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GET /v1/research/publication/?format=api&offset=152780&ordering=impactfactor
{ "count": 155764, "next": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=152800&ordering=impactfactor", "previous": "https://api-test.medunigraz.at/v1/research/publication/?format=api&limit=20&offset=152760&ordering=impactfactor", "results": [ { "id": 187927, "title": "Pressure injury characteristics and nursing interventions in older and very old persons.", "abstract": null, "authors": [ "Hoedl, M", "Osmancevic, S" ], "year": 2021, "source": "Abstract book of the 5th EPUAP Focus Meeting. 2021; 22-22.-5th EPUAP Focus Meeting; May 26,2021; Sonderborg. ", "category": 2, "document_type": 19, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "187927-14509" ], "persons": [ "187927-100525", "187927-59569" ], "imported": "2021-06-10T09:39:45+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": true, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 187928, "title": "Eating Habits and Eating Disorder associated Behaviour in Bipolar Disorder.", "abstract": "Objectives: An essential aspect of bipolar disorder (BD) research is the identification of psychiatric and somatic comorbidities. A variety of epidemiological data and clinical studies show correlations between eating disorders (ED) and BD. In particular, crossed vulnerability factors as eating disorder-specific symptoms (EDSS) may trigger the onset of both disorders in either direction.\r\nMethods: The present study used the self-rating questionnaire Structured Inventory for Anorexic and Bulimic Eating Disorders for Self-Report (SIAB-S) to examine the occurrence of DSM-IV diagnosis for anorexia nervosa, binge eating disorder, and bulimia nervosa in euthymic/subsyndromal individuals with BD (n=86) and healthy controls (HC; n=86). Both groups were adjusted in age and sex. Furthermore, we explored EDSS with the six subscales of SIAB-S: ‘general psychopathology and social integration’, ‘bulimic symptoms’, ‘body image and slimness ideal’, ‘sexuality and body weight’, ‘counteract’, and ‘atypical binge’.\r\nResults: There were no ED diagnosis, neither in the BD group nor in HC. A significantly higher rate of all EDSS was reported in BD participants, compared to HC. Younger individuals with BD show higher expression in ‘bulimic symptoms’, ‘body image and slimness ideal’, and ‘atypical binge’ subscales. No differences in EDSS between males and females were found in the BD group.", "authors": [ "Hirte, TS" ], "year": 2021, "source": " [ Diplomarbeit/Master Thesis (UNI) ] Karl-Franzens-University Graz; 2021. pp.21. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-10T10:03:50+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Karl-Franzens-University Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187931, "title": "Structural biology in medical research", "abstract": null, "authors": [ "Krebs, A." ], "year": 2020, "source": "Seminar, Clin. Inst. f. Med. & Chem. Laboratory Diagnostics, Med Uni Graz; Nov 3, 2020; Graz. 2020. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-10T11:21:25+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 187932, "title": "Die Welt mit molekularen Augen sehen", "abstract": null, "authors": [ "Krebs, A" ], "year": 2020, "source": "Science Lunch, Scientific Society of Med. Doctors in Styria; Nov 19, 2020; online, Med Uni Graz. 2020. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-10T11:27:10+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": false, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 187936, "title": "End of life: a concept analysis", "abstract": null, "authors": [ "Gerhilde Schüttengruber\r\nRuud Halfens\r\nChrista Lohrmann\r\n" ], "year": 2021, "source": "Interdisciplinary Perspective on Aging and Care: What Does It Mean to Grow Old? \r\n; June 10, 2021; Center for Interdisciplinary Research on Aging and Care. 2021. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "187936-14509" ], "persons": [ "187936-85011" ], "imported": "2021-06-10T20:28:12+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 187938, "title": "Choroidal Volume Measurements with Optical Coherence Tomography Before and After External Counterpulsation", "abstract": "External counterpulsation is a noninvasive therapy for coronary artery disease shown to improve peripheral flow-mediated dilation.\r\n\r\nThe purpose of this thesis is to examine potential changes in choroidal volume following external counterpulsation.\r\n\r\nThree groups of study participants (healthy, smokers and diabetics) were examined with Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography before and after a 45-minute session of External Counterpulsation. These investigations were part of a larger study focusing on retinal vessel analysis after personalized shear rate therapy (RAST).\r\n\r\nChoroidal volume across all groups increased significantly at an average of 2,59% ± 2,77% (range -3,09% to 10,19%, p < 0,001). The healthy subgroup showed a significant average augmentation of 3,22% ± 2,46% (range 0,26% to 7,67%; p < 0,001). The diabetics showed an average augmentation of 2,70% ± 2,93% (range 0,28% to 10,19%, p = 0,012), while smoking study participants showed an average increase in choroidal volume of 1,76% ± 2,98% (range -3,09% to 6,16%, p = 0,055).\r\nSubfoveal choroidal thickness increased significantly at an average of 4,26% ± 6,36% (range -9,69% to 18,21%, p < 0,001) across all groups. Subfoveal choroidal thickness increased at an average of 4,41% ± 6,58% (range -9,69% to 14,29%, p 0,009) in the healthy subgroup, 4,8% ± 6,17% (range -2,39% to 18,21%, p 0,0055) in the smoking group and 3,15% ± 6,73% (range -7,31% to 14,66%, p 0,152) in the diabetic group.\r\n\r\nThe results of this study suggest that external counterpulsation may in the short term increase choroidal volume in non-smoking, otherwise healthy individuals and early diabetics.", "authors": [ "Gran, J" ], "year": 2021, "source": "Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2021. pp. ", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University of Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187939, "title": "Ermittlung von Breakpoints für Amoxicillin/Clavulansäure und Ampicillin/Sulbactam für Klebsiella pneumoniae im Rahmen der beschleunigten Sensibilitätstestung von Bakterien aus positiven Blutkulturen nach EUCAST", "abstract": "Hintergrund: Trotz der Entwicklung neuer technischer Methoden für den Nachweis und die Identifizierung von Erregern aus positiven Blutkulturflaschen ist das konventionelle Kulturverfahren für die Erstellung eines Antibiogrammes nach wie vor obligat. Dessen Ergebnis bildet einen unverzichtbaren Eckpfeiler für Therapieentscheidungen und Behandlungsmöglichkeiten. Zudem spielt der zeitliche Faktor vor allem bei Verdacht auf Sepsis und/oder septischen Schock eine große Rolle, der auch durch das vermehrte Auftreten von nosokomialen Infektionen und die Verbreitung von Resistenzen zunehmend an Bedeutung gewinnt. Dem European Committee on Antimicrobial Susceptibility Testing (EUCAST) ist es mit der Entwicklung von Rapid Antimicrobial Susceptibility Testing (RAST) nun gelungen, das Zeitfenster zugunsten eines schnellstmöglichen Ergebnisses zu optimieren. Dabei erfolgt der Empfindlichkeitsnachweis direkt aus positiven Blutkulturen innerhalb einer Inkubationszeit von 4, 6 und 8 Stunden. \r\n\r\nZiel: Die RAST Methode ist derzeit nur für eine begrenzte Anzahl von Keimen und antiinfektiven Substanzen verfügbar. Das Ziel dieser Studie ist daher, die Festlegung neuer Breakpoints für Klebsiella pneumoniae, einen vielfach mit nosokomialen Infektionen assoziierten Keim, für zwei häufig eingesetzte antimikrobielle Substanzen in Österreich. Dabei handelt es sich um Amoxicillin/Clavulansäure und Ampicillin/Sulbactam. \r\n\r\nMethodik: Die Studie wurde mit insgesamt 81 Klebsiella pneumoniae Stämmen, die das Diagnostik- und Forschungsinstitut für Hygiene, Mikrobiologie und Umweltmedizin sowie die Sektion für Infektiologie und Tropenmedizin, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, zur Verfügung stellten, durchgeführt. Die Basis für die Grenzwertermittlung im Rahmen der RAST Methode bildeten Blutkulturflaschen mit 5 ml Blut, welches aus einer abgelaufenen Blutkonserve stammte. Die Blutkulturen wurden mit dem Keim gespiked und in ein automatisiertes Blutkulturgerät gegeben. Sobald die Blutkulturen ein positives Signal zeigten, wurde Blut auf die Agarplatten ausgestrichen, die entsprechenden Antibiotikaplättchen appliziert und anschließend inkubiert. Nach einer Inkubationszeit von 4 sowie 6 Stunden wurden die Hemmhofdurchmesser von der Vorderseite der Agarplatten abgelesen. Daneben wurden der Routinescheibendiffusionstest sowie Etest® durchgeführt und nach 24 Stunden abgelesen. Die Ergebnisse von RAST wurden zur minimalen Hemmkonzentration (MHK) in Beziehung gesetzt und Grenzwerte für die Kategorien „empfindlich“ und „resistent“ festgelegt. Die Studie erfolgte von Ende August 2020 bis Mitte Oktober 2020 im mikrobiologischen Labor des Universitätsklinikums für Innere Medizin Graz.\r\n\r\nErgebnisse: Aufgrund eines Doppelansatzes der 81 Klebsiella pneumoniae Stämme war es möglich, 162 Testergebnisse für die Ermittlung der neuen Grenzwerte zu erzielen. RAST Grenzwerte wurden für Klebsiella pneumoniae und Amoxicillin/Clavulansäure festgelegt: \r\nS ≥ 16 mm, ATU 13-15 mm, R < 13 mm nach 4 h und S ≥ 16 mm, ATU 14-15 mm, \r\nR < 14 mm nach 6 h. Für Ampicillin/Sulbactam gelten: S ≥ 12 mm, ATU 10-11 mm, \r\nR < 10 mm nach 4 h und S ≥ 13 mm, ATU 12 mm und R < 12 mm nach 6 h. \r\n\r\nFazit: Es konnten neue Grenzwerte für Klebsiella pneumoniae bei Amoxicillin/Clavulansäure und Ampicillin/Sulbactam für RAST für das Ablesen nach 4 Stunden und 6 Stunden festgelegt werden.", "authors": [ "Zechner-Sammer, T" ], "year": 2021, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2021. pp. 56", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universitaet Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187940, "title": "SGLT2 Inhibitors: Redefining Antidiabetic Therapy", "abstract": "Background\r\nSGLT2 inhibitors were developed to combat the growing epidemic of diabetes and the consequences of diabetes, e.g. chronic kidney disease and cardiovascular complications, by increasing the excretion of glucose in urine and thereby reducing blood sugar levels. These medications have shown to be effective both in lowering blood sugar as well as preventing adverse cardiac events. Why then are SGLT2 inhibitors not being used in all treatments of diabetes as the mortality rates of the two leading causes of death in diabetic patients could be lowered?\r\nMethods\r\nA basis of inquiry was formed by studies from the Pubmed and Cochrane library, as well as more clinical aspects in the form of lectures by the Medical University Graz or through further online sources and the guidelines issued by the OEDG (Austrian Diabetes Society). The risk benefit profiles of other antidiabetic medications were compared to SGLT2 inhibitors.\r\nResults\r\nWhilst the effectiveness of SGLT2 inhibitors’ ability to lower HbA1C values is similar to other antidiabetic agents, they have the ability to improve both cardiovascular and chronic kidney disease outcomes and lead to weight loss.\r\nThe often cited side effects of SGLT2 inhibitors were scrutinised and myths about SGLT2 inhibitors wide side effect spectrum could be dispelled.\r\nSome side effects and risks for certain substances in the SGLT2 inhibitor group could be confirmed by studies, RCTs and meta-analyses.\r\nConclusion\r\nThe ability of SGLT2 inhibitors to reduce cardiac and renal causes of mortality whilst reducing blood sugar at the same time in addition to their limited side effect profile, they play a critical role in today’s and the future treatment of type 2 diabetes. The fact that a few substances within the SGLT2 inhibitor group have been proven to have drastic side effects should not lead to a loss of confidence or a reduction of use in the remaining substances of the group. SGLT2 inhibitors position in the treatment scheme of the OEDG as one of the main secondary substances used is well justified.", "authors": [ "Lewis, J" ], "year": 2021, "source": "Humanmedizin; [ Diplomarbeit ] Medical University of Graz; 2021. pp. 53", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University of Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187941, "title": "Frontale fibrosierende Alopezie der Frau (Mb. Kossard) Mögliche Therapieansätze für die frontale fibrosierende Alopezie der Frau \r\n\r\n\r\nFrontale fibrosierende Alopezie der Frau (Mb. Kossard)\r\nMögliche Therapieansätze für die frontale fibrosierende Alopezie der Frau", "abstract": "Zusammenfassung\r\n\r\nHintergrund\r\nDie ‚frontale fibrosierende Alopezie’ gilt als seltene Variante des ‚Lichen planus’, welche am häufigsten postmenopausale Frauen betrifft. Es handelt sich um eine chronische lymphozytäre Entzündung des Haarfollikels, die zu einer schleichenden Follikelatrophie mit folgender Alopezie führt. Der bandförmige, symmetrisch progrediente und unwiderrufliche Rückgang der vorderen Haaransatzlinie, mit Untergang der Haarfollikel im vorderen Bereich der Kopfhaut, ist typisch für diese Erkrankung. Oft sind auch die Augenbrauen, beginnend lateralseitig, davon betroffen. \r\nMänner sind von dieser Erkrankung vergleichsweise selten betroffen. Ätiologisch geht man von einer autoimmunologischen Reaktion aus.\r\nEine wirksame standardisierte Therapie gibt es bislang nicht.\r\n\r\nZiel\r\nZiel dieser Arbeit ist eine Literaturrecherche über diese Erkrankung und das Erarbeiten eines sinnvollen Therapie-Algorithmus. Ein stufenweise aufgebauter Behandlungsplan wäre für die Betroffenen hilfreich, da sie unter einem enormen Leidensdruck stehen.\r\nEs gilt eine Informationssammlung aus verschiedenen Quellen durchzuführen und diese vor allem in Bezug auf eine mögliche Therapie zu analysieren und daraus eine Therapieanleitung zu entwickeln.\r\nDiese Arbeit wird sich vor allem auf weibliche Personen, welche die Diagnose ‚frontale fibrosierende Alopezie’ erhalten haben, konzentrieren.\r\n\r\nMethoden\r\nEs werden Patientinnen, welche die Diagnose ‚frontale fibrosierende Alopezie’ erhalten haben, für diese Arbeit näher betrachtet und die verordnete Therapie evaluiert. \r\nZur Wissensgewinnung dient eine Recherche aus dermatologischer Fachliteratur. \r\nErgebnisse\r\nDie frontale fibrosierende Alopezie ist eine seltene vernarbende Kopfhauterkrankung, welche sich durch das Zurückweichen des frontotemporalen Kopfhaaransatzes auszeichnet und die vor allem bei postmenopausalen Frauen auftritt. Aktuell ist keine klare Ursache bekannt, vermutet wird ein Zusammenspiel aus genetischen, hormonellen und Umweltfaktoren. \r\nDas primäre Ziel der Behandlung ist es das Fortschreiten des Haarausfalls zu verhindern. Da es bisher keinen schlüssigen Therapieplan gibt, hat die Literaturrecherche folgendes ergeben: \r\n5aRIs und intraläsionale Steroide gelten als First Line Therapie. Alternativ können topisch angewendete Calcineurin Inhibitoren, Minoxidil, Hydroxychloroquin, oder Excimer-Laser eingesetzt werden. Es wird zu einer Kombination unterschiedlicher Präparate geraten.\r\n\r\nSchlussfolgerung\r\nAufgrund des seltenen Auftretens ist die frontale fibrosierende Alopezie noch nicht ausreichend erforscht. Es müssen noch mehr Daten zu dieser Erkrankung erhoben werden, um die genaue Pathogenese feststellen zu können und um einen wirksamen Therapieplan für alle Betroffenen der frontalen fibrosierenden Alopezie erstellen zu können.\r\nDerzeit stellt eine Kombinationstherapie von mehreren Präparaten die wirksamste Behandlungsmöglichkeit dar.\r\n ", "authors": [ "Falkensteiner, K" ], "year": 2021, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2021. pp. 101", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universitaet Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187942, "title": "Epidemiologie schwerer CO-Intoxikationen in Ostösterreich - Retrospektive Analyse", "abstract": "Hintergrund: Kohlenmonoxid-Intoxikationen zählen weltweit zu den häufigsten Vergiftungen. Bis auf eine Studie aus dem Jahre 1995 aus Wien existiert keine epidemiologische Untersuchung zu schweren Kohlenmonoxidvergiftungen in Österreich. In der vorliegenden Diplomarbeit werden der Vergiftungshergang, Klinik und Laborbefunde sowie der Einfluss der hyperbaren Sauerstofftherapie auf die Intoxikation analysiert und Präventionsstrategien diskutiert.\r\n\r\nMaterial und Methoden: Die rektrospektive Analyse wurde auf der Basis der Daten von 305 Patient*innen die zwischen 2006 bis 2018 mit der Diagnose „Kohlenmonoxidvergiftung“ in der Druckkammer der Klinischen Abteilung Thorax- und Hyperbare Chirurgie im Universitätsklinikum Graz behandelt erstellt. Neben den Hauptzielgrößen CO-Quelle, Medium und Kontaktart, wurden als Nebenzielgrößen demographische Daten, Symptome, Begleitverletzungen und -intoxikationen, Blutgasanalysewerte vor und nach HBO, Anzahl an HBO-Sitzungen, Dauer und Art des Krankenhausaufenthalts und Komplikationen erhoben und mittels SPSS ausgewertet.\r\n\r\nErgebnisse: Häufigste CO-Quelle war die Gastherme [33,08 %], gefolgt von Wohnungsbrand [19,93 %], Kraftfahrzeugabgas [10,53 %] und Holzkohlegrill [9,02 %]. Meist führten Unfälle [52,67 %] oder Defekte [32,38 %], seltener Suizidversuche [10,32 %] und Arbeitsunfälle [4,63 %], über Abgas bzw. Rauchgas zur Vergiftung. Bei fast der Hälfte der Ereignisse [48,2%] war nur eine Person betroffen. 184 [60,3 %] der Vergiftungsopfer waren Männer und 121 [39,6 %] Frauen. Das mittlere Alter lag bei 38,1+/-18,3 Jahren (Range: 1 – 89). Die häufigsten Symptome waren Kopfschmerz, Schwindel und Übelkeit. In den meisten Fällen wurden 3 HBO-Sitzungen angewandt. Nur 19 von 293 Fälle wurden ambulant behandelt. 2 Patient*innen erlitten infolge der CO-Intoxikationen einen NSTEMI, 2 weitere verstarben.\r\n\r\nSchlussfolgerung: Eine Vielzahl an Kohlenmonoxid-Intoxikationen wäre durch Information, regelmäßige Wartung und Warnsysteme vermeidbar. Die HBO ist als Therapie der Wahl bei schweren CO-Intoxikationen zu werten.", "authors": [ "Starz, M" ], "year": 2021, "source": "Humanmedizin; [ Diplomarbeit ] Medizinische Universitaet Graz; 2021. pp. 70", "category": 5, "document_type": 15, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medizinische Universitaet Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187943, "title": "Role of microRNA-424(322)/503 in epidermal Langerhans cell\r\nand monocyte-derived dendritic cell differentiation", "abstract": "MicroRNAs are small non-coding RNAs, which regulate key biological processes in immune cells and define their phenotype and functions. Deficiency of Dicer, an enzyme critical for microRNA processing, in murine CD11c+ cells revealed dysregulated dendritic cell (DC) development and function. However, the implication of individual microRNAs in the process of DC differentiation remains poorly understood. Therefore, we focused our studies on the molecular mechanisms regulated by specific microRNAs in DC subset specification. \r\nOur group previously searched for the microRNAs that are differentially expressed by human DC subsets. We identified that miR-424(322)/503 is strongly upregulated in pro-inflammatory monocyte –derived dendritic cells (moDCs) in comparison to anti-inflammatory Langerhans cells (LCs). Using lentiviral gain- and loss-of-function approach we confirmed that miR-424(322)/503 is critical for moDC development. Conversely, LCs were unaffected by the miR-424(322)/503 deficiency. We identified that miR-424(322)/503 is required for moDC differentiation. \r\nTo determine whether miR-424/503 is also involved in molecular mechanisms of moDCs differentiation in vivo, we subjected miR-424(322)/503 (miR-KO) mice to a clinically relevant model of psoriasis-like skin inflammation. We observed that moDCs subsets were significantly reduced in the dermis of miR-KO mice under inflammatory conditions in comparison with the WT mice. However, DC-precursors in the fresh isolated bone marrow were equally present in both conditions. Similarly, the percentage of ex vivo differentiated bone marrow - derived DCs (BMDCs) was diminished in miR-KO mice. Consequently, our murine data corroborate our findings in human moDC vs. LC differentiation that moDCs development was selectively dependent on miR-424(322)/503. \r\nFinally, we characterized the transcriptional profile of BMDCs generated from miR-KO mice and found TGF-β signature genes to be upregulated in miR-KO cells. Consistent with that, loss of miR-424(322)/503 facilitated TGF-β1-dependent LC differentiation at the expense of moDC differentiation. Thereby, we proposed a model where miR-424(322)/503 acts as a molecular switch for LCs vs. moDCs cell fate lineage decision via modulating TGF-β signaling. Our findings substantiate the pivotal role of miR-424(322)/503 in moDCs differentiation both in vitro and in vivo. In the study we provided several novel insights into the mechanisms underlying differentiation of two functionally different DC subsets (moDCs and LCs) from the common monocytic precursor.", "authors": [ "Zyulina, V" ], "year": 2021, "source": "PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medical University of Graz; 2021. pp. 104", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University of Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187944, "title": "Gender-related differences in blood parameters and their influence on the intraoperative blood loss in orthognathic surgery", "abstract": "Orthognathic surgical interventions are common maxillofacial procedures that aim to correct complex dentofacial deformities and concomitant skeletal malocclusion. These elective procedures follow highly standardised intraoperative protocols, which optimise patient safety and help to accurately administer a surgical plan. However, owing to the well-vascularised anatomy of the midface, blood loss remains among the major issues associated with orthognathic surgery. In this context, patient gender has frequently been highlighted as a crucial factor, with males associated with a higher surgical blood loss. Specific underlying mechanisms leading to these gender-related differences in orthognathic bleeding volumes have scarcely been investigated. Hence, the aim of this study was to analyse blood loss related to standardised orthognathic procedures with a special emphasis on patient gender. An additional aim was to ascertain gender-based differences in blood and haemostatic parameters and subsequently correlate these parameters with orthognathic blood loss. \r\n\r\nHealthy male and female individuals, scheduled to undergo bimaxillary surgery or bilateral sagittal split osteotomy (BSSO), were considered eligible for this study. Blood loss was standardly measured at three time points by two well-established approaches in the field of orthognathic surgery. Intraoperative blood loss (IOB) was determined using the subtraction method; perioperative blood loss was calculated 24- and 48-hours after surgery (CBL-24h; CBL-48h) by means of the ‘haemoglobin balance method’. All bleeding volumes determined were analysed according to the treatment modality applied and patient gender. Prior to surgery, a detailed coagulation analysis was performed comprising routine coagulation assays, global coagulation assays (endogenous thrombin potential) and specific haemostatic parameters. Relevant parameters were correlated with the intra- and perioperative blood loss (IOB and CBL-48h) to investigate the effect of gender-related differences in the haemostatic profile on a patient’s blood loss. \r\n\r\nA total of 103 patients (38 male, 65 female) were included in the final analysis, 54 of whom underwent bimaxillary surgery and on 49 of whom BSSO was performed. \r\nRegarding patient sex, no gender-specific differences in terms of the intraoperative blood loss (IOB) were detected. With reference to CBL-24h and CBL-48h, however, statistically significant differences in terms of the bleeding volumes were found, but, were confined to the bimaxillary-cohort. In more detail, CBL-48h in males was found to significantly outreach that associated with females (male 907.7ml ± 246.1 vs female: 730.8ml ± 274.5; p=0.019). Regarding the haemostatic parameters analysed, few significant gender-related differences were detected including the parameters 'activated partial thromboplastin time (aPTT)', 'Antithrombin III', 'endogenous thrombin potential (ETP-auc)' and 'coagulation factor IX'. A significant correlation between the level of Antithrombin III and CBL-48h in the bimaxillary-cohort (r=0.474; p=0.001) was found. Regarding the IOB, the length of the procedure was identified as most significantly affecting the amount of blood loss.\r\n\r\nSeveral parameters were identified as responsible for affecting the amount of blood loss, whereby patient gender was found to be less of a contributing factor than previously suggested. While the amount of intraoperative blood loss (IOB) related to orthognathic surgical procedures appeared to be significantly affected by the treatment modality applied together with the length of the procedure, patient gender and associated differences in the haemostatic profile were irrelevant in this context. In contrast, our findings indicate that gender-related peculiarities in the haemostatic cascade are most visible in the immediate postoperative period, where bleeding into tissue spaces as well as the maxillary sinuses is likely to pertain.", "authors": [ "Schwaiger, M" ], "year": 2021, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medical University of Graz; 2021. pp. 148", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University of Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187945, "title": "Skin regeneration and wound healing after mesenchymal stromal/stem cell treatment is dose dependent", "abstract": "Background: Skin regeneration and wound healing is crucial, especially after a burn injury. Mesenchymal stromal cell (MSC) therapy is under investigation in promising (pre)clinical trials to restore the damaged skin; however, the optimal cell dosage for therapy remains unknown. \r\nHypothesis: Different low-to-high MSC dosages promote outcome measures differently in skin regeneration and wound healing.\r\n\r\nMethods: We conducted a porcine study (N = 8 Yorkshire pigs) and seeded between 200–2,000,000 cells/cm2 of umbilical cord mesenchymal stromal cells (UC-MSCs) on a biodegrada-ble collagen-based dermal regeneration template (DRT) Integra® and grafted it onto full-thickness burn excised wounds. On day 28, we compared the different low-to-high cell dose groups, the acellular control, a burn wound, and healthy skin. \r\n\r\nResult: We found that the low dose with 40,000 cells/cm2 regenerates the full-thickness burn excised wounds most efficaciously, followed by the dose groups 5,000 cells/cm2 and 200,000 cells/cm2. The low dose of 40,000 cells/cm2 accelerated re-epithelialization, reduced scarring, regenerated epidermal thickness superiorly, enhanced neovascularization, reduced fibrosis and reduced type 1 and type 2 macrophages compared to other cell dosages and the acellular control.\r\n\r\nImportance: This regenerative cell therapy study using MSCs shows efficacy when utilizing a low dose, which changes the paradigm that more cells lead to better wound healing outcome.", "authors": [ "Eylert, G" ], "year": 2021, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medical University of Graz; 2021. pp. 100", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University of Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187946, "title": "The gut-liver-axis in secondary sclerosing cholangitis after critical illness", "abstract": "Background: The rare chronic cholestatic liver disease secondary sclerosing cholangitis in critically ill patients (SC-CIP) occurs in patients after long-term intensive care treatment with invasive ventilation and hemodynamic support without prior liver pathology.\r\nAims: We aimed to describe the healthy gut-liver axis and to outline pathological disruptions of this equilibrium in chronic cholestatic liver diseases. We planned to assess the stool microbiome composition, gut permeability, bacterial translocation, and serum bile acid profiles of SC-CIP patients compared to patients after critical illness without liver disease (CIP controls), patients with cirrhosis, and healthy controls within a case-control study. Furthermore, we aimed to evaluate the frequency and characteristics of gastrointestinal bleedings in SC-CIP with a retrospective analysis.\r\nMethods: We conducted a narrative review outlining the actual knowledge about the gut-liver axis in chronic cholestatic liver diseases. 16S rDNA was isolated from stool of the four cohorts and sequenced using the Illumina technique. Diamine oxidase, zonulin, soluble CD14 and lipopolysaccharide-binding protein were determined in serum and calprotectin in stool. Serum bile acids were analyzed by high-performance liquid chromatography-mass spectrometry (HPLC-MS). For the retrospective part concerning gastrointestinal bleedings, patients with diagnosed SC-CIP were identified and compared to a control group of patients with history of intensive care treatment after cardiac surgery, but without development of SC-CIP.\r\nResults: With the conducted review, we could demonstrate that the gut-liver axis is altered in chronic cholestatic liver diseases and that observed alterations seem to play a role in the pathogenesis of these diseases. Eighteen SC-CIP patients, 11 CIP controls, 21 cirrhotic patients, and 21 healthy controls were included in the microbiome analysis. The microbiome of SC-CIP patients showed reduced alpha diversity and altered beta diversity compared to healthy controls. A shift towards pathogenic taxa and an oralization of the fecal microbiome was observed. Impaired gut permeability, elevation of biomarkers of bacterial translocation, and an altered serum bile acid profile were further recognized in SC-CIP. CIP controls also showed decreased diversity and a changed taxonomic composition of the microbiome compared to healthy controls. Fifty-three patients with SC-CIP and 19 controls were included in the retrospective study. Frequency of gastrointestinal bleeding was 30% in SC-CIP (16 patients) and 5% in the control group (1 patient) (p=0.03). In SC-CIP, 13 bleedings were reported in the upper gastrointestinal tract. Most common reasons for bleeding were gastroduodenal ulcers. \r\nConclusion: The gut–liver axis is altered in SC-CIP. The liver disease cannot solely be accused to induce these alterations, since there seems to be an additional lasting effect of the long-term intensive care treatment on microbiome composition. Gastrointestinal bleeding is a frequent complication in patients with SC-CIP, but it remains to be determined which factor is responsible for this susceptibility.", "authors": [ "Blesl, A" ], "year": 2021, "source": "Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medical University of Graz; 2021. pp. 103", "category": 5, "document_type": 16, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "187946-14081" ], "persons": [ "187946-74515" ], "imported": "2021-06-11T11:29:46+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": "Medical University of Graz", "country": "40", "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187948, "title": "\"Complete Mastery of the Subject\". The Connection between Forced Sterilization and Gynecological Fertility Research in National Socialism.", "abstract": null, "authors": [ "Czarnowski, G" ], "year": 2021, "source": " In: Hildebrandt, S; Offer, M; Grodin, M A; editors(s). Recognizing the Past in the Present. New Studies on Medicine before, during and after the Holocaust. New York, Oxford: Berghahn ; p. 125 - 139. 2021(ISBN: 9781789-207842) ", "category": 6, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "187948-14024" ], "persons": [ "187948-50862" ], "imported": "2021-06-11T14:22:09+02:00", "journal": null, "issn": null, "collection_publisher": "Hildebrandt, S; Offer, M; Grodin, M A;", "collection_title": "Recognizing the Past in the Present. New Studies on Medicine before, during and after the Holocaust", "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": true, "local_affiliation": true }, { "id": 187955, "title": "Invasive Fungal Infections (IFIs) in immunocompromised patients", "abstract": null, "authors": [ "Hoenigl, M" ], "year": 2021, "source": "CSH-EHA Joint Symposium as part of the Annual Conference of the Chinese Society for Hematology; MAY 30, 2021; Shanghai, CHINA. 2021. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "187955-29164" ], "persons": [ "187955-64754" ], "imported": "2021-06-14T11:25:19+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 187957, "title": "Performance of different lateral flow assays for rapid detection of aspergillosis.", "abstract": null, "authors": [ "Hoenigl, M" ], "year": 2021, "source": "Mycology 2021; JUNE 11, 2021; London, UNITED KINGDOM. 2021. ", "category": 3, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "187957-29164" ], "persons": [ "187957-64754" ], "imported": "2021-06-14T11:27:10+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": true, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 187959, "title": "Fungal superinfections complicating severe COVID-19 in the ICU.", "abstract": null, "authors": [ "Hoenigl, M" ], "year": 2021, "source": " . 2021; -EHA 2021 Virtual; JUN 11-16, 2021; Frankfurt, GERMANY. ", "category": 2, "document_type": 22, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [ "187959-29164" ], "persons": [ "187959-64754" ], "imported": "2021-06-14T11:33:20+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": true, "conference_place": true, "conference_international": true, "scientific_event": true, "invited_lecture": true, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": true }, { "id": 187961, "title": "Ernährungsmedizin", "abstract": null, "authors": [ "Widhalm, K", "Fallmann K", "" ], "year": 2020, "source": "1010 Wien: Verlagshaus der Ärzte GmbH; 2020. pp. 416. (ISBN: 978-3-99052-221-9) ", "category": 14, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [ "187961-108983" ], "imported": "2021-06-15T09:11:24+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false }, { "id": 187962, "title": "Ernährungsmedizinische Aspekte beim Kurzdarmsyndrom", "abstract": null, "authors": [ "Berger S", "Traub J", "" ], "year": 2020, "source": ". 2020", "category": 12, "document_type": null, "sci": null, "pubmed": null, "doi": null, "pmc": null, "organizations": [], "persons": [ "187962-108983" ], "imported": "2021-06-15T09:31:49+02:00", "journal": null, "issn": null, "collection_publisher": null, "collection_title": null, "edition": null, "university": null, "country": null, "case_report": false, "impactfactor": null, "impactfactor_year": null, "impactfactor_norm": null, "impactfactor_norm_year": null, "impactfactor_norm_category": null, "impactfactor_norm_super": null, "impactfactor_norm_super_year": null, "impactfactor_norm_super_category": null, "citations": null, "conference_name": null, "conference_place": null, "conference_international": false, "scientific_event": false, "invited_lecture": false, "keynote_speaker": false, "selected_presentation": false, "biobank_use": false, "bmf_use": false, "zmf_use": false, "local_affiliation": false } ] }