local_affiliation": true
        },
        {
            "id": 187221,
            "title": "Pediatric biobanks and parents of disabled children associations opinions on establishing children repositories in developing countries.",
            "abstract": null,
            "authors": [
                "Gramatiuk, SM",
                "Bagmut, IY",
                "Sheremet, MI",
                "Sargsyan, K",
                "Yushko, AM",
                "Filipchenko, SM",
                "Maksymyuk, VV",
                "Tarabanchuk, VV",
                "Moroz, PV",
                "Popovich, AI"
            ],
            "year": 2021,
            "source": "J Med Life. 2021; 14(1): 50-55. ",
            "category": 1,
            "document_type": 1,
            "sci": null,
            "pubmed": "33767785",
            "doi": "10.25122/jml-2020-0106",
            "pmc": "PMC7982269",
            "organizations": [],
            "persons": [
                "187221-54033-6"
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            "imported": "2021-04-06T02:00:00+02:00",
            "journal": "J Med Life",
            "issn": "1844-3117",
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            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 187230,
            "title": "The Infected Pilonidal Sinus – Comparison of Conservative versus Plastic Surgical Treatment after Excision.",
            "abstract": null,
            "authors": [
                "Dahmann, S",
                "Lebo, PB",
                "Meyer-Marcotty, MV"
            ],
            "year": 2017,
            "source": " In: Shiffman, M; Low, M; editors(s). Biofilm, Pilonidal Cysts and Sinuses. Recent Clinical Techniques, Results, and Research in Wounds, vol 1. . 1(1) : Cham: Springer; p. 231-240.  2017(ISBN: 978-3-030-03077-3) ",
            "category": 6,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
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            "persons": [],
            "imported": "2021-04-07T12:38:46+02:00",
            "journal": null,
            "issn": null,
            "collection_publisher": "Shiffman, M; Low, M;",
            "collection_title": "Biofilm, Pilonidal Cysts and Sinuses. Recent Clinical Techniques, Results, and Research in Wounds, vol 1. ",
            "edition": null,
            "university": null,
            "country": null,
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            "biobank_use": false,
            "bmf_use": false,
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            "local_affiliation": true
        },
        {
            "id": 187232,
            "title": "Laboratory Assisted Diagnosis of Functional neurological disorders (FND)",
            "abstract": null,
            "authors": [
                "Schwingenschuh, P"
            ],
            "year": 2021,
            "source": "Functional Neurological Disorder Society - Webinar Series; MAR 3, 2021; Virtuell. 2021. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "187232-14051"
            ],
            "persons": [
                "187232-50172"
            ],
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            "journal": null,
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            "conference_name": true,
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            "selected_presentation": true,
            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 187233,
            "title": "Positionspapier zum hereditären Angioödem  - Aktuelle Empfehlungen: Diagnose und Therapie des hereditären Angioödems",
            "abstract": null,
            "authors": [
                "Kinaciyan,T",
                "Aberer,W",
                "Hawranek,T",
                "Schöffl,C",
                "Zikeli,M"
            ],
            "year": 2021,
            "source": "Clinicum Derma. 2021; ",
            "category": 1,
            "document_type": 30,
            "sci": null,
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            "organizations": [
                "187233-14047"
            ],
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                "187233-95463"
            ],
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            "journal": null,
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            "local_affiliation": true
        },
        {
            "id": 213221,
            "title": "Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT.",
            "abstract": null,
            "authors": [
                "Koziński, M",
                "Oner, D",
                "Gwizdała, J",
                "Beigelman-Aubry, C",
                "Fua, P",
                "Koutsokera, A",
                "Casutt, A",
                "Vraka, A",
                "De, Palma, M",
                "Aubert, JD",
                "Bischof, H",
                "von, Garnier, C",
                "Rahi, SJ",
                "Urschler, M",
                "Mansouri, N"
            ],
            "year": 2025,
            "source": "Commun Med (Lond). 2025; 5(1): 18",
            "category": 1,
            "document_type": 1,
            "sci": "ISI:001400057900002",
            "pubmed": "39820581",
            "doi": "10.1038/s43856-025-00732-x",
            "pmc": "PMC11739420",
            "organizations": [
                "213221-14026"
            ],
            "persons": [
                "213221-63647-6",
                "213221-132960-1"
            ],
            "imported": "2025-01-20T01:00:00+01:00",
            "journal": "Commun Med (Lond)",
            "issn": "2730-664X",
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            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 187248,
            "title": "Do NTRK-positive lung tumors exist?",
            "abstract": null,
            "authors": [
                "Brcic, L"
            ],
            "year": 2021,
            "source": "Spring meeting ÖGPath/IAP Austria and joint meeting with IAP Arab Division; APR 8-10, 2021; Vienna, AUSTRIA. 2021. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
            "pmc": null,
            "organizations": [
                "187248-14020"
            ],
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            "imported": "2021-04-11T23:37:12+02:00",
            "journal": null,
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            "conference_name": true,
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            "biobank_use": false,
            "bmf_use": false,
            "zmf_use": false,
            "local_affiliation": true
        },
        {
            "id": 187249,
            "title": "Intestinal Microbiota Composition and Abundance in Preterm Infants Related to Prophylaxis Regimen of Necrotizing Enterocolitis",
            "abstract": null,
            "authors": [
                "Kurath-Koller, S",
                "Neumann, C",
                "Moissl-Eichinger, C",
                "Kraschl, R",
                "Canduth, C",
                "Hopfer, B",
                "Pausan, MR",
                "Urlesberger, B",
                "Resch, B. \r\n"
            ],
            "year": 2021,
            "source": "Perinatal Society of Australia and New Zealand Virtual Congress - Bridging Gaps in perinatal care - XXIV Annual Congress; MAR 29-31, 2021; Perinatal Society of Australia and New Zealand. 2021. ",
            "category": 3,
            "document_type": null,
            "sci": null,
            "pubmed": null,
            "doi": null,
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            "organizations": [
                "187249-14023",
                "187249-14048",
                "187249-14093",
                "187249-14094"
            ],
            "persons": [
                "187249-51743",
                "187249-100806",
                "187249-90021",
                "187249-59876"
            ],
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            "selected_presentation": true,
            "biobank_use": false,
            "bmf_use": false,
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            "local_affiliation": true
        },
        {
            "id": 187251,
            "title": "Im Blindflug",
            "abstract": null,
            "authors": [
                "Sprenger, M"
            ],
            "year": 2019,
            "source": "Österreichische Krankenhauszeitung. 2019; 60(08-09): 10-11. ",
            "category": 1,
            "document_type": 1,
            "sci": null,
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            "doi": null,
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            "organizations": [
                "187251-14024"
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