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GET /v1/research/publication/?format=api&offset=153300&ordering=-imported
{ "count": 157089, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=153320&ordering=-imported", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=153280&ordering=-imported", "results": [ { "id": 64220, "title": "Zusammensetzung und Stoffwechsel der Lipoproteine.", "abstract": null, "authors": [ "Kostner, GM", "Scharnagl, H", "Kostner, K", "März, W" ], "year": 2007, "source": " In: Schwandt, P; Parhofer, KG editors(s). Handbuch der Fettstoffwechselstörungen. Dyslipoproteinämien und Atherosklerose: Diagnostik, Therapie und Prävention. Stuttgart, Germany: Schattauer; 2007. p. 2-65. (ISBN: 3-7945-2370-9) ", "category": 6, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "64220-14013", "64220-14028" ], "persons": [ "64220-50886", "64220-51669" ], "imported": "2007-01-08T12:46:09+01:00", "journal": null, "issn": null, "collection_publisher": "Schwandt, P; Parhofer, KG", "collection_title": "Handbuch der Fettstoffwechselstörungen. Dyslipoproteinämien und Atherosklerose: Diagnostik, Therapie und Prävention", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 64219, "title": "Ultrafast-Computertomographie und transthorakale Echokardiographie in der Nachsorge herztransplantierter Patienten. Ergebnisse einer klinischen Studie bei therapiereten Akut-Allograft-Transplantatabstoßungsreaktionen. ", "abstract": null, "authors": [ "Kaspar, K" ], "year": 1997, "source": " [ Dissertation ] Karl-Franzens-Universität Graz; 1997. pp.51. ", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "64219-14073" ], "persons": [], "imported": "2007-01-08T12:32:06+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Karl Franzens University Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64218, "title": "Sinnhaftigkeit der chirurgischen Therapie der Morbiden Adipositas mit dem verstellbaren Magenband.", "abstract": null, "authors": [ "Jenic, G" ], "year": 2000, "source": " [ Dissertation ] Karl-Franzens-Universität Graz; 2000. pp.132. ", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "64218-14073" ], "persons": [], "imported": "2007-01-08T12:28:00+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Karl Franzens University Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64214, "title": "Angiotensinogen promoter haplotype dependent regulation of angiotensinogen gene expression", "abstract": "Hintergrund: Angiotensinogen (AGT) ist Teil des Renin-Angiotensin-Systems (RAS). Man kann zwischen systemischen RAS und lokalen RAS in verschiedenen Geweben ua. in Gehirn und Gefäßwand unterscheiden. In der vorangegangenen Austrian Stroke Prevention Study, einer populationsbasierenden Studie an cerebrovaskulären Erkrankungen (cSVD) in Graz, wurden 5 neue Promotorhaplotypen des AGT Genes beschrieben. Die fünf Haplotypen (A, B, C, D und E) unterscheiden sich durch verschiedene Nukleotide an den Positionen -6, -20, -152 und -217 (relative zum Transkriptionsstartpunkt). Menschen die homozygote für den Hyplotypen B sind (Genotype B/B) wiesen die höchste Frequenz (63,6%) und das höchste Risiko (8fach) für cSVD auf. Menschen die eine Kopie von #B in der Abwesenheit von A (Genotyp C/B, D/B oder E/B) aufwiesen hatten bereits eine erhöhte cSVC Frequenz im Vergleich zu allen anderen Kombinationen von Haplotypen. Dieser Zusammenhang zwischen AGT Promotorhaplotyp B und cSVD war unabhängig von Hypertension. Diese Erkenntnis impliziert, dass dieser Effekt eher durch das lokale als das systemische RAS hervorgerufen wird.\r\nHypothese und Zielsetzungen: Unsere Arbeitshypothese geht davon aus, dass AGT Promotorhaplotyp B zu einer Erhöhung der cerebralen AGT Expression im Gehirn RAS führt, die zu der Entwicklung von cSVD führt.\r\nUm diese Hypothese zu unterstützen haben wird die Aktivität der verschiedenen AGT Promotorhaplotypen in Astrozyten (A172 cells), sie sind die Hauptquelle von AGT im Gehirn, und Hepatozyten (HepG2 cells), sie sind die Hauptquelle von AGT in der Leber, getestet. Weiters haben wir den Einfluss von Single nucleotide polymorphism (SNPs) die den Haplotyp B kreieren (Position -6 und -20) auf die Promotoraktivität in beiden Zelltypen bestimmt. Weitere SNPs im AGT Promotor wurden ebenfalls auf ihre funktionelle Relevanz überprüft. Um den Mechanismus von Haplotyp A und B in cSVD zu untersuche, führten wir eine Deletionsanalyse von Haplotyp A und B und eine insilicio Transkriptionsfaktorensuche durch.\r\nMethoden: Das AGT Promotorfragment (nt -1222 to bis +44) der 5 Haplotypen wurde mittels PCR amplifiziert, in den Vektor pGL3-basic geklont und zusammen mit dem Kontrollplasmid phRG-TK in A172 und HepG2 Zellen transfektiert. 48 Stunden nach der Transfektion wurden Zellysate gewonnen und mittels dualem Luciferaseassay wurde deren Promotoraktivitäten bestimmt.\r\nMutationen wurden an den Positionen -6, -20, -152,-217, -1074 und -775 in Haplotyp A mittels PCR eingeführt. \r\n", "authors": [ "Schweighofer, N" ], "year": 2005, "source": "[ Dissertation ] Medical University; 2006. ", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "64214-14013" ], "persons": [], "imported": "2007-01-08T11:39:22+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64213, "title": "Charakterisierung der Terbinafinresistenz in Hefemutanten.", "abstract": null, "authors": [ "Schweighofer, N" ], "year": 2001, "source": " [ Diplomarbeit/Master Thesis ] Karl-Franzens-Univerisät Graz; 2001. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2007-01-08T11:33:04+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Karl Franzens University Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64211, "title": "Testung der Herzfrequenzvariabilität als biophysikalischer Surrogatparameter für komplexe autonome Signaltransduktion und Signlaverarbeitung bei kardialen Erkrankungen und Risikofaktoren.", "abstract": "Einleitung: Der erste Teil dieser Dissertation beschäftigt sich mit dem Literaturstudium über mögliche quantenphysikalische Einflüsse auf den Organismus, sowie Möglichkeiten der Nutzung dieser für Diagnostik und Therapie. Dabei werden die Grundlagen der Quantenphysik, bzw. der Quantenbiologie skizziert und darauf beruhende biologische Abläufe kritisch reflektiert. Der zweite Teil der Arbeit setzt sich mit der Überprüfung und Analyse eines Gerätes auseinander, dessen Hersteller Entwickler den Anspruch erhebt, dieses sei geeignet, quantenphysikalische Einflüsse unter deren Reperkussion auf das autonome Nervensystem zu untersuchen. Das autonome Nervensystem spielt eine wichtige Rolle bei Steurungsvorgängen der Herzfrequenz. Die Messung und Analyse der Herzfreuquenzvariabilität (HRV) ist ein diagnostisches Werkzeug, um Einblick in den Zustand des autonomen Nervensystems zu erhalten. Eine reduzierte HRV zeigt bei Diabetikern den Beginn der reduzierte HRV zeigt bei Diabetikern den Beginn der diabetischen Neuropathie, ist ein etablierter Risikofaktor für plötzlichen Herztod bei Patienten mit Zustand nach Myokardinfarkt und zeigt generell eine Schädigung des autonomen Nervensystems an. Für die Messung der HRV wurden verschiedene Methoden entwickelt: Die Zeitreihenanalyse, die Spektralanalyse und die nichtlineare Methoden. Ziel der Dissertation: Diese Arbeit hat eine zweifache Aufgabenstellung: Durch Literaturrecherchen soll eine theoretische Abhandlung erstellt werden, die quantenphysikalische Phänomene, welche in der Medizin für Diagnostik und Therapie relevant sein könnten (z.B. informationsträger oder Informationstransfer), in verständlicher Form darlegt und auf den möglichen wissenschaftlichen Wert bezogen auf die HRV diskutiert. Ein bislang nicht wissenschaftlich untersuchtes in Entwicklung befindliches gerät und Software zur Messung der HRV sollte kritisch getestet und mögliche Mängel und Fehler aufgezeigt werden. Der Hersteller hat sich zum Ziel gesetzt mittels hoher Auflösung und bestimmten Algorithmen quatenphysikalische Einflüsse auf den Organismus bildgebend darzustellen. Das Gerät sollte in diesem Zusammenhang an Patienten mit definierten kardiovaskulären Erkrankungen kritisch getestet werden. Methoden und Ergebnisse: In dieser Studie wurde der Cardiotest des Gerätes proQuant System der Firma Medical System AG als neues Werkzeug zur Messung der HRV untersucht. Es handelt sich dabei um ein Puls-Messgerät und Analysesoftware. ", "authors": [ "Hecking, C" ], "year": 2003, "source": "[ Dissertation ] Karl-Franzens-Universität Graz; 2003. pp.261. ", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2007-01-08T10:15:59+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Karl Franzens University Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64210, "title": "Cellulose sulfate (NaCS) for microencapsulation of pancratic ß-cells ", "abstract": "Indroduction. At the moment more than 150 million people suffer from diabetes mellitus worldwide. Although there is a wide range of possibilities to treat diabetes, it became apparent that the late complications cannot be prevented totally by exogenous insulin therapy. Islet transplantation may be a therapeutic option. As there is a lack of human donor organs, therefore, immunoisolation is needed to protect the cells from the host immune system. In this work a novel material for micoencapsulation of pancreatic islets is tested. Methods: An insulin producing cell line (HIT-T15) is established in our laboratory and the insulin secretion dependent on the glucose concentration in the nutrient solution is measured by using ELISA. Antibody-stains are used to show that HIT-T15 cells form islet-like clusters. Cells are encapsulated with sodium cellulose sulphate (NaCS) in co-operation with Austrianova, Vienna, and the insulin produced by these cells is detected in media with different amounts of glucose. A MTT cell proliferation test is used to estimate the cell number and the growth is observed by photo documentation. Moreover, insulin-producing cells are located by using an insulin-antibody-staining considering that the microcapsule is three-dimensional. The diffusion of the glucose through the microcapsules is observed with flouroescence maked glucose. Differences in the reaction time of encapsulated and non-encapsulated cells on a glucose stimulus are compared and lactate production as a sign for anaerobic metabolism is measured. Results: HIT-T15 cells show glucose dependent insulin secretion. Cells form islet-like clusters and never build a monolayer. Cell growth and mitose rate are relying on the glucose concentration in the medium. Encapsulation with NaCS is feasible and neither cell growth nor mitose rate are influenced. Insulin production dependent on the glucose concentration in the nutrient solution works in a proper way. Transport of the nutrients and of insulin through the membrane is not inhibited. Cell growth of encapsulated cells is still dependant on the glucose concentration in the medium. Reaction time of encapsulated cells on the glucose stimulus is only delayed about five min compared to non-encapsulated cells can be frozen an thawed according to the needs. Conclusions: HIT-t15 cells show insulin production relying on the amount of glucose in the nutrient solution. Encapsulation with NaCS is feasible and it is shown that the material is permeable for nutrients and that is why cell growth and cell division are guaranteed. ", "authors": [ "Stiegler, Ph" ], "year": 2004, "source": "[ Dissertation ] Medical University Graz\r\nDepartment of Surgery, Div. of Transplantation Surgery; 2004. pp.182. ", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "64210-14045", "64210-14073" ], "persons": [ "64210-50874" ], "imported": "2007-01-08T10:11:44+01:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University Graz\r\nDepartment of Surgery, Div. of Transplantation Surgery", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": false }, { "id": 64233, "title": "Investigation of ACTH responses of chickens with autoimmune disease.", "abstract": null, "authors": [ "Herold, M", "Brezinschek, HP", "Gruschwitz, M", "Dietrich, H", "Wick, G" ], "year": 1992, "source": "Gen Comp Endocrinol. 1992; 88(2):188-198", "category": 1, "document_type": 1, "sci": "ISI:A1992JV74300003", "pubmed": "1335939", "doi": "10.1016/0016-6480(92)90250-N", "pmc": null, "organizations": [], "persons": [ "64233-51807-6" ], "imported": "2007-01-08T01:00:00+01:00", "journal": "Gen Comp Endocrinol", "issn": "0016-6480", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 1.393, "impactfactor_year": 1994, "impactfactor_norm": 0.542168674698795, "impactfactor_norm_year": 1998, "impactfactor_norm_category": "ENDOCRINOLOGY & METABOLISM", "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64285, "title": "Antithrombin III in fetuses and newborn children.", "abstract": null, "authors": [ "Latin, V", "Jankovic, D", "Cervar, M", "Bernt, T", "Fuduric, I" ], "year": 1994, "source": "Acta Obstet Gynecol Scand. 1994; 73(1): 74-75. ", "category": 1, "document_type": 1, "sci": "ISI:A1994MU50200019", "pubmed": "8304033", "doi": "10.3109/00016349409013400", "pmc": null, "organizations": [], "persons": [ "64285-51978-6" ], "imported": "2007-01-08T01:00:00+01:00", "journal": "Acta Obstet Gynecol Scand", "issn": "0001-6349", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 0.767, "impactfactor_year": 1994, "impactfactor_norm": 0.547169811320755, "impactfactor_norm_year": 1998, "impactfactor_norm_category": "OBSTETRICS & GYNECOLOGY", "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64284, "title": "Aluminum poisoning", "abstract": null, "authors": [ "Cervar, M", "Stavljenic, A", "Vukicevic, S" ], "year": 1989, "source": "Lijec Vjesn. 1989; 111(4-5): 164-169. ", "category": 1, "document_type": 3, "sci": null, "pubmed": "2671563", "doi": null, "pmc": null, "organizations": [], "persons": [ "64284-51978-1" ], "imported": "2007-01-08T01:00:00+01:00", "journal": "Lijec Vjesn", "issn": "0024-3477", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64283, "title": "Effects of parathyroidectomy on tissue calcium, phosphorus, magnesium, and copper concentrations in aluminum-loaded uremic rats.", "abstract": null, "authors": [ "Vukicevic, S", "Stavljenic, A", "Boll, T", "Vujicic, G", "Degenhardt, C", "Cervar, M", "Krempien, B" ], "year": 1989, "source": "Biol Trace Elem Res. 1989; 22(1): 45-53. ", "category": 1, "document_type": 1, "sci": "ISI:A1989AY82800005", "pubmed": "2484227", "doi": "10.1007/BF02917415", "pmc": null, "organizations": [], "persons": [ "64283-51978-6" ], "imported": "2007-01-08T01:00:00+01:00", "journal": "Biol Trace Elem Res", "issn": "0163-4984", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": 0.799, "impactfactor_year": 1994, "impactfactor_norm": 0.46, "impactfactor_norm_year": 1998, "impactfactor_norm_category": "NUTRITION & DIETETICS", "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": true, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64282, "title": "Fractures with loss of substance of the middle and upper third of the face: nosographic classification, surgical indications and the prevention of meningeal infections with the new antibiotic, cefuroxime", "abstract": null, "authors": [ "Torrielli, F", "Camurati, R", "Cervar, MF", "Tel, A" ], "year": 1980, "source": "Minerva Stomatol. 1980; 29(3): 163-182. ", "category": 1, "document_type": 1, "sci": null, "pubmed": "6935507", "doi": null, "pmc": null, "organizations": [], "persons": [ "64282-51978-6" ], "imported": "2007-01-08T01:00:00+01:00", "journal": "Minerva Stomatol", "issn": "0026-4970", "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 64281, "title": "The influence of early parathyroidectomy on aluminum-induced rickets in growing uremic rats.", "abstract": null, "authors": [ "Vukicevic, S", "Stavljenic, A", "Boll, T", "Cervar, M", "Degenhardt, C", "Mihaljevic, T", "Krempien, B" ], "year": 1989, "source": "Bone Miner. 1989; 6(2): 125-139. 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